• Iron-deficiency anemia is caused by blood loss, insufficient dietary intake, or poor absorption of iron from food. (wikipedia.org)
  • Poor absorption of iron from food may occur as a result of an intestinal disorder such as inflammatory bowel disease or celiac disease, or surgery such as a gastric bypass. (wikipedia.org)
  • Human body regulates iron metabolism and justed with iron absorption in the small intestine and iron release from macrophages. (baskent.edu.tr)
  • The cells have a reduced capacity to incorporate 55Fe-transferrin, while they have an increased capacity to accumulate non- Hereditary hemochromatosis (HHC) is a common autoso- mal recessive disorder characterized by an upregulated iron absorption [1]. (healthdrugpdf.com)
  • Soluble transferrin receptor-1 (sTfR1) concentrations are increased in the plasma under two conditions that are associated with increased iron absorption, i.e. iron deficiency and increased erythropoiesis. (karger.com)
  • To determine the possible role of sTfR1 as a signaling mechanism for iron absorption, a hydrodynamic gene transfer technique was established to express transfected plasmid constructs of human sTfR1 (hsTfR1) and murine sTfR1 (msTfR1) from the livers of C57BL/6 mice. (karger.com)
  • Iron absorption, serum iron levels and hepcidin expression were then measured. (karger.com)
  • Although expression of high levels of sTfR1 significantly increased serum iron levels, repeated experiments showed that neither hsTfR1 nor msTfR1 had any effect on iron absorption or hepcidin mRNA expression levels. (karger.com)
  • Thus, despite its attractiveness as a potential modifier of iron absorption, sTfR1 levels do not exert a regulatory effect on iron absorption. (karger.com)
  • Because mammals lack mechanisms to excrete excess iron, intestinal iron absorption is regulated by a feedback mechanism [ 5 ]. (biomedcentral.com)
  • Hepcidin is a 25-amino acid peptide hormone produced mainly in the liver that regulates intestinal iron absorption by causing degradation of the enterocyte iron transporter ferroportin, iron recycling by macrophages, and iron release from hepatic stores [ 4 , 6 ]. (biomedcentral.com)
  • Lönnerdal B, Georgieff MK, Hernell O. Developmental Physiology of Iron Absorption, Homeostasis, and Metabolism in the Healthy Term Infant. (ucdavis.edu)
  • The main mechanisms by which sport leads to iron deficiency are an increased iron demand, an elevated iron loss and a blockage of iron absorption due to hepcidin bursts. (sems-journal.ch)
  • Hypoxia downregulates the expression of hepcidin, which leads to both increased intestinal iron absorption and increased release of recycled iron from the reticuloendothelial system [ 21 , 22 ]. (hindawi.com)
  • ProGo™ is characterised by instant absorption due to the unique degree of hydrolysis (50% of peptides have a molar mass of less than 1000 Da and the weight of 99% of peptides does not exceed 3000 Da). (mrsupps.com)
  • Third, H. pylori -related corporal gastritis may decrease acid secretion due to gland atrophy and results in the reduction of iron absorption from diet [ 25 ]. (biomedcentral.com)
  • We measured the serum concentrations of hepcidin, interleukin- 6 (IL-6) and selenium, red blood cell count, hemoglobin concentration, hematocrit, erythrocyte indices and biochemical markers of iron metabolism (serum iron, total iron-binding capacity, transferrin saturation and serum ferritin). (umbalk.org)
  • Most patients are asymptomatic and are diagnosed when elevated serum iron levels are noted on a routine chemistry screening panel or when screening is performed because a relative is diagnosed with hemochromatosis. (medscape.com)
  • Hemoglobin (Hb), serum iron (Fe 2+ ), serum ferritin (SF), soluble transferrin receptor (sTfR), hepcidin and the dosage of recombinant human erythropoietin (rhEPO) before and after intervention in patients were analyzed. (biomedcentral.com)
  • LC-06-JCK-bearing mice showed lower values of MCV, mean corpuscular hemoglobin (MCH), and serum iron as compared to NTB mice. (biomedcentral.com)
  • Our data show that FGF23 is induced as early as pro-inflammatory cytokines in response to LPS, followed by upregulation of hepcidin and downregulation of erythropoietin (Epo) expression in addition to decreased serum iron and transferrin saturation. (phoenixpeptide.com)
  • Accordingly, iron sequestration in liver and spleen caused by TLR4 activation was completely abrogated by FGF23 signaling inhibition, resulting in alleviation of serum iron and transferrin saturation deficit. (phoenixpeptide.com)
  • Chromium regulates carbohydrate and lipid metabolism. (redefinegrp.com)
