Fetal human mammalian embryonic. Medical search. Frequent questions

I also designed and constructed sgRNAs in preparation for the use of the CRISPR/Cas9 system to target the CD40 gene in human induced pluripotent stem cells as a rational approach to the production of tolerogenic dendritic cells. (ox.ac.uk)

When nonhuman mammalian development is compared with human development, the study subjects must be compared at the same developmental stage (fetal, perinatal, postnatal) When collected appropriately, data from experimental studies of nonhuman mammalian embryos elucidate important aspects of human facial development. (medscape.com)
Yamanaka worked to find new ways to acquire embryonic stem cells to avoid the social and ethical controversies surrounding the use of human embryos in stem cell research during the late twentieth and early twenty-first centuries. (asu.edu)
Since that time, these cells have given us a wealth of information of how mammalian embryos, including human babies, develop in the womb and how development continues following birth. (scitizen.com)
To educate its citizens about research into chimeras made from human and non-human animal cells, the United Kingdom's Human Fertilisation Embryology Authority published the consultation piece Hybrids and Chimeras: A Consultation on the Ethical and Social Implications of Creating Human/Animal Embryos in Research, in 2007. (asu.edu)
Even if these embryos were not permitted to mature to fetal stages, their ethical and political status became debated within nations attempting to use them for research. (asu.edu)
This historic 1957 paper by Padget describes human cranial venous development using a number 0f Carnegie Collection embryos. (edu.au)
In our lab, we seek to understand how the uterine microenvironment shapes the fetal-placental interface of various animals, by using early embryos and placental organoids. (biologists.com)
Also, I like to work on my own little project, which is focused on discovering similarities and differences in early embryonic development of different species of mammalian pre-implantation embryos. (biologists.com)

Moreover, we find that the distal NDRs are enriched specifically for binding motifs of the pluripotency and germ cell master regulators such as NANOG, SOX17, AP2γ and OCT4 in human FGCs, indicating the existence of a delicate regulatory balance between pluripotency-related genes and germ cell-specific genes in human FGCs, and the functional significance of these genes for germ cell development in vivo . (nature.com)
The analysis of the new fossil suggests that the evolutionary pattern of the mammalian ear is directly related to timing changes in growth, as well as in changes in genes for mammalian development. (eurekalert.org)
They used retroviruses to insert each of the twenty-four genes into the chromosomes of differentiated mouse embryonic fibroblasts. (asu.edu)
If one of the infected cells showed G418 resistance, then the scientists would know that one of the twenty-four genes influenced the cell to become an embryonic stem cell-like cell. (asu.edu)
He has also served as an Associate Editor at Genome Research (2009-2014) and Genes, Genomes and Genetics (2011-2018).Most recently, Dr. Hall has played a leadership role in several large collaborative projects funded by NIH/NHGRI including the Centers for Common Disease Genomics, the AnVIL cloud-based data repository and analysis platform, and the Human Pangenome Project. (yale.edu)
His current work is focused on two broad goals: (1) mapping variants and genes that confer risk to human disease, with ongoing projects focused on coronary artery disease and cardiometabolic traits in unique and underrepresented populations, and (2) developing methods for the detection and interpretation of human genome variation, with an emphasis on structural variation and other difficult-to-detect forms, and on comprehensive trait association in human disease studies. (yale.edu)
Chitosan microparticles containing reporter genes are being used for the transfection of mammalian cells both in vitro and in vivo conditions (28-30). (ualberta.ca)
A second strategy will also be employed: Using ATAC-Seq data from cardiomyocytes taken from both embryonic hearts and adult injured hearts, it will be possible to investigate putative enhancers of gata4 , 5 and 6 genes in the developing embryo and the regenerating heart. (ox.ac.uk)
These ATG genes are highly conserved in mammalian cells, allowing to study their functions also in higher eukaryotes [ 1 - 4 ]. (hindawi.com)
Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. (jax.org)
Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. (jax.org)
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. (jax.org)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)

