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  • fetuses
  • Hooker's methods, though broadly conforming to contemporary research practices and views of fetuses, would not have been feasible later. (jhu.edu)
  • But while Hooker and the 1930s medical and general public viewed live fetuses as acceptable materials for nontherapeutic research, they also shared a regard for fetuses as developing humans with some degree of social value. (jhu.edu)
  • Hooker's research and the various reactions to his work demonstrate the varied and changing perspectives on fetuses and fetal experimentation, and the influence those views can have on biomedical research. (jhu.edu)
  • At the end of 2016, the Select Investigative Panel of the House Energy and Commerce Committee published its report -all 485 pages-of its investigation into procurement of tissue from aborted fetuses for research. (bioethics.net)
  • In addition, researchers indicated that cloned pig cells can be used in stem cell research to "take fire from the debate over use of donated human fetuses" for such research. (californiahealthline.org)
  • known as fetal
  • During gestation, Brianna Marie suffered from a condition known as fetal hydrops in which abnormal amounts of fluid build in two or more body areas of a fetus or newborn. (marketwired.com)
  • Background: Stably persistent offspring-origin cells in a woman's circulation and tissues decades after pregnancy, also known as fetal microchimerism, is deficient in women with biologically unselected breast cancer and suggests a protective role. (aacrjournals.org)
  • restriction
  • There is no scientific or ethical basis for the proposed restriction on fetal tissue research, which would roll back decades of consensus in the U.S., irreparably delaying the development of new medical treatments. (scienceinpublic.com.au)
  • UCL researchers in a successful academic-industrial collaboration have been awarded an EU Framework Programme 7 Grant of almost €6 million to develop a therapy for foetal growth restriction. (ucl.ac.uk)
  • The consortium is developing a therapy for foetal growth restriction, a major problem of pregnancy affecting up to eight per cent of all pregnancies. (ucl.ac.uk)
  • Once severe early onset foetal growth restriction is identified in mid pregnancy, couples currently face a stark choice between delivering their baby very prematurely in the knowledge that they might die in the neonatal intensive care unit, or allowing the pregnancy to continue with the strong likelihood that the baby will die in the womb. (ucl.ac.uk)
  • If successful, this would be the first evidence based therapy for fetal growth restriction and could save thousands of lives. (ucl.ac.uk)
  • A leading bioethicist from Queen Mary University of London will engage with stakeholder groups and patients affected by foetal growth restriction to evaluate the ethical and social acceptability of the proposed EVERREST trial. (ucl.ac.uk)
  • For the trial, the consortium includes some of the leading foetal medicine centres and academic health science centres in Sweden (Lund University), Germany (University Medical Center Hamburg-Eppendorf), Spain (Hospital Clinic Barcelona and IDIBAPS) and the UK (UCL and UCLH) with strong backgrounds in the management of pregnancies affected by severe early onset foetal growth restriction. (ucl.ac.uk)
  • Foetal growth restriction affects approximately 60,000 babies per year in Europe and the USA. (ucl.ac.uk)
  • Potential benefits from the research could include reduced stillbirths and neonatal deaths, and improved outcome in pregnancies affected by severe early onset foetal growth restriction. (ucl.ac.uk)
  • Alterations of prenatal development: gestational obesity and restriction of fetal growth. (idibgi.org)
  • rubella
  • the National Institutes of Health spent $76 million on fetal research in 2014, and fetal tissue has contributed to vaccines for polio, rubella and chicken pox. (time.com)
  • Of the nearly 75 vaccine formulations currently approved by the Food and Drug Administration for use in the United States, only 11 (directed against Zoster, Varicella, Rabies, Rubella, Hepatitis A, Polio and Adenovirus) are produced using historic, fetal-derived cell lines, and none are produced using freshly isolated fetal tissue. (bioethics.net)
  • Importantly, alternative vaccine formulations that do not rely on fetal-derived cell lines are available or all but five of these diseases (Adenovirus, Hepatitis A, Rubella, Varicella and Zoster), and there is no scientific reason these vaccines could not be produced using animal cell lines. (bioethics.net)
  • Polio is now almost eradicated, and rubella, measles, chickenpox, and rabies are all preventable diseases because of fetal tissue research. (scienceinpublic.com.au)
  • Research using fetal tissue has led to the development of vaccines such as those for polio, rubella, and measles. (isscr.org)
  • vaccines
  • Science took this point on directly, listing several vaccines that are still produced in WI-38 or MRC-5, rebutting statements in the majority report that fetal cells had "never" been used to produce a polio vaccine, and that "none" of the currently-licensed vaccines in the US are produced using fetal cells. (bioethics.net)
  • The fetal-derived cell lines WI-38 and MRC-5 were adopted by the pharmaceutical industry as tools for the production of vaccines shortly after they were developed in the 1960s.And for a small minority of vaccines, these tools are still used today. (bioethics.net)
