DiseasesChemicals and DrugsPhenomena and Processes
Carboxypeptidase UFibrinolysisCarboxypeptidase BThrombomodulinCarboxypeptidasesalpha-2-AntiplasminAntifibrinolytic AgentsFibrinBlood CoagulationThrombinProtein CFibrinolysinPlasminogenHemostasisPlasminogen Activator Inhibitor 1Blood Coagulation FactorsEnzyme PrecursorsThrombosisProthrombinTissue Plasminogen ActivatorEnzyme ActivationFibrin Fibrinogen Degradation ProductsFibrinolytic Agents
TAFICoagulation and FibrinolysisProtease inhibitorInhibition of fibrinolysisPlasminogen activatorsComplete Plasminogen Activator InProteasesEndothelialLocal fibrinolysisSerine protease iPAI1Venous thrombosisThrombusSuperfamilyUrokinaseCardiovascularDirect thrombinHuman PlasminogenCarboxypeptidase B2RegulationThrombin-antithrombin complex2022Tissue typeClotsDeficiencyTrypsinEnzymesProteinClotInnate immunityPlateletRegulateGenesSlowsMarkersInflammationHeparinCharacterizationLungAcuteKallikreinUnclearPlasmaFactorsDecrease
TAFI7
  • Thrombin activatable fibrinolysis inhibitor (TAFI) is a procarboxypeptidase downregulating plasmin formation, thereby causing a tendency for thrombosis development. (nih.gov)
  • Plasmin activation is inhibited by thrombin-activatable fibrinolysis inhibitor (TAFI)-mediated cleavage of terminal lysine residues on plasminogen receptors. (uwo.ca)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in samples from plasma. (ksiazkiwnauce.pl)
  • Description: Quantitativesandwich ELISA kit for measuring Rat Thrombin activatable fibrinolysis inhibitor, TAFI in samples from serum, plasma, tissue homogenates. (ksiazkiwnauce.pl)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in Plasma. (ksiazkiwnauce.pl)
  • Here we show that Thrombin-activatable Fibrinolysis Inhibitor (TAFI), a zinc-dependent procarboxypeptidase, binds to the surface of group A streptococci of an M41 serotype. (wvu.edu)
  • Thrombin-thrombomodulin also activates thrombin-activatable fibrinolysis inhibitor (TAFI) that slows down fibrin degradation by plasmin. (hindawi.com)
Coagulation and Fibrinolysis5
  • This more in-depth analysis beyond routine conventional coagulation assays suggests a counterbalanced regulation of coagulation and fibrinolysis in patients with iTBI with hemostatic abnormalities. (springer.com)
  • This inhibits the intrinsic pathway of coagulation and fibrinolysis. (drugbank.com)
  • Age dependence of blood fibrinolytic components and the effects of low-dose oral contraceptives on coagulation and fibrinolysis in teenagers. (qxmd.com)
  • In this study we also determined the effect of low-dose oral contraceptives (OC) on coagulation and fibrinolysis in the teenager group. (qxmd.com)
  • To compare levels of tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute myocardial infarction and unstable angina in order to understand the use of high sensitivity C-reactive protein (hsCRP), coagulation and fibrinolysis markers for cardiovascular risk assessment. (org.pk)
Protease inhibitor14
  • Protease inhibitor received an intravenous infusion of 3 mg/kg/h of a synthetic protease inhibitor in lactate Ringers's solution soon after the induction of pancreatitis. (nii.ac.jp)
  • However, plasma beta-endorphin levels in the protease inhibitor group did not increase as in the control group. (nii.ac.jp)
  • The protease infusion improved hypotension, myocardial depression and plasma lactate, suggesting that the inhibitory effect of the protease inhibitor on beta-endorphin release contribute to the improvement. (nii.ac.jp)
  • Furthermore, protease inhibitor infusion 30min after the indication of pancreatitis showed the same effect. (nii.ac.jp)
  • Aprotinin is a serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery. (drugbank.com)
  • Aprotinin is a broad spectrum protease inhibitor which modulates the systemic inflammatory response (SIR) associated with cardiopulmonary bypass (CPB) surgery. (drugbank.com)
  • 0.000000001), complement component C9 (p = 0.00002), plasma serine protease inhibitor (p = 0.038) and heparin cofactor 2 (p = 0.00003) (Table 1 ). (biomedcentral.com)
