Fever coxiella. Medical search. Frequent questions

Infection with Coxiella burnetii , the causative agent of Q fever, can result in life-threatening persistent infection. (biorxiv.org)
We previously demonstrated long-lived immunoreactivity in individuals with past symptomatic and asymptomatic Coxiella infection (convalescents) to promiscuous HLA-class II C. burnetii epitopes, providing the basis for a novel T-cell-targeted subunit vaccine. (biorxiv.org)
Here we investigated in a cohort of 22 individuals with persistent infection (chronic Q fever) whether they recognize the same set of epitopes, or distinct epitopes that could be candidates for a therapeutic vaccine or aid in the diagnosis of persistent infection. (biorxiv.org)
T cell-mediated immunity plays a central role in the control and clearance of intracellular Coxiella burnetii infection, which can cause Q fever. (ox.ac.uk)
Infection with Coxiella burnetii can be asymptomatic, acute, or chronic. (cdc.gov)
Endocarditis is the most common chronic condition to result from Q fever infection and is associated with significant death rates. (cdc.gov)
Q fever is a rare zoonotic infection caused by Coxiella burnetii . (hindawi.com)
Q fever is a rare zoonotic rickettsiosis caused by infection with C. burnetii . (hindawi.com)
Some conditions such as immunosuppressive therapy, preexisting valvulopathy, or vascular graft expose to a risk of chronic Q fever infection. (hindawi.com)
The information from different databases allowed them to estimate the incidence of Q fever and mature B-cell NHL by postal code and model the adjusted relative risk of mature B-cell NHL after Q fever infection. (medpagetoday.com)
Detection of C. burnetii DNA by polymerase chain reaction (PCR) can rapidly confirm an acute Q fever infection. (cdc.gov)
in many cases serological assay confirmed the activity of Coxiella burnetii infection. (medscimonit.com)
These results suggest the possibility of the involvement of Coxiella burnetii infection in the evolution of chronic fatigue syndrome. (medscimonit.com)
In this report, psittacosis (also known as parrot disease, parrot fever, and chlamydiosis) refers to any infection or disease in humans caused by Chlamydia psittaci. (cdc.gov)
I have a general interest in Q fever (infection with Coxiella burnetii ). (ku.dk)
7 cases were reported as acute Q fever and 8 as seropositive for past infection. (who.int)
La fièvre Q est-elle une infection émergente en Turquie? (who.int)
We report a case of organizing pneumonia secondary to Coxiella burnetii infection. (clin-lab-publications.com)
Results: Percutaneous lung biopsy showed the existence of organizing pneumonia, and external examination of NGS showed the existence of Coxiella burnetii infection. (clin-lab-publications.com)
Serologic monitoring is recommended following acute Q fever infection to assess possible progression to chronic infection. (medscape.com)
Because wind currents can potentially carry the bacteria for miles and cause large outbreaks, Q fever infection has been documented in people living several miles from a source farm. (medscape.com)
Q fever is associated with both acute and chronic infection, and 2 distinct types of antibody response. (medscape.com)
The diagnosis of chronic Q fever requires both laboratory confirmation and evidence of clinical infection. (medscape.com)

IgA antibodies to phase I of the growth cycle of Coxiella burnetii were positive in two patients and negative in one. (medscimonit.com)
Evidence of IgA antibodies to phase I of the growth cycle of Coxiella burnetii is not a prerequisite for establishing a diagnosis of CFS. (medscimonit.com)
Detection of antibodies to Coxiella burnetii, the causative agent of Q fever, by ELISA. (tamu.edu)
If acute Q fever is suspected, physicians should order IgG IFA (indirect immunofluorescence assay) testing for both phase I and phase II antibodies in paired serum specimens, taken 3-6 weeks apart. (medscape.com)

Sheep are a major reservoir for Coxiella burnetii. (cdc.gov)
We studied the role of European rabbits ( Oryctolagus cuniculus ) as a reservoir for Coxiella burnetii in the Iberian region. (vetscite.org)