  • Pemafibrate, a novel selective peroxisome proliferator-activated receptor modulator, has beneficial effects on lipid metabolism. (bvsalud.org)
  • Lipid droplets serve as storage depots for lipids and play crucial roles in energy metabolism, lipid homeostasis, and cellular signaling. (com.ng)
  • Centrilobular localization of steatosis results from decreased energy stores caused by relative hypoxia and a shift in lipid metabolism, along with a shift in the redox reaction as a result of preferential oxidation of alcohol in the central zone. (medscape.com)
  • Recently, the sterol regulatory element binding protein SrbA was found to be essential for adaptation to iron starvation, thereby linking regulation of iron metabolism, ergosterol biosynthesis, azole drug resistance, and hypoxia adaptation. (frontiersin.org)
  • IRP1 is an iron-sulfur protein that functions as an aconitase in iron-replete cells. (nih.gov)
  • In V3^4-fold increase in transferrin receptor, and a V2-fold transfected cells an association between HFE and TfR occurs increase in iron regulatory protein activity. (healthdrugpdf.com)
  • These indices of in the endoplasmic reticulum/cis-Golgi compartment soon cellular iron deficiency were reversed by iron supplementation after synthesis, it stabilizes HFE protein from degradation complexes. (healthdrugpdf.com)
  • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O: A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. (karger.com)
  • protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
  • These include 37 proteases and antiproteases, which are likely to play a role in the formation of the yolk (vitellogenesis), as regulators of protein metabolism. (biomedcentral.com)
  • Als Basisblutentnahme sollen Hämoglobin, Hämatokrit, MCV (mittleres zelluläres Volumen), MCH (mittleres zelluläres Hämoglobin), C-reaktives Protein und Ferritin bestimmt werden. (sems-journal.ch)
  • Iron deficiency stimulates transcription of the osteocyte-secreted protein FGF23. (phoenixpeptide.com)
  • Our data suggest the existence of a relay system that transfers heme from one protein to the next across the cell envelope, explaining the requirement for multiple heme receptors for efficient heme-iron utilization. (prelekara.sk)
  • Iron plays a fundamental role in many biological processes such as cell growth, cell differentiation, protein expression, etc. (springeropen.com)
  • Iron plays a crucial role in many biological functions of the body, such as cell growth and differentiation, protein expression, cyclin accumulation, and the production of reactive oxygen species [ 1 ]. (springeropen.com)
  • HSC express the iron-uptake protein TfR1, and the iron-export protein ferroportin. (westminster.ac.uk)
  • Second, CagA protein of H. pylori has been shown to participate in iron acquisition from interstitial holotransferrin [ 23 ]. (biomedcentral.com)
  • ayda kontrol değerlere ulaşmaktadır Hepcidin is an antimicrobial peptide playing a key role in the regulation of iron metabolism and distribution of iron in the body. (baskent.edu.tr)
  • [ 69 ] The type of mutations for hereditary hemochromatosis, ferritin level, or the presence of cirrhosis were not predictive for diabetes mellitus development. (medscape.com)
  • CT scanning is neither sensitive nor specific for the detection of mild hepatic iron overload. (medscape.com)
  • Hepatic iron quantification with MRI might be helpful. (medscape.com)
  • Advances in the understanding of the pathogenesis of alcoholic steatosis have provided some useful insights, including the role of peroxisome proliferator-activated receptor alpha, which is crucial for the regulation of hepatic fatty acid metabolism. (medscape.com)
  • The studies show different results about the relationship between complete blood count, plasma iron parameters and liver iron concentration with hepcidin in liver diseases. (baskent.edu.tr)
  • Orthotopic liver transplantation is the only therapeutic option when end-stage liver disease progresses despite iron-reduction therapy. (medscape.com)
  • Despite a significant burden of iron, no features of chronic liver disease were found in affected members of the family, including individuals aged up to 80 years. (intrinsiclifesciences.com)
  • Impaired iron export from macro-phages in patients with mutations in the FPN1 gene has been proposed as the explanation for the accumulation of iron that occurs in organs containing abundant macro-phages such as the liver, spleen, and bone marrow. (intrinsiclifesciences.com)
  • Cirrhosis is due to progressive iron deposition in the liver parenchyma, and it is one of the most common disease manifestations of the tissue damage caused by hemochromatosis. (medscape.com)
