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Fibroblast Growth Factor 2Fibroblast Growth FactorsReceptors, Fibroblast Growth FactorFibroblast Growth Factor 1Receptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2FibroblastsReceptor, Fibroblast Growth Factor, Type 3Fibroblast Growth Factor 10Receptor, Fibroblast Growth Factor, Type 4Epidermal Growth FactorFibroblast Growth Factor 9Fibroblast Growth Factor 4Fibroblast Growth Factor 7Cells, CulturedVascular Endothelial Growth Factor AGrowth SubstancesCell DivisionFibroblast Growth Factor 8Signal TransductionPlatelet-Derived Growth FactorFibroblast Growth Factor 5Receptor, Epidermal Growth FactorEndothelial Growth FactorsRNA, MessengerTransforming Growth Factor betaReceptor Protein-Tyrosine KinasesVascular Endothelial Growth FactorsTransforming Growth FactorsCell LineFibroblast Growth Factor 3Insulin-Like Growth Factor IHepatocyte Growth FactorNerve Growth FactorsCell DifferentiationMolecular Sequence DataFibroblast Growth Factor 6LymphokinesTransforming Growth Factor alphaNeovascularization, PhysiologicHeparinReceptors, Growth FactorPhosphorylationCell ProliferationImmunohistochemistryReceptor, Fibroblast Growth Factor, Type 53T3 CellsIntercellular Signaling Peptides and ProteinsTransforming Growth Factor beta1Recombinant ProteinsNeovascularization, PathologicTransfectionGene Expression RegulationGene ExpressionBase SequenceNerve Growth FactorEndothelium, VascularCell MovementMitogensAmino Acid SequenceHeparitin SulfateCattleBlotting, WesternTumor Cells, CulturedSkinProtein-Tyrosine KinasesReverse Transcriptase Polymerase Chain ReactionReceptors, Platelet-Derived Growth FactorWound HealingMesodermIn Situ HybridizationChick EmbryoReceptors, Vascular Endothelial Growth FactorReceptors, Cell SurfaceInsulin-Like Growth Factor IIGene Expression Regulation, DevelopmentalDNATime FactorsCollagenDose-Response Relationship, DrugProtein BindingAngiogenesis Inducing AgentsHeparan Sulfate ProteoglycansProto-Oncogene ProteinsCulture Media, ConditionedStem CellsCell SurvivalHypophosphatemiaKineticsExtracellular MatrixUp-RegulationCell Line, TumorVascular Endothelial Growth Factor Receptor-2ProteoglycansEnzyme ActivationMutationRats, Sprague-DawleyConnective Tissue Growth FactorAcrocephalosyndactyliaMitogen-Activated Protein Kinases
ReceptorRecombination DNA repairProteinsFGF2ReceptorsProteinFHF2DefectiveFGF1BFGFResiduesSubstancesFGFREpidermalIntracellularEndothelialAminoProliferateChromosomeLungEpithelialProliferationMetastasisMacrophagesConstituteGenesMutantCellsTumor growthFGFsBlood vesselsExpressionHumanTissueCellPDGFENDOGENOUSActivityControlGeneticData
Receptor17
  • Orthologous to human FGFR2 (fibroblast growth factor receptor 2). (zfin.org)
  • Control fibroblasts exhibited the usual affinity labeling of the disulfide-linked Mr = 350,000 insulin and IGF-I receptor structures. (diabetesjournals.org)
  • The intensity of labeling of both receptor types in the patient's fibroblasts was less than in control fibroblasts. (diabetesjournals.org)
  • The highaffinity bIGF-II receptor in fibroblasts affinity labeled with 125 I-IGF-II or 125 I-IGF-I consists of a single polypeptide not disulfide linked to any other membrane component. (diabetesjournals.org)
  • The molecular size and intensity of labeling of the IGF-II receptor in the patient's fibroblasts were unaltered when compared with those of controls. (diabetesjournals.org)
  • These observations suggest that a common genetic defect alters the expression of the homologous receptor structures for insulin and IGF-I. (diabetesjournals.org)
  • [3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
  • It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase . (wikidoc.org)
  • b) multi-receptor tyrosine kinase inhibition with lenvatinib due to overexpression of FGFR1 (Fibroblast Growth Factor Receptor 1) and RET (Ret Proto-Oncogene) and, (c) later in the course of the disease, PARP (Poly(ADP-Ribose) Polymerase) inhibition with olaparib prompted by signs of defective homologous recombination DNA repair. (tu-dresden.de)
  • Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. (peprotech.com)
  • Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. (peprotech.com)
  • Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma. (uni-heidelberg.de)
  • This can either occur by cell surface receptor interactions, as in the case with peptide growth factors, or by interactions with intracellular molecules, as in the case with steroid hormones. (beauty104.com.tw)
  • Resveratrol is able to modulate the activity of numerous proteins through Sirt1 stimulation, as the peroxisome proliferator-activated receptor coactivator-1α (PGC-1 alpha), the forkhead family of transcription factors (FOXO) and protein kinase B (Akt). (encyclopedia.pub)
  • Normally, upon the stimulations by growth factors (GFs), the receptor tyrosine kinases (RTKs) are activated, and then recruit PI3K protein complex on the membrane to generate phosphatidylinositol-3,4,5-triphosphate (PIP3) from phosphatidylinositol-4,5-biophosphate (PIP2) [ 2 ]. (biomedcentral.com)
  • Their data support the clinical activity of fibroblast growth factor receptor (FGFR) inhibition and durvalumab monotherapy, but do not show increased activity for any of the combinations. (ogkologos.com)
