ProteinsPlateletGeneGamma chainDegradationELISA KitGlycoproteinPolymerase chain reThrombinReceptorRecombinantThrombosisCoagulation factorFragmentBiosynthesisAmyloidosisClotCleavageInflammationITGA2BReactivityBlood clotsMoleculeDisulfide-linkedBiol1978IntegrinGenesMolecularInteractPlasmaHumanAminoDomainsBeta chainsGPIIbFormMacroglobulinFactor
Proteins2
- It can not only degrade fibrinogen, but also break down proteins related to platelet aggregation, thus exerting a strong thrombolytic effect. (creativebiomart.net)
- Serum amyloid A and alpha-1 acid glycoprotein are transport proteins, and fibrinogen is a coagulation factor. (msdmanuals.com)
Platelet2
- Platelet membrane glycoprotein IIb-IIIa forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. (rupress.org)
- MW(Da) : 43 000 Due to its specification on fibrinogen (cleaves alpha chain) and its ability to clot platelet-rich plasma without affecting the integrity and functions of platelets, and thanks to its insensitivity to thrombin inhibitors, batroxobin has found several applications as a tool in blood coagulation research and diagnosis. (cryopep.com)
Gene8
- Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. (wikipedia.org)
- The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. (wikipedia.org)
- A new American kindred with amyloidosis was found by single-strand conformation polymorphism analysis to have a mutation in the fibrinogen A alpha chain gene. (fibrinogenamyloidosis.com)
- Two of the propositus' 4 children were positive for the mutant fibrinogen A alpha chain gene by restriction fragment length polymorphism analysis based on polymerase chain reaction. (fibrinogenamyloidosis.com)
- These two mutant gene carriers now in the second decade of life show no clinical symptoms of amyloidosis as yet but have lower plasma fibrinogen concentrations when compared with their normal siblings. (fibrinogenamyloidosis.com)
- Mutations in the fibrinogen aalpha gene account for the majority of cases of congenital afibrinogenemia. (medlineplus.gov)
- Molecular analysis of the fibrinogen gene cluster in 16 patients with congenital afibrinogenemia: novel truncating mutations in the FGA and FGG genes. (medlineplus.gov)
- 9: Fuller GM, Zhang Z. Transcriptional control mechanism of fibrinogen gene expression Ann N Y Acad Sci. (moleculardepot.com)
Gamma chain3
- Each unit has an alpha, beta, and gamma chain. (wikipedia.org)
- The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. (ukrbiochemjournal.org)
- Linkage of the A alpha and gamma chain genes J Biol Chem. (moleculardepot.com)
Degradation2
- Stimulation of fibrinogen synthesis in cultured rat hepatocytes by fibrinogen degradation product fragment D Proc Natl Acad Sci U S A. 1989 Nov;86(22):8788-92. (moleculardepot.com)
- It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. (lookformedical.com)
ELISA Kit2
- Description: A sandwich ELISA kit for detection of Fibrinogen Alpha from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ksiazkiwnauce.pl)
- Description: Quantitativecompetitive ELISA kit for measuring Human Fibrinogen alpha chain (FGA) in samples from serum, plasma, tissue homogenates. (ksiazkiwnauce.pl)
Glycoprotein1
- Integrin alpha 2b, (ITGA2b) also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. (rndsystems.com)
Polymerase chain re2
- A polymerase chain reaction search for infectious agents including EBV, cytomegalovirus and Leishmania is recommended in clinical settings characterised by non-remitting fever, organomegaly, cytopenia and hyperferritinemia. (biomedcentral.com)
- Tests of cerebrospinal fluid (CSF) specimens, including polymerase chain reaction (PCR) for herpes simplex virus types 1 and 2, varicella zoster virus, Epstein-Barr virus (EBV), cytomegalovirus, and human herpesvirus 6 were negative. (cdc.gov)
Thrombin6
- Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. (wikipedia.org)
- When fibrinogen is activated to form fibrin, an enzyme called thrombin cleaves the fibrinopeptides off of the alpha and beta chains. (wikipedia.org)
- Cleaved by the protease thrombin to yield monomerswhich, together with fibrinogen beta (FGB) and fibrinogen gamma(FGG), polymerize to form an insoluble fibrin matrix. (uth.edu)
- Fibrinogen B Arg448Lys and FXIII Val34Leu polymorphisms are associated with formation of more compact fibrin networks in acute PE patients, suggesting that despite heightened thrombin generation and inflammation typical of acute thromboembolism the 2 common generic variants have detectable effect on clot properties, similar to those reported in subjects at risk of venous thrombosis. (isth.org)
- Batroxobin can be used to determine fibrinogen in plasma, to measure the batroxobin clotting time (Reptilase® time) as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemias, and to test the contractile system of platelets. (cryopep.com)