  • Cirrhosis reversibility after iron removal has been reported, usually early in the course of liver disease, although reversal of advanced liver disease with varices has also been reported. (medscape.com)
  • The master regulator of iron balance in humans is hepcidin, a peptide produced by the liver [ 20 ]. (hindawi.com)
  • This may be related to mitochondrial proteins that regulate apoptosis and necrosis and that are shown to be induced in mouse fatty liver models. (medscape.com)
  • The peptide hepcidin is a hormone playing a key role in the regulation of iron metabolism, which is also closely connected with the homeostasis of other trace elements. (umbalk.org)
  • The identification and functional characterization of 24 genes that are involved in iron homeostasis in A. fumigatus and/or Aspergillus nidulans , respectively, revealed significant insights into iron metabolism and its regulation (Table 1 ). (frontiersin.org)
  • Discovery of iron-sulfur cofactors will lead to breakthroughs in several research areas involving DNA repair, ribosomal biogenesis, mRNA translation, intermediary metabolism, and regulation of the growth and energy-sensing pathways that are critical for determining the fates of many cell types. (nih.gov)
  • The findings indicate that but its physiological role in the regulation of body iron ab- HFE binding to transferrin receptor reduces cellular iron sorption and tissue distribution is unclear. (healthdrugpdf.com)
  • T3 is the active form of thyroid hormone in that it influences many body processes, in particular the regulation of metabolism. (imedical.com.au)
  • Our goal is to understand how mammals regulate intracellular and systemic iron metabolism to support processes that require iron and iron-sulfur clusters. (nih.gov)
  • The study demonstrated statistically significant differences in the serum concentrations of hepcidin, IL-6 and selenium between IDA children and healthy controls, a statistically significant higher proportion of children having below-threshold serum selenium concentrations in the study group compared to controls, statistically significant correlations between hepcidin and selenium serum concentrations, hematological indicators and biochemical markers of iron metabolism in the IDA children. (umbalk.org)
  • Serum hepcidin and ferritin levels were statistically elevated in mice bearing LC-06-JCK. (biomedcentral.com)
  • Despite its high abundance in the Earth's crust, the bioavailability of iron is low owing to its oxidation into sparingly soluble ferric (Fe 3+ ) hydroxides by atmospheric oxygen. (frontiersin.org)
  • Iron-deficiency anemia is anemia caused by a lack of iron. (wikipedia.org)
  • Children with iron deficiency anemia may have problems with growth and development. (wikipedia.org)
  • In the developing world, parasitic worms, malaria, and HIV/AIDS increase the risk of iron deficiency anemia. (wikipedia.org)
  • Iron deficiency anemia can be prevented by eating a diet containing sufficient amounts of iron or by iron supplementation. (wikipedia.org)
  • Iron-deficiency anemia affected about 1.48 billion people in 2015. (wikipedia.org)
  • of which consumption of ice, known as pagophagia, has been suggested to be the most specific for iron deficiency anemia. (wikipedia.org)
  • A diagnosis of iron-deficiency anemia requires further investigation into its cause. (wikipedia.org)
  • In women of childbearing age, heavy menstrual periods can be a source of blood loss causing iron-deficiency anemia. (wikipedia.org)
  • People who do not consume much iron in their diet, such as vegans or vegetarians, are also at increased risk of developing iron deficiency anemia. (wikipedia.org)
  • In the excess of hepcidin, iron deficiency anemia occurs. (baskent.edu.tr)
  • A total of 23 adolescents with iron deficiency anemia (IDA, n=12) and healthy controls (n=11) were included in the study. (umbalk.org)
  • We demonstrated that inhibition of the IL-6 signaling pathway by MR16-1 treatment resulted in significant recovery of iron-deficiency anemia and alleviation of cancer-related symptoms. (biomedcentral.com)
  • Patients suffering from iron deficiency anemia receive oral iron supplements as a treatment. (redefinegrp.com)
  • Currently, the role of H. pylori in idiopathic thrombocytopenic purpura and iron deficiency anemia is well documented. (biomedcentral.com)
  • The link between Iron deficiency anemia (IDA) and H. pylori infection was reported firstly in 1991 by Blecker et al. (biomedcentral.com)
  • We also found that RNAi-mediated knockdown of the key Fe modulator hepcidin increased intracellular ferritin and inhibited HCV replication. (microbiologyresearch.org)
