Fetal origins of adult rats fetal proteins. Medical search. Frequent questions

Here, we show that maternal exposure to a phthalate mixture interferes with the expression profile of mRNA and proteins in the ventral prostate of offspring and increases the susceptibility to prostate adenocarcinomas in aged animals. (bvsalud.org)
Evidence indicates that maternal undernutrition in early life promotes changes in key hormones, such as glucocorticoids, growth hormones, insulin-like growth factors, estrogens and androgens, during fetal development. (bvsalud.org)
Within the male reproductive system, maternal protein malnutrition alters development, structure, and function of the gonads, testes and prostate gland. (bvsalud.org)
This review assembles current thoughts on the concepts and mechanisms behind the developmental origins of health and disease as they relate to protein malnutrition, and highlights the effects of maternal protein malnutrition on rat prostate development and homeostasis. (bvsalud.org)
glucocorticoids, protein restrictions, and maternal diet and obesity. (cdc.gov)
Role Description: The goal of this study is to determine the effects of maternal Vitamin A upon fetal lung development in the context of mechanical ventilation. (childrensmercy.org)
In turn, chronic fetal hypoxaemia promotes oxidative stress, and maternal antioxidant therapy in animal models of hypoxic pregnancy has proven to be protective with regards to fetal growth and cardiovascula. (researchgate.net)
Factors that cause a low incidence of tumours in offspring after birth, compared contribute to fetal susceptibility to near the end of gestation, in offspring with the incidence and multiplicity of these agents include maternal, pla that were exposed trans placental y. the same types of tumours in their cental, and fetal metabolism, the im This pattern can be seen in the directly exposed mothers. (who.int)

The objective of the present study is to investigate the modulation of antioxidant defence status in neonatal persistent hypothyroid rats before their sexual maturation and also to identify the specific testicular cell populations vulnerable to degeneration during neonatal hypothyroidism in immature rats. (hindawi.com)
In our earlier studies, it was reported that transient hypothyroidism (from day 1 of neonatal age till day 30) modulated testicular antioxidant defence status as well as functions in adult stage [ 7 ]. (hindawi.com)
2007). It has been suggested that the intestinal transcription factor Blimp-1 is a critical driver of the postnatal epithelial phenotype, whose expression loss in the third postnatal week is a likely requirement for the maturation of the neonatal epithelium to adult epithelium (Harper, et al. (researchsquare.com)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)

Dr. Lane has actively participated in the US Developmental Origins and Health and Disease Society. (childrensmercy.org)
The concept of the early life developmental origins of health and disease (DOHaD) in adults has stimulated a new approach to understanding disease trajectories, with major public health implications. (researchgate.net)

Bone morphogenetic protein ( BMP ) signaling patterns tissues along the dorsal-ventral axis and simultaneously directs the cell movements of convergence and extension. (edu.au)
ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)

1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

Several investigations [ 5 - 7 ] have been carried out with isolated embryonic, fetal, and adult SCs in a well-defined culture microenvironment to define the sequential steps and intracellular pathways that are involved in their differentiation into the specific cell lineages. (biomedcentral.com)

Fetal nutrition and adult disease : programming of chronic disease through fetal exposure to undernutrition. (wikipedia.org)
In humans, low protein intake by women in late but intrauterine exposure was (20). (cdc.gov)
Their further maturation and expansion will depend on food protein re-exposure. (frontiersin.org)
Specific Treg then provide active tolerance to the harmless food proteins at all mucosal surfaces, either via cell contact or via their secretion of immunosuppressive factors that both prevent the induction of adaptive T helper (Th) lymphocytes in response to antigenic re-exposure ( 7 ). (frontiersin.org)
Prenatal nicotine exposure increases osteoarthritis susceptibility in male elderly offspring rats via low-function programming of the TGFβ signaling pathway [3] "Epidemiological investigations indicate that effects related to prenatal adverse environments on the organs of the offspring could continue to adulthood. (edu.au)
Fetal exposure to water disinfection by-products alters postnatal growth and glucose homeostasis. (mcmaster.ca)
This chapter exposed adults, with a shorter laten onal solid tumours, are observed as summarizes the literature that docu cy period from the time of exposure tumours of adult life in conventional ments this high susceptibility of the to the carcinogen until the appear rodents. (who.int)
Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
Most experimental studies of the predominant results of earlylife do not develop in rats exposed to the carcinogenesis during prenatal life exposure are what would be expect same carcinogen during adult life and infancy have been conducted ed from a higher effective dose to the (Diwan and Rice, 1995 ). (who.int)

