We assessed the degree of iron overload in thalassemia intermedia and major patients by measuring hepatic iron concentration in liver biopsy samples and serum ferritin, estimated erythropoietic drive by assaying soluble transferrin receptor and serum erythropoietin levels and correlated these with urinary hepcidin measurements. (nih.gov)
Oral iron supplementation (20.56 mg elemental Fe/kg bw) to aloin-treated rats normalized red blood corpuscles count, hemoglobin concentration, and serum levels of total iron binding capacity and saturated transferrin, as well as hepatic iron content, hepcidin level, and mRNA expression of ferritin heavy chain (Ferr-H) and transferrin receptor-1 (TfR-1) genes. (bvsalud.org)
15. Hepcidin-25, mean corpuscular volume, and ferritin as predictors of response to oral iron supplementation in hemodialysis patients. (nih.gov)
Secondary objectives were to investigate the development of hepcidin, plasma ferritin and inflammatory markers over the course of pregnancy dependent on weight status. (cambridge.org)
Often, hemoglobin concentrations are combined with serum ferritin measurements to identify IDA [ 7 ]. (nih.gov)
Research design and methods A total of 196 obese children were enrolled, and data regarding ferritin levels, blood glucose levels, intima-media thickness of carotid arteries, liver function and fibrosis index, hemoglobin, blood pressure, blood lipids, and inflammation indicators were collected. (bmj.com)
Ferritin level was positively correlated with hemoglobin and was related to metabolic disorders, including impaired glucose tolerance, higher blood pressure, dyslipidemia, and impaired hepatic function. (bmj.com)
Obese children had increased ferritin levels positively correlated with hemoglobin levels, which were also increased. (bmj.com)
Transferrin5
There was a strong inverse relationship between urinary hepcidin levels and both erythropoietin and soluble transferrin receptor, markers of erythropoietic activity. (nih.gov)
Without intrauterine transfusion, almost all affected patients die in-utero or shortly after birth.1 Similar to patients with transfusion-dependent beta-thalassemia (TDT-β), survivors of hemoglobin Bart's hydrops fetalis require lifelong regular transfusions.1 Without effective iron-chelation therapy, frequent transfusions of iron-rich erythrocytes ultimately results in saturation of transferrin and generation of toxic non-transferrin bound iron (NTBI). (cheoresearch.ca)
5. Hepcidin and diabetes are independently related with soluble transferrin receptor levels in chronic dialysis patients. (nih.gov)
20. The value of soluble transferrin receptor and hepcidin in the assessment of iron status in children with cystic fibrosis. (nih.gov)
With iron-deficiency erythropoiesis (also known as marginal iron deficiency), iron stores are depleted and transferrin saturation declines, but hemoglobin levels are usually within the normal range. (nih.gov)
Reticulocyte1
17. The association of hepcidin, reticulocyte hemoglobin equivalent and anemia-related indicators on anemia in chronic kidney disease. (nih.gov)
At each 5±1 weekly visit until delivery, information was collected about the pregnancy, as well as the results of blood tests taken as part of routine antenatal care, including haemoglobin values. (ox.ac.uk)
The outcome measures were maternal (gestational diabetes, pregnancy-induced hypertension, and preterm premature rupture of membranes) and neonatal outcomes (small for gestational age, preterm birth, and acute respiratory distress syndrome).FindingsBetween Feb 8, 2012, and Nov 30, 2019, 2069 women (mean age 30·7 years [SD 5·0]) had at least one routinely haemoglobin concentration measured at 14-40 weeks' gestation, contributing 4690 haemoglobin measurements for the analysis. (ox.ac.uk)
The current haemoglobin concentration cutoffs during pregnancy should not only consider thresholds for low haemoglobin concentrations that are associated with adverse outcomes but also define a threshold for high haemoglobin concentrations given the U-shaped relationship between haemoglobin concentration and adverse neonatal and maternal outcomes.FundingBill & Melinda Gates Foundation. (ox.ac.uk)
Pregnancy increases iron needs because of the expansion of maternal blood volume and fetal needs. (cambridge.org)
This is consistent with elevated hepcidin in the 3 rd trimester and higher inflammation throughout pregnancy. (cambridge.org)
3 Delivery itself is a factor as up to 20% of women with normal hemoglobin values in the last trimester of pregnancy, were discovered to have anemia at their first postpartum visit. (glowm.com)
However, a clear distinction is made between the relative strengths of biomarkers to assess hematological consequences of iron deficiency versus other putative functional outcomes, particularly the relationship between maternal and fetal iron status during pregnancy, birth outcomes, and infant cognitive, motor and emotional development. (umn.edu)
Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of iron from the diet and the recycling of iron by macrophages. (nih.gov)
On other hand, oral iron supplementation to rats treated with doxorubicin (15 mg/kg bw) lessened the increase in the spleen iron content concomitantly with hepatic hepcidin level, rebound hepatic iron content to normal level, and by contrast augmented serum levels of iron and transferrin saturation. (bvsalud.org)