  • In the last decades there is increased interest in the new factors' participation to maintain iron homeostasis. (umbalk.org)
  • The objective of the study was to evaluate hepcidin and selenium participation in the maintenance of iron homeostasis in adolescents. (umbalk.org)
  • The clinical studies investigating hepcidin and selenium participation in the iron homeostasis maintenance should be extended. (umbalk.org)
  • This review summarizes the current knowledge on iron homeostasis and its role in virulence in Aspergillus spp. (frontiersin.org)
  • The regulated release of these bioactive molecules from secretory granules is critical for maintaining homeostasis and coordinating physiological responses. (com.ng)
  • Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) regulate the expression of numerous proteins of iron metabolism. (nih.gov)
  • In iron-depleted cells, the proteins bind to RNA stem-loops in transcripts known as iron-responsive elements (IRE). (nih.gov)
  • Our ongoing work on iron-sulfur cluster biogenesis has led to new insights into how mammalian iron-sulfur clusters are synthesized and transferred to appropriate recipient proteins. (nih.gov)
  • By identifying a tri-peptide motif common to many iron-sulfur recipient proteins, we developed an algorithm that facilitates discovery of previously unrecognized mammalian iron-sulfur proteins. (nih.gov)
  • Our work suggests that there are hundreds of previously unrecognized mammalian iron-sulfur proteins. (nih.gov)
  • Transferrin receptor tein and by a strong activation of iron responsive element (IRE) binding activity of the iron regulatory proteins (IRPs) which are the typical indices of cellular iron de¢ciency. (healthdrugpdf.com)
  • Significant changes in gene expression of proteins that mediate oxidative metabolism, such as cytochrome d ubiquinol oxidase-encoding genes, cydA and cydB , were detected. (microbiologyresearch.org)
  • Iron is an essential element for mammals as it is a component of many key redox enzymes and oxygen storage and transporting proteins such as Hb and myoglobin [ 4 ]. (biomedcentral.com)
  • On a molecular level, lead can alter or interfere with the activity of proteins and nucleic acids, ultimately resulting in changes in cell metabolism and physiology leading to pathologic states. (edu.pl)
  • We propose that these particles likely had a crucial role in the preservation of the proteins, and may be remnants partially contributed from haemoglobin and other iron-rich proteins from the original blood. (nature.com)
  • A Relay Network of Extracellular Heme-Binding Proteins Drives Iron Acquisition from Hemoglobin. (prelekara.sk)
  • 14. WeissmanZ, KornitzerD (2004) A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization. (prelekara.sk)
  • HSC express iron transport proteins. (westminster.ac.uk)
  • As mono or diiron center as well as incorporated into heme or iron-sulfur clusters, this metal is an indispensable cofactor for a variety of cellular processes including electron transport, amino acid metabolism, and biosynthesis of DNA and sterols. (frontiersin.org)
  • Hepcidin increases in response to increase in plasma iron, ferritin and in response to inflammation, whereas decreases in hypoxia and increased erythropoesis in healthy people. (baskent.edu.tr)
  • Secretory granules are essential for the storage and regulated release of bioactive molecules within cells. (com.ng)
  • Wada Y, Lönnerdal B. Bioactive peptides released by in vitro digestion of standard and hydrolyzed infant formulas. (ucdavis.edu)
  • Wada Y, Lonnerdal B. Bioactive peptides released from in vitro digestion of human milk with or without pasteurization. (ucdavis.edu)
  • Serum leptin, a cytokine-type peptide hormone mainly produced by adipocytes, may play an important role in the pathogenesis of steatosis. (medscape.com)
  • Activation of toll-like receptors (TLRs), the key sensors of the innate immune system, induces hypoferremia mainly through the rise of the iron hormone hepcidin. (phoenixpeptide.com)
  • Thyroid hormone (TH) signaling is a relevant component of the adaptive response of the myocardium to stress, and plays a critical role in regulating both heart rate and contractility of myocytes: hyperthyroidism is correlated with atrial arrhythmias, hypertension, and heart failure, and increases the risk of heart failure and mortality in cardiopathic patients [ 1 ] . (encyclopedia.pub)
