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  • cytokines
  • Assessment of CAF-conditioned media after autophagy blockade revealed levels of secreted IL-6 and IL-8, and other cytokines to be modulated by autophagy. (ku.edu)
  • Pro-inflammatory cytokines and growth factors are involved in the pathophysiological responses of asbestos-related lung diseases. (cdc.gov)
  • tumor necros
  • Infected human host cells have been found to significantly increase the release of interleukin (IL) 1b, IL-6, IL-8, IL-12, tumor necrosis factor alpha (TNF-a), intercellular cell adhesion molecule 1(ICAM-1/CD54) and gamma interferon (IFN-y). (cpnhelp.org)
  • Publications] Kimitoshi Kohno: 'Morphological change and destabilization of β-actin mRNA by tumor necrosis factor in human microvascular endothelial cells. (nii.ac.jp)
  • Furthermore
  • Furthermore, extracellular HS 6- O -endosulfatase enzymes, Sulf 1 and Sulf 2, were expressed at a significantly lower level by SCs compared with OECs, and siRNA reduction of Sulfs in OECs was, in itself, sufficient to induce boundary formation. (jneurosci.org)
  • Furthermore, elevated IL-6 levels were found in bronchoalveolar lavage fluids from patients diagnosed with lung fibrosis and work-related histories of long-term asbestos exposure. (cdc.gov)
  • Furthermore TNF-alpha could further induce expression of IL-6, bFGF and collagenase genes in HOME cells. (nii.ac.jp)
  • Interleukin
  • Although interleukin-6 (IL-6) has been characterized as a pleiotropic cytokine with multiple biological activities, its induction and role in asbestos diseases have not been studied. (cdc.gov)
  • promoter
  • IL-6 induction paralleled increased DNA binding activity to the NF-kB and NF-IL-6 recognized sites in the IL-6 promoter. (cdc.gov)
  • Asbestos and H2O2-induced DNA binding activity to the NF-kB and NF-IL-6 binding sites of the IL-6 promoter were inhibited by antioxidants. (cdc.gov)
  • Taken together, the results suggest that asbestos-induced oxidative stress is involved in the activation of NF-kB and NF-IL-6 transscription factors recognizing IL-6 promoter. (cdc.gov)
  • angiogenesis
  • Angiogenesis is a normal biological process wherein new blood vessels form from the growth of pre-existing blood vessels. (edu.au)
  • mRNA
  • Asbestos fibers were found to stimulate IL-6 secretion and mRNA transcripts in pulmonary type II-like epithelial A549 cells. (cdc.gov)
  • morphogenesis
  • FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (antibodies-online.com)
  • secretion
  • Thus, we hypothesized that autophagy-dependent secretion of tumor-promoting factors by HNSCC-associated CAFs may explain their role in malignant development. (ku.edu)
  • IL-6 induction was dependent on the intracellular redox-oxidative state since asbestos, as well as H2O2-induced IL-6 secretion was abrogated by intracellular-acting hydroxyl scavengers and N-acetylcysteine. (cdc.gov)
  • Recombinant
  • The effect of platelets on fibrin gel structure formed in the presence of recombinant factor VIIa in hemophilia plasma and in plasma from a patient with Glanzmann thrombasthenia. (springer.com)
  • nuclear
  • In addition CPn activates nuclear factor kappa B (NF-kB) and down regulates major histocompatibility complex class I molecules (MHC-1). (cpnhelp.org)
  • Cells
  • Previously, it has been shown that rat Schwann cells (SCs), but not olfactory ensheathing cells (OECs), form a boundary with astrocytes, due to a SC-specific secreted factor. (jneurosci.org)
  • The epithelial compartment of the HIO possesses an array of small intestinal cell types, including absorptive enterocytes and secretory Paneth, goblet, and enteroendocrine cells, in addition to Lgr5 + intestinal stem cells ( 6 ). (asm.org)