Fetal origins of adult disease maternal and fetal fetal proteins. Medical search. Frequent questions

We showed that maternal blueberry diet protects mice against breast cancer development by up-regulation of growth suppressor proteins and hormones that are associated with obesity and inflammation. (usda.gov)
The maternal diet habits or macronutrient intakes such as fast food or junk food eaters contribute to gestational diabetes and maternal obesity. (iium.edu.my)
Maternal malnutrition results in poor foetal or infant programming, which leads to childhood obesity and an increase in diabetes and cardiovascular disease later in life. (iium.edu.my)
First, prenatal and early life perspectives on nutrition and obesity from gestation to experiences influence the trajectory of weight into adult- adolescence. (cdc.gov)
abilities are intensified to specific maternal and environ- mental exposures that can lead to obesity (2). (cdc.gov)
Although a person is at risk for During gestation, risk factors for obesity include maternal obesity throughout his life, we focus on specific develop- diet, overweight, and smoking. (cdc.gov)
glucocorticoids, protein restrictions, and maternal diet and obesity. (cdc.gov)
Many disease conditions-including obesity, arthritis and heart disease-- are affected by an ongoing inflammation even when there is no infection. (ohsu.edu)
We now have a better appreciation of how overweight and obesity cause chronic non-communicable diseases which are increasingly the major causes of ill health and reduced life expectancy in all countries across the globe. (southampton.ac.uk)
Early nutrition and lifestyle before and during pregnancy, breastfeeding, infancy, and early childhood can affect the risk of developing common non-communicable diseases during adulthood such as obesity and metabolic syndrome. (mdpi.com)
Because glucocorticoid can inhibit the Nrf2-dependent antioxidant response and the Nrf2 activator can prevent HF diet-induced obesity and related diseases [ 15 - 17 ], we hypothesize that the activation of Nrf2 could be a therapeutic approach in the prevention of prenatal DEX- and postnatal HF-induced programmed hypertension via the regulation of oxidative stress, SEH, and nutrient sensing. (hindawi.com)
Many human and experimental studies have shown the relationship between low-birth-weight and obesity, insulin-resistance and the MS. Recently studies showed that fetal IUGR is an independent risk factor for insulin-resistance that it is amplified by obesity in childhood. (redsamid.net)
Inflammation seems to be the major initiator of many processes that leads to self-healing as well as pathogenesis of major metabolic diseases, including, atherosclerosis, obesity, metabolic syndrome, type-2 diabetes, ischemic heart disease and stroke. (crimsonpublishers.com)
In this webinar, we will discuss the current knowledge on how maternal obesity impacts children's neurodevelopment and its developmental origin. (tufts.edu)
We will review the epidemiological associations between maternal obesity and childhood neurodevelopmental disorders and their potential underlying mechanisms. (tufts.edu)
In this webinar, we will also discuss recent studies, including Tarui Laboratory, to investigate the impact of maternal obesity on fetal and neonatal brain development by utilizing advanced fetal and neonatal brain neuroimaging technologies. (tufts.edu)
We used a Japanese macaque model to investigate whether maternal obesity combined with a Western-style diet (WSD) impairs offspring muscle insulin action. (diabetesjournals.org)
Jillian Tutuo Wate, Deputy Director-Research, Pacific Research Centre for the Prevention of Obesity and Non-Communicable Diseases (C-POND), Fiji National University, consultant for reviewing the policy. (who.int)

His principal contribution was the development of experimental models to test the hypothesis that variation in maternal nutrition during pregnancy could programme long-term health and disease. (wikipedia.org)
According to the Developmental Origins of Health and Disease hypothesis, environmental exposures in early life affects later life risk. (frontiersin.org)
The "fetal origins" hypothesis proposes that the fetus adapts its growth rate as a response to variations in the supply of nutrients and oxygen, which may lead to permanent changes in the structure and physiology of the fetal body. (bmj.com)
According to an NIH summary, the main basis of the Barker hypothesis is that under nutrition in pregnancy impairs fetal growth or promotes disproportionate fetal growth, and as a trade-off these adaptations that promote survival in adverse conditions, lead to limited physiological functions and development of adult diseases (CMDs) of fetal origin. (crimsonpublishers.com)
The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. (bmj.com)
The programming of blood pressure, insulin responses to glucose, cholesterol metabolism, blood coagulation, and hormonal settings are all areas of active research.The BMJ's recent editorial on the fetal origins hypothesis stated that it rests only on the "very general" proposition that fetal undernutrition causes coronary heart disease. (bmj.com)
The hypothesis states that coronary heart disease is associated with specific patterns of disproportionate fetal growth that result from fetal undernutrition in middle to late gestation. (bmj.com)
The results support the hypothesis that maternal metabolic syndrome classification during pregnancy is associated with some child developmental outcomes at age 5. (biomedcentral.com)

