• This is a peptide that is 39 to 42 amino acids long, toxic to nerve cells and is able to form elongated fibrils (fibres). (medicalxpress.com)
  • In a joint project between the Swiss Federal Institute of Technology in Zurich, University of Lyon, and the Goethe University in Frankfurt am Main, and in cooperation with colleagues at the University of Irvine and Brookhaven National Laboratory, researchers have succeeded in clarifying the structure of a beta-amyloid peptide 1-42 fibril at an atomic resolution . (medicalxpress.com)
  • Unexpectedly, each peptide was slightly non-planar, and shallowly tilted with respect to the fibril axis. (alzforum.org)
  • This peptide dissolves in water, and at a concentration of approximately 400 µM, forms amyloid-like fibrils in a few hours. (esrf.eu)
  • That tendency to adopt different structures carries over in vivo, as recently illustrated by researchers in Robert Tycko's lab at the National Institutes of Health in Bethesda, Maryland, who used NMR to define multiple structural variants of Aβ fibrils from postmortem brains ( Jan 2017 news ). (alzforum.org)
  • The staggered rearrangement was also found in the recent tau fibril structure ( Jul 2017 news ). (alzforum.org)
  • Jülich / Düsseldorf / Hamburg / Maastricht, 7 September 2017 - A team of researchers from Germany and the Netherlands have determined the structure of an amyloid fibril with previously unachieved resolution. (eurekalert.org)
  • Using intense synchrotron sources we observed that six different ex vivo amyloid fibrils and two synthetic fibril preparations all gave similar high-resolution X-ray fibre diffraction patterns, consistent with a helical array of beta-sheets parallel to the fibre long axis, with the strands perpendicular to this axis. (nih.gov)
  • The publications released by these European and American teams, which confirm each other, have caused great excitement in expert circle, as they have enabled a targeted, structure-based search for medicinal products that will attack the beta-amyloid fibrils . (medicalxpress.com)
  • The fibrils are made up of beta-amyloid peptides. (sciencephoto.com)
  • Moreover, the conformation of preformed H2 fibrils changed reversibly depending on the pH of the solution, implying that interactions between side-chains modulated the conformation of amyloid fibrils. (springer.com)
  • Disease-associated α-synuclein adopts a conformation that causes it to form oligomers and fibrils, which have reduced solubility, become hyperphosphoryl ated, and contribute to the spatiotemporal spreading of pathology in the CNS. (medworm.com)
  • Numerous oxygen bridge connections parallel to the long axis lend the fibrils their high stability. (medicalxpress.com)
  • Each sheet is related to a mating sheet by a two-fold axis, and a translation along the fibril axis by one half the inter-strand separation. (esrf.eu)
  • The fibrils provide the major biomechanical scaffold for cell attachment and anchorage of macromolecules, allowing the shape and form of tissues to be defined and maintained. (biochemj.org)
  • However, we now had a fairly unique specimen [obtained by Lothar Gremer] with very homogeneous fibrils - 90 % of them had the same shape and symmetry," explains Schröder. (spectroscopynow.com)
  • In the new study, first author Lothar Gremer induced recombinant Aβ42 to form fibrils by incubation at low pH with an organic co-solvent for several weeks, yielding stable, highly uniform, unbranched fibrils several micrometers long (see image below). (alzforum.org)
  • found that polyphenols having a) aromatic elements and b) vicinal hydroxyl groups present on a single phenyl ring could effectively inhibit and destabilize α-synuclein fibrils 23 . (nature.com)
  • Recent attention has been focused on 'early fibrils' or 'fibril segments' of ~10 μm in length which appear to be intermediates in the formation of mature fibrils that can grow to be hundreds of micrometres in length. (biochemj.org)
  • This wrinkle resulted in a staggered arrangement of the subunits in the fibril, rather than straight stacks of dimers seen previously. (alzforum.org)
  • Standard approaches sequentially analyse two-dimensional (2D) slices to gain knowledge on the spatial arrangement and dimension of the fibrils, whereas the reconstructed three-dimensional (3D) image yields better information about these characteristics. (archives-ouvertes.fr)
  • This accurate determination of the spatial arrangement of the fibrils within a 3D data set will be most relevant in biomedical applications. (archives-ouvertes.fr)
  • In this study, molecular docking, molecular dynamics and binding free energies were used to investigate the multiple binding sites exhibited by β-amyloid fibrils. (nih.gov)
  • Like most biopolymers, stress-strain relationships of fibrils tend to show a characteristic toe-heel region before a linear, elastic region. (wikipedia.org)
  • This is a step that can be very complicated if the sample is heterogeneous, that is to say if it consists of differently formed fibrils. (eurekalert.org)
  • Although amyloid fibrils are known to have multiple binding sites, we demonstrated that model 2MXU possesses one site which is druggable and can bind with common scaffolds currently being used in the imaging of amyloid fibrils. (nih.gov)
  • We include preliminary evidence from invertebrates which suggests that the principles for bipolar fibril assembly were established at least 500 million years ago. (biochemj.org)