  • For example, although vaccines against Hepatitis A are produced using the historic fetal-derived cell line MRC-5, modern vaccines against the related Hepatitis B virus are produced using genetically engineered yeast cells. (bioethics.net)
  • Research using fetal tissue has saved millions of lives through the development of vaccines for diseases that once ravaged communities across the world. (scienceinpublic.com.au)
  • It is currently being used to develop and test vaccines for potential treatment of influenza, dengue fever, HIV/AIDS, and hepatitis B and C. It is vital for research in other areas as well. (statnews.com)
  • centers
  • The purpose of this funding opportunity announcement (FOA) is to announce the competition of the Obstetric-Fetal Pharmacology Research Centers (OPRC) - a specialized cooperative multicenter program in the obstetric pharmacology research. (nih.gov)
  • The centers will also serve as national resources for clinical pharmacological research in women during normal and abnormal pregnancies. (nih.gov)
  • The organization also serves as a liaison between families affected and the many fetal treatment centers around the country providing groundbreaking care. (marketwired.com)
  • The network currently includes three research centers. (nih.gov)
  • prenatal
  • Yet research on prenatal alcohol consumption and interventions has only gained significant ground in recent decades. (minnpost.com)
  • For more than 12 years, Jeffrey Wozniak, Ph.D., associate professor in the University of Minnesota's department of psychiatry , has been studying the impact of prenatal alcohol exposure on children through his work at the Fetal Alcohol Spectrum Disorders Clinic at the University of Minnesota . (minnpost.com)
  • S., Raivio, K., and Karjalainen, O.: Prenatal diagnosis and fetal pathology of I-cell disease (mucolipidosis type II). (springer.com)
  • ethically
  • The tissue used in this research would otherwise be discarded, and safeguards have been in place for decades to ensure that the tissue is obtained and used ethically. (statnews.com)
  • The fetal tissue that is used for research would otherwise be discarded if not used for research, and is ethically obtained under long-standing regulations supported by both Republican and Democratic administrations. (isscr.org)
  • diseases
  • With the consent of donors, this unique and valuable tissue can be used for research into basic biological processes and human development, as well as creating new treatments for life-threatening diseases. (isscr.org)
  • The ISSCR endorses fetal tissue research as essential to the prevention and treatment of life-threatening diseases. (isscr.org)
  • Contrast this to the over 5,800 successful clinical trials using non-fetal stem cells to treat diseases that are already advancing to phase II and phase III trials. (lozierinstitute.org)
  • gestational
  • What is most promising is that relatively small increases in foetal growth and gestational age at delivery are associated with major improvements in survival and morbidity. (ucl.ac.uk)
  • pulmonary
  • Patent Ductus Arteriosus is a congenital defect of the heart where the fetal passage between pulmonary artery and aorta remains open and causes excess pulmonary blood flow. (medindia.net)
  • Previous studies showed that synthetic bradykinin produced in-vitro constriction of the ductus arteriosus of the fetal lamb and guinea pig, constriction of isolated human and lamb umbilical vessels, and pulmonary vasodilatation in the fetal lamb. (ahajournals.org)
  • Parkinson's
  • While recent efforts to transplant fetal tissue to treat conditions like Parkinson's haven't been as consistently successful, it's still critical to scientific progress. (time.com)
  • pregnancy
  • Ultrasound during pregnancy is a non-invasive procedure and is an integral part of the fetal monitoring during the pregnancy. (medindia.net)
  • Indeed, there is no reason to believe that the use of fetal tissue in medical research has any influence on a woman's decision to terminate a pregnancy. (statnews.com)
  • The mission of the OPRC Network, formerly the Obstetric-Fetal Pharmaceutical Research Units Network, is to improve the safety and effective use of therapeutic drugs in women during pregnancy and lactation. (nih.gov)
  • donation
  • This effort, to separate tissue donation from any incentive, is accompanied by laws that apply significant criminal and civil penalties for the purchase or sale of fetal tissue, or for soliciting or acquiring fetal tissue after providing "valuable consideration" for the costs associated with the abortion itself. (statnews.com)
  • The $25,000 donation from the Brianna Marie Foundation will be utilized primarily to fund research and/or therapy that aids unborn babies who suffer from birth defects affecting the lungs. (marketwired.com)
  • development
  • In particular, the editors of Nature called the report "fantasy politics" that revised "the long history of the role of fetal-tissue research in vaccine and therapy development. (bioethics.net)
  • David Ayares, head of research and development at the U.S. division of PPL Therapeutics, said, "This changes the whole dialogue. (californiahealthline.org)
  • The development of the polio vaccine, which relied on the use of cultured cells from fetal tissue, has prevented hundreds of thousands of cases of polio each year and was recognized with a Nobel Prize in 1954. (isscr.org)
  • We are looking for abnormalities in the way these children's brains have developed as result of having been exposed to alcohol during fetal development. (minnpost.com)