- These factors are joined by coagulation factor V. Through the two factors coagulation factor Xa and coagulation factor Va, thrombin is produced, which then uses fibrinogen alpha, beta, and gamma chains to create fibrin (loose). (smpdb.ca)
Receptor2
- Gorlatov S, Medved L. Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains. (ukrbiochemjournal.org)
- Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. (abcam.cn)
Recombinant2
- Medved L, Litvinovich S, Ugarova T, Matsukav Y, Ingham K. Domain structure and functional activity of the recombinant human fibrinogen gamma-module (gamma148-411). (ukrbiochemjournal.org)
- Burton RA, Tsurupa G, Medved L, Tjandra N. Identification of an ordered compact structure within the recombinant bovine fibrinogen alphaC-domain fragment by NMR. (ukrbiochemjournal.org)
Thrombosis5
- In addition, it can also promote the activation of fibrinogen, thereby preventing thrombosis. (creativebiomart.net)
- Medved L, Weisel JW, Fibrinogen and Factor XIII Subcommittee of Scientific Standardization Committee of International Society on Thrombosis and Haemostasis. (ukrbiochemjournal.org)
- In 2010, I joined the laboratory of Prof Robert Ariëns, focussing on the roles of Fibrinogen and Factor XIII in the aethiology of thrombosis and thromboembolism. (leeds.ac.uk)
- I hold numerous national and international positions, such as Co-Chair of the International Society on Thrombosis and Haemostasis (ISTH) Scientific SubCommittee (SSC) on FXIII and Fibrinogen (2022-2026), Committee Member of the British Society for Haemostasis and Thrombosis (BSHT) (2019-present), and Review Editor for Frontiers in Cardiovascular Medicine (Thrombosis) (2020-present). (leeds.ac.uk)
- Generation of a FGA-4X murine model: Role of fibrin alpha-chain cross-linking in fibrin clot stability and thrombosis. (leeds.ac.uk)
Coagulation factor3
- This is then turned into coagulation factor XIIIa, which is activated through coagulation factor XIII A and B chains. (smpdb.ca)
- Coagulation factor XIIa is introduced through chain of activation starting in the endothelial cell with collagen alpha-1 (I) chain, which paired with coagulation factor XII activates coagulation factor XIIa. (smpdb.ca)
- It is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain pairing to activate coagulation XIIa. (smpdb.ca)
Fragment4
- Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. (ukrbiochemjournal.org)
- Madrazo J, Brown JH, Litvinovich S, Dominguez R, Yakovlev S, Medved L, Cohen C. Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution. (ukrbiochemjournal.org)
- Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. (abcam.cn)
- Stimulation of fibrinogen synthesis in cultured rat hepatocytes by fibrinogen fragment E Biochim Biophys Acta. (moleculardepot.com)
Biosynthesis2
- Fibrinogen biosynthesis. (wikipedia.org)
- 6: Hirose S, Oda K, Ikehara Y. Biosynthesis, assembly and secretion of fibrinogen_ in cultured rat hepatocytes Biochem J. 1988 Apr 15;251(2):373-7. (moleculardepot.com)
Amyloidosis5
- We previously learned that the first published report of a fibrinogen mutation that causes familial amyloidosis occurred in 1993 with the Arg554Leu mutation, followed in 1994 with the reporting of the Glu526Val mutation. (fibrinogenamyloidosis.com)
- This [is] the first description of a kindred with renal amyloidosis and low plasma fibrinogen and also the first report of amyloidosis caused by a frame shift mutation. (fibrinogenamyloidosis.com)
- thus, patients with these amyloidoses are now said to have light chain amyloidosis (AL). (medscape.com)
- Abdominal large-vessel vasculitis after initial dezamizumab dosing (300 mg) occurred in the first patient with immunoglobulin light chain amyloidosis enrolled in the Phase 2 study. (bvsalud.org)
- A group of rare renal diseases, characterized by amyloid fibril deposition of apolipoprotein A-I or A-II (AApoAI or AApoAII amyloidosis), lysozyme (ALys amyloidosis) or fibrinogen A-alpha chain (AFib amyloidosis) in one or several organs. (nih.gov)
Clot3
- To our knowledge, no reports assessed the impact of fibrinogen and factor XIII (FXIII) polymorphisms on plasma fibrin clot features in acute PE. (isth.org)
- We investigated whether a fibrinogen alpha chain ( FGA ) Thr312Ala, fibrinogen beta chain ( FGB ) Arg448Lys and FXIII Val34Leu polymorphisms are associated with fibrin clot properties assessed on admission in acute PE patients. (isth.org)
- Klajmon A, Chmiel J, Ząbczyk M, Natorska J, Undas A. Fibrinogen B Arg448Lys and Factor XIII Val34Leu Polymorphisms Are Associated with Prothrombotic Fibrin Clot Properties in Patients with Acute Pulmonary Embolism [abstract]. (isth.org)
Cleavage1
- In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. (wikipedia.org)
Inflammation1
- Increased fibrinogen levels are the main reason the erythrocyte sedimentation rate (ESR) is elevated in acute inflammation. (msdmanuals.com)
ITGA2B1