Those insults to the brain occurred during the foetal, neonatal or early post-neonatal periods, and although the specific mechanisms are complex and vary, all are related to cerebral hypoxia and ischemia, and reperfusion (Hilario E. Current Pediatr Review 2006;2:131). (redsamid.net)
Tomo Tarui, MD, is a child neurologist and Director of Fetal Neonatal Neurology at Hasbro Children's Hospital in Rhode Island, USA. (tufts.edu)
Mesenchymal stem/stromal cells (MSCs) can be isolated from neonatal tissues, most of which are discarded after birth, including placental tissues, fetal membranes, umbilical cord, and amniotic fluid. (stemcellsgroup.com)
Thus, neonatal tissues are easily available and they have biological advantages in comparison to adult sources that make them a useful source for stem cells including MSCs. (stemcellsgroup.com)
Changes in UCB proteins (a- fetoprotein, adiponectin, leptin) have been used as diagnostic and therapeutic parameters to monitor fetal and neonatal disorders. (juniperpublishers.com)
[1] , [2] An article in Nature's Mucosal Immunology this month explores some of the key events in foetal and neonatal immune management. (clinicaleducation.org)

For example, even though glucocorticoids are recommended to women at risk of preterm birth to accelerate fetal lung maturation [ 2 ], a growing body of evidence indicates that prenatal glucocorticoid exposure induces a variety of adult diseases, including hypertension [ 3 - 5 ]. (hindawi.com)
Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. (researchgate.net)

Research investigates the effects of maternal diet on fetal central nervous system development, such as protein restriction, manipulation of dietary fatty acid composition, and examination of the effects of a high-fat (western style) diet. (ohsu.edu)
Role Description: The goal of this study is to determine the effects of maternal Vitamin A upon fetal lung development in the context of mechanical ventilation. (childrensmercy.org)
A study was undertaken of people born around the time of the Dutch famine in 1944-5 to determine the effects of maternal malnutrition during specific periods of gestation on the prevalence of obstructive airways disease and atopy. (bmj.com)
After adjusting for maternal, child, and environmental covariates, maternal metabolic syndrome classification during pregnancy was associated with children's LIT domain through direct effects of maternal metabolic health and indirect effects of cord blood markers (total effects), and COM and PSE domains via changes only in a child's cord blood markers (total indirect effects). (biomedcentral.com)

The group speculates that the environment in the womb will hamper the cells' ability to respond to disease states later in the child's life and will lead to cardiovascular disease. (ohsu.edu)
This research team is determined to find the mechanisms in the fetus that lead to adult cardiovascular disease. (ohsu.edu)
Cardiovascular disease: Chicken or the egg? (scienceblogs.com)
Beneficial roles for vitamin D in a spectrum of pathologic processes, including autoimmunity, insulin resistance, cardiovascular disease, and malignancies, are emerging concomitantly with the appreciation of a global pandemic of vitamin D deficiency (Figure 3) [5, 13, 14]. (vitamindwiki.com)
1077) introduced the concept of early programming induced by altered intrauterine environment related to the maternal or fetal protein restrictions, and induces epigenetic gene regulation, in the context of the developmental origins (foetal) of health and cardiovascular disease (Gluckman PD et al 2004;15;183). (redsamid.net)
Patients should have a careful history and physical exam to assess for presence of cardiovascular disease. (nih.gov)
Furthermore, dysfunction in foetal programming is linked with higher susceptibility for immune function and cardiovascular disease from childhood and even into adolescence [ 4 ]. (biomedcentral.com)
He serves on the editorial board of numerous national and international journals, and is a frequent lecturer and presenter at national and international pediatric cardiac conferences on complex cardiovascular disease in both fetal and pediatric patients. (chop.edu)

This group's goal is to better understand how the growth of the placenta affects fetal development and long-term disease risk. (ohsu.edu)
Maternal antibodies primed to react to specific allergens can cross the placenta, passing on transiently allergic reactions to offspring, according to new preclinical research from a collaborative study by the Agency for Science, Technology and Research, KK Women's and Children's Hospital, and Duke-NUS Medical School in Singapore. (a-star.edu.sg)
Studies in the laboratory also showed that maternal IgE can bind to human foetal mast cells, indicating they might cross the placenta in humans in a similar way. (a-star.edu.sg)
This study further showed that the IgE transfer across the placenta requires the help of another protein, FcRN. (a-star.edu.sg)
Placenta-associated pregnancy complications, such as preeclampsia and intrauterine growth restriction, are all associated with aberrant patterns of DNA methylation and expression which are only now being linked to disease risk later in life. (frontiersin.org)
Many pregnancy complications are linked to placenta function and birth outcomes can have a large effect on later disease risk. (frontiersin.org)
Gestational hypoxia is a major contributor to fetal growth restriction (FGR) and perinatal morbidity and mortality and has been closely linked to the activation of the unfolded protein response (UPR) in the placenta. (researchgate.net)
The placenta is a fetomaternal organ from which either fetal or maternal tissue can be isolated. (stemcellsgroup.com)
The placenta is a fetomaternal organ consisting of both fetal and maternal tissue, and thus MSC of fetal or maternal origin can be, theoretically isolated. (stemcellsgroup.com)
Maternal medications can cross the placenta and cause problems in the developing fetus and neonate on delivery. (medscape.com)
Placenta is the principal contributor to the pathogenesis of preeclampsia and delivery of placenta remains the only treatment for the clinical disease. (juniperpublishers.com)

