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  • Novel
  • Novel variants of this new glu 3 ,5 basic fibroblast growth factor, such as those in which cysteine 78 and cysteine 96 are replaced, e.g., with serine or other amino acids, to produce stabilized versions of the glu 3 ,5 basic FGF and eliminate disulfide scrambled forms, are also described. (google.com)
  • mitogenic
  • FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (wikipedia.org)
  • pituitary
  • In the course of study of these factors, a number have been identified on the basis of the ability of extracts from various tissues, such as brain, pituitary and hypothalamus, to stimulate the mitosis of cultured cells. (google.com)
  • tumor
  • Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. (ebi.ac.uk)
  • The essential role of angiogenesis in tumor growth was first proposed in 1971 by Judah Folkman, who described tumors as "hot and bloody," illustrating that, at least for many tumor types, flush perfusion and even hyperemia are characteristic. (wikipedia.org)
  • expression
  • showed that SFRP1 expression in UMRC3 cells (clear cell renal cell carcinoma cell line) resulted in a growth-inhibited phenotype. (wikipedia.org)
  • Pathways
  • The exact pathways and elements activated depend on the cell type being stimulated plus other factors such as the stimulated cells microenvironment and previous as well as concurrent history of stimulation Activation of the gamma isoforms of phospholipase C (PLCγ) (see PLCG1 and PLCG2 illustrates one mechanism by which FGFR1 activates cell stimulating pathways. (wikipedia.org)
  • angiogenesis
  • The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease. (wikipedia.org)
  • Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. (wikipedia.org)
  • novel
  • Novel variants of this new glu 3 ,5 basic fibroblast growth factor, such as those in which cysteine 78 and cysteine 96 are replaced, e.g., with serine or other amino acids, to produce stabilized versions of the glu 3 ,5 basic FGF and eliminate disulfide scrambled forms, are also described. (google.com)
  • Expression
  • showed that SFRP1 expression in UMRC3 cells (clear cell renal cell carcinoma cell line) resulted in a growth-inhibited phenotype. (wikipedia.org)