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  • epithelial cell
  • now provide evidence for the involvement of the c-Jun N-terminal kinase (JNK) pathway and the phosphatidyinositol 3-kinase (PI3K) pathway in the alternative splicing of fibronectin transcripts in a mammary epithelial cell line (EpH4) in response to laminin-rich basement membrane (lr-BM). (sciencemag.org)
  • cellular
  • The principal functions of fibronectin appear to be in cellular migration during wound healing and development, regulation of cell growth and differentiation, and haemostasis/thrombosis. (corning.com)
  • Gene
  • The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. (thermofisher.com)
  • tumor
  • This suggests that fibronectin promotes lung tumor growth/survival and resistance to therapy and could represent a novel target for the development of new anticancer drugs. (bionity.com)
  • A tumor‐associated fibronectin isoform generated by alternative splicing of messenger RNA precursors. (currentprotocols.com)
  • Fibrillogenesis
  • Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. (abcam.com)
  • migration
  • Intensive research has focused on their role in platelet function, cell migration, the cytoskeleton, reticuloendothelial function, and on alterations in fibronectin distribution during development and disease. (springer.com)
  • Expression
  • In lung carcinoma, fibronectin expression is increased, especially in non-small cell lung carcinoma. (bionity.com)
  • Fibronectin has been shown to stimulate the phosphatidylinositol 3-kinase (PI3K), which is capable of controlling the expression of cyclin D and related genes involved in cell cycle control. (bionity.com)
  • Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models. (nih.gov)
  • Additionally, a study of renal cell cancer showed that the mRNA expression of fibronectin 1 was higher in patients with renal cell cancer as compared to patients with healthy kidneys. (novusbio.com)