Fetal nutrition and adult disease : programming of chronic disease through fetal exposure to undernutrition. (wikipedia.org)
The risk of adult diseases such as breast cancer can be modified by exposure to certain environmental factors such as diet during early stages of life such as pregnancy and lactation. (usda.gov)
We investigated whether in utero/lactational exposure to blueberry (BB) via maternal diet alters the trajectory of Wnt1-induced mammary tumorigenesis in offspring. (usda.gov)
In humans, low protein intake by women in late but intrauterine exposure was (20). (cdc.gov)
Environmental insults include fetal exposure to alcohol and anesthetics during pregnancy. (ohsu.edu)
A previous study of ours showed that prenatal dexamethasone (DEX) exposure induces hypertension in adult offspring, which is driven by renal programming [ 8 ]. (hindawi.com)
After birth, newborn mice develop allergic reactions to the same type of allergen as their mothers at the time of first exposure - unlike adult mice, which require two exposures. (a-star.edu.sg)
This review will summarise current knowledge on the effect of early environmental exposure on later disease risk, especially where this may be mediated by DNA methylation. (frontiersin.org)
The link between exposure to famine in mid and early gestation and obstructive airways disease in adulthood suggests that fetal lungs can be permanently affected by nutritional challenges during periods of rapid growth. (bmj.com)
Renal Insufficiency - Higher systemic exposure to atomoxetine than healthy subjects for EM subjects with end stage renal disease - no difference when exposure corrected for mg/kg dose. (nih.gov)
There is considerable variability in the incidence of infection and severe disease following exposure to SARS-CoV-2. (thieme-connect.com)
Fetal exposure to water disinfection by-products alters postnatal growth and glucose homeostasis. (mcmaster.ca)

Researchers in this group are investigating how the maternal/intrauterine environment affects brain development in the fetus and in subsequent offspring. (ohsu.edu)
In mammals, this can occur as a result of maternal hypoxia, preeclampsia as well as anemia in the fetus resulting in less red blood cells that can carry oxygen. (scienceblogs.com)
Various maternal factors such as inflammatory, metabolic and immunological disorders during pregnancy can affect the environment in which the fetus is developing and may produce immune, metabolic, hemodynamic, vascular and renal alterations. (juniperpublishers.com)
Since umbilical cord blood (UCB) is in contact with all the fetal tissues and can reflect the state of fetus (both physiological and pathological if any) and UCB can be compared with maternal blood. (juniperpublishers.com)
During fetal development many regulatory substances are exchanged and released into UCB which could reflect physiological and pathological condition of fetus and pregnancy status. (juniperpublishers.com)
During fetal development many regulatory factors influences the fetus and metabolic products from fetus are released into UCB. (juniperpublishers.com)
The mission of the Fetal Heart Program is to offer compassionate, state-of-the-art care to the fetus and the family. (chop.edu)
AN - PRENATAL NUTRITION is also available HN - 2008 BX - Mother Nutrition BX - Nursing Mother Nutrition FX - Maternal Nutrition Physiology DH - Prenatal Nutrition DI - 052506 MN - SP6.021.082 MS - Nutrition of FETUS and mother during PREGNANCY. (bvsalud.org)

It is the second leading cause of maternal mortality worldwide 7 , 8 and may also lead to other serious maternal complications, including stroke, eclampsia, and organ failure. (aafp.org)
The USPSTF found adequate evidence that the well-established treatments of preeclampsia result in a substantial benefit for the mother and infant by reducing maternal and perinatal morbidity and mortality. (aafp.org)
Preeclampsia (PE) is a multisystem disorder and a leading cause of maternal and fetal mortality and morbidity. (juniperpublishers.com)
Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. (juniperpublishers.com)