  • There's also emerging literature that shows that kids with FASD have higher incidence of later-life medical problems related to the early insults to their fetal development caused by alcohol exposure. (minnpost.com)
  • Adults with FASD may have higher rates of certain conditions, including obesity and diabetes, related to the earlier insult to their fetal development. (minnpost.com)
  • Indeed, the use of donated fetal tissue has shown us how the Zika virus crosses the placenta and alters human brain development. (statnews.com)
  • Federal law was adjusted in 1975 to add language clarifying that this research be "conducted only in accordance with any applicable State or local laws regarding such activities," and only for "the development of important biomedical knowledge which cannot be obtained by other means. (statnews.com)
  • Fetal Health awarded its first $25,000 research grant, the Nathanael & Gabriel Stowell Research Grant, in October of 2014 to a team at Children's Hospital of Los Angeles that will further study the impact of Twin-to-Twin Transfusion Syndrome (TTTS) on fetal brain development. (marketwired.com)
  • The development of the human fetal adenohypophysis Research supported by grant HD 00557 from the National Institute of Child Health and Human Development, National Institutes of Health. (umich.edu)
  • The main industrial collaborator engaged in the research is Ark Therapeutics Group plc, London, UK, a contract development and manufacturing organisation with specialist expertise and facilities for the development of viral based products. (ucl.ac.uk)
  • The sequencing identified two gene mutations that affected a metabolic pathway vital for foetal development. (thewarrencentre.org.au)
  • interventions
  • We participate in several multicenter clinical studies at the national and international levels, and conduct ongoing studies in which we are able to offer the latest fetal interventions for appropriate patients. (lifespan.org)
  • lungs
  • The hypothesis is presented diat bradykinin is produced from kininogen in the lungs of the fetal lamb when oxygenated, and that the maximal rate of production occurs during the first few minutes after expansion of the lungs or exposure of the ewe and fetus to hyperbaric O 2 . (ahajournals.org)
  • stem cell res
  • The resulting debate hampered stem cell research in the U.S. for nearly a decade, after the George W. Bush Administration prevented federal research money from being used to study excess embryos that couples had donated after IVF. (time.com)
  • proposals
  • With the demise of the Department of Health and Human Services' Ethics Advisory Board in September 1980, there has been little federal review of fetal research proposals. (georgetown.edu)
  • These proposals, if enacted, would obstruct critical biomedical research and inhibit efforts to improve human health. (isscr.org)
  • health
  • Fetal tissue has been used for research in the U.S. since the 1930s , with bipartisan support from the Congress and funding from the National Institutes of Health. (statnews.com)
  • DENVER, CO--(Marketwired - Mar 12, 2015) - The Fetal Health Foundation announced the creation of a new research grant named to honor the memory and inspiration of Brianna Marie Hissam. (marketwired.com)
  • The Fetal Health Foundation, which was founded in 2006, is a national nonprofit based in Littleton, Colorado. (marketwired.com)
  • For more information about the Fetal Health Foundation, visit www.fetalhealthfoundation.org or call 877-789-HOPE (4673). (marketwired.com)
  • The ISSCR is troubled by the recent decision by the U.S. Department of Health and Human Services to "conduct a comprehensive review of all fetal tissue research. (isscr.org)
  • Decisions about how best to conduct research and to advance human health should be based on science and medicine, not ideology or politics. (isscr.org)
  • She says the National Institutes of Health funds about $70 million a year in such research, but there's much more than that. (usf.edu)
  • In a recent five-year period (2010-2014), only 0.2% of grants funded by the National Institutes of Health (NIH) and only 0.01% of the clinical trials use fetal tissue. (lozierinstitute.org)
  • adult
  • When compared to adult dermal cells, fetal cells display several advantages, including a greater cellular yield after isolation, the ability to proliferate longer, and the retention of differentiation potential," said study co-author Dr. C.M. Chinnici of the Fondazie Ri.MED, Regenerative Medicine and Biomedical Technologies Unit in Palermo, Italy. (medindia.net)
  • proven
  • Cells from fetal dermis have been proven safe and efficacious in the treatment of pediatric burns, but proper characterization of these cells has not yet been provided. (medindia.net)
  • circulation
  • Fetal heart ultrasound is used to view your unborn baby s heart, assess fetal heart circulation, flow of blood in the various chambers of heart and fetal heartbeat. (medindia.net)
  • Young women may regulate fetal microchimerism differently and surprisingly our data may suggest that as fetal microchimerism emerges later in life in the circulation, so does the protection against breast cancer - a finding consistent with population based studies of parity as a risk factor for breast cancer. (aacrjournals.org)
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  • 1970s
  • Three major Pharmaceutical players (Merck, GlaxoSmithKline and Sanofi) adopted the fetal cell lines MRC-5 and WI-38 in the 1970s, shortly after they were developed. (bioethics.net)