Background/aim: The main aim of the study is to assess expression levels of CDH1, FHIT, PTEN, and TTPAL genes in tumors and peripheral bloods of colorectal cancer patients in staged I-IV. (biruni.edu.tr)
The TP53 gene mutation is the most common gene alteration in many tumors, including esophageal cancer. (spandidos-publications.com)
Background/aim: The aim of the study is to assess expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in tumors and peripheral bloods of colorectal cancer patients in stages I-IV. (afsu.edu.tr)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
HSVtk/ganciclovir (GCV) gene therapy has been extensively studied in tumors and relies largely on the gene expression of HSVtk . (biomedcentral.com)
We have evaluated the antitumor effect of HSVtk/ganciclovir gene therapy under Tet-On regulation by means of adeno-associated virus-2 (AAV-2)-mediated HSVtk gene transfer with direct intratumoral injections in mice bearing breast cancer tumors. (biomedcentral.com)
The expression of HSVtk gene in MCF-7 cells and BALB/C nude mice tumors was up-regulated by Tet-On under Dox induction with reverse transcription-PCR (RT-PCR) analysis. (biomedcentral.com)
The antitumor effect of rAAV-mediated HSVtk/GCV gene therapy under the Dox induction with direct intratumoral injections may be a useful treatment for breast cancer and other solid tumors. (biomedcentral.com)
The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK , which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. (biomedcentral.com)
Chromosome7
The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. (wikipedia.org)
Tumor protein 53 ( TP53 ) is a recognized tumor suppressor gene located on chromosome 17q13.1. (spandidos-publications.com)
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene. (cellosaurus.org)
See also {614327} for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene ( OMIM ) on chromosome 3p21. (mendelian.co)
A number sign (#) is used with this entry because pachyonychia congenita-4 (PC4) is caused by heterozygous mutation in the KRT6B gene (148042) on chromosome 12q13. (findzebra.com)
Mutations3
On the other hand, for the immune checkpoint inhibitors, such as anti-PD-1 antibodies (nivolumab and pembrolizumab) and anti-PD-L1 antibodies (atezolizumab and durvalumab), as well as molecular targeted drugs for various driver gene mutations, there is little data at the time of publication of the statement and no categorization by risk. (encyclopedia.pub)
Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. (lookformedical.com)
Mutations in this gene predispose humans to breast and ovarian cancer. (lookformedical.com)
Mutation2
Although the biological significance of TP53 gene mutation is well characterized, its clinical significance in esophageal cancer remains controversial, especially as a prognostic biomarker. (spandidos-publications.com)
Therefore, the overexpression of p53 does not always indicate a mutation in the TP53 gene. (spandidos-publications.com)
Locus2
In this study, 8 of 42 patients with esophageal cancer had microsatellite instability (MSI), and 29 cases demonstrated allelic loss (loss of heterozygosity or homozygous deletion) at the FHIT/FRA3B locus. (elsevierpure.com)
This result indicated that the disruption of the mismatch repair system of Msh2 does not mainly lead to allelic loss of the FHIT/FRA3B locus as well as MSI in esophageal cancer. (elsevierpure.com)
Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake (PubMed:12574506, PubMed:19622739). (wuxibiortus.com)
Replication3
report that transcription of a large gene is indeed essential for its instability under replication stress, as revealed by promoter ablation experiments. (github.io)
That affect correlates closely with replication delays seen under stress when transcribed, but not with R-loop levels, which are always low in the body of these genes. (github.io)
Functional and pathway enrichment analysis showed that up-regulated genes were significantly involved in cell cycle, oocyte meiosis, DNA replication and p53 signaling pathway, while down-regulated genes were enriched in Huntington's disease,metabolic pathways. (oncotarget.com)
Cell Proliferation1
Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (PubMed:18077326). (wuxibiortus.com)
Deletion3
The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)
Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) were performed to detect the expression of p53 protein and gene deletion in ESCC tissue samples from different ethnic groups in Xinjiang, in order to analyze their association with clinicopathological characteristics and patient prognosis, as well as the sensitivity and specificity of the two methods. (spandidos-publications.com)
Fluorescence in situ hybridization (FISH) is a molecular pathological method with high sensitivity and specificity, which uses specific DNA probes to detect chromosomal aberrations, as well as gene deletion and amplification ( 21 , 22 ). (spandidos-publications.com)
TTPAL3
While the mRNA levels of CDH1 decreased, the mRNA level of the FHIT and TTPAL genes increased in the tumor tissues. (biruni.edu.tr)
The mRNA levels of the CDH1 and PTEN genes were increased while the mRNA levels of FHIT and TTPAL genes decreased in the blood (total). (biruni.edu.tr)
Conclusion: Although related expression levels in tissue did not correlate with its expression in blood, consistent with previous studies FHIT and TTPAL genes upregulation and CDH1 downregulation, in especially tumoral tissues, may serve as predictive determinants for the patients with colorectal cancer. (biruni.edu.tr)
Upregulation1