When rat dams consume a diet low in protein during pregnancy, their offspring develop high blood pressure. (portlandpress.com)
In the present study, five groups of Wistar rats were provided during pregnancy with one of five diets: a control diet containing 18% (w/w) casein (CON), a low-protein diet containing 9% casein (MLP), or the low-protein diet supplemented with 3% glycine (MLPG), alanine (MLPA) or urea (MLPU). (portlandpress.com)
Micronutrients (iron, folate, zinc, iodine, and choline) or vitamins (Vit B12, A, D, E) deficiencies or excesses during pregnancy have been linked to an increased risk of noncommunicable diseases and musculoskeletal problems in adulthood. (iium.edu.my)
Antibodies that block the fetal form of the AChR are occasionally present in mothers who develop MG after pregnancy, especially in those whose babies are born with arthrogryposis multiplex congenita. (ox.ac.uk)
subsequent spread to involve adult AChR could explain development of maternal MG in those cases who first present after pregnancy. (ox.ac.uk)
This was the first study to suggest that smoking tension and vascular defects (8,9), altered fetal pancreatic during pregnancy is linked to adverse changes in the lipo- development and structure (10), altered glucose tolerance protein levels of children (19). (cdc.gov)
PE not only affects the foetus, generating complications during pregnancy but also predisposes them to chronic diseases in adulthood. (biomedcentral.com)
However, in the third trimester of pregnancy, which is also when foetal growth is greatest, overall LPL activity decreases, coupled with increased lipolytic and catabolic activity due to insulin resistance that occurs at the time of pregnancy [ 11 ]. (biomedcentral.com)
[ 1 ] beginning with a summary of key general considerations, proceeding to a review of the main neurologic complications that may arise in pregnant people who were previously free of neurologic disease, and concluding with a discussion of individual neurologic disorders in the context of pregnancy. (medscape.com)
If neural tube defects occurred in a woman's previous pregnancy, increased antepartum fetal surveillance is required for the current pregnancy. (medscape.com)
Here, we discovered that foetal mast cells phenotypically mature through the course of pregnancy, and can be sensitised by IgE of maternal origin that cross the placental barrier. (a-star.edu.sg)
Chronic fetal hypoxaemia is a common pregnancy complication that increases the risk of infants experiencing respiratory complications at birth. (researchgate.net)
In turn, chronic fetal hypoxaemia promotes oxidative stress, and maternal antioxidant therapy in animal models of hypoxic pregnancy has proven to be protective with regards to fetal growth and cardiovascula. (researchgate.net)
Adult females were fed a control or WSD prior to and during pregnancy through lactation, and offspring subsequently weaned to a control or WSD. (diabetesjournals.org)
There is limited evidence on how the classification of maternal metabolic syndrome during pregnancy affects children's developmental outcomes and the possible mediators of this association. (biomedcentral.com)
There is limited evidence from human studies on how maternal cardiometabolic health during pregnancy affects a child's cognitive and behavioural development. (biomedcentral.com)
Important clinical conditions associated with increased risk include a history of eclampsia or preeclampsia (particularly early-onset preeclampsia), previous adverse pregnancy outcome, maternal comorbid conditions (type 1 or 2 diabetes, gestational diabetes, chronic hypertension, renal disease, and autoimmune diseases), and multifetal gestation. (aafp.org)
The USPSTF found adequate evidence that testing for protein in the urine with a dipstick test has low diagnostic accuracy for detecting proteinuria in pregnancy. (aafp.org)
In terms of pregnancy and birth, much of the focus on the developmental origins of disease has focused on birth size and growth in postnatal life and the availability and quality of the macro nutrients, energy and protein during these critical developmental periods, but micro nutrient deficiencies also play an important role in foetal growth and development. (clinicaleducation.org)
Because the foetus is able to respond to maternal immune communication, including her microbial communities, the role of probiotics during pregnancy and in the early months of breastfeeding has been attracting increasing research, from an outcome and safety perspective. (clinicaleducation.org)
The management of different pregnancy diseases could be improved by knowing their metabolic background. (peertechzpublications.com)

The panel findings, along with gestational age, can suggest a number of fetal abnormalities, depending on the results pattern. (medscape.com)
Thus, the overall objective of this group includes defining how abnormalities in maternal nutrition and metabolism affect critical developmental processes that lead to later disease. (ohsu.edu)
Consideration should be given to not using atomoxetine in adults with clinically significant cardiac abnormalities. (nih.gov)
As the Director of the Fetal Heart Program and the Fontan Rehabilitation, Wellness, Activity and Resilience Development (FORWARD) Program at Children's Hospital of Philadelphia (CHOP), Dr. Rychik specializes in the early detection and long-term treatment of complex forms of heart disease and developmental abnormalities. (chop.edu)
Thus, abnormalities in this pathway could mediate maternal smoking effects. (biomedcentral.com)
One possible pathway that could mediate some of the lung abnormalities caused by maternal smoking is the retinoic acid (RA) signaling pathway. (biomedcentral.com)

This includes studies of germ cell development and epigenetic effects that persist following fertilization, the uterine environment during implantation, as well as placental and organ formation and function and related development of chronic diseases after birth. (ohsu.edu)
From a clinical point of view, developing a further understanding in placental transfer of IgE, and the mechanism of foetal mast cell activation would be key to developing strategies to reduce the chance of eczema or other allergies from being transferred from mother to baby. (a-star.edu.sg)
Studies in humans have shown that men and women whose birth weights were at the lower end of the normal range, who were thin or short at birth, or who were small in relation to placental size have increased rates of coronary heart disease. (bmj.com)

We now have a clear understanding of what should be done to reduce the very high global burden of ill-health manifest as starvation, undernutrition and associated complications as a consequence of the complex interaction with infection, inflammation and clinical disease. (southampton.ac.uk)
PE can cause foetal loss, intrauterine growth restriction, or developmental complications. (biomedcentral.com)
Now that I have clarified the role of inflammation in the initiation, promotion of metabolic diseases and their clinical complications, I would briefly describe how researchers are addressing this issue when it comes to diagnosis as well as management [3,4]. (crimsonpublishers.com)
Proteomic or metabolomic approaches are under study [ 6 ], however, insufficient evidences are available regarding possible biomarkers and biologically active molecules which are diagnostic and predictive for early and later fetal and maternal complications. (juniperpublishers.com)

