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  • doses
  • By using two novel models of human prostate development involving embryonic stem cells , this study is the first to show that low doses of BPA can actually reprogram human fetal prostate tissue in a manner that raises the risk of prostate diseases as men age," said the study's presenting author, Esther Calderon-Gierszal, a PhD student at the University of Illinois at Chicago, Chicago, IL. (medicalxpress.com)
  • When the human fetal prostate model grown in the laboratory was exposure to low doses of BPA, investigators reported that exposure altered fetal prostate formation and increased the number of stem cells in the adult prostate, which could lead to aberrant growth and disease with aging. (medicalxpress.com)
  • Previous studies in rodents have demonstrated that maternal exposure to very low doses of BPA can significantly alter fetal development, resulting in a variety of adverse outcomes in the fetus. (eurekalert.org)
  • Ohsako, Seiichiroh 2018-06-04 00:00:00 Background: There is still considerable debate about the effects of exposure to bisphenol A (BPA) an endocrine disrupter at low doses. (deepdyve.com)
  • Subsequently, in experimental animal stu- Bisphenol A (BPA), an endocrine disruptor, has still been the dies, exposureofpregnantanimals to BPA ata low focusofattentionofscientistsinthe fieldofenvironmental doses (2-20 μg/kg) altered the development of male health since the last century. (deepdyve.com)
  • Fertility decreased over time in female mice that had been exposed during fetal and neonatal (perinatal) development to doses of bisphenol-A (BPA) that were lower than or equal to human environmental exposure levels. (scienceblog.com)
  • At the highest of three doses tested, only 60% of the BPA-exposed mice had four or more deliveries over a 32-week period, compared with 95% in the unexposed control group. (scienceblog.com)
  • Similar to BPA, low doses of DES had failed to cause obvious reproductive problems when evaluated only at first pregnancy as in the standard tests used by regulatory agencies to determine toxicity. (scienceblog.com)
  • The three doses of BPA tested are within the range of human exposure and below the Environmental Protection Agency (EPA) reference dose (i.e., the maximal acceptable daily dose). (scienceblog.com)
  • Inappropriate exposure to EDCs during development, even at low doses, can predispose individuals to an increased lifetime risk of disease, including cancer. (aacrjournals.org)
  • Yet another study--this one by Canada's University of Calgary--focused on the effects of very low doses of BPA and bisphenol S (BPS)--a BPA alternative--on zebrafish embryos. (foodsafetymagazine.com)
  • Recent studies have reported that BPA is hormonally active at low doses, emphasizing the debate of a risk for human health. (pnas.org)
  • We first examined the endocrine disrupting potency of BPA on colonic paracellular permeability (CPP), experimental colitis, and visceral sensitivity in ovariectomized rats orally exposed to 5 mg/kg/d BPA (i.e., the no observed adverse effect level), 50 μg/kg/d BPA (i.e., tolerable daily intake), or lower doses. (pnas.org)
  • This study first demonstrates that the xenoestrogen BPA at reference doses influences intestinal barrier function and gut nociception. (pnas.org)
  • However, recent studies revealed that chronic exposure to these reference doses alters some biological endpoints ( 8 , 9 ), warranting a request for reevaluation of human safe daily intake limits ( 4 , 10 ). (pnas.org)
  • perinatal
  • T4 DNA ligase show that low-dose BPA exposure in the perinatal period and restriction enzymes Hpa II, Msp I, Sbf I were from affected behavioral and brain development [16- (deepdyve.com)
  • Recent data indicate that perinatal exposure to EDCs increases cancer risk by (re)programming the epigenome via alterations in DNA and histone methylation. (aacrjournals.org)
  • We then examined the impact of perinatal exposure to BPA on intestinal permeability and inflammatory response in the offspring. (pnas.org)
  • In female rats, but not in male rats, perinatal BPA evoked a decrease of CPP in adulthood, whereas the proinflammatory response of colonic mucosa was strengthened. (pnas.org)
  • Moreover, perinatal exposure promotes the development of severe inflammation in adult female offspring only. (pnas.org)
  • mice
  • The experiment modeled human BPA exposure feeding the mice low-dose BPA which led to the development of lesions in the human prostate tissue , including a precancerous lesion known as prostate intraepithelial neoplasia, or PIN. (medicalxpress.com)
  • Vom Saal determined that BPA not only affects mice and rat subjects adversely, but also can cause fetal and hormonal imbalances in primates. (eurekalert.org)