  • We conducted bioinformatic analyses of genome and transcriptome data to determine the protease inhibitor (PI) repertoire in Amblyomma americanum and in 25 other ixodid tick species. (biomedcentral.com)
  • In parasites including ticks, protease inhibitor function is viewed from two perspectives: one being their significance in regulating the homeostasis of the tick itself, and the other being their significance in regulating the parasite-host interaction. (biomedcentral.com)
  • Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. (researchgate.net)
  • PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). (thermofisher.com)
  • Objective - The use of the HIV protease inhibitor ritonavir (RTV) is frequently associated with hypertriglyceridemia and lipodystrophy. (tno.nl)
  • Serine protease inhibitor. (drugbank.com)
  • Implications on the evolution of the serine-protease inhibitor family. (drugbank.com)
Inhibition of fibrinolysis3
Plasminogen activators3
Complete Plasminogen Activator In1
Proteases4
  • When mechanical or chemical damage of the vascular wall occurs, subendothelial TF is expressed/exposed to blood flow and binds plasma factor VIIa, which circulates as an enzyme at a concentration of approximately 0.1 nM (1% of plasma factor VII) [ 4 ] and escapes the inhibition by serine proteases inhibitors because of its poor enzymatic qualities [ 1 , 5 ]. (hindawi.com)
  • The balance between proteases and protease inhibitors is essential for the regulation of normal homeostasis across life: from microbes, to plants, to animals. (biomedcentral.com)
  • The balance between proteases and protease inhibitors plays a critical role in tissue remodeling during cardiovascular diseases. (researchgate.net)
  • Active serine proteases and their regulation by inhibitors in the circulating blood form the basis for both clot-formation and clot-solubilization cascades [6]. (researchgate.net)
Endothelial1
  • Pannekoek H, Veerman H, Lambers H, Diergaarde P, Verweij CL, van Zonneveld AJ, van Mourik JA: Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family. (drugbank.com)
Local fibrinolysis3
  • Physiologic examples of increased local fibrinolysis include ovulation and the fluidity of menstrual blood loss. (medscape.com)
  • Patients with menorrhagia may have excessive local fibrinolysis and may benefit from antifibrinolytic therapy, but no relationship to reduced levels of alpha 2-PI has been proven in these patients. (medscape.com)
  • Intra-alveolar fibrin formation in ALI occurs after capillary alveolar leakage of plasma fibrinogen, activation of coagulation and suppression of local fibrinolysis 7 - 10 . (ersjournals.com)
Serine protease i3
  • Different serine protease inhibitors termed serpins, which are expressed in the cardiovascular system, can exert a fine-tuned regulation of protease activities. (researchgate.net)
  • Accumulated knowledge about the tick saliva composition at the molecular level has revealed that serine protease inhibitors play a key role in the tick-host interact. (researchgate.net)
  • Also in that study, we found several genes cording for serine protease inhibitors (SERPINs), being expressed in both healthy and atretic follicles. (biomedcentral.com)
PAI11
Venous thrombosis1
  • This review summarizes the recent advances in our understanding of the interplay between inflammation, innate immunity and fibrinolysis focusing on venous thrombosis and its resolution. (frontiersin.org)
Thrombus3
  • In addition, inflammatory cells play crucial roles in thrombus recanalization and restoration of blood flow via fibrinolysis and vascular remodeling. (frontiersin.org)
  • Conversely, the immune cells involved in the initiation of the blood clot formation also express and release fibrinolytic factors and thus orchestrate the resolution of the venous thrombus by modulation of the fibrinolysis system. (frontiersin.org)
  • Abnormal levels of the components of the fibrinolysis pathway also occur including tissue plasminogen activator, urokinase, or increases in plasminogen activator inhibitor which inhibit resolution of a thrombus. (bmj.com)