Different tissues and organs undergo different periods of rapid growth, and the effect of fetal undernutrition will therefore depend on its timing. (bmj.com)

Diet is a highly modifiable determinant of breast cancer risk, and the effects of the in utero nutritional environment persist beyond fetal life. (usda.gov)
Feeding low-protein diets to pregnant rats produces a increased more than in children not exposed to tobacco in broad spectrum of disorders in their offspring (7): hyper- utero. (cdc.gov)
It is therefore likely that increased concentrations of IgE and obstructive airways disease have origins in utero. (bmj.com)
but the same cannot be said about what happens in utero, as increasing evidence supports the understanding that the maternal nutritional environment and early feeding affects the health of the foetus beyond infancy and into adulthood. (clinicaleducation.org)
Omics in IUGR field could help to discover novel biomarkers for early diagnosis, the molecular link between nutrient deprivation in utero and the increase in risk of developing cardiovascular illness and metabolic syndrome in adults. (peertechzpublications.com)

The objective of the review was to analyse the information the current information about exists about the impact generated by the oxidation of LDL and HDL lipoproteins in neonates of women with preeclampsia and how these alterations can predispose the neonate to develop diseases in adulthood. (biomedcentral.com)
Management strategies for diagnosed preeclampsia may include close fetal and maternal monitoring, antihypertension medications, and magnesium sulfate. (aafp.org)
2 , 3 Although pregnant women can have other hypertensive conditions along with preeclampsia, preeclampsia is defined as new-onset hypertension (or, in patients with existing hypertension, worsening hypertension) occurring after 20 weeks of gestation, combined with either new-onset proteinuria (excess protein in the urine) or other signs or symptoms involving multiple organ systems. (aafp.org)

In the 1980s, a foetal programming concept emerged that suggested that the intrauterine environment determines and programmes physiology and metabolism throughout life [ 8 ]. (biomedcentral.com)

Both pre- and postnatal environmental insults have an influence on developmental programming, leading to the development of hypertension in adulthood through a process known as "developmental origins of health and disease" (DOHaD) [ 1 ]. (hindawi.com)
High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)

This can be accomplished by promoting maternal and child health, reducing malnutrition through the provision of high-quality complementary foods, encouraging a well-balanced dietary pattern, and increasing health literacy. (iium.edu.my)
It is concluded that this cycle can be broken by improving the nutritional status of women in their productive years, whereby foetal malnutrition, arrested mental development and physical stunting in children, adolescents and adults can be prevented. (scielo.org.za)
The MHMS is strongly committed to reducing Non-Communicable Diseases (NCD) and malnutrition in Solomon Islands. (who.int)
The problem of protein energy malnutrition that affects millions of children in the world is firmly rooted in the cultural pattern, dietary habits and the general soci.o-economic condition of the people. (who.int)
The paucity of information on some aspects of these factors prompted me to under this study In this project the epidemiology of protein energy malnutrition :was studied. (who.int)
Estates in the Kandy SHS: area were selected for the prevalence of protein energy malnutrition (PEM) i8 hisrne!3t in the Kandy SHS area and also because , out of the three island wide population sectors (viz. (who.int)

Dr. Albers develops mathematical models of physiology, machine learning models, and their associated inference methods to support the extraction and creation of new knowledge from data related to diabetes, to support clinician-centric decision support, and to support patient-centric decision support for chronic disease self-management. (cuanschutz.edu)
As more people live longer, the burden of chronic disease has now largely exceeded that of acute and genetic diseases and represents the largest financial and social burden governments and populations will have to bear in the coming decades. (clinicaleducation.org)

This study uses a cohort sample of 12,644 to 13,832 mother-child pairs from the UK Born in Bradford Study to examine the associations between maternal metabolic syndrome classification (MetS) and child development outcomes at age 5, using cord blood markers as candidate mediators. (biomedcentral.com)
Mediation models were used to examine the associations between the classification of maternal metabolic syndrome and child developmental milestones. (biomedcentral.com)

Fetal medicine is a complex undertaking that involves a multidisciplinary team for prenatal diagnosis and fetal therapy. (medscape.com)
We found that postnatal HF intake aggravated prenatal DEX-induced hypertension in adult male offspring, which could be prevented by DMF treatment. (hindawi.com)
Barker, D.J.P., 1997, 'Prenatal influences on disease in later life', in P.S. Shetty & K. McPherson (eds. (scielo.org.za)

Cholecalciferol is bound to serum vitamin D-binding protein (DBP) and through a two-step enzymatic pathway involving 25-hydroxylase of the liver and 1a-hydroxylase (CYP27B1) of the kidney and extrarenal tissues, it is converted to the biologically active hormone calcitriol (1a,25(OH)2D3) [1]. (vitamindwiki.com)
Her work on the T cell tyrosine kinase ITK has revealed a critical role for this TCR signaling protein in autoreactive T cell trafficking into tissues such as the pancreas and the intestine. (cuanschutz.edu)