Other research groups such as Masako Tada's group in Japan in 2001 and Chad CowanÆs group in Massachusetts in 2005 combined embryonic stem cells with somatic cells to produce pluripotent cells. (asu.edu)

The human brain undergoes gyrification during fetal and neonatal development. (wikipedia.org)
In embryonic development, all mammalian brains begin as smooth structures derived from the neural tube. (wikipedia.org)
As development continues, gyri and sulci begin to take shape on the fetal brain, with deepening indentations and ridges developing on the surface of the cortex. (wikipedia.org)
Lissencephaly (smooth brain) is a rare congenital brain malformation caused by defective neuronal migration during the 12th to 24th weeks of fetal gestation resulting in a lack of development of gyri and sulci. (wikipedia.org)
Here we use nucleosome occupancy and methylation sequencing method to analyze both the genome-wide chromatin accessibility and DNA methylome at a series of crucial time points during fetal germ cell development in both human and mouse. (nature.com)
increased public sensitivity and awareness together with the development of national regulations of governance of human cloning and embryo research in general. (lifeissues.net)
The ectoderm is well around the stomodeum by the fourth week of embryonic development and contributes to the formation of the face and the nasal and oral cavities. (medscape.com)
At the early stages of embryonic development, the vertebrate face has a common plan. (medscape.com)
Each gene was inserted near the mouse Fbx15 gene, a gene that embryonic stem cells express during development in mice. (asu.edu)
In the following chapter we will look more closely at mammalian, then specifically human, embryonic and fetal development. (umn.edu)
During early mammalian embryonic development, trophoblast cells play an essential role in establishing cell-cell interactions at the maternal-fetal interface to ensure a successful pregnancy. (edu.au)
Just as importantly, research on these cells has been providing us with what happens when foetal development goes wrong, either because of a genetic defect or one that is imposed, for example, by a chemical or drug. (scitizen.com)
As a faculty member at the University of Virginia (2007-2014), Washington University (2014-2020) and Yale (2020-present), his work has sought to understand the causes and consequences of genome variation in mammals, with an increasing focus on computational methods development and human genetics. (yale.edu)
Human HPV-16 E7 was also chosen for vaccine development because HPVs, particularly HPV-16, are associated with most cervical cancers. (biomedcentral.com)
It has previously been demonstrated in Xenopus that gata6 overexpression holds embryonic myocardial cells in a precursor state, but once normal levels are resumed, development continues, but the myocardium is thicker. (ox.ac.uk)
No human fetal-derived cell lines or tissue, including HEK293 cells, are used in the development, manufacture, or production of the Novavax COVID-19 vaccine candidate, NVX-CoV2373. (personhood.org)
Mammalian chimeras are valuable for studying early embryonic development. (asu.edu)
The present communication is the logical outcome of the author's companion study of the development of the cranial arteries in the human embryo (Padget, 1948, 1954). (edu.au)
Near the close of the present author's study, attention was directed to a monograph on the development of the dural sinuses and vessels of the human brain by Markowski (1922), which work, essentially completed but delayed in publication, had been summarized earlier (191r). (edu.au)
Tmem70 ablation resulted in profound growth retardation and embryonic lethality at 9.5 days of fetal development. (cas.cz)
Development of the human heart during the first eight weeks (top) and the formation of the heart chambers (bottom). (cvw-r.de)
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
In mammals, whether an individual develops as a male or female depends on its sex chromosome constitution: those with a Y chromosome become males because of the development of the embryonic gonad into a testis. (plos.org)
We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)
We predict that loss of MAP3K4 or other MAPK components may underlie disorders of sexual development (DSD) in humans as well. (plos.org)
During mouse embryonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incorporates into a subregion of the cochlear epithelium, forming the intermediate cell layer of the stria vascularis. (jneurosci.org)
The neural crest (NC) is comprised of specialized cells that arise from the lateral border of the neural plate and migrate into specific locations during vertebrate embryonic development. (jneurosci.org)
NC cells contribute to several inner ear structures during embryonic development. (jneurosci.org)
I work on the role of oxygen sensing mechanisms during early human placenta development. (biologists.com)
The development of the human blood-CSF-brain barrier. (cdc.gov)
Several drugs cross the placental barrier and some have teratogenic effects on the fetus, which may cause dysfunction and disorders during embryonic development, particularly during the first three months of intrauterine life 2 . (bvsalud.org)

