• E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. (journalsmededu.pl)
  • An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. (idrblab.net)
  • Long noncoding RNAs (lncRNAs) regulate a number of physiological and pathological processes, including gene transcription and translation, chromatin modification, cell cycle progression, cell proliferation, and oncogenic and tumor-suppressive signals in cancer 6 . (researchsquare.com)
  • Ear2 is an orphan nuclear hormone receptor that belongs to the chicken ovalbumin upstream promoter-transcription factors (COUP-TF) gene family [ 14 ]. (biomedcentral.com)
  • C-Myc is a potent transactivator of ODC promoter-reporter gene constructs in fibroblasts that requires the CACGTG repeat. (idrblab.net)
  • Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). (idrblab.net)
  • Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. (idrblab.net)
  • E2F2 effects the cell cycle, tumor suppressor proteins, and can also be transformed by proteins of small DNA tumor viruses. (journalsmededu.pl)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates or other biological fluids. (1elisakits.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in serum, plasma, tissue homogenates and other biological fluids. (1elisakits.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
  • E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. (journalsmededu.pl)
  • To further explore the molecular function of Rasd1, we performed a yeast two-hybrid screen and identified Ear2, a negative regulator of renin transcription, as an interaction partner of Rasd1. (biomedcentral.com)
  • Acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), cause severe endothelial dysfunction in the lung, and vascular endothelial growth factor (VEGF) is elevated in ARDS. (bvsalud.org)
  • Moreover, real-time RT-PCR showed upregulation of endogenous renin transcription in As4.1 cells over-expressing Rasd1. (biomedcentral.com)
  • The main risk factor is exposure to endogenous and exogenous estrogens associated with obesity, diabetes, and the use of tamoxifen 5 . (researchsquare.com)
  • Domańska J, Poboży K, Domański P, Fudalej M, Deptała A, Badowska-Kozakiewicz A. The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies. (journalsmededu.pl)
  • E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer. (journalsmededu.pl)
  • In addition, we demonstrated that shRNA-mediated knockdown of Rasd1 results in further repression of Ear2-mediated renin transcription, whereas induction of Rasd1 by dexamethasone counteracts the effects of shRNA-mediated Rasd1 knockdown. (biomedcentral.com)
  • Description: A sandwich ELISA kit for detection of Myogenic Factor 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
  • Description: Quantitative sandwich ELISA for measuring Human Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
  • Description: Quantitative sandwich ELISA for measuring Mouse Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
  • Immunocytochemistry/ Immunofluorescence: SR-BI Antibody [NB400-104] - SR-BI antibody was tested in human fibroblast samples fixed in 4% PFA and permeabilized in PBS (0.2% Tween). (novusbio.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myogenic Factor 5 (MYF5) in Tissue homogenates and other biological fluids. (1elisakits.com)
  • Finally, our study showed that Rasd1 missense mutations not only attenuate their physical interaction with Ear2 but also abolish their ability to counteract repression of renin transcription mediated by Ear2. (biomedcentral.com)
  • The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2. (journalsmededu.pl)
  • 11. Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors. (nih.gov)
  • This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. (thermofisher.com)
  • In addition to a constitutively occupied E2F1-Sp1 site immediately upstream of the cyclin E transcription start region, there is downstream a cell cycle-regulated site (termed CERM) that may function as a cyclin E-repressor module. (nih.gov)
  • The mixture altered genes associated with pathways such as "genotoxicity" and "nuclear factor erythroid 2-related factor 2 (Nrf2). (nih.gov)
  • The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2. (journalsmededu.pl)
  • Numerous studies have demonstrated a role for E2F2 in various signaling pathways. (journalsmededu.pl)
  • Further investigations of E2F2 pathways are warranted for a clearer understanding of neoplastic processes and to identify novel pharmacological treatments. (journalsmededu.pl)
  • Domańska J, Poboży K, Domański P, Fudalej M, Deptała A, Badowska-Kozakiewicz A. The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies. (journalsmededu.pl)
  • The vertebrate Myb transcription factors comprise a small family of important regulatory proteins. (123dok.net)
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
  • E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. (journalsmededu.pl)
  • Its expression regulation is critically modulated by multiple physiopathological factors such as inflammation, stress, Epstein-Barr virus infection and sex hormones. (medscape.com)
  • One of the genes regulated through this mechanism en-codes the B-Myb transcription factor, which has been shown to be critically required for early embryonal de-velopment in the mouse. (123dok.net)
  • HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
  • 15. Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2. (nih.gov)