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  • Fetus
  • An inflammatory protein that triggers a pregnant mouse's immune response to an infection or other disease appears to cause brain injury in her fetus, but not the premature birth that was long believed to be linked with such neurologic damage in both rodents and humans, new Johns Hopkins-led research suggests. (hopkinsmedicine.org)
  • Amino acid-stimulated increases in fetal glucagon, cortisol, and NE may contribute to a shift in substrate oxidation by the fetus from glucose to amino acids. (physiology.org)
  • Disruption of normal rates of amino acid transport into the fetus and, thus, abnormal fetal plasma amino acid concentrations could limit fetal protein synthesis and/or lead to abnormal amino acid metabolism, even to the point of producing metabolic acidosis. (physiology.org)
  • It is not known whether these observations are specific to the mode of delivery of supplemental amino acids to the fetus (via the mother and placenta vs. a direct fetal infusion) or to the excess amino acids themselves. (physiology.org)
  • mRNA
  • Using a differential mRNA display approach, we identified a cDNA of the cold shock domain protein A (CSDA), a trans-acting factor previously reported to interact in vitro with the gamma-globin gene promoter. (unina.it)
  • exposure
  • A third group first got an injection of a compound known to block the effects of interleukin-1 beta (IL-1), a protein involved in activating the inflammatory immune response and shown in previous research to be a key player in modulating fetal brain injury following exposure to inflammation in the womb. (hopkinsmedicine.org)
  • human
  • According to the manufacturer-produced package inserts included with each vaccine batch, many vaccines are made with disturbing ingredients like aborted human fetal proteins, altered DNA material, and even genetically-modified (GM) human albumin. (naturalnews.com)
  • MMR II is the only known vaccine that contains GM human protein, according to NVIC, but its unique presence in this contentious combination vaccine could help explain the unusual uptick in vaccine-induced neurological damage associated with it in recent years. (naturalnews.com)
  • According to NVIC, there are three main sources of human protein in vaccines: fetal cell lines, human albumin derived from human blood, and human albumin genetically engineered from yeast. (naturalnews.com)
  • So what we know is that aborted fetal cell lines, GM human albumin, and human albumin and DNA derived from other unknown sources are all being used to develop many of the vaccines being injected into society's most fragile and sensitive members today. (naturalnews.com)
  • This nonspecific protein was abundantly detected by SC-7196 in U937 and COS-1 cells as well as across all human fetal protein samples. (hindawi.com)
  • This band was subjected to digestion, peptide extraction, and sequence analysis using MALDI-MSMS, and the protein was identified as cytoplasmic actin with a decisive score (human SwissProt database, 60% protein coverage using the 15 highest scoring peptide groups and two lower scoring but acceptable peptides). (hindawi.com)
  • sheep
  • Experiments using normal pregnant sheep have led to some testable explanations for how high-protein supplementation during pregnancy might adversely affect fetal outcomes ( 4 ). (physiology.org)
  • mechanisms
  • In research designed to identify the exact mechanisms behind preterm birth and fetal brain injury, Burd says she and her term were surprised to learn that they may have different pathways and origins. (hopkinsmedicine.org)
  • Fetal hemoglobin levels are regulated by complex mechanisms involving factors linked or not to the beta-globin gene locus. (unina.it)
  • alpha
  • Herein, we constructed a dual amplification fluorescence sensor by incorporating immunohybridization chain reaction (immuno-HCR) and metal-enhanced fluorescence (MEF) of CDs for the detection of alpha fetal protein (AFP). (figshare.com)
  • what else can elevated alpha fetal protein indicate? (brainscape.com)
  • brain
  • The researchers say that blocking IL-1 halted a cascade of inflammatory responses that would otherwise lead to the activation of neuronal nitric oxide synthase in the fetal brain, an enzyme implicated in neurotoxicity. (hopkinsmedicine.org)
  • expression
  • With state-of-the art molecular biology and protein biochemistry labs, we work with our clients to rapidly evaluate in parallel to identify the optimal expression system for candidate proteins. (abgent.com)
  • Based on this reanalysis, the expression of PPAR γ protein shown in (c) of Figures 1-9 are replaced by Figure 2 . (hindawi.com)
  • The data summary described in Table 1 of the above-mentioned paper regarding the change in PPAR γ protein expression with fetal age is replaced by Table 1 . (hindawi.com)
  • pregnant
  • Down the road, we hope to be able to treat pregnant women whose babies are at risk for this type of neurologic damage and prevent it from happening," says study leader Irina Burd, M.D., Ph.D. , an assistant professor of gynecology and obstetrics and neurology at the Johns Hopkins University School of Medicine and director of the Integrated Research Center for Fetal Medicine . (hopkinsmedicine.org)
  • gene
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • Similar
  • Fetal protein accretion (2.6 ± 0.5 and 2.2 ± 0.6 μmol·min −1 ·kg −1 in AA and Con, respectively), synthesis (6.2 ± 0.8 and 7.0 ± 0.9 μmol·min −1 ·kg −1 in AA and Con, respectively), and degradation (3.6 ± 0.6 and 4.5 ± 1.0 μmol·min −1 ·kg −1 in AA and Con, respectively) rates were similar between groups. (physiology.org)
  • total
  • Three different blood test that are offered as part of prenatal screening for birth defects.Total of 6 fetal proteins that can be tested. (smore.com)
  • high
  • in vivo it appears to influence the degree of steroid binding to albumin rather than acting primarily as a high affinity saturable binding protein. (uea.ac.uk)
  • different
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)