SARS-CoV-2 causes high C-reactive protein (CRP), a maternal inflammatory marker that is associated with fetal brain involvement. (iium.edu.my)
Prevalence of type 2 inflammatory diseases in pediatric patients with atopic dermatitis: Real-world evidence. (luriechildrens.org)
RESULTS AND CONCLUSIONS: Opioid prescription filling differed among adults with inflammatory conditions and longstanding physical disability compared to the comparison group (44.93% and 40.70% vs 18.10%, respectively). (cdc.gov)

CONCLUSIONS The observed increase in the prevalence of obstructive airways disease in people exposed to famine in mid and early gestation was not parallelled by effects on IgE concentrations or lung function. (bmj.com)
4 Lower body weight at birth was shown to be associated with reduced forced expiratory volume and vital lung capacity, 5-7 with an increased risk for asthma, 8-13 as well as with increased death rates from chronic obstructive airways disease. (bmj.com)
Maternal smoking is a risk factor for pediatric lung disease, including asthma. (biomedcentral.com)
It is feasible that disruption of retinoic acid signaling contributes to the pediatric lung dysfunction caused by maternal smoking. (biomedcentral.com)
Currently, however, the mechanisms of lung injury in children exposed to maternal smoking have not been fully clarified. (biomedcentral.com)

This surveillance should include consultation with a geneticist and targeted fetal ultrasonography to assess the fetal spine and cranium. (medscape.com)

The beneficial effects of DMF treatment include an increase in renal Nrf2 gene expression, reduction of oxidative stress, decrease in plasma asymmetric dimethylarginine (ADMA) and renal soluble epoxide hydrolase protein levels, increase in the L -arginine-to-ADMA ratio, and activation of genes related to nutrient sensing and autophagy (e.g. (hindawi.com)
Furthermore, we have also previously observed that DEX + HF induces hypertension concurrently with increases in both renal protein levels and the activity of soluble epoxide hydrolase (SEH) in adult offspring, which is prevented by SEH inhibition [ 10 ]. (hindawi.com)

25-OHD (25-hydroxyvitamin D), the major circulating metabolite of vitamin D, was measured in serum by competitive protein-binding (CPB) assay and radioimmunoassay kit (Nichols, San Juan Capistrano, California). (who.int)
These factors are not IgG and could be IgM or even non-Ig serum proteins. (ox.ac.uk)
Abnormal level of maternal serum endothelial, soluble form like tyrosine kinase 1(SFlt-1), angiotensin II have been reported. (juniperpublishers.com)

Dr. Lane's research program focuses upon on how perinatal events affect in vivo epigenetic determinants of gene expression and lead to adult disease. (childrensmercy.org)
We consider the effects of the environment and both intergenerational and transgenerational epigenetic inheritance on biology, disease and evolution. (nature.com)
Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)

The amount and composition of maternal micronutrients from different diets and supplements have significant short- and long-term effects on foetal and infant neurodevelopment. (iium.edu.my)
The National Institute of Health Research Southampton Biomedical Research Centre delivers a programme of translational research in nutrition the objective of which is to reduce the burden of ill-health caused by poor diets and their interaction with disease in patients and populations. (southampton.ac.uk)

Subsequent functional assays revealed that BA dose dependently inhibited VEGF-stimulated survival, proliferation, migration, and triggered apoptosis activity in human umbilical vein endothelial cells (HUVECs), as well as suppressed the expression of antiapoptotic protein Bcl-2, increased the expression of proapoptotic protein caspase-3 and Bax, and suppressed PI3K/AKT pathway. (bvsalud.org)

Despite the well-accepted notion of peri-natal origins of adult diseases, the factors and regulatory mechanisms underlying breast cancer development at later adult life remains unclear. (usda.gov)
The measurements of thousands of molecular biomarkers at multiple life stages should lead to new discoveries in disease mechanisms, and crucially, the effect of alterable environmental risk factors. (ukri.org)
We investigate essential functions of biological processes and fundamental mechanisms of diseases and disorders affecting children's health. (luriechildrens.org)

Allergies begin very early in life," said Associate Professor Ashley St. John, an immunologist at Duke-NUS' Emerging Infectious Diseases Programme and a senior co-author of the study. (a-star.edu.sg)
In hierdie artikel word 'n kort oorsig van die voedingsprobleme in Suid-Afrika sowel as die noodlottige siklus van wanvoeding en armoede wat oor generasies strek, gebruik om aan te voer dat dit noodsaaklik is om 'n voedingsintervensie-komponent in programme gemik op die verligting van armoede in te sluit. (scielo.org.za)

90 publications are devoted to how perinatal events lead to adult disease. (childrensmercy.org)

Proteomics analysis of biological samples has the potential to identify novel protein expression patterns and/or changes in protein expression patterns in different developmental or disease states. (peertechzpublications.com)