Erythropoietin1
11. Serum pro-hepcidin level and iron homeostasis in Japanese dialysis patients with erythropoietin (EPO)-resistant anemia. (nih.gov)
Systemic2
1. Systemic inflammation up-regulates serum hepcidin in exacerbations and stabile chronic obstructive pulmonary disease. (nih.gov)
Overweight/obesity (owob) causes low-grad systemic inflammation and thereby an up-regulation of hepcidin and a reduction in fractional iron absorption (FIA) even with low iron stores. (cambridge.org)
Regulator1
Hepcidin, a circulating peptide hormone, is the key regulator of both iron absorption and the distribution of iron throughout the body, including in plasma [ 1 , 2 , 6 ]. (nih.gov)
Concentrations3
Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study. (ox.ac.uk)
IDA is characterized by low hemoglobin concentrations, and decreases in hematocrit (the proportion of red blood cells in blood by volume) and mean corpuscular volume (a measure of erythrocyte size) [ 2 , 10 ]. (nih.gov)
Hemoglobin concentrations lower than 11 g/dL in children under 10 years of age, or lower than 12 g/dL in individuals age 10 years or older, suggest IDA [ 8 ]. (nih.gov)
Maternal2
Trimester-specific results are also presented.InterpretationOur data suggests that the current WHO haemoglobin cutoffs are associated with reduced risk of adverse maternal and neonatal outcomes. (ox.ac.uk)
Although as noted above, there are significant maternal-fetal implications even with mild reductions in hemoglobin. (glowm.com)
In contrast, hepcidin levels were elevated in thalassemia major, presumably due to transfusions that reduce erythropoietic drive and deliver a large iron load. (nih.gov)
Hematocrit2
Overview of Decreased ErythropoiesisAnemia, a decrease in the number of red blood cells (RBCs), hemoglobin (Hb) content, or hematocrit (Hct), can result from decreased RBC production (erythropoiesis), increased RBC destruction. (msdmanuals.com)
Hemoglobin and hematocrit tests are the most commonly used measures to screen patients for iron deficiency, even though they are neither sensitive nor specific [ 5 , 7 , 17 ]. (nih.gov)
Inflammation2
10. Hepcidin, iron status, and inflammation variables among healthy pregnant women in the Turkish population. (nih.gov)
From PW 12 until PW 36 iron-, inflammation and hepcidin were monitored. (cambridge.org)
Functional1
9. Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery. (nih.gov)
Trimester1
Hepcidin was still significantly higher in the owob women in the 3 rd trimester. (cambridge.org)
Anemia1
Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. (wikipedia.org)
Obese1
8. Iron homeostasis and serum hepcidin-25 levels in obese children and adolescents: relation to body mass index. (nih.gov)
Tissues2
Iron is an essential component of hemoglobin, an erythrocyte (red blood cell) protein that transfers oxygen from the lungs to the tissues [ 1 ]. (nih.gov)
But the reality is that your body will consume the weight to maintain the development of different tissues of breasts and allow fetal development. (didgitalsence.com)
Acute1
12. Hepcidin expression in patients with acute leukaemia. (nih.gov)
Blood1
A man with 5 L of blood volume has 2.5 g of iron incorporated into the hemoglobin, with a daily turnover of 20 mg for hemoglobin synthesis and degradation and another 5 mg for other requirements. (medscape.com)
Expression2
Role of MFHAS1 in regulating hepcidin expression via the BMP/SMAD and MAPK/ERK1/2 signalling pathways. (nih.gov)
Hepcidin expression is modulated in response to this increased iron demand to facilitate iron availability 8 . (nature.com)
Levels3
3. Serum hepcidin levels in patients with end-stage renal disease on hemodialysis. (nih.gov)
4. Increased serum iron in preeclamptic women is likely due to low hepcidin levels. (nih.gov)
Mitochondria retention in mature RBCs from haemoglobin SC patients. (amedeo.com)
Level3
The goal of long-term hypertransfusional support is to maintain the patient's hemoglobin level at 9-10 g/dL, thus improving his or her sense of well being while simultaneously suppressing enhanced erythropoiesis. (medscape.com)
16. Association between hepcidin, haemoglobin level and iron status in stage 4 chronic kidney disease patients with anaemia. (nih.gov)
18. Serum hepcidin level correlates with hyperlipidemia status in patients following allograft renal transplantation. (nih.gov)
Iron status1
2. Serum hepcidin in haemodialysis patients: associations with iron status and microinflammation. (nih.gov)
Results1
Homozygous α0-thalassemia (hemoglobin Bart's hydrops fetalis) results from deletion of all duplicated α-globin genes on chromosome 16p. (cheoresearch.ca)
Development1
And they are based on physiological fetal development. (didgitalsence.com)
Increase1
Intramuscular or subcutaneous injections of interferon IFN-α2a or IFN-α2b are given two or three times a week or peginterferon-α2b once a week to increase hemoglobin and decrease iron overload. (nih.gov)
Greater1
Variation in the SITAR size parameter was ≥90% explained by the combination of average length within the first 60 days of birth (as a proxy for fetal growth) and intensity, regardless of sex, with much greater contribution by postnatal intensity (r≥0.89 between size and intensity). (ox.ac.uk)