Therefore, we aimed to develop a novel T cell-targeted vaccine that induces pathogen-specific cell-mediated immunity to protect against Q fever in humans while avoiding the reactogenicity of the current inactivated whole cell vaccine. (ox.ac.uk)
Coxiella burnetii is a category B bioterrorism agent because it is highly infectious, rather resistant to heat and drying, and can become airborne and inhaled by humans. (cdc.gov)
Q fever is a disease caused by the bacterium Coxiella burnetii, which can be transmitted to humans from animals such as sheep, goats, and cattle. (cdc.gov)
Now that we know Q fever is seriously underreported, we are working on new ways to prevent transmission to humans and diagnose cases early. (cdc.gov)
Epidemiology of Q-fever in domestic ruminants and humans in Africa. (ed.ac.uk)
The clinical manifestations of Q fever in and neighbouring provinces with symp- humans are highly variable. (who.int)
Title : Epidemic Genotype of Coxiella burnetii among Goats, Sheep, and Humans in the Netherlands Personal Author(s) : Tilburg, Jeroen J.H.C.;Roest, Hendrik-Jan I.J.;Buffet, Sylvain;Nabuurs-Franssen, Marrigje H.;Horrevorts, Alphons M.;Raoult, Didier;Klaassen, Corné H.W. (cdc.gov)
Q fever in humans is usually either asymptomatic or mistaken for an acute viral illness due to the symptoms of fever, chills, headache, weakness, malaise (a general sick feeling), and severe sweats. (floridahealth.gov)
Develop laboratory capabilities within FBiH to diagnose Q fever in humans and animals. (cdc.gov)
To assess the occurrence of and risk factors for Q fever among humans. (cdc.gov)
Rhipicephalus pulchellus has been linked to Rickettsia conorii, the agent of boutonneuse fever in humans, Crimean-Congo hemorrhagic fever orthonairovirus, and Nairobi sheep disease orthonairovirus. (bvsalud.org)
In humans the disease is recognized commonly as undulant fever, characterized by headache malaise, and arthritis. (bvsalud.org)

The genus Coxiella is morphologically similar to Rickettsia, but with a variety of genetic and physiological differences. (wikipedia.org)
As it became clear that the species differed significantly from other Rickettsia, it was first elevated to a subgenus named after Cox, Coxiella, and then in 1948 to its own genus of that name, proposed by Cornelius B. Philip, another RML researcher. (wikipedia.org)
Q fever is a zoonotic disease with acute and chronic stages caused by the rickettsia-like organism Coxiella burnetii. (cdc.gov)

The bacterium Coxiella burnetii (which causes Q fever) had the highest incidence because of a goat-related Q fever epidemic in the Netherlands from 2007 to 2019, peaking at 2,424 cases in 2009. (umn.edu)
Q fever is caused by the intracellular bacterium Coxiella burnetii . (hindawi.com)
Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. (cascadiaresearch.org)

Viral hemorrhagic fevers (filoviruses [e.g. (cdc.gov)
BSL-4 labs work with pathogens such as ebola and other hemorrhagic fevers. (cityoffrederick.com)

Q fever is a common and acute but rare chronic zoonosis caused by Coxiella burnetii. (medscimonit.com)
Q fever (see the image below) is a zoonosis caused by Coxiella burnetii, an obligate gram-negative intracellular bacterium. (medscape.com)

This compendium provides information on AC (also known as psittacosis, ornithosis, and parrot fever) and psittacosis (also known as parrot disease, parrot fever, and chlamydiosis) to public health officials, veterinarians, physicians, the companion-bird industry, and others concerned with control of the disease and protection of public health. (cdc.gov)

The first description of what may have been Coxiella burnetii was published in 1925 by Hideyo Noguchi, but since his samples did not survive, it remains unclear as to whether it was the same organism. (wikipedia.org)
Q fever is a bacterial zoonosis (disease capable of being transmitted from animals to people) caused by Coxiella burnetii , a rickettsial organism. (floridahealth.gov)

Dr. David Swerdlow] Coxiella burnetii is an intracellular bacterium that causes Q fever. (cdc.gov)

Coxiella burnetii is an obligate intracellular bacterial pathogen, and is the causative agent of Q fever. (wikipedia.org)
C. burnetii, the causative agent of Q fever Shaw EI, Voth DE (January 2019). (wikipedia.org)
Coxiella burnetii, the agent of Q fever, enters human monocytes through alpha(v)beta(3) integrin and survives inside host cells. (nih.gov)

Q fever is caused by the intracellular bacterial pathogen Coxiella burnetii . (medpagetoday.com)
Coxiella burnetii is a bacterial pathogen of both ruminant livestock and human beings, and most human Q Fever outbreaks have been blamed on ruminant livestock. (usda.gov)
Coxiella burnetii, a highly adapted obligate intracellular bacterial pathogen and the cause of the zoonosis Q fever, is a re-emerging public health threat. (usda.gov)

However, up to 50% of patients with acute Q fever are asymptomatic. (hindawi.com)
The results of a 2013 seroprevalence study suggested that only a small fraction of Q fever cases have been reported largely because of the high frequency of asymptomatic infections. (medpagetoday.com)