During preimplantation stages, differentiation occurs between precursors of embryonic and extraembryonic structures. (medscape.com)
Once spermatogonia enter the "differentiation" pathway, they become known as A1 spermatogonia in the mouse and A- pale spermatogonia in humans and begin a series of irreversible differentiation steps leading to meiosis and spermiogenesis ( 1 ) (Figure 1 ). (jci.org)
We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. (hindawi.com)
Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity. (springer.com)
I am investigating the impact of specific genetic mutation on human trophoblast stem cell differentiation and trophoblast organoid self-organization. (biologists.com)

Takahashi and Yamanaka's 2006 and 2007 experiments showed that scientists can prompt adult body cells to dedifferentiate, or lose specialized characteristics, and behave similarly to embryonic stem cells (ESCs). (asu.edu)
In the adult mammalian heart, gata6 is known to be re-employed to mediate cardiac hypertrophy. (ox.ac.uk)
Destruction or damage to neural circuits in the adult mammalian central nervous system (CNS) is notoriously difficult to repair. (hindawi.com)
Past studies have shown that some fetal nigral cells transplanted in this way can grow a limited number of axonal projections towards the striatum, but most are generally incapable of growing over the distance required to establish functional connections in the striatum in the adult brain [ 8 - 10 ]. (hindawi.com)
In respect to the arteries, the author was forearmed, from the literature and from personal observation, with a reasonably wide knowledge_of the human adult conﬁguration and its variations. (edu.au)
Viable offspring derived from fetal and adult mammalian cells. (springer.com)
PKM2 is normally portrayed during embryonic advancement but it is normally absent from many adult tissue [23]. (healthandwellnesssource.org)

He has led genome-wide studies of human genome variation, heritable gene expression variation, human genetic disorders, tumor evolution, mouse strain variation, genome stability in reprogrammed stem cells, and single-neuron somatic mosaicism in the human brain. (yale.edu)
Little is known concerning lambda phage-mediated gene transfer and expression in mammalian hosts. (biomedcentral.com)
For this purpose, we constructed recombinant λ-phage nanobioparticles containing a mammalian expression cassette encoding enhanced green fluorescent protein (EGFP) and E7 gene of human papillomavirus type 16 (λ-HPV-16 E7) using Lambda ZAP- CMV XR vector. (biomedcentral.com)
Different strategies have been employed for gene delivery and expression in mammalian cells. (biomedcentral.com)
Since little is known concerning phage-mediated gene transfer in mammalian cells [ 26 ], we therefore performed experiments to examine phage-mediated gene transfer in vitro . (biomedcentral.com)
In zebrafish, cardiac regeneration is thought to require at least in part, reactivation of foetal gene programs. (ox.ac.uk)
TMEM70 gene mutations turned out to represent the most frequent cause of ATP synthase deficiency resulting in a severe mitochondrial disease, neonatal encephalo-cardiomyopathy in humans (OMIM 604273). (cas.cz)
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. (jax.org)
Analysis of embryonic XY gonads suggests that sex reversal is caused by delayed and reduced expression of the sex-determining gene SRY . (plos.org)

fetal bovine serum (FBS Gibco). (healthandwellnesssource.org)