In our earlier reports, it was demonstrated that experimentally hypothyroidism modulates several oxidative stress and antioxidant defence parameters in mitochondria and postmitochondrial fractions in adult rat testis [ 18 , 19 ]. (hindawi.com)
We also reported about the effects of transient and persistent hypothyroidism on testicular antioxidant defence system in mature rats to know the role of hypothyroidism-induced oxidative stress in testicular development and maturation [ 7 ]. (hindawi.com)

When rat dams consume a diet low in protein during pregnancy, their offspring develop high blood pressure. (portlandpress.com)
In the present study, five groups of Wistar rats were provided during pregnancy with one of five diets: a control diet containing 18% (w/w) casein (CON), a low-protein diet containing 9% casein (MLP), or the low-protein diet supplemented with 3% glycine (MLPG), alanine (MLPA) or urea (MLPU). (portlandpress.com)
This was the first study to suggest that smoking tension and vascular defects (8,9), altered fetal pancreatic during pregnancy is linked to adverse changes in the lipo- development and structure (10), altered glucose tolerance protein levels of children (19). (cdc.gov)
Chronic fetal hypoxaemia is a common pregnancy complication that increases the risk of infants experiencing respiratory complications at birth. (researchgate.net)
If neural tube defects occurred in a woman's previous pregnancy, increased antepartum fetal surveillance is required for the current pregnancy. (medscape.com)
During pregnancy, rats were divided into a PNE group and a control group. (edu.au)

The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. (bmj.com)
The programming of blood pressure, insulin responses to glucose, cholesterol metabolism, blood coagulation, and hormonal settings are all areas of active research.The BMJ's recent editorial on the fetal origins hypothesis stated that it rests only on the "very general" proposition that fetal undernutrition causes coronary heart disease. (bmj.com)
The hypothesis states that coronary heart disease is associated with specific patterns of disproportionate fetal growth that result from fetal undernutrition in middle to late gestation. (bmj.com)

Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. (researchgate.net)

Dr. Lane's research program focuses upon on how perinatal events affect in vivo epigenetic determinants of gene expression and lead to adult disease. (childrensmercy.org)
90 publications are devoted to how perinatal events lead to adult disease. (childrensmercy.org)
Gestational hypoxia is a major contributor to fetal growth restriction (FGR) and perinatal morbidity and mortality and has been closely linked to the activation of the unfolded protein response (UPR) in the placenta. (researchgate.net)

which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)

We transplanted, as a single cell suspension, cells dissociated from the mature and immature olfactory epithelium of rats or TgR(ROSA26)26Sor mice expressing constitutively the LacZ gene into the developing brain (cerebellum, striatum, inferior colliculus, lateral ventricles) of E15 rat fetuses. (unipv.it)
With uterine somites in proteins and epub CCD Astrophotography:High Quality Imaging from cell, displays are impressed generally conducted out for mice increasing from the Post of a neural aircraft to Christian church parent. (dreamsheet.de)

First, prenatal and early life perspectives on nutrition and obesity from gestation to experiences influence the trajectory of weight into adult- adolescence. (cdc.gov)
High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)

Despite the high prevalence of fetal alcohol spectrum disorder (FASD), there are few interventions targeting its core neurocognitive and behavioral deficits. (biomedcentral.com)
Diagnoses were 12.9% fetal alcohol syndrome (FAS), 41.9% partial FAS, and 45.1% alcohol-related neurodevelopmental disorder. (biomedcentral.com)

An altered antioxidant defence system marked by elevated SOD, CAT, and GR activities, with decreased GPx and GST activities were observed along with increased protein carbonylation, disturbed redox status in hypothyroid immature rat testis. (hindawi.com)
However, information about the role of deprivation of thyroid hormone in early developmental growth and function of testis in relation to antioxidant status in immature rats is inadequate. (hindawi.com)

Estates in the Kandy SHS: area were selected for the prevalence of protein energy malnutrition (PEM) i8 hisrne!3t in the Kandy SHS area and also because , out of the three island wide population sectors (viz. (who.int)

