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LamininFibronectinsCollagenReceptors, LamininReceptors, FibronectinCollagen Type IExtracellular MatrixCell AdhesionCollagen Type IVBiological MarkersBasement MembraneFibrillar CollagensCollagen Type IIIIntegrinsReceptors, CollagenExtracellular Matrix ProteinsCells, CulturedCollagen Type IIFibroblastsGelatinPeptide FragmentsAntigens, CD29Collagen Type VICollagen Type VMolecular Sequence DataAmino Acid SequenceIntegrin alpha5beta1Cell MovementProcollagenFluorescent Antibody TechniqueRNA, MessengerOligopeptidesTumor Markers, BiologicalProtein BindingSkinTenascinCollagen DiseasesProteoglycansCollagen Type XVIIICell LineImmunohistochemistryHydroxyprolineVitronectinIntegrin alpha6beta1CartilageChick EmbryoGelsCollagen Type XIIntegrin alpha5Microscopy, ElectronGlycoproteinsTransforming Growth Factor betaReceptors, ImmunologicHeparinBinding SitesElectrophoresis, Polyacrylamide GelCattleAntibodies, MonoclonalCell Adhesion MoleculesFibrosisWound HealingIntegrin alpha3beta1Microbial CollagenaseTime FactorsMolecular WeightDystroglycansAntibodiesConnective TissueTransforming Growth Factor beta1Recombinant ProteinsProteomicsBlotting, WesternPeptidesSignal TransductionIntegrin alpha6Base SequenceTendonsCell DifferentiationAdhesins, BacterialHydroxylysineMicroscopy, Electron, ScanningBiomarkers, PharmacologicalTumor Cells, CulturedReceptors, VitronectinPepsin ACollagenasesGene ExpressionGlycosaminoglycansActinsFibrinogenGene Expression RegulationEpitheliumFibril-Associated CollagensCollagen Type XCartilage, ArticularKineticsCollagen Type XIIProtein Structure, TertiaryEpithelial CellsElastin
ProteoglycansExtracellular matrix pTumorElastinProteinsCOL1A1TumorigenesisMembraneSerumDepositionMMPsProgressionClinicalAlterationsTumorsEarly stagesTargetsProvideProteinsFibrosisAdhesionDesminTumorsProteinInteractsExpressionMiRNAsSignificantlyCancerProliferationTissueMigrationPotentialMouseComponents
Proteoglycans3
  • To acquire a comprehensive understanding of the biological functions of the matrisome and its components, including proteoglycans and glycosaminoglycans (GAGs), in GBM tumorigenesis, and to identify potential biomarker candidates, we studied the alterations of GAGs, including heparan sulfate (HS) and chondroitin sulfate (CS), the core proteins of proteoglycans, and other glycosylated matrisomal proteins in GBM subtypes vs. control human brain tissue samples. (bu.edu)
  • MMP7, also known as Matrilysin, is a definite relative with proteolytic activity against an array of biomolecules including proteoglycans, laminin, fibronectin, casein and moreover cellar membrane collagen type IV [17,18]. (scienceexhibitions.org)
  • This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. (cancerindex.org)
Extracellular matrix p2
Tumor7
  • Different prognosis noticed for patients from the same scientific stage emphasizes the actual fact that the scientific stage cannot effectively reflect the natural behavior from the tumor and brand-new biological elements (e.g. biomarkers) are obligatory to complement scientific variables for more specific decision-making [3]. (scienceexhibitions.org)
  • Our findings highlight fibronectin and tumor ECM mechanics as attractive targets in cancer therapy and support the need to identify new anti-fibrotic drugs to abrogate aberrant ECM mechanics in metastases. (ibecbarcelona.eu)
  • Imaging of the tumor-stromal interface in live tumor tissue ex vivo was performed with multiphoton laser-scanning microscopy (MPLSM) to generate multiphoton excitation (MPE) of endogenous fluorophores and second harmonic generation (SHG) to image stromal collagen. (biomedcentral.com)
  • Moreover, we observed and defined three tumor-associated collagen signatures (TACS) that provide novel markers to locate and characterize tumors. (biomedcentral.com)
  • Consistent with this observation, primary tumor explants cultured in a randomly organized collagen matrix realigned the collagen fibers, allowing individual tumor cells to migrate out along radially aligned fibers. (biomedcentral.com)
