Teratomas (from Greek teras, meaning "monster," and - oma, a suffix denoting a tumor or neoplasm) and other germ cell tumors are relatively common solid neoplasms in children. (medscape.com)
These tumors are grouped together because they all appear to arise from postmeiotic germ cells. (medscape.com)
The best evidence suggests that most are due to abnormal differentiation of fetal germ cells that arise from the fetal yolk sac. (medscape.com)
Normal migration of these germ cells may cause gonadal tumors, whereas abnormal migration produces extragonadal tumors. (medscape.com)
In 1965, Teilum first suggested the germ cell origin of gonadal tumors. (medscape.com)
They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs). (wikipedia.org)
Teratomas (from Greek teras, "monster," and - oma, a suffix denoting a tumor or neoplasm) and other germ cell tumors (GCTs) are relatively common solid neoplasms in children. (medscape.com)
In clinical practice, she concentrates on germ cell tumors, while her epidemiologic research primarily focuses on colorectal cancer screening and prevention. (dana-farber.org)
and (3) treatment of germ cell tumors in pediatric patients. (dana-farber.org)
In clinical care, Dr. Frazier is the national expert on germ cell tumors in pediatric patients and oversees the care of these patients referred to DFCI. (dana-farber.org)
In addition, she is cochair of two national protocols that opened in 1999 for the treatment of low-risk and high-risk pediatric germ cell tumors and chair of the COG Germ Cell subcommittee in COG Rare Tumors. (dana-farber.org)
Embryonal1
Immature teratoma is the malignant counterpart of the mature teratoma and contains immature tissues which typically show primitive or embryonal neuroectodermal histopathology. (wikipedia.org)
Teratomas8
Teratomas may be classified as mature or immature on the basis of the presence of immature neuroectodermal elements within the tumor. (medscape.com)
Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (wikipedia.org)
Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (wikipedia.org)
The most diagnosed fetal teratomas are sacrococcygeal teratoma (Altman types I, II, and III) and cervical (neck) teratoma. (wikipedia.org)
Because these teratomas project from the fetal body into the surrounding amniotic fluid, they can be seen during routine prenatal ultrasound exams. (wikipedia.org)
When strictly defined, the most common forms of congenital neoplasia are teratomas and astrocytomas. (touchoncology.com)
11 Of the larger studies that were more strictly confined to the congenital time period, i.e. all cases less than or equal to two months of age, teratomas and astrocytomas were usually the most frequent tumour type. (touchoncology.com)
in 2008 of 27 foetal cases included 13 teratomas and four glial tumours (subtype unspecified) without any medulloblastomas/PNETs. (touchoncology.com)
Neoplasms1
2,3 The majority of these neoplasms reside in the supratentorial compartment and, as noted by Volpe, the clinical manifestations of congenital brain tumours usually involve one or more of four typical syndromes. (touchoncology.com)
Immature2
Mature tumors (grade 0) have no immature elements. (medscape.com)
Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (wikipedia.org)
Genitourinary1
Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
Pediatric2
The first section will cover those tumors that characteristically are associated with the pediatric population. (abdominalkey.com)
Evaluation of prevalence and outcomes of serial tyrosine kinase inhibitor use in pediatric patients with advanced solid tumors. (dana-farber.org)
Suffix1
The term comes from the Greek word for "monster" plus the "-oma" suffix used for tumors. (wikipedia.org)
Anomalies1
Wilms tumor may be associated with hemihypertrophy and aniridia and with genital anomalies, such as cryptorchidism and hypospadias ( 5 ). (abdominalkey.com)
Typically1
These malignant elements are typically yolk sac tumors but may also represent primitive neuroectodermal tumor (PNET). (medscape.com)
Adult1
However, based on a recent analysis of congenital glioblastomas, congenital gliosarcomas may constitute an entity that is genetically and prognostically distinct from adult cases. (touchoncology.com)
Tissues2
Wilms tumor is believed to arise from embryonic tissues called nephrogenic rests that fail to undergo normal involution ( 7 ). (abdominalkey.com)
The tumor is usually circumscribed by a pseudocapsule formed of compressed renal and perirenal tissues. (abdominalkey.com)
Arise1
A diverse array of tumors can arise in the human kidney. (abdominalkey.com)
Classification1
The classification of epithelial tumors of the kidney has in particular undergone substantial progress in the last two decades with major contributions from genetic typing of renal cell carcinomas (RCCs). (abdominalkey.com)
Genetically1
Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (wikipedia.org)
Types4
Locations and specific tumor types depend on the age of the child. (medscape.com)
A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, teeth, or bone. (wikipedia.org)
2,3,5-13 Ascertaining the frequency of individual congenital tumour types is often made difficult by the inclusion of older children in some analyses (up to 18 months of age in one study). (touchoncology.com)
The purpose of this chapter is to familiarize the reader with the tumor types encountered in the human rather than to provide a comprehensive diagnostic reference, which is better handled in more comprehensive textbooks and monographs. (abdominalkey.com)
Small1
Symptoms may be minimal if the tumor is small. (wikipedia.org)
Chapter1
In this chapter, these will be covered using an approach that has become a standard one in dealing with this group of tumors. (abdominalkey.com)
Development4
Mutter described genetic imprinting as a major factor in the development of some of these tumors. (medscape.com)
Although neuroimaging modalities are increasingly identifying cases during foetal development, aggressive surgical and chemo-/radiotherapeutic regimens have yet to significantly alter the dismal prognosis for most of these unfortunate patients. (touchoncology.com)
Denys-Drash syndrome, due to mutations of the WT1 gene, is also associated with a congenital nephropathy and disorders of sexual development. (abdominalkey.com)
The development of Wilms tumor has been linked to mutations of the WT1 and WT2 genes located on chromosome 11 at 11p13 and 11p15.5, respectively ( 8 , 9 ). (abdominalkey.com)
Children1
Most Wilms tumor occurs in children between the ages of 2 and 4 years ( 3 ). (abdominalkey.com)
Individual1
Specific discussions of etiology and pathogenesis are dealt with in each of the sections on individual tumors, rather than as a freestanding section, as is used elsewhere in this text. (abdominalkey.com)