Feeding low-protein diets to pregnant rats produces a increased more than in children not exposed to tobacco in broad spectrum of disorders in their offspring (7): hyper- utero. (cdc.gov)

This reproducible immune reaction results from an impaired induction of oral tolerance, i.e., a suppressive immune process at local and systemic levels that physiologically allows harmless dietary proteins to be tolerated by the immune system, thus avoiding chronic intestinal inflammation due to their regular consumption. (frontiersin.org)

Fetal tissue allografts in the central visual system of rodents. (org.es)
It has long been believed that the number of neurons does not increase after birth, but some studies have shown that in adult rodents and primates new neurons are formed after damage (Rakic, 2002). (encyclopedia.com)

Some of them were immunoreactive for the olfactory marker protein. (unipv.it)
Our findings show that cells dissociated from the developing and adult olfactory organs when transplanted into the rat fetal brain can either completely change their fate and differentiate according to their final position or generate an olfactory epithelium if they reaggregate into large clusters. (unipv.it)
With the recent discovery that adult olfactory bulb neurogenesis in the human brain likely ceases after 18 months of age, there is increased interest in studying the NPs of the neonate [ 1 ]. (karger.com)

2023. A comprehensive phylogeny and revised taxonomy illuminate the origin and diversification of the global radiation of Papilio (Lepidoptera: Papilionidae). . (ncbs.res.in)

1997). Within 14 days of postnatal development, Paneth cells mature and express cryptdin proteins as a specific marker (Bry, et al. (researchsquare.com)

Prenatal and postnatal choline supplementation also affects choline acetyltransferase levels in the hippocampus and frontal cortex in rats which are associated with improved memory functioning, especially visual-spatial memory [ 21 , 22 ]. (biomedcentral.com)
These effects of choline are correlated with modifications in histone and DNA methylation in brain, and with alterations in the expression of genes that encode proteins important for learning and memory processing, suggesting a possible epigenomic mechanism of action. (mdpi.com)

n\nIntervention\n\nTwenty-five grams of isoflavone-rich soy protein (91mg of aglycone weight isoflavones: 52mg genistein, 36mg daidzein, 3mg glycitein) ABT-737 in vivo or milk protein-matched placebo provided daily. (peroxidasessignaling.com)
An in vivo method was utilized in order to determine any anti-implantation, early abortifacient and/or foetal resorption effects of these extracts. (who.int)

No mouse passage was involved, but the original stool sample had been passaged several times in Wistar Institute-38, human fetal diploid lung-645, and human fetal diploid kidney cells. (cdc.gov)

For example, in the mouse, NANOS2 plays a role in meiosis suppression by preventing Stra8 expression in male foetal gonads 4 . (nature.com)
Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
Osteonectin expression was evaluated using immunohistochemistry with anti-secreted protein acidic and rich in cystein (anti-SPARC) antibody. (bvsalud.org)

This stimulation of cAMP was not Ca 2+ -sensitive and was unaffected by a range of protein kinase inhibitors. (jneurosci.org)
In all TiO 2 -treated rats, stimulation of immune cells isolated from PP showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased. (nature.com)

Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)

In this method the isotonic contractions of the isolated uterine horn of the oestrogenised rat were observed in the presence of various plant extracts. (who.int)

FA is an adverse reaction that results from an inappropriate and excessive immune response against dietary proteins. (frontiersin.org)
The problem of protein energy malnutrition that affects millions of children in the world is firmly rooted in the cultural pattern, dietary habits and the general soci.o-economic condition of the people. (who.int)

Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. (thermofisher.com)

A census of actin-associated proteins in humans. (ncbs.res.in)

The paucity of information on some aspects of these factors prompted me to under this study In this project the epidemiology of protein energy malnutrition :was studied. (who.int)

Colocalization experiments with marker proteins revealed that Rma1H1 resides in the endoplasmic reticulum (ER) membrane. (peroxidasessignaling.com)

This compromised testicular antioxidant status might have contributed to poor growth and development by affecting the spermatogenesis and steroidogenesis in rats before puberty as indicated by reduced germ cell number, complete absence of round spermatids, decreased seminiferous tubule diameter, and decreased testosterone level. (hindawi.com)
Nanos are RNA-binding proteins playing crucial roles in germ cell development and maintenance. (nature.com)
The Nanos proteins family regroups highly conserved RNA-binding proteins in higher eukaryotes implicated in germ cell development and maintenance. (nature.com)

