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  • PMID
  • Fibrinogen occurs as a dimer, where each monomer is composed of three non-identical chains, alpha, beta and gamma, linked together by several disulphide bonds [ PMID: 11460466 ]. (ebi.ac.uk)
  • molecule
  • FPL correlate with retinal detachment extent, which implicates an acute inflammatory response to detachment traumatic phenomenon or a role of the fibrinogen molecule in retinal adhesiveness. (dovepress.com)
  • peripheral
  • High fibrinogen levels have also been associated with coronary heart disease , myocardial infarction , and peripheral arterial disease. (labtestsonline.org)
  • It is known from many prospective studies that fibrinogen is a risk indicator for cardiovascular disease, including coronary heart disease, stroke, and peripheral arterial disease. (ahajournals.org)
  • The high preoperative peripheral serum fibrinogen level was related to poor survival in penile cancer patients, suggeting fibrinogen may serve as a powerful predictor of cancer specific survival ( CSS (show CMAS ELISA Kits )) in penile cancer patients. (antibodies-online.com)
  • fragment
  • The crystal structure of the isolated γC domain, as well as that of the γC and βC domains in the fibrinogen D fragment, revealed that both domains are similarly folded. (springer.com)
  • Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution. (ebi.ac.uk)
  • Human
  • Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain. (ebi.ac.uk)
  • residue
  • Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. (abcam.com)
  • chain
  • A minor 420 kDa form of fibrinogen (fibrinogen-420) has an alternative extended form of the alpha chain (αE), which has a C-terminal domain (designated αEC) whose sequence and fold are highly homologous to those of the βC and γC domains. (springer.com)
  • levels
  • However, many health practitioners feel that fibrinogen activity measurements give them additional information that may lead them to be more aggressive in treating those risk factors that they can treat (such as unhealthy levels of cholesterol ). (labtestsonline.org)
  • Acutely low levels are often related to consumption of fibrinogen such as may be seen with disseminated intravascular coagulation (DIC) and abnormal fibrinolysis , which occurs when the body is overactive in clearing blood clots. (labtestsonline.org)
  • Reduced fibrinogen levels may also occur following rapid, large-volume blood transfusions and in people who are malnourished. (labtestsonline.org)
  • I also found out through my blood work the Fibro & Fatigue Centers did that my Fibrinogen levels are extremely high. (fightingfatigue.org)
  • Drugs known to influence fibrinogen levels, such as fibric acid derivatives, also alter many other factors related to the risk of MI. (ahajournals.org)
  • An alternative approach is to study genetic markers that are associated with elevated fibrinogen levels. (ahajournals.org)
  • Disease
  • In some cases, fibrinogen activity testing is performed along with other tests when a health practitioner wants to evaluate an individual's risk of developing cardiovascular disease . (labtestsonline.org)
  • If fibrinogen is a causal risk factor for cardiovascular disease, it may be 1 of the variables that explain the protective effect of moderate alcohol consumption on cardiovascular disease. (ahajournals.org)
  • Alcohol seems to be related to cardiovascular disease in a U-shaped fashion, 21 22 23 24 25 and fibrinogen may be 1 of the mediators for its effect on cardiovascular disease. (ahajournals.org)
  • Data suggest that the interaction between Abeta and fibrinogen may be an important contributor to the vascular abnormalities found in Alzheimer's disease. (antibodies-online.com)
  • adhesion
  • In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. (novusbio.com)
  • consumption
  • Cross-sectional data on self-reported alcohol consumption and fibrinogen, measured by the immunonephelometric method, of 4967 men and women aged 30 to 64 years were used. (ahajournals.org)
  • Consumption of wine and spirits was associated with fibrinogen, whereas consumption of beer or cider was not. (ahajournals.org)
  • Data on alcohol consumption and fibrinogen were available for 2499 women and 2468 men, who accounted for 4967 of the 5214 subjects participating in this study. (ahajournals.org)
  • To evaluate the association with fibrinogen, alcohol consumption was divided into the following 6 groups: nondrinkers and those who consumed 0 to 19, 20 to 39, 40 to 59, 60 to 79, and ≥80 g/d of alcohol. (ahajournals.org)