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Gene FusionMembrane FusionOncogene Proteins, FusionCell FusionRecombinant Fusion ProteinsArtificial Gene FusionOncogene FusionSpinal FusionMolecular Sequence DataViral Fusion ProteinsBase SequenceFetal ProteinsTranslocation, GeneticAmino Acid SequenceReceptor, Fibroblast Growth Factor, Type 3Receptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2beta-GalactosidaseCloning, MolecularMicrotubule-Associated ProteinsEscherichia coliPlasmidsMutationReceptors, Fibroblast Growth FactorGenes, BacterialReceptor, Fibroblast Growth Factor, Type 4Transcription FactorsLac OperonPromoter Regions, GeneticBacterial ProteinsTranscription, GeneticCentrosomeChromosome BreakpointsCell LineCore Binding Factor Alpha 2 SubunitMyeloid-Lymphoid Leukemia ProteinGene Expression Regulation, BacterialRhabdomyosarcoma, AlveolarClathrin Heavy ChainsRNA-Binding Protein EWSIn Situ Hybridization, FluorescenceDNA-Binding ProteinsSpindle ApparatusGreen Fluorescent ProteinsGene RearrangementOperonRestriction MappingGenes, ReporterProtein BindingGenesCarrier ProteinsMutant Chimeric ProteinsDNA, RecombinantGalactosidasesGenetic VectorsRNA, MessengerLuminescent ProteinsReverse Transcriptase Polymerase Chain ReactionProtein Structure, TertiaryMembrane ProteinsGene ExpressionProto-Oncogene Proteins c-etsNuclear ProteinsReceptor Protein-Tyrosine KinasesChromosomes, Human, Pair 21TransfectionGene Expression RegulationCell Line, TumorProto-Oncogene Protein c-fli-1Genes, RegulatorNeoplasms, Ductal, Lobular, and MedullaryDNA PrimersTrans-ActivatorsHeLa CellsHIV Fusion InhibitorsNeoplasm ProteinsRepressor ProteinsMembrane Fusion ProteinsProstatic NeoplasmsSaccharomyces cerevisiaeSequence Homology, Amino AcidGlucuronidaseAurora KinasesChromosomes, Human, Pair 12Sequence Analysis, DNASequence AlignmentSNARE ProteinsVirus InternalizationPhenotypeGenes, FungalChloramphenicol O-AcetyltransferaseSignal TransductionAlkaline PhosphataseCell MembranePolymerase Chain ReactionSarcoma, SynovialPAX7 Transcription FactorGene Expression Regulation, NeoplasticMicrotubulesBlotting, Western

MutationsFGFR2ProteinCancerIntronsCancersSequenceTargetsReceptorsTranslocationDataSetsChromosomeHumanAnaplasticInsightsProteinsDiseasesSequencingDefectsTranscriptionTranscriptDisorderMemberExpressionResultsTypeDevelopmentMultiplePanelCell

Mutations5

• During the trial screening process, the patient's tumor tissue from prior surgery will be tested for the FGFR-TACC3 fusion gene or mutations in FGFR1 and FGFR3 genes. (bridgebio.com)
• Patients with tumors that have these fusions or mutations are eligible for this study. (bridgebio.com)
• Normal meninges harbor oncogenic somatic mutations in meningioma-driver genes. (amedeo.com)
• FGFR3 GAs were identified in 9 pts (17%, 2 FGFR3-TACC3 fusions, and 7 SNVs, including two novel mutations P250R and K650M). (unlv.edu)
• Gain of function mutations in FGFR3 inhibits chondrocyte proliferation and underlies achondroplasia and hypochondroplasia. (kyinno.com)

FGFR21

• Our lead investigational candidate is infigratinib (BGJ398), an orally administered, FGFR1-3 selective tyrosine kinase inhibitor that has shown activity that we believe to be meaningful in clinical measures, such as overall response rate, in patients with chemotherapy-refractory cholangiocarcinoma with FGFR2 fusions and advanced urothelial carcinoma with FGFR3 genomic alterations. (bridgebio.com)

Protein3

• This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. (cancerindex.org)
• What does this gene/protein do? (cancerindex.org)
• the location varies depending on the isoform of the FGFR3 protein. (kyinno.com)

Cancer2

• By way of example, in prostate cancer, the TMPRSS2-ERG fusion genes are generated from interstitial deletion of chromosome 21q22 [8]. (calcimimeticagent.com)
• When choosing our CTP TUM Panel, more than 760 cancer-associated genes are covered in this panel. (cegat.com)

Introns1

• A and B indicate involved genes and boxes signify introns or exons. (calcimimeticagent.com)

Cancers1

• Formation of Fusion Genes Different fusion genes can lead to cancers, so it is extremely required to comprehend their causes. (calcimimeticagent.com)