An in-depth analysis aiming at re-defining this terminology according to the new developments in human embryo research would be highly beneficial . (lifeissues.net)
3. National regulations of governance of human cloning and embryo research in general adopted so far confirm the convergence of views of the refusal to adopt legislation or guidelines permitting reproductive cloning , while they still show variations on the legitimacy of human cloning carried out as part of research agendas. (lifeissues.net)
The moment the human embryo is fertilized to the week of the baby's birth is an important period for human appearance in the normally developing embryo. (medscape.com)
Among the factors thought to contribute to the greater success in cloning cattle are the relatively late embryonic genome activation speciﬁc for this species [16 -18] and the optimization of reproductive technologies, such as in vitro embryo production and embryo transfer, brought about by the cattle industry [19]. (sibi.org)
The first of our time-traveling studies in this rejuvenation face-off takes inspiration from nature and studies the dynamics and mechanisms associated with the rejuvenation of DNA methylation profiles in the cells of the early mammalian embryo. (epigenie.com)

Moreover, the connected jaw-ear structure of Maotherium is similar to the ear structure of modern mammals at embryonic and fetal growth stages. (eurekalert.org)
Fascinatingly, the young whippersnappers from the Gladyshev lab now reveal some fascinating insights into the dynamics and the mechanisms involved in the rejuvenation of DNA methylation profiles during the very early stages of mammalian embryogenesis. (epigenie.com)

Testing was conducted to compare the structural integrity of the SARS-CoV-2 spike protein produced in the Sf9 insect cells versus the spike protein produced in the mammalian human embryonic kidney HEK 293F cells. (personhood.org)

Prior to SCNT, the somatic cell (differentiated) must be reprogramed to a similar state of a pluripotent embryonic cell (undifferentiated) before the nucleus is extracted and transferred. (sibi.org)

Reverse transcription-polymerase chain reaction of total lung RNA showed low levels of UGT1A10 expression in human lung tissue. (aspetjournals.org)
Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity of the constructs during and after their transplantation. (hindawi.com)
Recent research has shown that pieces of fetal nigral tissue placed in the striatum of 6-OHDA lesioned rats offer greater cell survival and predictability of graft function (in comparison to dissociated nigral cells) in the animal model of Parkinson's disease [ 20 ]. (hindawi.com)
PKM1 PKM2 PKL and PKR BMN673 are four isoforms of PK and they're expressed in various types of mammalian cells and tissue [22]. (healthandwellnesssource.org)

A ) The mammalian testis is composed of seminiferous tubules intertwined so that the "start" and "end" of these tubules are both connected to the rete testis. (jci.org)

The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)

In the case of PD, where the progressive and selective loss of dopaminergic neurons within the substantia nigra (SN) leads to dopaminergic denervation of the striatum, one possible solution has been to transplant embryonic nigral cells into the host substantia nigra (SN), in an attempt to rewire nigrostriatal circuit. (hindawi.com)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)
In the human brain, the first 5-HT-releasing neurons are present from the fifth week and their numbers increase markedly by the tenth week of gestation 6 . (bvsalud.org)

The gyri are part of a system of folds and ridges that create a larger surface area for the human brain and other mammalian brains. (wikipedia.org)

Although the genome-wide histone modification landscapes of mouse in vivo germ cells and in vitro PGCLCs have been profiled and several germline-specific properties of epigenetic reprogramming have been revealed, the study of genome-scale chromatin states in human FGCs is still challenging, due to the scarcity of materials and technical difficulties. (nature.com)

In a recent study, we showed that human fibroblasts can be reprogrammed into induced trophoblast stem (iTS) cells by transcription factor-mediated nuclear reprogramming using the Yamanaka factors OCT4, KLF4, SOX2 and c-MYC (OKSM) and a selection of TS cell culture conditions. (edu.au)
Here we describe a step-by-step protocol for the generation and establishment of human iTS cells directly from dermal fibroblasts using a non-integrative reprogramming method. (edu.au)
The protocol consists of four main sections: (1) recovery of cryopreserved human dermal fibroblasts, (2) somatic cell reprogramming, (3) passaging of reprogramming intermediates and (4) derivation of iTS cell cultures followed by routine maintenance of iTS cells. (edu.au)