Reactogenicity hinders worldwide implementation of the only licensed human Q fever vaccine. (biorxiv.org)
In conclusion, we have validated and expanded a previously published set candidate epitopes for a novel T-cell targeted subunit Q fever vaccine in the context of chronic Q fever patients and demonstrated that they successfully mounted a T-cell response comparable to that of convalescents. (biorxiv.org)
Research in the 1960s-1970s by French Canadian-American microbiologist and virologist Paul Fiset was instrumental in the development of the first successful Q fever vaccine. (wikipedia.org)
Epitopes were selected for vaccine inclusion based on long-lived human T cell recall responses to corresponding peptides in individuals that had been naturally exposed to the bacterium during a 2007-2010 Q fever outbreak in the Netherlands. (ox.ac.uk)
There is a Q fever vaccine that is currently not available for general use, but may be available through the Department of Defense for persons who are known to be at high risk of exposure. (floridahealth.gov)

3. No notifications have been received during 2000 for the following rare diseases: lymphogranuloma venereum, plague, rabies, yellow fever, or other viral haemorrhagic fevers. (health.gov.au)
Frequently underreported and misdiagnosed, acute Q fever often resembles a nonspecific viral illness. (medscape.com)

ABSTRACT Between 4 May and 8 August 2002, 46 cases of acute fever were reported near the Black Sea region in northern Turkey. (who.int)

2 Because other microbial pathogens have been associated with NHL, this finding raised concerns that people who had been infected with Coxiella burnetii were at an increased risk of NHL. (medpagetoday.com)

Coxiella burnetii, bacteria that cause Q fever. (umn.edu)

Coxiella burnetii , which is the cause of Q fever, is a zoonotic pathogen that infects multiple hosts. (vetscite.org)

Since Q fever is not notifiable in many states and many human infections are inapparent, there is not reliable way of assessing how many cases of Q fever are actually occurring in the U.S Because of this, stored sera form NHANES 2003-2004 have been tested to establish baseline Q fever seroprevalence for the U.S. (cdc.gov)
We compared the risks of having adverse events from antibiotic treatment with the benefits derived from preventing cases of Q fever. (cdc.gov)
Researchers in The Netherlands conducted a population-based study of all known cases of Q fever and mature B-cell NHL in The Netherlands between 2002 and 2017 to assess a possible link between the 2 conditions. (medpagetoday.com)
There were 4310 cases of Q fever during the same period, with most occurring between 2007 and 2010. (medpagetoday.com)
They acknowledged, however, that the inability to link cases of Q fever and mature B-cell NHL at the level of the individual because of privacy restrictions, migration within the country, and missed diagnoses of Q fever could have resulted in some misclassifications. (medpagetoday.com)
Fewer than 200 cases of Q fever are reported each year in the United States, meaning that most cases of Q fever are going unnoticed. (cdc.gov)
As of September 2005, thirteen confirmed and probable cases of Q fever have been reported within the state of Florida. (floridahealth.gov)

The illness was first called "Query (Q) Fever" because its etiopathognesis was not known. (cdc.gov)
Symptoms of the acute disease include a flu-like illness with fever and chills, which usually resolves. (cdc.gov)
Dr. David Swerdlow] If there were an intentional spread of Coxiella burnetii , we didn't know who should be given preventative treatment, called post-exposure prophylaxis or PEP, to prevent illness. (cdc.gov)
Q fever can cause acute or chronic illness, and people are commonly exposed from contact with infected animals or exposure to contaminated environments. (cdc.gov)
Treatment with doxycycline will shorten the course of illness for acute Q fever. (cdc.gov)
The good news: Most people infected with C. burnetii show no signs of disease or develop a mild illness, and the vast majority of infected people recover from Q fever, even without treatment. (cdc.gov)
Acute Q fever usually presents as a self-limiting febrile illness with a good prognosis, but there are few cases of coexisting organizing pneumonia. (clin-lab-publications.com)
The guidelines address treatment of acute and chronic phases of Q fever illness in children, adults, and pregnant women and the management of occupational exposures. (medscape.com)
A negative acute titer does not rule out Q fever because an IFA is negative during the first stages of acute illness. (medscape.com)
Patients without obvious risk factors for chronic Q fever should receive a clinical and serologic follow-up approximately 6 months after diagnosis of acute illness to identify potential progression to chronic disease. (medscape.com)

