• During the femtosecond laser dissection process, the corneal collagen fibers inevitably undergo biomechanical and thermal changes on a sub-micro- or even a nanoscale level, which can potentially lead to post-surgical complications. (nus.edu.sg)
  • Lung tissues from IPF and non-IPF subjects were examined for collagen structure (second harmonic generation imaging) and LO gene (microarray analysis) and protein (immunohistochemistry and western blotting) levels. (sigmaaldrich.com)
  • Full length native protein (purified) corresponding to Human Collagen I aa 1-1464. (abcam.com)
  • This is called staggering and in the fibrillar collagens, the molecules are staggered from each other by about 67 nm (a unit that is referred to as 'D' and changes depending upon the hydration state of the aggregate). (news-medical.net)
  • The data obtained for collagens type I, II and III, as well as confirming the results obtained in ELISA, suggest that another binding site is present on the collagen molecules and is located upstream in a more central region. (tesionline.it)
  • These an receptors comprise an α and β transmembrane subunit, which are noncovalently bound.Collagen binding is primarily provided by integrins α1β1, α2β1, α10β1 a α11β1. (wikipedia.org)
  • Structural remodelling of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes (LOX, LOXL1-4)] might contribute to disease pathogenesis and represent a therapeutic target. (sigmaaldrich.com)
  • When damage occurs, endotelial collagen is uncovered and is bound by GPVI receptor on platelets. (wikipedia.org)
  • These include a platform technology to produce secondary metabolites from a wide range of sponge species, a novel in vitro method for the production of biosilica and recombinant technology for the production of marine collagen. (europa.eu)
  • Silica structures, collagen and entire skeletons are also valuable materials that we may derive from them. (europa.eu)
  • This review summarizes the data on 278 different mutations found to date in the genes for types I, II, III, IX, X, and XI collagens from 317 apparently unrelated patients. (embl-heidelberg.de)
  • In this study, we utilized helium ion microscopy, complemented with transmission electron microscopy to examine the femtosecond laser-induced collagen fibrillar damage in ex vivo human corneas. (nus.edu.sg)
  • One of these domains is found at the C terminus of fibrillar collagens. (embl-heidelberg.de)
  • Specifically, the project will focus on potential anticancer drugs and novel biomedical/industrial applications of biosilica and collagen, hereby taking advantage of the unique physico-chemical properties of these extracellular sponge products. (europa.eu)
  • Functions include: Platelet adhesion and activation - the most important platelet collagen receptor in terms of signaling. (wikipedia.org)
  • It's ectodomain consists of a collagen-binding discoidin domain followed by ~200 residues of unknown structure. (wikipedia.org)
  • However, in clinical settings, the importance of collagen-associated decorin as a moderate antitumor modality would be undermined by its ability to attenuate the efficiency of chemotherapeutics. (aacrjournals.org)
  • A postulated solution to the problem of denaturation based on current research, is that newly formed collagen gets stored in vacuoles. (wikipedia.org)
  • Interestingly, collagen within the body has a denaturation temperature between 32-40 degrees Celsius, the physiological temperature also falls within this range and thereby poses a significant problem. (wikipedia.org)
  • In the body, fibrillar collagens have over 50 known binding partners. (wikipedia.org)