Gyri and sulci create the folded appearance of the brain in humans and other mammals. (wikipedia.org)
image: All modern mammals (platypus, opossum and human) have a middle ear separated from the lower jaw (see example from living opossum). (eurekalert.org)
The ear bones in Maotherium are partly separated from the jaw, and more similar to those in modern mammals than to mammaliaforms, but still retain the pre-mammalian condition in which the jaw and the ear are connected to each other. (eurekalert.org)
Mammals have highly sensitive hearing, far better than the hearing capacity of all other vertebrates, and hearing is fundamental to the mammalian way of life. (eurekalert.org)
Thanks to their intricate middle ear structure, mammals (including humans) have more sensitive hearing, discerning a wider range of sounds than other vertebrates. (eurekalert.org)
This middle ear connection, also known as the ossified Meckel's cartilage, resembles the embryonic condition of living mammals and the primitive middle ear of pre-mammalian ancestors. (eurekalert.org)

It is quite possible that the advances in human biology in the remainder of the twentieth century will be remembered as the most significant scientific achievement of the animal species known as Homo sapiens . (lifeissues.net)
During the mid- to late-nineties, this possibility was realised, with the isolation of ES cells from various species including rabbit, pig, cow, and primates (monkey and marmoset), culminating with the publication in 1998 of two articles on the isolation of human ES cells 2 . (scitizen.com)

Mouse is a well-established model for the study of mammalian embryology, and parallel comparison between mouse and human samples can be very informative and lead to a better understanding of human embryogenesis. (nature.com)
In 2007, the Human Fertilisation and Embryology Authority in London, UK, published Hybrids and Chimeras: A Report on the Findings of the Consultation, which summarized a public debate about research on, and suggested policy for, human animal chimeras. (asu.edu)

restorative research provides evidence for natural rejuvenation processes occurring at the epigenetic level during mammalian embryogenesis. (epigenie.com)
For example, the rejuvenation of the germline in mammalian offspring removes any deleterious aging-associated changes passed on by parents and returns epigenetic aging to " ground zero " during early embryogenesis to prevent accumulated damage from affecting future generations. (epigenie.com)

The invention provides an artificial antigen presenting cell (AAPC) comprising a eukaryotic cell expressing an antigen presenting complex comprising a human leukocyte antigen (HLA) molecule of a single type, at least one exogenous accessory molecule and at least one exogenous T cell-specific epitope. (patsnap.com)
The stage-specific embryonic antigen 4 (SSEA4) is brain. (lu.se)

On June 6, 1994, the U.S. Public Health Service convened a workshop in Bethesda, Maryland, to develop recommendations for the use of zidovudine to reduce the risk for perinatal transmission of human immunodeficiency virus (HIV). (cdc.gov)
These recommendations update the interim guidelines (1) developed by the U.S. Public Health Service for the use of zidovudine (ZDV) to reduce the risk for perinatal transmission of human immunodeficiency virus (HIV) infection. (cdc.gov)
Worldwide, perinatal (i.e., mother-to-infant) transmission accounts for most human immunodeficiency virus (HIV) infections among children. (cdc.gov)

It has been transformed into a tumor cell line with 50 percent more chromosomes than a normal human cell line. (personhood.org)

CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

Twenty years have passed since Dolly the sheep was born by cloning (somatic cell nuclear transfer, SCNT) but the results of non-human mammalian cloning are very poor, and cause animal diseases and huge biological losses. (sibi.org)
I believe that the reprogramming errors are not the only cause of these low rates of cloning: the mammalian SCNT fails with a very high frequency mainly due to the damage that the technique itself inflicts in the egg and the somatic nucleus, and the very few successful cases occur only when the damage is not significant. (sibi.org)