  • The presentation of these tumor-associated collagen signatures allowed us to identify pre-palpable tumors and see cells at the tumor-stromal boundary invading into the stroma along radially aligned collagen fibers. (biomedcentral.com)
  • Glycosaminoglycan, CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on collagen known to inhibit changes of ECM, leading to tumor cell invasion and progression. (biomedcentral.com)
Elastin3
Proteins2
  • Although the mechanisms mediating the effects of the extracellular matrix (ECM) on breast carcinoma development in vivo are largely unknown, contributing factors may be adhesion mediated signaling and mechanical signals imparted on mammary epithelial cells from surrounding type-I collagen-rich stroma, either directly or across basement membrane proteins. (biomedcentral.com)
  • mPEG-SCM (Amine PEGylation of Proteins) - PEGylation of lysine residues improves the proteolytic stability of fibronectin while retaining biological activity, Biotechnol. (creativepegworks.com)
COL1A11
Tumorigenesis1
  • Moreover, collagen-dense breast tissue increases the risk of breast carcinoma, although the relationship between collagen density and tumorigenesis is not well understood. (biomedcentral.com)
Membrane1
  • The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)
Serum3
  • Many serum biomarkers have been evaluated in melanoma but their clinical significance remains a matter of debate. (hindawi.com)
  • In this paper, a review of the serum biomarkers for melanoma will be detailed and will be discussed from the point of view of their practical usefulness. (hindawi.com)
  • New serum biomarkers of melanoma progression and metastatic disease are still awaited in order to provide efficient rationale for followup and treatment choices. (hindawi.com)
Deposition1
  • CONCLUSIONS: LCE70 improved hyperglycemia-induced renal function by enhancing the Nrf2 activation, reducing collagen deposition, and alleviating inflammation and oxidative stress, which suggested its potential as a therapeutic agent for DN. (bvsalud.org)
MMPs1
  • Matrix metalloproteinase (MMPs) are among the cancer-related biomarkers which have lately attracted notable interest [4]. (scienceexhibitions.org)
Progression1
Clinical4
  • The aim of this narrative review is to summarize contemporary evidence on the use of circulating cardiac biomarkers of heart failure (HF) and to identify a promising biomarker model for clinical use in personalized point-of-care HF management. (annlabmed.org)
  • We focus on the benefits and drawbacks of biomarker-guided assistance in daily clinical management of patients with HF. (annlabmed.org)
  • However, a lack of clinical biomarkers to predict response represents a critical unmet need to identify potential responders and dissect resistance mechanisms to personalize immunotherapy and combinatorial therapy. (elifesciences.org)
  • We believe that ECM interaction is an accurate biomarker for functional islets integrity and by maintaining high levels of its expression we hope to be able to improve islet cells graft function for current clinical islet transplantation programmes. (brighton.ac.uk)
Alterations1
  • Local alterations in collagen density were clearly seen, allowing us to obtain three-dimensional information regarding the organization of the mammary stroma, such as radiating collagen fibers that could not have been obtained using classical histological techniques. (biomedcentral.com)
Tumors3
  • Galectin-3: a useful biomarker for differential diagnosis of brain tumors. (jsurgmed.com)
  • We used both laser-scanning multiphoton and second harmonic generation microscopy to determine the organization of specific collagen structures around ducts and tumors in intact, unfixed and unsectioned mammary glands. (biomedcentral.com)
  • In particular, local cell invasion was found predominantly to be oriented along certain aligned collagen fibers, suggesting that radial alignment of collagen fibers relative to tumors facilitates invasion. (biomedcentral.com)
Early stages2
  • In this review, we focus on early stages of the disease and we address both biomarkers and therapeutic approaches currently available and under research. (hindawi.com)