B: Chest radiograph demonstrating Q fever pneumonia. (medscape.com)
Human Q Fever can involve varying degrees of fever, aches and pains, pneumonia, hepatitis, adverse pregnancy outcomes, and endocarditis (potentially fatal swelling in the heart). (usda.gov)

People at highest risk for Q fever are those who work with infected animals, including veterinarians, researchers, meat workers, sheep workers and farmers. (floridahealth.gov)
A documented cluster of Q fever in Florida occurred during 1999 in Alachua County among researchers exposed to an infected sheep. (floridahealth.gov)
5. Harrison RJ, Vugia DJ, Ascher MS. Occupational health guidelines for control of Q fever in sheep research . (floridahealth.gov)

Pregnant women are also at high risk following exposure to Coxiella burnetii . (cdc.gov)
Dr. David Swerdlow] We found that following a likely exposure, the risk of Q fever is greater than the risk of adverse events from antibiotic treatment. (cdc.gov)
Guidelines for the management of occupational exposure to Q fever are also included. (medscape.com)

Individuals with chronic Q fever showed strong class II epitope-specific cultured ELISpot responses largely overlapping with the peptide repertoire identified previously for convalescents. (biorxiv.org)
Five additional peptides were recognized more frequently by chronic subjects, but there was no combination of epitopes uniquely recognized by or non-reactive in chronic Q fever subjects. (biorxiv.org)
Finally, we demonstrate that individuals treated for chronic Q fever mount a broader ex vivo response to class II epitopes than convalescents, which could be explored for diagnostic purposes. (biorxiv.org)
The patient's physical condition improved as the fever stopped and he was checked on regularly for signs of progression to chronic Q fever. (hindawi.com)
Anyone who was infected with C. burnetii may be at risk for developing chronic Q fever, however, people with a history of valvular defects, arterial aneurisms, or vascular grafts are at increased risk. (cdc.gov)
Women infected by C. burnetii during pregnancy and those with immunosuppression have also been linked to the development of chronic Q fever. (cdc.gov)
Endocarditis is the most commonly identified manifestation of chronic Q fever and is fatal if untreated. (cdc.gov)
Other forms of chronic Q fever include infections of vascular aneurysms, bone, liver, or reproductive organs. (cdc.gov)
Chronic Q fever is a risk for anyone with a history of acute Q fever, but are more frequent in persons with valvular disease, blood vessel abnormalities, immunosuppressed persons, and women who were pregnant when they became infected. (cdc.gov)
Endocarditis with negative culture findings and seropositivity (culture positivity and seropositivity or culture negativity and seronegativity are relatively uncommon) is the main clinical presentation of chronic Q fever, usually occurring in patients with preexisting cardiac disease including valve defects, rheumatic heart disease, and prosthetic valves. (medscape.com)
In contrast, treatment of chronic Q fever should be initiated only after diagnostic confirmation. (medscape.com)
Treatment for acute or chronic Q fever should only be given in clinically compatible cases and not based on elevated serologic titers alone (see Pregnancy section below for exception). (medscape.com)
Chronic Q fever most commonly manifests as culture-negative endocarditis. (medscape.com)
Management of chronic Q fever requires long-term treatment with multiple antibiotics and intensive patient monitoring for years for possible relapse. (medscape.com)

Short report: isolation and identification of two spotted fever group rickettsial strains from patients in Catalonia, Spain. (ajtmh.org)
Coxiella burnetii, the causal agent of an important rickettsial zoonosis called Q fever, has a worldwide distribution with the notable exception of. (cabi.org)

In view of liver enzyme elevation and positive serology for Coxiella burnetii , the overall features are compatible with the clinical suspicion of Q fever associated hepatitis. (pathologyoutlines.com)

A population-based study of all diagnoses of Q fever and mature B-cell NHL in The Netherlands before, during, and after the largest known outbreak of Q fever found no association between Q fever and mature B-cell NHL. (medpagetoday.com)
The researchers obtained acute Q fever data from the National Institute for Public Health and Environment, which included cases occurring before and after a large outbreak in 2007-2010. (medpagetoday.com)
The authors concluded in their report that "no increased risk of mature B-cell NHL after Q fever was found in the entire Dutch population that suffered the largest Q fever outbreak ever recorded. (medpagetoday.com)
A very large outbreak of both ruminant coxiellosis and human Q Fever in The Netherlands had costs exceeding 300 million Euros. (usda.gov)
In response to this outbreak, Q fever was listed as a reportable disease. (floridahealth.gov)
She has worked extensively on epidemiologic research, outbreak response and national surveillance related to Q fever. (medscape.com)

