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  • plasticity
  • One explanation for the multitude of potential mechanisms underlying E-S potentiation is that different patterns of synaptic activity induce this form of plasticity by recruiting distinct postsynaptic signaling pathways. (jneurosci.org)
  • The current approaches have mainly focused on electrical stimulation of the peripheral nervous system, but there is also potential of employing the principles of synaptic function, synaptic plasticity, and brain biochemistry for the implementation of bioelectronic approaches in the CNS. (biomedcentral.com)
  • mechanism
  • Owing to the importance of Wnt signaling in a wide range of biological fields, a better understanding of the precise mechanism of Wnt signaling might provide fundamental insights regarding its role in disease development and may provide novel targets for therapeutic applications. (hindawi.com)
  • test
  • For the open field (OF) test, each animal was placed in the middle of a brightly illuminated 80 × 80-cm enclosure with transparent walls and a floor marked with 16 (20 × 20 cm) squares. (pnas.org)
  • effects
  • Nanotoxicology and the potential effects on human body have grown in significance over recent years fueled by the surge of nanomaterial-based consumer products or building materials in the market. (biomedcentral.com)
  • significant
  • Our data illuminate significant mechanistic differences in oligomeric and fibril recognition and suggest the considerable potential of KW1 in future studies to detect or inhibit specific types of Aβ conformers. (pnas.org)
  • application
  • Slice cultures were loaded by 45-minute application of carboxyfluorescein diacetate (30 μmol/L). CA1 fields of view were photobleached for 2 minutes using the 488-nm laser line of a confocal microscope (Nikon RCM 8000) and images acquired at 1-minute intervals. (ahajournals.org)
  • This presented the potential application in treatment of diseases or some possible neuroprotection. (biomedcentral.com)