  • Fibronectin was overexpressed from the early stages (~118%) to developed macrometastases (~260%) in both models. (ibecbarcelona.eu)
Targets1
  • Understanding the biology and the mechanism of metastasis provides new molecular targets and may help us to discover new biomarkers. (hindawi.com)
Provide2
  • In addition, we provide clear information on the role of alternative biomarkers and future directions with the aim of improving the predictive ability and reproducibility of multiple biomarker models and advancing genomic, transcriptomic, proteomic, and metabolomic evaluations. (annlabmed.org)
  • We also used a machine learning approach to identify robust BCNHL biomarkers that include YES1, FERMT2, and FAM98B, which have not previously been associated with BCNHL in the literature, but together provide ~99.9% combined specificity and sensitivity for differentiating lymphoma cells from healthy B-cells based on measurement of transcript expression levels in B-cells. (fortunepublish.com)
Proteins8
  • Novel proteins identified by proteomic technology and genetic polymorphisms from genome association studies offer the possibility for further refinement and individualization of biomarker fibrosis models in the future. (medscape.com)
  • Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. (nih.gov)
  • This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. (cancerindex.org)
  • Biopsies before initiation of methotrexate (n = 36) showed minimal immunohistochemical expression of desmin, transforming growth factor alpha, matrix proteins, and collagen. (nih.gov)
  • Immunohistochemical quantification of matrix proteins and collagens type III and IV may be early, sensitive and dose responsive markers of methotrexate hepatotoxicity which progress with increasing cumulative doses of methotrexate. (nih.gov)
  • In this context, the glial proteins myelin basic protein (MBP) and the 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNP) as well as the vasculature-associated basement membrane proteins laminin and collagen IV have been identified as ischemia-sensitive elements. (frontiersin.org)
  • Some of these secreted proteins play important roles in the progression of inflammatory diseases in the brain, and serve as biomarkers that can be used to guide diagnosis and drug therapy. (biomedcentral.com)
  • While other constitutively expressed proteins in the extracellular matrix, such as osteopontin and osteocalcin, are expressed in osteoblast cells, DMP1 is expressed in osteocytes, making it a candidate biomarker for osteocyte activity. (takarabio.com)
Fibrosis7
  • Blood-based biomarkers offer a number of advantages over the traditional standard of fibrosis assessment of liver biopsy, including safety, cost-savings and wide spread accessibility. (medscape.com)
  • Current biomarker algorithms include indirect surrogate measures of fibrosis, including aminotransaminases and platelet count, or direct measures of fibrinogenesis or fibrinolysis such as hyaluronic acid and tissue inhibitor of metalloproteinase-1. (medscape.com)
  • Current limitations of biomarker models include a significant indeterminate range, and a predictive ability that is limited to only a few stages of fibrosis. (medscape.com)
  • However its well-acknowledged limitations have led to the search for alternative, non-invasive methods for fibrosis assessment, including clinical and serum biomarker algorithms. (medscape.com)
  • The number of serum biomarker algorithms for liver fibrosis has increased significantly over the past decade, and they are beginning to be incorporated into routine clinical practice. (medscape.com)
  • This review will examine the development, accuracy, clinical utility and pitfalls of biomarkers as diagnostic tools to assess hepatic fibrosis. (medscape.com)
  • Cite this: Biomarkers of Liver Fibrosis - Medscape - May 01, 2011. (medscape.com)
Adhesion1
  • Additionally, we observe that restoration of miR-200c to ovarian cancer cells causes a decrease in adhesion to laminin. (hindawi.com)
Desmin2