  • Until now, most studies involving BPA have been conducted on laboratory mice and rats, leading U.S. regulatory agencies to call for studies in primates. (eurekalert.org)
  • Although we examined the methylation levels of 43,840 CpG sites in the control and BPA (200 μg/kg/day)-treated group (6 mice per group), we found no statistically significant changes in methylation levels in any CpG sites. (deepdyve.com)
  • His research team published study that showed pregnant Agouti mice fed BPA had offspring that were, instead of lean and brown-haired as they normally would have been, obese and blond haired. (thesmartmama.com)
  • It was at this time of early development that his study determined that exposure to BPA would change the coat color of Agouti mice. (thesmartmama.com)
  • Mice exposed to BPA in the womb and during nursing subsequently had fewer successful pregnancies and delivered fewer pups over the course of the study," reported one of the study's co-senior authors, Ana M. Soto, MD, professor of anatomy and cellular biology at Tufts University School of Medicine (TUSM) and member of the cell, molecular and developmental biology program faculty at the Sackler School of Graduate Biomedical Sciences. (scienceblog.com)
  • Prins investigated the effect of BPA on human cells by implanting human prostate stem cells taken from deceased young-adult men into mice. (healthcanal.com)
  • To mimic exposure to BPA during embryonic development, for two weeks following implantation the mice were fed BPA - in amounts in line with those seen in pregnant American women - as the cells produced humanized prostate tissue. (healthcanal.com)
  • The amount of BPA we fed the mice was equivalent to levels ingested by the average person," Prins said. (healthcanal.com)
  • Prins found that a third of tissue samples taken from mice fed BPA had either pre-cancerous lesions or prostate cancer, compared to only 12 percent in a control group of mice fed oil. (healthcanal.com)
  • If the prostate stem cells were exposed to BPA before implantation and again as they produced prostate tissue in the mice, 45 percent of the tissue samples had pre-cancerous lesions or cancer. (healthcanal.com)
  • Further, female BALB/c mice were exposed to BPA from 1 week before mating until delivery, and weight development of their pups was monitored ( n ≥ 8/group). (beds.ac.uk)
  • This effect could be confirmed in mice in which prenatal BPA exposure altered Mest promoter methylation and transcription with a concomitant increase in the body weight of the juvenile offspring. (beds.ac.uk)
  • She treated young female mice with a BPA solution that was comparable to estimated human exposure in the United States, and then examined their ovaries after one month of treatment. (treehugger.com)
  • cans
  • Since BPA is also present in epoxy linings of metal cans, choose glass containers for 'canned' goods instead. (thesmartmama.com)
  • BPA is found in polycarbonate plastic food and beverage containers, such as water and infant bottles, as well as in the epoxy resin lining of cans and other sources. (thaindian.com)
  • The most prominent continuing use of BPA is in the lining of aluminum and tin cans, where it prevents corrosion. (wkhs.com)
  • The linings of tin cans is probably the biggest source of our exposure," Swan said. (wkhs.com)
  • There is almost no canned food that comes in BPA-free cans. (wkhs.com)
  • To minimize pregnant women's exposure, a "Cans, Not Cancer" campaign was launched, pressuring manufacturers and policy makers to eliminate BPA from all food cans because dietary intake is thought to be the greatest exposure source. (emagazine.com)
  • Most often associated with plastic water bottles, BPA is also founding inside the metal lining of food or drink cans or other plastic tools, household goods, or cleaning products. (fertilitysmarts.com)
  • Bisphenol A, commonly known as BPA, is an ingredient used in polycarbonate plastics, protective liners in food cans and tins, thermal coatings on paper receipts, epoxy-lined beer cans, and dental sealants. (treehugger.com)
  • The xenoestrogen bisphenol A (BPA), a food contaminant with endocrine disruptor activity, is the monomer widely used to manufacture polycarbonate plastics including baby bottles, infant feeding containers or tableware (plates and mugs), and epoxy resin lining food and beverage cans ( 1 , 2 ). (pnas.org)
  • Previous animal studies have linked BPA, a chemical used in plastic bottles and metal food and beverage cans, with breast and prostate cancer, and reproductive and behavioral problems. (bio-medicine.org)
  • Saal
  • Although BPA is considered a toxic chemical in other countries such as Canada, the U.S. has been slow to address the issue, said vom Saal. (eurekalert.org)