Animal studies have shown that PCBs induce effects in monkeys at lower doses than in other species, and that immunological, dermal/ocular, and neurobehavioral changes are particularly sensitive indicators of toxicity in monkeys exposed either as adults, or during pre- or postnatal periods. (cdc.gov)

However, various subsequent studies revealed that thyroid hormone plays a key role in rat testis development [ 4 - 7 ]. (hindawi.com)
Well-controlled intrauterine development is an essential condition for many aspects of normal adult physiology and health. (bvsalud.org)
In the fifth week of fetal development, neuroblastic cells migrate from the thoracic neural crest to form the sympathetic chains and preaortic ganglia. (medscape.com)
Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. (thermofisher.com)
This study confirmed the developmental origin of OA, and clarified the congenital and the living environment impact on the occurrence and development of OA. (edu.au)

Furthermore, these targets showed strong relationships with 12 transcriptional factors (TF), which regulate the phosphorylation of eight protein kinases. (bvsalud.org)

Sixty one plants reputed to have anti-fertility activity were tested on female Sprague-Dawley rats, in order to isolate active compounds with a potential for use in human fertility regulation. (who.int)

Fetal type Leydig cells disappear soon after birth (during first 2 weeks after birth) and are replaced by adult type Leydig cells [ 22 , 23 ]. (hindawi.com)
Scattered cells, despite their placodal origin, differentiated into neuron or glial cells with a central phenotype. (unipv.it)
This was demonstrated by anatomical methods and selective amplification of cDNA encoding for neuronal specific transcripts (microtubule-associated protein 2 and middle-molecular-mass neurofilament protein) expressed by the engrafted cells. (unipv.it)
Treatment of the pertussis toxin-treated cells with cholera toxin before CB1 receptor activation amplified the stimulatory pathway, suggesting that this response was mediated through a G s -type G-protein. (jneurosci.org)
In addition, Nanos1B protein was predominantly located in the nuclei of male germinal cells. (nature.com)
A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)
Taken together, these data identify Nanos as primordial genes with highly conserved functions for both, the migration of the germinal cells and their maintenance in adults. (nature.com)
In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer's patches (PP) as observed with the TiO 2 -NP model NM-105. (nature.com)
The establishment of oral tolerance is dependent on the controlled uptake of food proteins through the intestinal epithelial barrier and its delivery to local dendritic cells (DC) that matured in the intestinal pro-tolerogenic environment. (frontiersin.org)
The "pro-tolerogenic" antigen-loaded DC will migrate to draining mesenteric lymph nodes, where they will present the food protein-derived peptides to naive T cells and favour the induction of a subpopulation of T cells, namely regulatory T cells (Treg). (frontiersin.org)
In addition, Paneth cells provide a niche for leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing stem cells in crypts (Sato, et al. (researchsquare.com)
Our previous study showed that the absorptive cells of the jejunum and ileum change rapidly and dramatically from suckling to adult type during the weaning period (Fujita, et al. (researchsquare.com)
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

In the fetal period, from nine weeks after conception onwards, there begins the phase of rapid growth that continues until after birth. (bmj.com)
After birth, rats were given a high-fat diet for 6 months and long-distance running for 6 weeks. (edu.au)
The rats were euthanized at 18 months after birth (PM18) and on gestational day 20 (GD20), respectively. (edu.au)

These results suggested that PNE enhanced the susceptibility of OA in male elderly offspring rats by down-regulating TGFβ signaling, which increased articular cartilage local inflammation, matrix degradation, and cell apoptosis. (edu.au)
The susceptibility of but a few known transplacental car and reach the fetus, a carcinogenic the fetus relative to that of adult rats cinogens are organic compounds chemical may have no transplacen is measured as the incidence and that act principal y or entirely by a ge tal carcinogenic activity or may only multiplicity of tumours that develop notoxic mode of action. (who.int)

The main feature of fetal growth is cell division. (bmj.com)
To test for [the possibility that the bone length gain was due to residual gain due to growth plate growth], we partitioned the sample into those cases whose younger-adult age at examination was less than 25 years and those with a radiograph after 25 years of age. (heightquest.com)
Anti-Müllerian hormone ( AMH ) is also a member of the Transforming Growth Factor-β family of secreted signaling proteins. (edu.au)

become manifest only during adult life than in adulthood. (who.int)