  • 1. Leiomyosarcoma of the mandible: diagnosis as aided by immunohistochemical demonstration of desmin and laminin. (nih.gov)
  • Increases in desmin, smooth muscle actin and collagen type I also occurred but the changes were less consistent. (nih.gov)
Tumors1
  • Since circulating miRNAs are used as molecular markers for the early warning and diagnosis of various diseases, such as tumors and cardiovascular diseases, the purpose of the present study was initially to identify differential expression circulating miRNAs in plasma, and then explore potential biomarkers for DVT. (bvsalud.org)
Protein3
  • Collagen is the major structural protein in the extracellular matrix, its triple-helical structure providing strength and performing an essential role supporting angiogenesis, tissue morphogenesis and repair. (nordicmubio.com)
  • Here, immunofluorescence labeling using polyclonal antibodies revealed an increased immunofluorescence intensity of MBP, CNP, laminin and collagen IV in ischemic areas, although Western blot analyses did not reveal increased protein levels. (frontiersin.org)
  • Our results suggest that the combination of annotation/protein sequence analysis, transcript profiling, immunohistochemistry, and immunoassay is a powerful approach for delineating candidate biomarkers with potential clinical significance and may be broadly applicable to other human diseases. (edu.au)
Interacts1
Expression1
  • Expression of laminin, fibronectin, collagens III and IV increased significantly and progressively over baseline values after cumulative doses of 1.5 +/- 0.25 g (n = 20) and 3 +/- 0.5 g methotrexate, respectively. (nih.gov)
MiRNAs1
  • Thus, miRNAs hold promise as biomarkers for several types of cancer [ 12 , 13 ]. (hindawi.com)
Significantly3
  • Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. (afpm.org.my)
  • RESULTS: Myoblast migration and proliferation was enhanced significantly by synergistic stimulation of laminin and EGF (0.61 ± 0.14 µm/min, 0.008 ± 0.001 h-1) compare to that by EGF alone (0.26 ± 0.13 µm/min, 0.004 ± 0.0009 h-1). (afpm.org.my)
  • Compared to the untreated conditions, myoblasts cultured on the laminin-coated surface and EGF demonstrated elongated morphology, and average cell length increase significantly. (afpm.org.my)
Cancer2
  • Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. (nih.gov)
  • Analysis of major human breast cancer samples Formalin fixed, paraffin embedded deidentified sections from invasive ductal breast cancer samples have been derived from the Breast Biomarker Task at Royal Melbourne Hospital and from the Division of Tissue Pathology at SA Pathology. (pka-signal.com)
Proliferation2
  • In this study, we investigated the synergistic effect of laminin and epidermal growth factor (EGF) on co-cultured myoblasts and fibroblasts for cell attachment, proliferation and migration. (afpm.org.my)
  • CONCLUSION: Laminin and EGF preferentially enhance the proliferation and migration of myoblasts, and Rho kinase and EGF-R play a role in this synergistic effect. (afpm.org.my)
Tissue1
Migration2
  • Inhibition of Rho kinase resulted in the increase of the myoblast migration on the laminin-coated surface with EGF condition (0.64 ± 0.18 µm/min). (afpm.org.my)
  • In contrast, inhibition of EGF-R resulted in the decrease of myoblast migration on the laminin coated surface with EGF supplemented condition (0.43 ± 0.05 µm/min) in comparison to the untreated control (0.53 ± 0.05 µm/min). (afpm.org.my)
Potential1
  • together with the classic biomarker D-dimer, they can be used as a potential biomarker for diagnostic and therapeutic process of DVT. (bvsalud.org)
Mouse1
  • Top selling product highlight: Suitable for use in multiple applications, polyclonal rabbit anti mouse fibronectin (FI24951) can be utilised in studies on wound healing, tumour progression and tumour invasion. (nordicmubio.com)
Components1
  • When fibroproliferation ensues after a single discrete injury, the process can be reversible or result in a durable scar comprising highly cross-linked collagens and other extracellular matrix (ECM) components. (jci.org)