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  • decreases iron
  • In chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, resulting in hypoferremia and iron restricted erythropoiesis, in despite of normal iron stores, and finally anemia of chronic disease (ACD), which can further evolve to ACD plus true ID (ACD + ID). (scielo.br)
  • inhibition
  • We found that the Y64N and C326Y mutants of FPN are completely resistant to hepcidin inhibition and that N144D and N144H are partially resistant. (ox.ac.uk)
  • novel
  • The two streams will coalesce during the final round of development to produce a series of novel cyclic hepcidin drug leads. (edu.au)
  • A novel hepcidin-like in turbot (Scophthalmus maximus L.) highly expressed after pathogen challenge but not after iron overload. (nih.gov)
  • molecular
  • This connection between hepcidin and inflammatory pathways has provided a molecular explanation for the pathophysiology of the anemia of chronic disease, a common and heretofore poorly understood consequence of many common medical conditions, including cancer. (aacrjournals.org)
  • importantly
  • More importantly, the investigators showed that a greater magnitude of ferroportin reduction was observed in more aggressive breast cancer subtypes, and that low ferroportin levels were significantly correlated with other well-established prognostic markers for poor breast cancer outcome, such as absence of estrogen receptors, high histological grade, and spread of disease to the lymph nodes. (biomedcentral.com)