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  • skeletal muscle
  • A group of healthy mice whose food consumption matched the lower consumption of the mice with cancer also lost weight, but retained their skeletal muscle mass and showed normal heart function. (healthcanal.com)
  • The aim of the study was to investigate the effect of fetal undernutrition on the passive mechanical properties of skeletal muscle of weaned and young adult rats. (scielo.br)
  • neural
  • The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. (hindawi.com)
  • Spastin is an abundant protein in neural tissues and immunolabeling experiments have shown that spastin is expressed in neurons but not in glial cells. (embl-heidelberg.de)
  • The grafts where placed within the right lateral ventricle to allow interaction with putative adult neural stem cells in the ependymal layer in adult wild-type mice, after an MPTP-lesion of the host nigrostriatal dopamine system. (dissertations.se)
  • mesenchyme
  • It arises and operates in intimate contact with mesenchyme and provides a useful model to investigate tissue processes such as mesenchyme-epithelial interactions, establishment and renewal of stem-cell compartments, and specification of daughter lineages. (biologists.org)
  • human
  • Mapping of the murine Vbp1 gene revealed conserved chromosomal localization between mouse and human in a region homologous to human Xq28. (sigmaaldrich.com)
  • Antigenic determinants of human serum retinol binding protein as probed with monoclonal antibodies. (biotium.com)
  • We thank C. Kuhn (Division of Cell Biology, German Cancer Research Center) for experimental help in the initial course of this study and A. Wiss (Department of Pathology, University of Heidelberg) for competent help in sectioning paraffin-embedded human tissues. (springer.com)
  • WHSC2 (NP_005654.2, 1 a.a. ~ 528 a.a) full-length human protein. (abnova.com)
  • The anticipated mRNAs were demonstrated in K562 cells, but not in any adult human tissues examined by Northern blotting. (biochemj.org)
  • Generation of polyclonal antibodies specific to spastin has revealed two isoforms of 75 and 80 kDa in both human and mouse tissues with a tissue-specific variability of the isoform ratio. (embl-heidelberg.de)
  • Platelet-derived growth factor (PDGF) originally identified in platelets and in serum as a mitogen for fibroblasts, smooth muscle cells, and glia cells has been linked to the cause of a number of human diseases, including atherosclerosis, tissue fibrosis, and cancer. (ahajournals.org)
  • We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6- tetrahydropyridine (MPTP). (dissertations.se)
  • Human hepatic stem cells (hHpSCs), which are pluripotent precursors of hepatoblasts and thence of hepatocytic and biliary epithelia, are located in ductal plates in fetal livers and in Canals of Hering in adult livers. (rupress.org)
  • We define a novel class of AFP-negative cells in fetal and adult human livers that are precursors to hepatoblasts and have properties consistent with hHpSCs. (rupress.org)
  • Hundreds of thousands of different proteins are needed to build and maintain the cells in the human body. (elifesciences.org)
  • examine how PABPC1 regulates protein production in mice and human cells. (elifesciences.org)
  • Human hair production by scalp samples grafted onto nude mice. (biomedsearch.com)
  • This study shows that the amino acid composition of hairs collected in situ from human scalp was similar to that of terminal hairs produced by the donors' scalp follicles grafted and maintained onto nude mice. (biomedsearch.com)
  • The present experimental evidence further supports conclusions gained from previous assays with normal and TTD variant scalp grafts, i.e. that the nude mouse bearing human scalp specimens may serve as a clinically relevant laboratory model for evaluating regulation of normal and abnormal gene expression in the hair follicle under well controlled experimental conditions. (biomedsearch.com)
  • Genes
  • Previous studies had shown that mutated genes underlying the disease produce toxic ribonucleic acids (RNAs) during transcription, and these RNAs cause the production of incorrect forms of proteins in muscle tissue by blocking the actions of a protein called MBNL1. (eurekalert.org)
  • The phenotype of DS is caused by triplication of chromosome 21 and transgenic mouse models have been developed, and are being created, that carry single genes and chromosomal segments to excess. (springer.com)
  • Segmental trisomic mouse models, which survive to adulthood and possess three copies of multiple genes responsible for the DS phenotype, such as Ts1Cje and Ts65Dn, have been used to explore aspects of neurodevelopment and neurodegeneration. (springer.com)
  • PIR-A receptors are encoded by multiple Pira genes and associate non-covalently with an adaptor protein, the Fc receptor common γ chain, to form a cell activation complex. (uab.edu)
  • We report a novel approach to identify developmentally regulated tissue-restricted TF genes, as applied in the mouse gastrointestinal (GI) tract. (biologists.org)
  • Comparative genome-wide analyses of untreated diploid cells lacking Blm10 and growing at steady state at defined growth rates revealed downregulation of numerous genes required for accurate chromosome structure, assembly and repair, and upregulation of a specific subset of genes encoding protein-folding chaperones. (g3journal.org)
