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  • HAMP
  • In Hep3B cells, SMAD5 or SMAD1 but not SMAD8, knockdown inhibited hepcidin ( HAMP ) messenger RNA (mRNA) expression. (bloodjournal.org)
  • Patients with juvenile hemochromatosis caused by HJV mutations (type 2A) share the same phenotype as that of patients with mutations that disrupt the hepcidin gene ( HAMP , type 2B). (haematologica.org)
  • HAMP mRNA expression in Huh-7 cells exposed to sera form C-Donors, HFE -HH and THAL reproduced, at lower level, the results observed in HepG2, suggesting the important but not critical role of HFE in hepcidin regulation. (pubmedcentralcanada.ca)
  • induces
  • This proposal will test the hypothesis that fetal exposure to chorioamniontis induces a systemic inflammatory response that is initiated by IL-1 signaling in the amniotic compartment and is modulated by systemic innate immune responses. (grantome.com)
  • anemia
  • Decreased hepcidin leads to tissue iron overload, whereas hepcidin overproduction leads to hypoferremia and the anemia of inflammation. (sciencemag.org)
  • Associations with hepcidin were measured by using linear regression, and hepcidin's diagnostic test accuracy [area under the receiver operating characteristic curve (AUCROC), sensitivity, specificity, cutoffs] for iron deficiency at each time point was analyzed.Results:The prevalence of anemia increased from 34.6% at 14 wk of gestation to 50.0% at 20 wk. (ox.ac.uk)
  • However, correction of hepcidin levels in those mice does not improve anemia of β-thalassemia. (bloodjournal.org)
  • assays
  • The SW480 colorectal cancer cells were co-cultured with DAS in the presence or absence of leptin, IL-6 or hepcidin inhibitors and cellular viability and proliferation assays were performed. (spandidos-publications.com)
  • Pregnancy
  • Obesity during pregnancy and fetal iron status: is Hepcidin the link? (biomedsearch.com)
  • Serum Hepcidin Concentrations Decline during Pregnancy and May Identify Iron Deficiency: Analysis of a Longitudinal Pregnancy Cohort in The Gambia. (ox.ac.uk)
  • To address these gaps in knowledge the investigators will monitor weight gain, hematological measures, Fe status indicators and serum hepcidin across pregnancy in approximately 120 women carrying twins and triplets. (ichgcp.net)
  • cord blood
  • Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery? (gu.se)
  • Neonatal hematological measures will be assessed in cord blood from each neonate at birth for assessment of hematological measures, Fe status and hepcidin. (ichgcp.net)
  • bone marrow
  • The aim of the present study was to evaluate the in vitro antibacterial potential against S. aureus of conditioned medium (CM) from MSC derived from fetal bovine bone marrow (BM-MSC) and adipose tissue (AT-MSC). (springer.com)
  • Protein
  • To determine whether hepcidin interacts with Fpn, we generated a stable cell line (HEK293-Fpn) expressing mouse Fpn with a C-terminal green fluorescent protein (GFP) under the control of the ecdysone-inducible promoter. (sciencemag.org)
  • Gene expression of β-defensin 4A (bBD-4A), NK-lysine 1 (NK1), cathelicidin 2 (CATHL2), hepcidin (HEP) and indoleamine 2,3 dioxygenase (IDO) and protein expression of bBD-4A were determined in activated and non-activated cells. (springer.com)
  • Activated AT-MSC increased mRNA levels of bBD4A and NK1, and protein levels of bBD4A in CM. Thus, CM from fetal bovine BM-MSC and AT-MSC has the capacity to reduce in average ~30% of S. aureus relative growth under in vitro conditions. (springer.com)
  • exposure
  • Similarly, studies using animal models of PAE have recapitulated this concept by demonstrating differential patterns of anxiety-like behaviors dependent on the timing of ethanol exposure during fetal development (trimester-equivalents) and/or the dosage of alcohol administered/consumed within an exposure period ( Marquardt and Brigman, 2016 ). (frontiersin.org)
  • morbidity
  • Chorioamnionitis or inflammation in the fetal membranes is present in about 70% of the preterm infants born before 30 weeks gestation and is a major contributor to the morbidity and mortality in this population. (grantome.com)
  • infants
  • We hypothesized that obese (Ob) pregnant women would have increased inflammation, hepcidin levels, and that their infants would have impaired iron status compared with lean (Lc) controls. (biomedsearch.com)
  • Fetal inflammatory response syndrome (FIRS) is present in about 50% of preterm infants exposed to chorioamnionitis and thought to be the mediator of chorioamnionitis induced fetal injury responses. (grantome.com)
  • The aims of this study were to describe hepcidin levels and to assess their associations with iron status and the main variants in the HFE gene in healthy and full-term newborns during the first year of life, as a longitudinal study conducted on 140 infants. (readbyqxmd.com)
  • The European consensus on resuscitation of preterm infants recommends delayed cord clamping (DCC) for at least 60 s to promote placenta-fetal transfusion in uncompromised neonates. (readbyqxmd.com)
  • Assessment
  • Dilmen G, Turhan NO, Toppare MF, Seçkin NC, Öztürk M, Gökşin E. Scapula length measurement for assessment of fetal growth and development. (nilgunturhan.com.tr)