- ITGA2b associates with integrin beta 3 to form complexes that interact with fibrinogen, von Willebrand factor, fibronectin, and vitronectin. (rndsystems.com)
Reactivity1
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Fibrinogen Alpha (FGa) in samples from plasma with no significant corss-reactivity with analogues from other species. (ksiazkiwnauce.pl)
Blood clots1
- In response to injury, fibrinogen is converted to fibrin, the main protein in blood clots. (medlineplus.gov)
Molecule2
- Domains in the fibrinogen molecule. (ukrbiochemjournal.org)
- Medved' LV, Litvinovich SV, Privalov PL. Domain organization of the terminal parts in the fibrinogen molecule. (ukrbiochemjournal.org)
Disulfide-linked2
- It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. (rndsystems.com)
- GPIIb is a two-chain protein containing disulfide-linked alpha and beta subunits. (rupress.org)
Biol1
- Leukocyte activation primes fibrinogen for proteolysis by mitochondrial oxidative stress Redox Biol. (moleculardepot.com)
19781
- 7: Van Ruijven-Vermeer IA, Nieuwenhuizen W. Purification of rat_fibrinogen and its constituent chains Biochem J. 1978 Mar 1;169(3):653-8. (moleculardepot.com)
Integrin1
- Detects mouse Integrin alpha 2b/CD41 in direct ELISAs. (rndsystems.com)
Genes4
- DNA sequencing showed a single nucleotide deletion at the third base of codon 524 of the fibrinogen A alpha chain genes (4904delG) that resulted in a frame shift and premature termination of the protein at codon 548. (fibrinogenamyloidosis.com)
- Each of these genes provides instructions for making one part (subunit) of a protein called fibrinogen. (medlineplus.gov)
- 3: Uzan G, Courtois G, Stanckovic Z, Crabtree GR, Marguerie G. Expression of the fibrinogen_ genes in rat megakaryocytes Biochem Biophys Res Commun. (moleculardepot.com)
- 5: Kant JA, Crabtree GR. The rat fibrinogen genes. (moleculardepot.com)
Molecular1
- Human tPA has a molecular weight of ~70 kDa in the single-chain form. (wikidoc.org)
Interact1
- Fibrinogen alpha chain has been shown to interact with tissue plasminogen activator. (wikipedia.org)
Plasma6
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fibrinogen Alpha (FGa) in plasma. (ksiazkiwnauce.pl)
- Description: A competitive ELISA for quantitative measurement of Human fibrinogen alpha chain(FGA) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (ksiazkiwnauce.pl)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Fibrinogen Alpha (FGa) in samples from plasma. (resourcerecovery.be)
- Description: A competitive ELISA for quantitative measurement of Mouse fibrinogen alpha chain(FGA) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (resourcerecovery.be)
- Fibrinogen is a polyfunctional plasma protein involved in various physiological and pathological processes through the interaction of its multiple domains with different ligands and cell receptors. (ukrbiochemjournal.org)
- Rat Fibrinogen is a high quality Rat Fibrinogen purified from fresh rat plasma. (moleculardepot.com)
Human2
- Amino acid sequence studies on the alpha chain of human fibrinogen. (wikipedia.org)
- Crystal structure of human fibrinogen. (ukrbiochemjournal.org)
Amino2
- Among fibrinogen domains, two BβN-domains are formed by the N-terminal portions of its two Bβ chains including- amino acid residues Bβ1-64. (ukrbiochemjournal.org)
- Removal of fibrinopeptides B (amino acid residues Bβ1-14) from these domains upon fibrinogen to fibrin conversion results in the exposure of multiple binding sites in fibrin βN-domains (residues β15-64). (ukrbiochemjournal.org)
Domains1
- The objective of this review is to summarize the current view of the structure and function of these domains in fibrinogen and fibrin and their role in the above-mentioned processes. (ukrbiochemjournal.org)
Beta chains1
- The alpha and beta chains have a small peptide called fibrinopeptide. (wikipedia.org)
GPIIb2
- Immunoprecipitation of [35S]methionine pulse-chase-labeled cell extracts by antibodies specific for the alpha or beta subunits of GPIIb indicated that GPIIb was derived from a precursor of Mr 130,000 that contains the alpha and beta subunits. (rupress.org)
- The GPIIb precursor is then processed with conversion of high-mannose to complex type carbohydrates yielding the mature subunits GPIIb alpha (Mr 116,000) and GPIIb beta (Mr 25,000). (rupress.org)
Form2
- Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. (lsbio.com)
- The monomeric form binds with high affinity to muscular and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (nAChR). (snakevenomdb.org)
Macroglobulin1
- In addition, alfimeprase's thrombolytic activity appears to be localized to the site of delivery because it is rapidly inactivated by alpha-2 macroglobulin, a naturally occurring protein in the blood, as it moves away from the site of delivery and into the general blood circulation. (creativebiomart.net)
Factor1
- Henschen A, McDonagh J. Fibrinogen, fibrin and factor XIII. (ukrbiochemjournal.org)