Furthermore, Module analysis revealed that the ten hub genes except TOP2A were belonged to module 1, indicating the upregulation of these hub genes associated molecular pathways in nasopharyngeal carcinoma might activate nasopharyngeal carcinoma pathogenesis. (oncotarget.com)
Pathways1
What pathways are this gene/protein implicaed in? (cancerindex.org)
Genomic1
For some of the genomic regions that are deleted in some neuroblastomas, on 1p, 3p and 11q, candidate tumor suppressor genes have been identified. (biomedcentral.com)
Cancer9
Furthermore FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. (wikipedia.org)
FHIT also acts as a tumor suppressor of HER2/neu driven breast cancer. (wikipedia.org)
Materials and methods: Gene expression analysis of related genes were performed for tumor tissues and peripheral blood samples of 51 colorectal cancer patients and colon tissues and blood samples of 5 healthy individuals. (biruni.edu.tr)
Results: Alteration of mRNA levels of related genes in tumor tissues of colorectal cancer cases was determined compared to control tissues. (biruni.edu.tr)
This characteristic of the TP53 gene limits the use of IHC in TP53 gene research, which may be the cause of the conflicting results in the study of TP53 in esophageal cancer. (spandidos-publications.com)
Aqeilan, RI 2014, ' Role of common fragile sites and corresponding genes in cancer development ', Cellular and Molecular Life Sciences , vol. 71, no. 23, pp. 4487-4488. (huji.ac.il)
This observation led us to investigate the effect of an allelic loss of the FHIT gene on esophageal cancer when coupled with a deficient mismatch repair system. (elsevierpure.com)
We concluded that MSI is significantly related to the allelic loss in the FHIT/FRA3B region, but Msh2 might be unrelated to the progression or oncogenic process in esophageal cancer. (elsevierpure.com)
Most studies, however, have failed to demonstrate any significant benefit of a controlled gene expression strategy in cancer treatment. (biomedcentral.com)
Transcripts3
In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. (wikipedia.org)
Abnormalities of the FHIT transcripts in osteosarcoma and Ewing sarcoma. (uni-muenster.de)
functional-described genes and transcripts orthology relationship models with the tunicates, and echinoderms, cephalochordates and vertebrates. (symapdb.org)
Colorectal1
We have previously reported a significant correlation between the progression of colorectal carcinoma and the loss of Fhit and Msh2 expression. (elsevierpure.com)
Methylation2
DNA methylation status of CDKN2A, RASSF1A, KLF4 and ZIC2 genes were quantitatively analyzed with pyrosequencing in 44 ependymoma tumor tissues. (turkjpath.org)
In the present study, we aimed to investigate the methylation status of the RASSF1A, CDKN2A, KLF4 and ZIC2 genes and to address the relationship of the methylation profiling of the selected genes with tumor subtype, histological grade or age group, as well as to highlight their significance in precision medicine. (turkjpath.org)
Carcinogenesis2
Similarly, loss of heterozygosity at chromosomal loci such as 3p and 9p are frequent early changes occurring in lung and upper aerodigestive carcinogenesis, suggesting that the tumor suppressor genes found at these loci (i.e. (nih.gov)
FHIT at 3p) may have important roles in these early phases of carcinogenesis and thereby be reasonable mechanistic targets. (nih.gov)
Enzyme1
Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. (wikipedia.org)
This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. (wikipedia.org)
Protein expression1
On the other hand, only 1 of the 8 MSI-positive patients exhibited neither Msh2 nor Fhit protein expression in both normal and carcinoma epithelial tissues, but neither a relationship between Msh2 expression and Fhit expression nor with the incidence of MSI was noted. (elsevierpure.com)
Ontology1
Gene expression profiles of several thousand genes are formalized in both wild-type and experimental conditions-manipulated, using anatomy formal ontology. (symapdb.org)
Molecular2
Though the exact molecular function of FHIT is still partially unclear, the gene works as a tumor suppressor as it has been demonstrated in animal studies. (wikipedia.org)
In conclusion, this study indicated that the identified differentially expressed genes and hub genes enrich our understanding of the molecular mechanisms of nasopharyngeal carcinoma, which could eventually translate into additional biomarkers to facilitate the early diagnosis and therapeutic approaches. (oncotarget.com)
Translocations2
Τhis Hematology/Fusion/Expression Profile provides clinically relevant information on Fusion/translocations and expression of various genes that are relevant in hematologic neoplasms. (genomictestingcooperative.com)
Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene. (cellosaurus.org)
The mRNA levels of the CDH1 gene decreased at each stage (I-IV) in the tumor tissues and increased at each stage (I-IV) in the blood. (biruni.edu.tr)
Genetic3
Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. (biomedcentral.com)
The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive. (lookformedical.com)
Outside the system genes describe other genetic elements, including repetitive elements and cis-regulatory modules. (symapdb.org)
Human1
FHIT is also known as human accelerated region 10. (wikipedia.org)
Profiles1
Two gene expression profiles (GSE12452 and GSE13597) containing 56 nasopharyngeal carcinoma samples and 13 normal control samples were analyzed to identify the differentially expressed genes. (oncotarget.com)
Type1
Click on a tumor type to see its full list of significant genes. (tumorportal.org)