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  • Dose
  • Subjects randomized to this arm will receive a single daily dose (3mg/kg) of a 15 mg/ml elemental iron preparation, NovaFerrum®, for 12 weeks. (clinicaltrials.gov)
  • Details regarding prior or current iron oral therapy (dose, preparation, timing, response) or recent blood transfusions. (clinicaltrials.gov)
  • sulfide
  • Though acidophiles have an important place in the iron and sulfur biogeochemical cycles, strongly acidic environments are overwhelmingly anthropogenic in cause, primarily created at the cessation of mining operations where sulfide minerals, such as pyrite (iron disulfide or FeS2), are present. (wikipedia.org)
  • Geologically classified as a "massive sulfide ore deposit", the site was mined for iron, silver, gold, copper, zinc and pyrite intermittently from the 1860s until 1963. (wikipedia.org)
  • ascorbate
  • Astrocytes are central to iron and ascorbate homoeostasis within the brain. (biochemj.org)
  • We demonstrate that iron accumulation by ascorbate-deficient astrocytes is insensitive to both membrane-impermeant Fe(II) chelators and to the addition of the ferroxidase caeruloplasmin. (biochemj.org)
  • However, when astrocytes are ascorbate-replete, as occurs in vivo , their rate of iron accumulation is doubled. (biochemj.org)
  • The acquisition of this additional iron depends on effluxed ascorbate and can be blocked by the DMT1 inhibitor ferristatin/NSC306711. (biochemj.org)
  • Our data suggest that an Fe(III)-uptake pathway predominates when astrocytes are ascorbate-deficient, but that in ascorbate-replete astrocytes, at least half of the accumulated iron is initially reduced by effluxed ascorbate and then imported by DMT1. (biochemj.org)
  • These results suggest that ascorbate is intimately involved in iron accumulation by astrocytes, and is thus an important contributor to iron homoeostasis in the mammalian brain. (biochemj.org)
  • encodes
  • Thirty-two independently isolated metronidazole-resistant mutants had a transposon insertion in BF638R_1421 that encodes the ferrous transport fusion protein (feoAB). (nih.gov)
  • anemia
  • Anemia is the commonest blood disorder that may occur in pregnancy and is usually due to low iron or folate reserves of the body and this is reflected as anemia. (medindia.net)
  • Ferrous carbonate has been used as an iron dietary supplement to treat anemia. (wikipedia.org)
  • strains
  • Transcription analysis of feoAB mRNA expression in BF638R parent and furA mutant strains grown in semi-defined medium under high-iron (+Fe) and iron-limiting (−Fe) conditions. (nih.gov)
  • zinc
  • Ferrous iron (Fe) and zinc (Zn) at high concentration in the soil cause heavy metal toxicity and greatly affect rice yield and quality. (biomedcentral.com)
  • Ferrous iron (Fe) and zinc (Zn) are essential trace elements for rice, as they are involved in numerous physiological and biochemical processes. (biomedcentral.com)
  • grown
  • The metronidazole MIC for the feoAB mutant was similar to that for the parent strain when grown on media supplemented with excess iron, suggesting that the increase seen in the MIC of metronidazole was due to reduced cellular iron transport in the feoAB mutant. (nih.gov)
  • belongs
  • Tet belongs to the iron and 2-oxoglutarate (2OG, alternatively known as α-ketoglutarate)-dependent dioxygenase family which utilizes labile Fe(II) as a cofactor and 2OG as a co-substrate. (elifesciences.org)
  • PHF8 belongs to the family of ferrous iron and 2-oxoglutarate (2OG)-dependent dioxygenase superfamily. (wikipedia.org)
  • molybdenum
  • The initial specific iron-oxidizing and molybdenum blue-oxidizing activities of this bacterium were 88.85 mMh-1mg-1 and 196.86 mMh-1mg-1, respectively, which were similar to the activities observed in the type strain At. (scientific.net)
  • present
  • The furA gene repressed feoAB transcription in an iron-dependent manner and disruption of furA resulted in constitutive transcription of feoAB, regardless of whether or not iron was present. (nih.gov)
  • Supplements
  • It says to be "careful if you have IBD" - anyone else had problems with iron supplements causing flares? (healingwell.com)
  • I also got B-12 shots, they are supposed to help you get your iron levels up, make the supplements work better or something. (healingwell.com)
  • cell
  • It has been proposed that cosubstrate and iron concentrations poise the HIF hydroxylases to respond to an appropriate "hypoxic window" for a particular cell type or tissue. (wikipedia.org)
  • vivo
  • However, disruption of feoAB also diminished the capacity of BF638R to grow in a mouse intraperitoneal abscess model, suggesting that inorganic ferrous iron assimilation is essential for B. fragilis survival in vivo. (nih.gov)
  • Although NTBI (non-transferrin-bound iron) may be a major form of iron imported by astrocytes in vivo , the mechanisms responsible remain unclear. (biochemj.org)
  • higher
  • S. metallicus up-regulates genes that help it grow in environments with higher sulfur and iron concentrations. (wikipedia.org)
  • Mercury's core has a higher iron content than that of any other major planet in the Solar System, and several theories have been proposed to explain this. (wikipedia.org)
  • energy
  • For some substrates, such as ferrous iron, the cells must cull through large amounts of inorganic substrate to secure just a small amount of energy. (wikipedia.org)
  • cause
  • While mutations in feoAB are probably not a direct cause of clinical resistance, this study provides a key insight into intracellular metronidazole activity and the link with intracellular iron homeostasis. (nih.gov)
  • Accidental overdose of products containing iron is a leading cause of fatal poisoning in children under the age of 6. (empowher.com)