Sequence2

• Stable Ba/F3 clone expressing exogenous FGFR3-TACC3 fusion sequence bearing L608V mutation. (kyinno.com)
• Ba/F3-FGFR3-TACC3-L608V cell line was generated using a lentiviral vector expressing the human FGFR3-TACC3 sequence bearing L608V mutation. (kyinno.com)

Targets1

• download history Thanks and genes Activation include the acid of and precursor between targets with exciting regulated students and SRC-phosphorylated types. (erik-mill.de)

Receptors1

• There is a total of seven signalling receptors, encoded by four FGFR genes, FGFR1-4 [15]. (123dok.org)

Translocation2

• This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)
• A lot of fusion genes are generated via translocation,?017 Bentham Science Publishers1389-2029/17 58.00+.Recurrent Fusion Genes in LeukemiaCurrent Genomics, 2017, Vol. 18, No.Fig. (1). (calcimimeticagent.com)

DataSets1

• Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Chromosome3

• At times a fusion gene is brought on by deletion, which only entails 1 chromosome. (calcimimeticagent.com)
• The CBFB-MYH11 fusions are formed by inversion on chromosome 16, that are presented within the M4E0 subtype of AML [10]. (calcimimeticagent.com)
• 2. Research Techniques OF FUSION GENES Historically, the exploration of chimeric genes started with all the observation on chromosomal rearrangement by means of chromosome banding analysis (karyotyping). (calcimimeticagent.com)

Human1

• Up until now, the underlying gene regulatory networks (GRNs) at the single cell resolution for human LUAD remain unclear. (biomedcentral.com)

Anaplastic1

• Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions. (amedeo.com)

Insights1

• These products offer insights into more than 20,000 genes. (cegat.com)

Proteins1

• download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)

Diseases2

• Our CTP PAT Panel covers 55 genes highly relevant to tumor diseases. (cegat.com)
• In contrast to the other two DNA panels, the CTP FUS Panel is an RNA panel focusing on fusions relevant to tumor diseases. (cegat.com)

Sequencing2

• Whole exome sequencing identifies MRVI1 as a susceptibility gene for moyamoya syndrome in neurofibromatosis type 1. (cancerindex.org)
• If you are interested in only a subset of genes relevant for profiling a tumor, we offer different Panel Sequencing products within our Comprehensive Tumor Profiling product portfolio. (cegat.com)

Defects1

• [ 1 ] They described a child with midline fusion defects. (medscape.com)

Transcription4

• Transcription factors (TFs) function by recognizing and binding specific sequences to regulate gene expression. (biomedcentral.com)
• Fusion genes are mainly generated from chromosomal rearrangements and abnormal transcription, however the former 1 is a lot more prevalent. (calcimimeticagent.com)
• Fusion genes can also arise by means of transcription-induced chimeras, that is unrelated to chromosomal rearrangements. (calcimimeticagent.com)
• Fig 9: Detection of transcription factor immediate early gene and activity marker Cfos (Green) and GPCR Chrm3 (Red) in mouse hippocampus using the RNAscope™ Multiplex Fluorescent assay on Fresh Frozen samples. (acdbio.com)

Transcript1

• Read-through refers to a chimeric transcript which can be produced of two neighboring genes by a splicing event. (calcimimeticagent.com)

Disorder1

• This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. (cancerindex.org)

Member1

• FGFR3 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. (kyinno.com)

Expression1

• The combinations of TFs and their target genes can sometimes control gene expression which may determine cell identity. (biomedcentral.com)

Results1

• For instance, the PPP1R1B-STARD3 chimeric RNA final results in the fusion between PPP1R1B within the upstream and STARD3 inside the downstream, with exon 7 of PPP1R1B and exon 1 of STARD3 removed by splicing [11]. (calcimimeticagent.com)

Type1

• The most abundant surfactant elongation is TACC3, a translocated model type transcribed in viral family storm. (erik-mill.de)

Development1

• This N-acetylneuraminic development is the FGFR3 process under the retardation of the Nevertheless post-translated rare skin and has ER and analog cycle of FGFR3. (erik-mill.de)

Multiple1

• Each gallery contains multiple examples of gene specific in situ RNA detection achieved using one of our RNAscope™ Reagent Kits. (acdbio.com)

Panel1

• Methods: We analyzed cohorts from 2 academic centers, WCM and UNLV, with serial (≥2) ctDNA targeted NGS using the Guardant360 panel of 73 genes, ctDNA was collected within four weeks of restaging scans. (unlv.edu)

Cell1

• Throughout the similar period, some other fusion genes had also been discovered in B cell lymphomas, like IGH?MYC, IGL YC and IGK YC. (calcimimeticagent.com)