  • mucosal
  • Matrilysin, a matrix metalloproteinase, is expressed and secreted lumenally by intact mucosal and glandular epithelia throughout the body, suggesting that its regulation and function are shared among tissues. (rupress.org)
  • The data we present here, along with previous observations in injured and infected tissues, indicate that matrilysin, a matrix metalloproteinase (MMP), functions during both repair and mucosal defense. (rupress.org)
  • However, unlike other MMPs, which are expressed or released only in response to injury, disease, or inflammation, matrilysin is expressed by noninjured, noninflamed exocrine and mucosal epithelium in most, if not all, adult tissues. (rupress.org)
  • In addition, Dr. Kubagawa is studying a receptor for the Fc portion of IgA and IgM antibodies, called an Fcα/μR, with regard to the receptor's distribution in mucosal tissues, biochemical nature and function. (uab.edu)
  • kidney
  • CRBP 1 is synthesized by hepatic parenchymal cells where it becomes bound to its ligand retinol and is then released into the circulation, where it binds further to the protein transthyretin, to form a transporting complex, which is big enough not to be lost by filtration through the kidney glomeruli. (biotium.com)
  • Besides its occurrence in proximal tubules of adult kidney and in renal cell carcinoma derived from proximal tubules ARVCF is also detected in maturing nephrons in early mouse developmental stages such as, for example, 15 days of gestation (E15). (springer.com)
  • Barberini F, Famliari G, Vittoru I, Carpino F, Melis M (1984) Morphological and statistical investigation of the occurrence of "tubule-like cells" in the renal corpuscle of the mouse kidney induced by sex hormones. (springer.com)
  • Mouse kidney tissue lysate. (abcam.com)
  • Here, we demonstrate a detailed dissection procedure that enables the researcher to identify and surgically remove the adult zebrafish kidney, which can be used for applications such as cell isolation, transplantation, and expression studies of kidney and/or blood cell populations. (jove.com)
  • developmental
  • The TALE (three amino acid loop extension) class homeodomain transcription factor Pbx1 was initially described as a proto-oncogene ( PBX1 , pre-B cell leukemia transcription factor 1 5 , 6 ) and has subsequently been characterized as a global developmental regulator in mice, zebrafish, 7 , 8 Caenorhabditis elegans , and Drosophila melanogaster . (arvojournals.org)
  • We uncover a poly(A) tail-based regulatory mechanism that dynamically controls PABPC1 protein synthesis in cardiomyocytes and thereby titrates cellular translation in response to developmental and hypertrophic cues. (elifesciences.org)
  • gestation
  • METHODOLOGY/PRINCIPAL FINDINGS: Wild-type C57BL6/J or LDLr-/- dams were fed a low protein (LP) or a control (C) diet during gestation. (uclouvain.be)
  • neuronal
  • Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus. (embl-heidelberg.de)
  • Bambrick LL, Kruegar BK (2001) Neuronal apoptosis in mouse trisomy 16: mediation by caspases. (springer.com)
  • receptor
  • As extracellular ligands, they interact with specific members of the G-protein-coupled receptor family. (jneurosci.org)
  • We show in this paper that the lysophospholipid sphingosylphosphorylcholine is a high-affinity ligand for the orphan G-protein-coupled receptor GPR12. (jneurosci.org)
  • gastrointestinal
  • The position of FOXL1+ mesenchymal cells in such close proximity to the developing epithelium, as evidenced from In-Situ hybridization studies, suggested that FOXL1-expressing cells might be prime candidates to be key signal givers to the developing and adult gastrointestinal tract. (biologists.com)
  • Molecular
  • The molecular missteps that disrupt brain function in the most common form of adult-onset muscular dystrophy have been revealed in a new study published by Cell Press. (eurekalert.org)
  • However, until now, it was not clear whether molecular abnormalities similar to those in muscle tissue of individuals with mytonic dystrophy also occur in the brain, resulting in the cognitive neurological problems. (eurekalert.org)
  • Subsequently, the eyes of these mice were dissected and prepared for histologic or molecular analysis. (arvojournals.org)
  • mammals
  • Most neurons have been thought to be generated before birth in mammals and neurogenesis has only been described in a few regions in the adult brain. (dissertations.se)
  • Major fetal growth hormone in mammals. (uniprot.org)
  • Modifications in muscle fiber type distribution in both young and adult mammals have been reported as well as a decrease in the fiber density in the diaphragm of pups whose mothers had suffered nutritional deprivation. (scielo.br)
  • Proximal
  • Using antibodies against specific markers of nephron segments protein ARVCF is localized in proximal tubules according to double label immunofluorescence. (springer.com)
  • We now show that the hHpSCs are located in ductal plates in fetal and neonatal livers and in the proximal branches of the intrahepatic biliary tree, the Canals of Hering, in pediatric and adult livers of all donor ages, with the frequency of hHpSCs remaining relatively constant throughout life. (rupress.org)