  • Vom Saal said that for levels to be higher in people when measured, their exposure dose must be greater than that given to the monkeys. (thaindian.com)
  • These results suggest that the average person is likely exposed to a daily dose of BPA that far exceeds the current estimated safe daily intake dose," vom Saal said. (thaindian.com)
  • Frederick vom Saal and colleagues say that BPA can cause fetal and hormonal imbalances in primates. (science20.com)
  • Citation: Frederick S. vom Saal, Catherine A. VandeVoort, Julia A. Taylor, Wade V. Welshons, Pierre-Louis Toutain, Patricia A. Hunt, 'Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures', Reproductive Toxicology , 25 February 2014, DOI: 10.1016/j.reprotox.2014.01.007. (science20.com)
  • Since the 1990s, Dr. vom Saal has been conducting research concerning the health effects of low level exposures to estrogenic chemicals, such as Bisphenol A (BPA) used in plastic and other products, and estrogenic drugs, such as ethinylestradiol and diethylstilbestrol. (nipro.com)
  • development
  • CNPRC scientists Drs. Laura S. Van Winkle, Respiratory Diseases Unit, and Catherine A. VandeVoort, Reproductive Sciences and Regenerative Medicine Unit, along with co-authors Drs. Shannon R. Murphy and Miriam V. Boetticher (UC Davis Center for Health and the Environment), conducted this collaborative study to investigate the effects of BPA on fetal development. (ucdavis.edu)
  • Their data indicate that exposure to environmentally relevant levels of BPA during fetal lung development can alter expression of secretory genes (Muc5B, Clara cell secretory protein (CCSP)) and proteins (Muc5B mucins and CCSP) in the conducting airways. (ucdavis.edu)
  • Thus, fetal and infant exposure at critical development stages may cause significant health effects, as Dr. Jirtle's research indicates. (thesmartmama.com)
  • The non-profit Breast Cancer Fund (BCF) summarized the evidence that fetal exposure to BPA sets the stage for diseases in adulthood in a Sept. 2013 report titled "Disrupted Development: the Dangers of Prenatal BPA Exposure. (emagazine.com)
  • Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day lives, increases the risk for prostate cancer in human prostate tissue," Prins said. (healthcanal.com)
  • They arise during early fetal development and produce and maintain a man's prostate tissue throughout his life. (healthcanal.com)
  • With consumers demanding more transparency in terms of food safety, much attention has been placed on the synthetic compound and how it can negatively affect the human body--specifically fetal development, brain development and future behavior. (foodsafetymagazine.com)
  • To obtain a deeper insight into the role of prenatal bisphenol A (BPA) exposure in children's overweight development, we combine epidemiological data with experimental models and BPA-dependent DNA methylation changes. (beds.ac.uk)
  • Our study provides evidence that MEST mediates the impact of prenatal BPA exposure on long-term body weight development in offspring by triggering adipocyte differentiation. (beds.ac.uk)
  • The growing knowledge about the human epigenome emphasized the importance of environmental exposure-related epigenetic modifications predisposing an individual to the development of disease. (beds.ac.uk)
  • Understanding the underlying effects leading to a disruption in epigenetic programming by EDCs during fetal development is important and might aid future prevention strategies for such diseases. (beds.ac.uk)
  • One EDC with a well-described impact on the human epigenome during development is bisphenol A (BPA). (beds.ac.uk)
  • Further analysis showed that estradiol, the sex hormone essential for normal reproductive development, was not being produced at normal levels. (treehugger.com)
  • The report also expresses "minimal concern" that BPA exposure will affect development of the mammary gland or accelerate puberty in females. (emaxhealth.com)
  • The different outcomes may be because Donohue's team measured BPA later in fetal development, during the third trimester, Braun said. (ecochildsplay.com)
  • To date, most studies examining the estrogenic impact of BPA have focused on reproductive function ( 11 - 13 ) and, more recently, on brain development ( 14 , 15 ). (pnas.org)
  • Thyroid hormone in pregnant women plays an essential role in fetal growth and brain development," said Jonathan Chevrier, UC Berkeley epidemiologist and study co-author. (nbcbayarea.com)
  • ovaries
  • A New York Times article explains the work of bioscientist Jodi Flaws, from the University of Illinois, who noticed the plethora of studies linking BPA with damage to developing ovaries. (treehugger.com)
  • adult
  • The necessary liver enzyme is not expressed until after birth, with the full complement at 3 months, but at about 25% of the adult level. (thesmartmama.com)
  • pregnancy