Superfamily1
  • The SERPINE1 protein is a serine proteinase inhibitor (serpin) superfamily. (nih.gov)
Urokinase2
Cardiovascular2
  • Prothrombotic properties of the fibrin clot structure, impaired fibrinolysis and enhanced thrombin generation have been reported to be associated with increased cardiovascular risk. (medscape.com)
  • Ozone has been associated with respiratory diseases as well as cardiovascular morbidity and mortality and can reduce lung function and alter systemic markers of fibrinolysis. (nih.gov)
Direct thrombin2
  • 3. UPLC MS/MS assay for routine quantification of dabigatran - a direct thrombin inhibitor - in human plasma. (nih.gov)
  • In these cases, argatroban, a direct thrombin inhibitor (DTI), might be a potential alternative anticoagulatory strategy. (bvsalud.org)
Human Plasminogen4
  • Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. (medlineplus.gov)
  • Loskutoff DJ, Linders M, Keijer J, Veerman H, van Heerikhuizen H, Pannekoek H: Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns. (drugbank.com)
  • Strandberg L, Lawrence D, Ny T: The organization of the human-plasminogen-activator-inhibitor-1 gene. (drugbank.com)
  • Bosma PJ, van den Berg EA, Kooistra T, Siemieniak DR, Slightom JL: Human plasminogen activator inhibitor-1 gene. (drugbank.com)
Carboxypeptidase B21
  • Term thrombin-activatable fibrinolysis inhibitor may refer to: Carboxypeptidase B2, an enzyme that in humans is encoded by the CPB2 gene Lysine carboxypeptidase, an enzyme class This disambiguation page lists articles associated with the title Thrombin-activatable fibrinolysis inhibitor. (wikipedia.org)
Regulation1
Thrombin-antithrombin complex2
  • However, after placental separation, an increase in plasmin-alpha2-PI complex levels occurred together with an increase in fibrinopeptide A and thrombin-antithrombin complex levels, indicating activation of fibrinolysis before the development of a hypercoagulable state induced by placental separation. (medscape.com)
  • Levels of thrombin-antithrombin complex (TATc), D -dimer, plasminogen activator inhibitor (PAI) activity and PAI-1 antigen in bronchoalveolar lavage fluid were measured. (ersjournals.com)
20221
Tissue type3
  • The cause for thrombophilia in type II fibrinogen abnormalities often is uncertain but may involve defective calcium binding, impaired tissue-type plasminogen activator-mediated fibrinolysis, resistance to fibrinolysis, or reduced thrombin binding to fibrin. (mhmedical.com)
  • The cross-sectional case-control study compared circulating concentrations of high sensitivity C reactive protein (hsCRP), fibrinogen, tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) between patients of acute myocardial infarction (AMI) (n = 67), Unstable Angina Pectoris (UA) (n = 35) and healthy control subjects (n = 39) at the King Khalid University Hospital, Riyadh, Saudi Arabia, from June 2006 to August 2007. (org.pk)
  • Initially, several cross-sectional studies of patients with angina pectoris or previous myocardial infarction suggested that such patients had an impaired fibrinolytic system, and subsequently a few prospective cohort studies supported the notion that fibrinolytic factors such as plasminogen activator inhibitor (PAI-1) and tissue-type plasminogen activator (tPA) mass concentrations were predictors of future events in this type of patients. (org.pk)
Clots1
Deficiency2
  • Family studies in the few cases reported thus far suggest that alpha2-plasmin inhibitor (alpha2-PI) deficiency is inherited as an autosomal recessive trait. (medscape.com)
  • Untreated complete plasminogen activator inhibitor 1 (PAI-1) deficiency is characterized by mild-to-moderate bleeding, although in some instances bleeding can be life-threatening. (nih.gov)
Trypsin2
  • Protease inhibitors can inhibit serine protease such as trypsin, kallikrein etc. which suggests that beta-endorphin release during acute pancreatitis may be prevented by protease inhibitors through the inhibition of trypsin-like enzymes and bradykinin release. (nii.ac.jp)
  • Aprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI). (drugbank.com)
Enzymes1
  • The components of these multistep processes are illustrated as follows: enzymes (pink circles), inhibitors (blue circles), zymogens (green boxes), or complexes (cream ovals). (hindawi.com)
Protein1
Clot1
  • Plasminogen activator inhibitor (PAI)-1 is an inhibitor of fibrinolysis, the physiological process involved in blood clot degradation. (cdc.gov)
Innate immunity1
  • Clinical observations and accumulating laboratory evidence support a complex interplay between coagulation, inflammation, innate immunity and fibrinolysis in venous thromboembolism (VTE). (frontiersin.org)
Platelet1
  • 6) Our in vitro aggregation studies show that platelets in the presence of the aggregation inhibitor become activated and change shape in response to platelet agonists but fail to maintain the aggregated state. (cdc.gov)
Regulate1
  • Specific inhibitors regulate them. (tno.nl)
Genes1
  • plasma and histologic indices of regeneration were determined, as well as expression of key genes involved in hepatic regeneration.PHx promoted transient fibrin deposition by activating coagulation and concomitantly decreasing fibrinolysis. (nih.gov)
Slows1
Markers1
  • Ozone exposure at 22°C resulted in a decrease in markers of fibrinolysis the next day. (nih.gov)
Inflammation2
  • Here, we review the recent advances in our understanding of fibrinolysis and inflammation in the resolution of VTE. (frontiersin.org)
  • Plasminogen activator inhibitor-1 (PAI-1) and vitronectin are cofactors involved in pathological conditions such as injury, inflammation, and cancer, during which local levels of PAI-1 are increased and the active serpin forms complexes with vitronectin. (nih.gov)
Heparin1
  • The authors of this review recommend using DTIs such as argatroban as an alternative anticoagulant in critically ill patients suffering from sepsis or COVID-19 with suspected or confirmed HIT, HIT-like conditions, impaired fibrinolysis , in patients on extracorporeal circuits and patients with heparin resistance, when closely monitored. (bvsalud.org)
Characterization1
  • Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). (cathdb.info)
Lung3
  • In conclusion, mechanical ventilation creates an alveolar/pulmonary anti-fibrinolytic milieu in endotoxin-induced lung injury which, at least in part, might be due to an increase in plasminogen activator inhibitor activity. (ersjournals.com)
  • In the present study, the effects of different ventilation strategies on alveolar fibrinolysis were examined in rats with "pre-injured" lungs due to endotoxin-induced lung injury. (ersjournals.com)
  • Carbon nanotube acute lung exposure induces plasminogen activator inhibitor 1. (cdc.gov)
Acute2
  • Recently, various protease inhibitors have been developed and widely used for the treatment of acute pancreatitis, but been developed and widely used for the treatment of acute pancreatitis, but their efficacy is controversial. (nii.ac.jp)
  • However, there are no reports of the effect of protease inhibitors on beta-endorphin release or on hemodynamic changes during acute pancreatitis. (nii.ac.jp)
Kallikrein1
  • Aprotinin, through its inhibition of multiple mediators [e.g., kallikrein, plasmin] results in the attenuation of inflammatory responses, fibrinolysis, and thrombin generation. (drugbank.com)
Unclear1
Plasma3
  • None of the PI treatments tested were associated with increases in bleeding time, decreases in plasma coagulation factors, or increase in fibrinolysis. (nih.gov)
  • 5. UPLC-MRM Mass Spectrometry Method for Measurement of the Coagulation Inhibitors Dabigatran and Rivaroxaban in Human Plasma and Its Comparison with Functional Assays. (nih.gov)
  • 7. Determination of rivaroxaban--a novel, oral, direct Factor Xa inhibitor--in human plasma by high-performance liquid chromatography-tandem mass spectrometry. (nih.gov)
Factors1
Decrease1
  • There was a 51.8% net decrease in PAI-1 (plasminogen activator inhibitor-1), a 12.1% net decrease in plasminogen, and a 17.8% net increase in D -dimer. (nih.gov)