In the early twentieth century Karl Lashley carried out experiments on newborn rats. (encyclopedia.com)

Such insights on developmental trajectories of adult-onset prostate disease may help provide a foundation for future studies in this field. (bvsalud.org)

B, solute carrier relatives six member 2, solute carrier relatives 18 member one, and transcription factors and homeobox genes involved in neural crest derived cell de velopment, paired like homeobox 2a and 2b, GATA binding protein two and 3, heart and neural crest derivatives expressed two. (pdpksignaling.com)

Bone marrow oedema (BME) and avascular osteonecrosis (AVN) are disorders of unclear origin. (biomedcentral.com)

Cannabinoids exert many of their effects through activation of G i -protein-coupled receptors. (jneurosci.org)
BSEP , Na + -taurocholate cotransporting polypeptide, and organic anion transporting polypeptide B were downregulated with most cholestatic and some noncholestatic drugs, whereas deregulation of multidrug resistance-associated proteins was more variable, probably mainly reflecting secondary effects. (aspetjournals.org)
Information on health effects of PCBs is available from studies of people exposed in the workplace, by consumption of contaminated rice oil in Japan (the Yusho incident) and Taiwan (the Yu-Cheng incident), by consumption of contaminated fish, and via general environmental exposures, as well as food products of animal origin. (cdc.gov)
Administration of the glutamate-modulating drug, riluzole, after stress prevents its delayed effects on the amygdala in male rats. (ncbs.res.in)

Most vertebrates are unable to grow and reach their normal adult form without the thyroid hormone [ 1 , 2 ]. (hindawi.com)

Animals, human infants, and human adults, show the same ratio signatures (based on Weber's Law). (scienceblogs.com)
Adult tamarins are on par with 9-month-old human infants. (scienceblogs.com)

These phthalate-induced targets were enriched for pathways such as: dysregulation in post-translational protein modification (PTPM), cell homeostasis, HSP90 chaperone activity, gap junctions, and kinases. (bvsalud.org)
Whole cell extracts (30 µg lysate) of HeLa (Lane 1), SH-SY5Y (Lane 2), A549 (Lane 3), A-431 (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). (thermofisher.com)

In 2012 he was awarded a DSc from the University of Nottingham in recognition of his contribution to research into the early life origins of adult disease. (wikipedia.org)
For many years, he collaborated closely with David Barker to lay the nutritional foundations and molecular basis of the early life origins of adult disease. (southampton.ac.uk)
Dexamethasone phosphate/DEMO is indicated in the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with body weight at least 40 kg) who require supplemental oxygen therapy. (who.int)
METHODS: We conducted a prospective cohort study comparing adults with SARS-CoV-2 infection (coronavirus disease-positive [COVID+]) with adults who tested negative (COVID-), enrolled within 28 days of a Food and Drug Administration (FDA)-approved SARS-CoV-2 test result for active symptoms. (cdc.gov)

Earlier this week I wrote about the developmental and evolutionary origins of large number representation. (scienceblogs.com)

Anatomy15

Organisms6

Diseases4

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Psychiatry and Psychology1

Phenomena and Processes18

Disciplines and Occupations1

Information Science4

Named Groups1

Health Care1

Maternal8

Neonatal4

Developmental Origins2

Tissues2

Progenitor cells1

Embryonic1

Exposure9

Oxidative stress2

Pregnancy6

Undernutrition3

Glucocorticoids1

Perinatal3

Carcinogenesis1

Mice2

Gestation2

Alcohol2

Immature2

Prevalence1

Diets1

Chronic intestinal inflammation1

Rodents2

Olfactory3

20231

Postnatal development1

Choline2

Vivo2

Lung1

Expression4

Stimulation2

Recombinant1

Uterine1

Dietary2

Kinase1

Humans1

Malnutrition1

Marker1

Germ cell3

Monkeys1

Development5

Phosphorylation1

Isolate1

Cells14

Birth3

Susceptibility2

Growth3

Adulthood1

Experiments1

Trajectories1

Neural crest1

Disorders1

Effects4

Vertebrates1

Infants2

Cell2

Disease4

Evolutionary1