  • ET) - Exposure to a ubiquitous environmental chemical during pregnancy may impair reproductive capacity of female offspring, according to a study published online in advance of print on December 2 in Environmental Health Perspectives . (scienceblog.com)
  • Tolerable Daily Intake
  • And just last year, the agency confirmed that exposure levels--measured as Tolerable Daily Intake (TDI)--of 5 micrograms per day is safe--a finding based on 300 scientific studies over a 5-year span. (foodsafetymagazine.com)
  • BPA dose-dependently decreased basal CPP, with a half-maximal inhibitory dose of 5.2 μg/kg/d, 10-fold below the tolerable daily intake. (pnas.org)
  • As a protective measure the US Environmental Protection Agency and European Food Safety Agency have established a tolerable daily intake (TDI) of 50 μg/kg/d, applying an uncertainty factor of 100 to the no observed adverse effect level (NOAEL) of 5 mg/kg/d. (pnas.org)
  • linings
  • BPA is also regulated by the Food and Drug Administration (FDA) as an "indirect food additive" that leaches into foods from can linings and polycarbonate packaging. (emagazine.com)
  • When the participants drank soy milk from glass bottles--which do not use BPA linings--their BPA levels and blood pressure showed no significant changes. (foodsafetymagazine.com)
  • hormonally active
  • The authors compared the effects of BPA to those of diethylstilbestrol (DES), a hormonally active chemical that is known to have caused reproductive impairment in women exposed during fetal life, and concluded that the effects of these two chemicals on fertility were comparable. (scienceblog.com)
  • hormone
  • Results: BPA showed the sex-hormone like effects on male reproductive organs. (deepdyve.com)
  • That is, the higher the BPA level, the lower the level of the important testicular hormone. (wkhs.com)
  • Fenichel speculated that BPA, considered a hormone disruptor, might repress expression of the gene that promotes production of INSL3. (wkhs.com)
  • Though the FDA has found BPA safe after numerous studies, because it can exhibit hormone-like properties the public has grown concerned about conflicting claims. (science20.com)
  • But the male babies of those women had thyroid hormone levels consistent with a more active thyroid gland. (nbcbayarea.com)
  • rats
  • Other studies have also shown exposure to pregnant female rats led to male offspring with decreased testes, seminal vesicle and prostate gland weights, as well as decreased sperm count and motility. (novamagazine.com.au)
  • When ovariectomized rats were fed with BPA at the no observed adverse effect level, the severity of colitis was reduced, whereas the same dose increased pain sensitivity to colorectal stimuli. (pnas.org)
  • found
  • This dose was comparable to the initial study found that BPA monomer released from a poly- maximum exposure levels (375-857 ng/kg/day) for in- carbonate dish has an estrogenic activity in a cell culture fants . (deepdyve.com)
  • BPA has been found in the urine of over 92% of Americans tested, with higher levels in children and adolescents relative to adults. (scienceblog.com)
  • BPA also is found in cash register receipts. (wkhs.com)
  • To have a cash register receipt that doesn't require ink, it is coated in BPA," Swan said, noting that studies have found increased BPA levels in the urine of people who have touched a receipt. (wkhs.com)
  • In a study, school children with asthma were found to be more likely to suffer an asthma attack after exposure to vapour from someone else's e-cigarette. (health24.com)
  • DES was taken off the market, BPA found its way into plastic production, mainly polycarbonated plastics and epoxy resins. (legalexaminer.com)
  • Fetal exposure to a commonly used plasticizer found in products such as water bottles, soup can liners and paper receipts can increase the risk for prostate cancer later in life, according to a study from the University of Illinois at Chicago published Jan. 7 online in the journal Endocrinology. (healthcanal.com)
  • Abnormal levels of phthalates have been found in men with decreased sperm quality, testicular cancer and in women with endometriosis. (positivepcos.com)
  • A new study conducted at Columbia University has found that increased exposure to BPA at ages 3, 5, and 7 strengthened the likelihood these same children would suffer from asthma between the ages of 5 and 12. (ecochildsplay.com)
  • BPA is used to make polycarbonate plastics and is found in some canned foods and beverages, paper receipts and dental sealants. (ecochildsplay.com)
  • pharmacokinetics
  • The focus of his current research is one the pharmacokinetics of BPA at different life stages, and effects during fetal life on the urogenital system and metabolic processes. (nipro.com)
  • study
