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  • fibroblasts
  • Human fetal synovial fibroblasts (hfSFs) were characterized and found to include hfSDSCs, as evidenced by their multi-differentiation capacity and the surface phenotype markers typical of mesenchymal stem cells. (springer.com)
  • 3 These cells are identified in vitro by their ability to form colony-forming unit fibroblasts (CFU-F) and, phenotypically, by their expression of surface markers, such as CD105, CD73, CD90, integrins and adhesion molecules in addition to the absence of CD14, CD34 and CD45 haematopoietic-related antigen. (bmj.com)
  • 2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (springer.com)
  • 2008). Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. (springer.com)
  • 2009). Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. (springer.com)
  • engraftment
  • In conclusion, my thesis supports the use of hfMSC as an attractive source for cell therapy and provides the background for further studies to optimise their engraftment and differentiation to underpin future clinical applications. (bl.uk)
  • therapeutic
  • With the advent of tissue engineering, there is great interest in the potential therapeutic application of stem cells for periodontal regeneration, and there has been a marked increase in publications in this area over the past 5 years. (springer.com)
  • Regrettably, serious preclinical concerns remain and differentiation, cell fusion, senescence and signalling crosstalk with growth factors and biomaterials are still challenges for this promising multidisciplinary therapeutic modality. (mdpi.com)
  • This review summarizes findings and therapeutic applications of ESCs and their alternatives: adult stem cells and iPS cells. (springer.com)
  • donors
  • Instead, typical signs of cellular ageing are reverted in the process of iPSC reprogramming, and iPSCs from older donors do not show diminished differentiation potential nor do iPSC-derived cells from older donors suffer early senescence or show functional impairments when compared with those from younger donors. (frontiersin.org)
  • Due to the potential severity of GVHD, researchers try to use stem cell donors who are either related to the patient and/or have specific proteins of the stem cell called HLA proteins that are matched as closely as possible. (cancerconnect.com)
  • systemic
  • Severe burns have several indications for stem cell therapy, including enhancement of wound healing, replacement of damaged skin and perfect skin regeneration - incorporating skin appendages and reduced fibrosis -, as well as systemic effects, such as inflammation, hypermetabolism and immunosuppression. (mdpi.com)
  • Furthermore, stem cells may be able to address the other systemic effects of burn injury, such as hypermetabolism and inflammation [ 5 ]. (mdpi.com)
  • Devine SM, Cobbs C, Jennings M et al (2003) Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. (springer.com)
  • Therapy
  • The use of mesenchymal stem cell (MSC) therapy offers the potential to develop a completely novel and improved method of periodontal regeneration compared to existing methods. (springer.com)
  • Stem Cell Therapy: A New Treatment for Burns? (mdpi.com)
  • Stem cell therapy has emerged as a promising new approach in almost every medicine specialty. (mdpi.com)
  • however, augmenting immunotolerance via stem cell therapy may overcome this problem. (mdpi.com)
  • There is this problem of delivering the cells, or in the case of gene therapy, the viral vector, to all of the muscles. (innovations-report.com)
  • More research is also needed for the "genetic correction" step of the therapy, which involves inserting the healthy version of a gene into the stem cell. (innovations-report.com)
  • These infused stem cells can grow in the patient's body and replace the patient's own stem cells that were destroyed by the chemo-radiation therapy, resulting in a new line of white blood cells, red blood cells, or platelets that the patient will need to survive. (cancerconnect.com)
  • In addition to restoring low levels of a patient's stem cells following therapy, donor stem cells may also attack the patient's cancer cells, providing an additional source of anticancer activity. (cancerconnect.com)
  • lung
  • Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer. (pubfacts.com)
  • vessels
  • A study on mice suggests that a type of stem cells found in blood vessels may someday be able to regenerate wasting muscle in muscular dystrophy (MD) patients. (innovations-report.com)
  • The approach Cossu and his colleagues are envisioning would involve collecting mesoangioblasts from a patient s blood vessels, genetically "correcting" the cells in the laboratory, allowing them to multiply, and then injecting the cells back into the patient s bloodstream. (innovations-report.com)