MuSK antibody positivity appears to be associated with more severe bulbar disease that can be difficult to treat effectively. (ox.ac.uk)
When inside the foetus, the antibody binds to foetal mast cells, a type of immune cell that releases chemicals that trigger allergic reactions, from runny noses to asthma. (a-star.edu.sg)

Maternal WSD reduced insulin-stimulated glucose uptake and impaired insulin signaling at the level of Akt phosphorylation in fetal muscle. (diabetesjournals.org)
In juvenile offspring, insulin-stimulated glucose uptake was similarly reduced by both maternal and postweaning WSD and corresponded to modest reductions in insulin-stimulated Akt phosphorylation relative to controls. (diabetesjournals.org)

In our project we propose to use structural equation models, which are able to model the relations between several different types of biomarkers and disease pathways in a single model. (ukri.org)
Our aim is to combine SEM with Bayesian variable selection priors, in order to select small sets of biomarkers most relevant to the disease pathways of interest. (ukri.org)
The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)

The technology has emerged in numerous fields of research, including fetal medicine aiming to facilitate the understanding of fetal disease pathophysiology and discovery of predictive biomarkers [2]. (peertechzpublications.com)

While it has been established that a mother's metabolic state during gestation plays an essential role in foetal early-life programming, less is known about the subsequent effects of this programming on a child's development beyond immediate birth outcomes [ 1 ]. (biomedcentral.com)

Vaccination may also cause high CRP to the level of maternal infection. (iium.edu.my)

A variety of Nrf2 pathway-activating agents, including dimethyl fumarate (DMF), have been tested for in several diseases and disorders [ 18 ]. (hindawi.com)
Although the incidence of some of these disorders has been specifically measured, the overall burden and long-term sequelae have not been capture in estimates of the total burden of disease measured by disability-free years, either in Spain or at an international level (Olusanya BO. (redsamid.net)
Dr. Rychik has authored more than 250 peer-reviewed research publications, books, reviews, and chapters on fetal and pediatric cardiac disorders and treatment. (chop.edu)
Micro nutrient status in foetal and early life it seems may alter metabolism, vasculature, and organ growth and function, leading to increased risk of cardio-metabolic disorders, adiposity, altered kidney function, and, ultimately, to type 2 diabetes and cardiovascular diseases as well as psychological problems. (clinicaleducation.org)

On a low-protein diet, the endogenous formation of the amino acid glycine is thought to become constrained. (portlandpress.com)
It is important to understand how a mother's diet or diabetes will affect the endothelium's ability to sense changes in disease states. (ohsu.edu)
In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)
It is possible that associations of GWG with outcomes do not result from GWG itself, but rather to underlying factors that influence both weight gain and the outcomes (e.g., maternal diet composition or physical activity level). (nationalacademies.org)

Although we cannot rule out the possible spread of A(H7N9), substantial spread causing severe disease in humans is unlikely. (cdc.gov)
Variant Creutzfeldt-Jakob disease (vCJD) is a rare, fatal prion disease resulting from transmission to humans of the infectious agent of bovine spongiform encephalopathy. (cdc.gov)
She has been active in experimental studies with humans on lipoprotein response to several vegetable oils, trans fats and soy protein, and the glycemic response as modified by various meal components. (tufts.edu)
Emergence of a novel swine-origin influenza A (H1N1) virus in humans. (cdc.gov)
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. (cdc.gov)

Retrospective studies of the survivors of famines, such as those exposed to the Dutch Hunger Winter of 1944-45, have linked exposures around conception to later disease outcomes, some of which correlate with DNA methylation changes at certain genes. (frontiersin.org)
Many biomarkers reflect environmental exposures, including lifestyle, occupational and dietary factors, and thus serve to study in a comprehensive way the interaction between genes and environment in relation to disease outcomes. (ukri.org)
It can quickly evolve into a severe disease that can result in serious, even fatal health outcomes for the mother and infant. (aafp.org)

It has become clear that early life nutritional exposures, combined with poor choices in lifestyle in adult life, can result in increased risk of chronic diseases. (clinicaleducation.org)

check also tag CHILD or specific HN - 2008 FX - Adolescent Nutrition FX - Infant Nutrition DH - Maternal Nutrition DI - 052505 MN - SP6.021.072 MS - Nutrition of a mother which affects the health of the INFANT as well as herself. (bvsalud.org)

Screening tests screen for various fetal metabolic, chromosomal, and anatomic defects. (medscape.com)

During fetal development, maternal under-nutrition and over-nutrition are associated with an elevated risk of chronic diseases later in life. (ohsu.edu)
Neonates of mothers with PE have a high risk of cardiovascular diseases, stroke, mental retardation, sensory deficiencies and an increased risk of developing metabolic diseases. (biomedcentral.com)
Diagnostic tests are indicated when conditions that increase the risk of chromosomal anomaly are present or suspected (eg, advanced maternal age, suggestive fetal ultrasonographic findings). (medscape.com)
We will review several projects based on the use of panels of biomarkers for a better understanding of risk of disease and prognosis. (lu.se)
COVID-19 in Newborns and Infants-Low Risk of Severe Disease: Silver Lining or Dark Cloud? (thieme-connect.com)