  • Clinical characteristics and their influences on the survival of leptomeningeal metastasis derived from lung adenocarcinoma harboring epithelial growth factor receptor mutation]. (cdc.gov)
Recombination DNA repair1
  • Defective homologous recombination DNA repair as therapeutic target in advanced chordoma. (uni-heidelberg.de)
Proteins6
  • FGF13 is a member of the Fibroblast Growth Factor family of proteins. (goldbio.com)
  • Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family. (bvsalud.org)
  • Whereas spike initiation at the axon initial segment relies on sodium channel (Nav)-associated fibroblast growth factor homologous factor (FHF) proteins to delay Nav inactivation, distal axonal Navs show little FHF association or FHF requirement for high-frequency transmission, velocity and waveforms of conducting action potentials. (modeldb.science)
  • A linear correlation between normoxic and hypoxic growth conditions exists for expression levels of eight of eleven angiogenesis-related proteins tested including: VEGF, IL-8, PDGF-AA, PDGF-AA/BB, TGF-β1, TGF-β2, EGF, and IP-10. (biomedcentral.com)
  • Fibroblast growth factor 23 (FGF-23), which is produced by bone cells, is a novel member of a large family of related proteins. (quidel.com)
  • Proteins that act both at the cell surface and intracellularly will be discussed in this thesis, with particular emphasis on the fibroblast growth factors. (beauty104.com.tw)
FGF23
  • FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
  • They then further fractionated the extract using acidic and basic pH and isolated two slightly different forms that were named 'acidic fibroblast growth factor' (FGF1) and 'basic fibroblast growth factor' (FGF2). (beauty104.com.tw)
  • Not long after FGF1 and FGF2 were isolated, another group isolated a pair of heparin -binding growth factors which they named HBGF-1 and HBGF-2, whilst a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells which they called ECGF-1 and ECGF-2. (beauty104.com.tw)
Receptors3
  • The receptors for insulin and the insulin-like growth factor (IGF) I are two structurally homologous disulfide-linked multisubunit complexes of apparent Mr = 350,000. (diabetesjournals.org)
  • The receptors for IGF-I and insulin in skin fibroblasts from this patient were affinity labeled with 125 I-IGF-I and 125 I-insulin, respectively, and visualized by electrophoresis and autoradiography in polyacrylamide gels. (diabetesjournals.org)
  • HSPGs interact with growth factors and receptors through heparan sulfate (HS) chains. (scielo.br)
Protein9
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (prosci-inc.com)
  • The solubility of protein is related to many factors, among them, pH and ionic strength are relatively important. (stratech.co.uk)
  • The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
  • These data suggest that FGF21 stimulates thermogenesis under protein malnutrition, but this is not the causative factor underlying the protective role of FGF21 against liver lipid accumulation. (bvsalud.org)
  • Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)
  • Recombinant Human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF-homologous portion of the Epigen precursor. (peprotech.com)
  • Further studies should be performed to correlate in vitro protein expression levels of angiogenesis-related factors with in vivo patient response. (biomedcentral.com)
  • In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. (beauty104.com.tw)
FHF21
  • Database searches and analysis of available genomic DNA sequence from the region revealed the presence of the fibroblast growth factor homologous factor gene, FHF2, within the duplication breakpoint interval. (edu.au)
Defective1
  • Renal phosphate wasting disorders leading to hypophosphatemia are among the causes of defective mineralization of bone and growth plate development. (quidel.com)
FGF11
BFGF1
Residues2
  • This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. (prosci-inc.com)
  • The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively. (or.jp)
Substances1
  • A wide array of chemical substances can influence cell growth and differentiation. (beauty104.com.tw)
FGFR1
  • The study team combined durvalumab with relevant targeted therapies in biomarker-selected chemotherapy-refractory advanced urothelial cancer populations including FGFR inhibitors in tumours with FGFR DNA alterations, PARP inhibitor in tumours with and without DNA homologous recombination repair deficiency and TORC1/2 inhibitors in tumours with DNA alteration to the mTOR/PI3K pathway. (ogkologos.com)
Epidermal1
Intracellular1
  • Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs (Olsen et al. (beauty104.com.tw)
Endothelial2
  • One angiogenic factor whose expression is induced in response to a hypoxic environment is vascular endothelial growth factor (VEGF). (biomedcentral.com)
  • This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
Amino1
  • A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. (bvsalud.org)
Proliferate2