We find 116 887 and 137 557 nucleosome-depleted regions (NDRs) in human and mouse FGCs, covering a large set of germline-specific and highly dynamic regulatory genomic elements, such as enhancers. (nature.com)
Although the global and thorough DNA demethylation patterns of human FGCs have been revealed, the accompanying chromatin states in human germline remains unexplored. (nature.com)

Evans MD, Kelley J. US attitudes toward human embryonic stem cell research. (springer.com)

From this point forward, the steps and cell types of spermatogenesis are conserved between mice and humans. (jci.org)
Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)

The derivation of TS cells from human blastocysts or first-trimester placenta can be limited by difficulties in obtaining adequate material as well as ethical implications. (edu.au)
Several controversies surround the use of human embryonic stem cells: Is it ethical to use them? (scitizen.com)
There are alternative human cell lines that are not only free of ethical controversy but also offer scientific advantages to the HEK293 cell line for vaccines or routine drug testing. (personhood.org)

Since the 1950s, scientists have developed interspecies blastocysts in laboratory settings, but not until the 1990s did proposals emerge to engineer interspecies blastocysts that contained human genetic or cellular material. (asu.edu)
Embryonic stem cell lines derived from human blastocysts. (springer.com)

According to previous studies performed at the Institute Physiology CAS, the mitochondrial ATP synthase, the key producer of cellular ATP, uniquely depends on a TMEM70, a 21-kDa protein that facilitates the biogenesis of mammalian enzyme. (cas.cz)

Strategies Cell lifestyle The human breasts cancer tumor cell lines MCF-7 SK-BR-3 and MDA-MB-468 had been extracted from American Type Lifestyle Collection and preserved in DMEM supplemented with 10? (healthandwellnesssource.org)

Our work offers a comprehensive and high-resolution roadmap for dissecting chromatin state transition dynamics during the epigenomic reprogramming of human and mouse FGCs. (nature.com)
Early progenitor cells, which are designated A spermatogonia in the mouse and A- dark spermatogonia in humans, are defined as "undifferentiated. (jci.org)
Within their article, hereafter "Part-Human Chimeras," the authors offer corrections on "Thinking About the Human Neuron Mouse," a report published in The American Journal of Bioethics in 2007 by Henry Greely, Mildred K. Cho, Linda F. Hogle, and Debra M. Satz, which discussed the debate on the ethics of creating part-human chimeras. (asu.edu)
These results thus showed that Tmem70 knockout in the mouse leads to embryonic lethality due to the lack of ATP synthase and impairment of mitochondrial energy provision and fully confirmed the expected mechanism of human TMEM70 disease. (cas.cz)

The 5-HT neurotransmitter regulates important pathways of mammalian metabolism and is synthesized from the phenylalanine, tyrosine and tryptophan amino acids 5 . (bvsalud.org)

But in order to become a part of medical history, parahuman reproduction and human genetic engineering must circumvent the recalcitrance of an antiquated culture. (lifeissues.net)

Quantification evaluation of bromodichloromethane metabolism by recombinant rat and human cytochrome P450s. (cdc.gov)

In vitro characterization and delivery of chitosan-DNA microparticles into mammalian cells. (ualberta.ca)

Takahashi and Yamanaka also experimented with human cell cultures in 2007. (asu.edu)
This time, there were twenty-two cell colonies that showed a resistance to G418, meaning that there were colonies in which the cells exhibited embryonic stem cell properties. (asu.edu)
Transfection efficiency of chitosan-DNA microparticles into mammalian cells was determined by measuring the b -galactosidase activity in cell lysates. (ualberta.ca)
By Sarah Quale - Despite Novavax's public statements that its COVID-19 vaccine does not have any connection to abortion-derived cell lines, evidence from a private letter and Novavax's own published study shows that the HEK293 aborted fetal cell line was used in the testing phase. (personhood.org)
In this same letter, Novavax also stated that "fetal-derived cell lines were not used in the manufacture, testing, or production of the Novavax COVID-19 vaccine. (personhood.org)
The use of aborted human cell lines is not necessary at any point in the vaccine creation process-design, production, or testing. (personhood.org)
The cell line does not have the normal cellular machinery of native human cells. (personhood.org)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