0.05) decreased mRNA and protein expression of retinoic acid signaling pathway elements, including retinoic acid receptor alpha and retinoic acid receptor beta, with the greatest number of changes observed between postnatal days 3-5. (biomedcentral.com)

The effects are heavily influenced by the stages of foetal and infant development. (iium.edu.my)
The team uses state-of-the-art magnetic resonance imaging (MRI) brain imaging to map the fetal central nervous system's development over time. (ohsu.edu)
The challenge in tackling and reducing this double burden of disease, to better enable healthy growth and development from very early in life is substantial, but achievable. (southampton.ac.uk)
These biomarkers range from genetic variants which are fixed for each person throughout their life, through gene products such as proteins which are produced dynamically and vary with time and across different cells in the body, to large molecule metabolites which more closely reflect the processes involved in both normal functioning and disease development. (ukri.org)
Cohort studies enable life-course analysis of environmental, lifestyle, occupational and dietary effects on normal biological functioning and on disease development. (ukri.org)
If these investigations (CNMH/KEM) develop a strong correlation between the maternal adipose tissue signals and the development of altered metabolism of the children from obese mothers, then one has to consider various strategies for the prevention of this well-known phenomenon of the fetal origin of adult diseases. (crimsonpublishers.com)
Dr. Tarui's research focuses on developing non-invasive neuroimaging and genomic technologies to assess human fetal brain development and its clinical implications. (tufts.edu)
This specialized division allows most maternal components to be maintained in the oocytes for early embryo development. (bioone.org)
NSAID use is one of the factors in the development of peptic ulcer disease in children older than 1 year. (medscape.com)
In the fifth week of fetal development, neuroblastic cells migrate from the thoracic neural crest to form the sympathetic chains and preaortic ganglia. (medscape.com)
Jack Rychik, MD, is Director of the Fetal Heart Program and the Fontan Rehabilitation, Wellness, Activity and Resilience Development (FORWARD) Program at Children's Hospital of Philadelphia. (chop.edu)

B ) The reported COVID-19 cases in adults, pediatrics and infant population in United States. (thieme-connect.com)

In recent years, new methods for biological measurements using sophisticated technologies have enabled the simultaneous measurement of thousands of potential molecular biomarkers of disease. (ukri.org)
In recent years, new methods for biological measurements using sophisticated technologies (genomics, epigenomics, transcriptomics, proteomics, metabolomics) have enabled the simultaneous measurement of thousands of potential molecular biomarkers of disease. (ukri.org)

In addition to publishing more than 150 papers in scientific journals and has contributed to several books on early life programming as editor and author, Langley-Evans is the author of an academic textbook entitled Nutrition, Health and Disease: A Lifespan Approach, of which the third edition was published in 2021, and is the editor-in-chief of the Journal of Human Nutrition and Dietetics. (wikipedia.org)
Dr. Lane has actively participated in the US Developmental Origins and Health and Disease Society. (childrensmercy.org)
The concept of the early life developmental origins of health and disease (DOHaD) in adults has stimulated a new approach to understanding disease trajectories, with major public health implications. (researchgate.net)

Models were adjusted for potential maternal, socioeconomic, and child confounders such as maternal education, deprivation, and gestational age. (biomedcentral.com)

The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the US Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
Centers for Disease Control and Prevention. (cdc.gov)
Centers for Disease Control and Prevention (CDC) estimated the overall cumulative hospitalization rate from influenza was 68 per 100,000 population across all age groups in the United States and 94 per 100,000 in 0 to 4 year age group. (thieme-connect.com)

We recently found that resveratrol is also involved in mediating the nutrient-sensing signaling pathway for the prevention of maternal and postweaning HF-induced hypertension [ 15 ]. (hindawi.com)
Societal benefits include creation and maintenance of herd immunity against communicable diseases, prevention of disease outbreaks, and reduction in health-care--related costs. (cdc.gov)

Anatomy5

Diseases11

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes17

Information Science3

Named Groups2

Health Care4

Obesity18

Hypothesis8

Neonatal6

Accelerate fetal lung maturation2

Effects of maternal4

Cardiovascular disease8

Placenta11

Exposure12

Fetus8

Mortality4

Pregnancy21

Abnormalities6

Placental3

Complications4

Undernutrition1

Utero5

Preeclampsia3

Intrauterine environment1

Adulthood2

Malnutrition6

Chronic disease2

Metabolic syndrome2

Prenatal3

Tissues2

Inflammatory3

Lung5

Ultrasonography1

Renal2

Serum3

Epigenetic3

Diets2

Umbilical1

Mechanisms3

Programme2

Perinatal1

Patterns1

Antibody2

Insulin2

Pathways3

Pathophysiology1

Role in foetal1

Level of maternal1

Disorders4

Diet4

Humans5

Outcomes3

Exposures1

Affects1

Defects1

Risk5

Postnatal1

Development11

Infant1

Biomarkers2

Health and Dis3

Gestational age1

Centers for Diseas3

Prevention2