• Using proteomic approaches, we identified filamins as proteins that associate with the extreme CFTR N terminus. (jci.org)
  • Filamins are an important family of actin-binding and crosslinking proteins that mediate remodeling of the actin cytoskeleton and maintain extracellular matrix connections by anchoring transmembrane proteins to actin filaments and linking them to intracellular signaling cascades. (nih.gov)
  • Filamins are large proteins that cross-link actin filaments and connect to other cellular components. (portlandpress.com)
  • The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain. (nih.gov)
  • In cells, filamins tethered plasma membrane CFTR to the underlying actin network. (jci.org)
  • We recently found that filamins are targeted for proteasomal degradation by the E3 ubiquitin ligase specificity subunit ASBα and that acute degradation of filamins through this ubiquitin-proteasome pathway correlates with cell differentiation. (nih.gov)
  • Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. (wikipedia.org)