Human eyes are highly sensitive in discerning minimal differences in the structure of human faces and in distinguishing persons. (medscape.com)
Results demonstrated that CSG viruses differ in neuropathogenesis in vitro and in vivo, which correlates with the differences in pathogenesis reported in humans. (cdc.gov)

HA557 trade name] is indicated for the treatment of of Human Immunodeficiency Virus Type 1 (HIV-1) infection in children weighing less than 25 kg. (who.int)

Hence, this chapter summarizes the biological plausibility of EDCs exposure and elucidates the mechanism of action underlying EDCs affecting the regulatory circuits of the mammalian HPG axis and reproductive function. (intechopen.com)

Our protocol allows researchers to generate patient-specific iTS cells to interrogate the trophoblast and placenta biology as well as their interactions with embryonic cells in health and diseases. (edu.au)

Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. (nature.com)

The results demonstrated that the recombinant λ-phages, due to their capabilities in transducing mammalian cells, can also be considered in design and construction of novel and safe phage-based nanomedicines. (biomedcentral.com)

This new remarkably well preserved fossil, as reported in the October 9 issue of the prestigious journal Science , offers an important insight into how the mammalian middle ear evolved. (eurekalert.org)
The mammalian ear evolution is important for understanding the origins of key mammalian adaptations. (eurekalert.org)
As with many important scientific discoveries, embryonic stem (ES) cells came onto the scene long before the media and most of the rest of us became intensely interested in the subject. (scitizen.com)
Together, these studies implicate UGT1A10 as an important detoxifier of polycyclic aromatic hydrocarbons in humans and that the UGT1A10 codon 139 polymorphism may be an important determinant in risk for tobacco-related cancers. (aspetjournals.org)
This difference is extremely important because many of the metals are harmful to human health and living organisms. (cdc.gov)

Polymicrogyria (meaning "many small gyri") is a developmental malformation of the human brain characterized by excessive folding of the gyri and a thickening of the cerebral cortex. (wikipedia.org)

The mammalian functional screening approach can serve as a cornerstone for further optimization and screening for OP-resistant hBChEs for potential therapeutic applications. (aspetjournals.org)

The hypothalamic-pituitary-gonadal (HPG) axis plays a crucial and integrative role in the mammalian endocrine regulation to maintain homeostasis. (intechopen.com)

A philosophy of reason will define a human being as one which demonstrates self-awareness volition and rationality. (lifeissues.net)

Unlike humans, zebrafish can fully regenerate their hearts after injury. (ox.ac.uk)

To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)

Addressing this, we established the Human Aging and Longevity Landscape (HALL), a comprehensive multi-omics repository encompassing a diverse spectrum of human cohorts, spanning from young adults to centenarians. (bvsalud.org)
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. (jax.org)

The dimensions of the lambda phage particles are broadly similar to those of many mammalian viruses and recent structural evidence points to a shared ancestry between tailed bacteriophages and mammalian DNA viruses [ 25 ]. (biomedcentral.com)
The California serogroup of orthobunyaviruses comprises a group of mosquitoborne viruses, including La Crosse (LACV), snowshoe hare (SSHV), Tahyna (TAHV), Jamestown Canyon (JCV), and Inkoo (INKV) viruses, that cause neurologic disease in humans of differing ages with varying incidences. (cdc.gov)

Will embryonic stem cells ever be used to treat human diseases? (scitizen.com)
Instead, as we know, interest and debate has centred largely on the ethics and morals of using human ES cells to treat, potentially, a range of human diseases, many of which are virtually intractable with respect to a cure. (scitizen.com)
Animal models of human mitochondrial diseases enable detailed insight into pathogenic mechanisms, from molecular to organismal levels. (cas.cz)

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