Polymerase chain reaction (PCR) of whole blood or serum provides rapid results and can be used to diagnose acute Q fever in the first 2 weeks after symptom onset but before antibiotic administration. (medscape.com)

And Salmonella ingestion can result in diarrhea, fever, stomach cramps, and other symptoms. (umn.edu)
Acute Q fever manifests as a febrile disease with nonspecific symptoms including headaches, myalgias, chills, and night sweats. (hindawi.com)
The following is a list of symptoms commonly seen with acute Q fever. (cdc.gov)
People who work with animals that may be infected need to know the signs and symptoms of Q fever and seek treatment if they feel they could be infected. (floridahealth.gov)
This is because many acute Q fever patients with resolved symptoms will have increased phase I titers for several months. (medscape.com)

A 41-year-old male farmer with a history of chronic hepatitis B treated with entecavir, and ankylosing spondyloarthritis treated since last year with weekly etanercept injections, presented to our internal medicine ward for prolonged fever and malaise two weeks prior to evaluation. (hindawi.com)

Immunohistochemical detection of Coxiella burnetii in resected cardiac valve of a 60-year-old man with Q fever endocarditis, Cayenne, French Guiana. (cdc.gov)

The definitive descriptions were published in the late 1930s as part of research into the cause of Q fever, by Edward Holbrook Derrick and Macfarlane Burnet in Australia, and Herald Rea Cox and Gordon Davis at the Rocky Mountain Laboratory (RML) in the United States. (wikipedia.org)

Although the majority of people with acute Q fever recover completely, a post-Q fever fatigue syndrome has been reported to occur in up to 20% of patients with acute Q fever. (cdc.gov)

Stillbirths can be caused by near-term situations such as ketosis, milk fever, selenium deficiency, dystocia, or several infectious causes. (oregonstate.edu)
Coxiella burnetii is an infectious and etiological agent responsible for causing Q fever. (benthamscience.com)

By the end of the investigation, serologic diagnosis of Q fever appeared to be positive for both IgG and IgM. (hindawi.com)
Diagnosis of Q fever is based on the serologic test. (hindawi.com)
To test whether the incidence of mature B-cell NHL increased during a specific time interval after Q fever, the researchers modeled yearly lag times of 1 to 4 years between the diagnosis of Q fever and the diagnosis of mature B-cell NHL. (medpagetoday.com)
The diagnosis of Q fever relies on a high index of suspicion as suggested by the epidemiologic features and is proven by serologic analysis. (medscape.com)

No consensus has been reached in the medical community on the pathogenesis or treatment of post Q fever fatigue syndrome. (cdc.gov)
The effect of antibiotic therapy on post-Q-fever fatigue syndrome has not been studied in south-east Europe thus far. (medscimonit.com)
Three patients are presented with post-Q-fever fatigue syndrome. (medscimonit.com)
After 4-12 months they developed post-Q-fever fatigue syndrome and were treated with intracellular active antibiotics (fluoroquinolones and tetracycline) for 3-12 months. (medscimonit.com)
This is the first report on post-Q-fever fatigue syndrome in Mediterranean countries. (medscimonit.com)
The recommendation of antibiotic treatment in post-Q-fever fatigue syndrome requires further investigation. (medscimonit.com)

The epidemiological sis of Q fever since clinical diagnosis, in investigation was carried out from 4 May most instances, lacks specificity. (who.int)
In March 2013, the CDC issued the first national guidelines for Q fever recognition, clinical and laboratory diagnosis, treatment, management, and reporting for health-care and public health workers. (medscape.com)
These recommendations address the clinical presentation, appropriate diagnostic testing, laboratory interpretation, and treatment of acute and chronic phases of Q fever in children, adults, and pregnant women. (medscape.com)

Anatomy2

Organisms11

Diseases21

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Health Care1

Infection23

Antibodies4

Reservoir for Coxiella burnetii2

Humans12

Rickettsia3

Bacterium Coxiella burnetii3

Hemorrhagic2

Zoonosis caused2

Psittacosis1

Organism2

Intracellular bacterium1

Agent of Q fever3

Bacterial pathogen3

Asymptomatic2

Vaccine5

Viral2

Abstract1

Pathogens1

Bacteria1

Pathogen1

Cases of Q fever7

Illness10

Pneumonia2

Sheep3

Exposure3

Chronic Q fever14

Rickettsial2

Serology1

Outbreak6

Serum1

Symptoms5

Malaise1

Endocarditis1

Cause of Q fever1

Patients with acute Q fever1

Infectious2

Diagnosis of Q fever4

Post-Q fever fatigue syndrome6

Clinical3