  • Conclusions: At least under the experimental condition in this study, it is considered that the effect of low-dose BPA exposure during the fetal stage on hippocampal DNA methylation levels is extremely small. (deepdyve.com)
  • In addition, the infertility effect of BPA was dose-specific in our study. (scienceblog.com)
  • In other words, although our study clearly indicates that BPA-induced thyroid disruption is possible, it does not indicate how probable such a disruption is to occur in real conditions," added Viguié. (innovations-report.com)
  • This appears to be the first study that shows a link between INSL3 levels and BPA, said Shanna Swan, a professor and vice chair for research and mentoring in the department of preventive medicine at the Icahn School of Medicine at Mount Sinai, in New York City. (wkhs.com)
  • Trasande said the study "certainly raises another set of health concerns that haven't been raised before about BPA exposure. (wkhs.com)
  • Unfortunately, there seems little chance the federal government will step in any time soon to protect pregnant women, even though scientists who study BPA say there is more than enough scientific evidence to warrant it. (emagazine.com)
  • This is the first study that shows a single exposure to BPA can have a direct, immediate impact on cardiovascular health. (foodsafetymagazine.com)
  • but when it comes to BPA and ovarian toxicity, there is definite consensus among scientists and study results. (treehugger.com)
  • The study doesn't mean BPA causes asthma or wheezing. (ecochildsplay.com)
  • But "it's an important study because we don't know a lot right now about how BPA affects immune response and asthma," said Kim Harley, an associate professor at the University of California, Berkeley, who studies environmental chemicals and children's health but did not participate in the new research. (ecochildsplay.com)
  • cord blood
  • In prenatally BPA-exposed children two CpG sites with deviating cord blood DNA-methylation profiles were identified, among them a hypo-methylated CpG in the promoter of the obesity-associated mesoderm-specific transcript ( MEST) . (beds.ac.uk)
  • A mediator analysis suggested that prenatal BPA exposure was connected to cord blood MEST promoter methylation and MEST expression as well as BMI z scores in early infancy. (beds.ac.uk)
  • effects
  • AllPrep DNA/RNA particular, the effects of low-dose BPA exposure on the mini kit was from Qiagen (Hilden, Germany). (deepdyve.com)
  • POP-7™ Polymer, GeneScan™ 500 LIZ® Size Such effects of BPA can be regarded as the Developmental Standard and BigDye® Terminator v3.1 Cycle Sequencing Origins of Health and Disease (DOHaD), that is fetal/neo- Kit were from ThermoFisher Scientific Inc., (San Diego, natal environmental factors are the causes of diseases after CA, USA). (deepdyve.com)
  • Most investigations have focused on reproductive functions, but there is evidence that BPA might have negative effects on other endocrine systems including thyroid function. (innovations-report.com)
  • We used an analytical strategy conditioning on matched set and total pool-level values of covariates to estimate individual-level effects. (mdpi.com)
  • The apparent effects of BPA, though, are hard to swallow. (foodsafetymagazine.com)
  • Especially the prenatal and early postnatal period is highly vulnerable to adverse effects by environmental exposure, promoting developmental reprogramming by epigenetic alterations. (beds.ac.uk)
  • In both men and women, the long-term effects of BPA are still being studied. (fertilitysmarts.com)
  • The NTP also expressed "negligible concern" that exposure to BPA causes reproductive effects in non-occupationally exposed adults and "minimal concern" for workers exposed to higher levels in occupational settings. (emaxhealth.com)
  • epoxy
  • China has nothing like OSHA in the U.S. so workers in an epoxy resin factory there were exposed to levels about 50 times greater than non-factory workers. (legalexaminer.com)
  • laboratory
  • Previous studies have shown that people who avoided all contact with plastics or other BPA-containing objects for up to a month or more still had BPA in their urine, which means they must have come into contact with BPA in the last 24 to 48 hours, since it clears the body rather quickly," said Prins, who is director of the UIC andrology laboratory. (healthcanal.com)
  • leaches
  • BPA leaches from the polymers into food and water under normal conditions, and exposure to elevated temperatures (boiling, heating) greatly increases its rate of migration ( 5 , 6 ). (pnas.org)
  • sexual dysfunction
  • Even men who worked at the BPA factory for a year or less, had sexual dysfunction, which raises questions about the blanket assurances of safety from scientists and industry, even the U.S. FDA. (legalexaminer.com)