  • When activated by injury, satellite cells reenter the cell cycle and proliferate in response to extracellular growth factors ( Relaix & Zammit, 2012 Relaix F, Zammit PS. (scielo.br)
  • Fibroblast growth factor was found in a cow brain extract by Gospodarowicz and colleagues and tested in a bioassay which caused fibroblasts to proliferate (first published report in 1974). (beauty104.com.tw)
Chromosome1
  • XLH is considered to be a systemic disorder, from mutation of the phosphate-regulating gene homologous to endopeptidases on the X chromosome ( PHEX ). (medscape.com)
Lung3
  • In addition, pirfenidone decreased endogenous transforming growth factor (TGF)-beta level in lung allografts, and TGF-beta stimulated arginase activity in a dose-dependent manner in both lung tissue and fibroblasts. (nih.gov)
  • Prognostic value of genes related to cancer-associated fibroblasts in lung adenocarcinoma. (cdc.gov)
  • A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)
Epithelial1
Proliferation1
  • In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
Metastasis1
  • The growth and metastasis abilities of cells are evaluated in vitro and in vivo. (biomedcentral.com)
Macrophages2
  • At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
Constitute1
  • Nonhomologous end-joining (NHEJ) and homologous recombination (HR) constitute the two main pathways to repair DSB in mammalian cells. (academicediting.org)
Genes1
  • Following this the BAT-enriched miRNAs predicted to target genes potentially involved in growth and development were identified. (biomedcentral.com)
Mutant1
Cells7
  • 4) Interferon, GM-CSF, IL-3 and IL-4 and other cytokines are species-specific and almost have no activity on non-homologous cells. (stratech.co.uk)
  • 5) In contrast, fibroblast growth factor (FGF) and neurotrophin are highly conserved and both have good activity on cells of different species. (stratech.co.uk)
  • the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. (wikidoc.org)
  • As linear correlations exist between expression levels of angiogenic factors under normoxic and hypoxic conditions in vitro , we propose that explanted primary cells may be used to probe the in vivo hypoxic environment. (biomedcentral.com)
  • In vitro studies have shown that stromal cells cultured in hypoxic growth conditions secrete higher levels of critical angiogenesis-inducing factors than cells cultured in normoxic conditions [ 3 ]. (biomedcentral.com)
  • After growth factor treatment for 6 d, a population of nestin-positive cells responding to both EGF and FGF-2 were identified. (beauty104.com.tw)
  • To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)
Tumor growth2
  • FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. (prosci-inc.com)
  • A localized hypoxic environment occurs during tumor growth necessitating an angiogenic response or tumor necrosis results. (biomedcentral.com)
FGFs2
  • Fibroblast growth factors , or FGFs , are a family of growth factors involved in wound healing and embryonic development. (beauty104.com.tw)
  • However, FGFs 11-14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functional differences compared to the FGFs. (beauty104.com.tw)
Blood vessels1
  • It thus promotes angiogenesis , the growth of new blood vessels from the pre-existing vasculature. (beauty104.com.tw)
Expression1
  • Results were analysed using ExpressionSuite software with the global mean expression value of all expressed miRNAs in a givensample used as the normalisation factor. (biomedcentral.com)
Human4
  • GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption! (goldbio.com)
  • We characterized the importance of the homologous recombination aspect RAD54 for the developing mouse human brain cortex in normal circumstances or after ionizing rays exposure. (academicediting.org)
  • In the developing human brain RAD54-reliant homologous recombination made an appearance absolutely necessary for the fix of problems induced by ionizing rays during S and G2 stages however not for the fix of endogenous problems in normal conditions. (academicediting.org)
  • Comparing and contrasting the molecular mechanisms controlling BAT growth and development in mice and humans will increase our understanding or how human BAT is developed and may identify potential therapeutic targets to increase EE. (biomedcentral.com)
Tissue1
  • Fibroblast Growth Factor 21 (FGF21) is a metabolic hormone regulating lipid homeostasis, insulin sensitivity, energy balance and adipose tissue function. (bvsalud.org)
Cell1
PDGF1
ENDOGENOUS1
  • Note that the term "ENDOGENOUS" can refer to a substance or factor that is produced or synthesized within an organism or system such as a hormone. (blog-biosyn.com)
Activity1
  • Enables fibroblast growth factor binding activity. (zfin.org)
Control1
  • Various factors are effective in the local control of the tumor and the response to therapy. (researchsquare.com)
Genetic1
  • The cholesterol-fed LDLR-/- mice offer a new model for the study of environmental and genetic factors that modify the processes of atherosclerosis and xanthomatosis. (jci.org)
Data1
  • Entirely our data support the existence of -independent and RAD54-dependent homologous recombination pathways. (academicediting.org)