  • Nakil öncesi düşük olan serum prohepsidin düzeyinin, hemoglobin, hematokrit ve eritrosit sayıları ile birlikte nakil sonrası anlamlı şekilde yükseldiği, nakil öncesi normalin üst sınırında olan serum demiri ve normalden yüksek olan retikülosit, ferritin ve eritropoetin düzeylerinin, nakil sonrası izlemde anlamlı şekilde düştüğü gözlendi. (baskent.edu.tr)
  • To overcome this iron limitation, C. albicans is able to extract iron from heme and hemoglobin, the largest iron pools in the human body, via a pathway that involves endocytosis into the cell. (prelekara.sk)
  • During iron starvation, HapX represses iron-consuming pathways, including heme biosynthesis and respiration, to spare iron and activates synthesis of ribotoxin AspF1 and siderophores, the latter partly by ensuring supply of the precursor, ornithine. (frontiersin.org)
  • As in the majority of hormones, TH is regulated by a number of pathways, and its production and endocrine release is impaired by the continuous flow determined by VADs. (encyclopedia.pub)
  • 8. WeissmanZ, ShemerR, KornitzerD (2002) Deletion of the copper transporter CaCCC2 reveals two distinct pathways for iron acquisition in Candida albicans. (prelekara.sk)
  • For example, in endocrine cells, secretory granules store and release peptide hormones such as insulin or glucagon. (com.ng)
  • Progesterone is one of the hormones in our bodies that stimulates and regulates various functions. (imedical.com.au)
  • A lack of dietary iron is estimated to cause approximately half of all anemia cases globally. (wikipedia.org)
  • In 2015, anemia due to iron deficiency resulted in about 54,000 deaths - down from 213,000 deaths in 1990. (wikipedia.org)
  • In mouse models, loss of IRP2 results in mild anemia, erythropoietic protoporphyria, and adult-onset neurodegeneration-all likely the result of functional iron deficiency. (nih.gov)
  • The application of dietary fiber (DF) to regulate the gut microbiota has shown effective therapeutic effects in some diseases, but its role in renal anemia is not clear. (biomedcentral.com)
  • The aim of this study was to explore the effect of DF on renal anemia by regulating the gut microbiota and its metabolite, short-chain fatty acids (SCFAs). (biomedcentral.com)
  • DF may improve renal anemia in ESRD patients by regulating the gut microbiota and SCFAs. (biomedcentral.com)
  • showed that although there is heterogeneity in the conclusions of numerous current basic and clinical studies on DF for the improvement of anemia associated with iron metabolism, its potential role in the improvement of anemia and intestinal biomarkers should be emphasized [ 5 ]. (biomedcentral.com)
  • Our results suggest that overproduction of hepcidin by IL-6 signaling might be a major factor that leads to functionally iron-deficient cancer-related anemia in the LC-06-JCK model. (biomedcentral.com)
  • If left untreated, three main factors are responsible for the clinical sequelae of NTDT: ineffective erythropoiesis, chronic hemolytic anemia, and iron overload. (hindawi.com)
  • who cured IDA of a 15 year-old female presenting with anemia-related syncope and H. pylori -induced chronic active hemorrhagic gastritis by eradication therapy without iron supplements [ 14 ]. (biomedcentral.com)
  • IRP binding stabilizes the mRNA that encodes the transferrin receptor and represses the translation of transcripts that contain IREs near the 5′ end of the ferritin H and L chains. (nih.gov)
  • IREs are RNA stem-loops found in the 5′ end of ferritin mRNA and the 3′ end of transferrin receptor mRNA. (nih.gov)
  • IRPs bind to IREs when iron levels are depleted, resulting in either inhibition of translation of ferritin mRNA and of other transcripts that contain an IRE in the 5′-untranslated regions (UTR) or stabilization of the transferrin receptor mRNA and possibly other transcripts that contain IREs in the 3′ UTR. (nih.gov)
  • The overexpressed HFE immunoprecipitated to- [16], and reduces cellular iron uptake [17,18]. (healthdrugpdf.com)
  • The pH-dependent association with TfR appears a major in non-transferrin iron incorporation from 55Fe-NTA, evident and important linkage of HFE with cellular iron metabolism, after prolonged, 18 h, incubations. (healthdrugpdf.com)
  • availability and regulates the balance between transferrin- We describe the production of a HeLa cell clone expressing mediated and non-transferrin-mediated cellular iron incorpora- HFE under the control of a tetracycline-inducible promoter. (healthdrugpdf.com)
  • These inclusions can serve various functions, including storage of nutrients, waste products, or pigments, as well as participating in cellular metabolism and signaling. (com.ng)
  • As a baseline set of blood tests, haemoglobin, haematocrit, mean cellular volume (MCV), mean cellular haemoglobin (MCH) and serum ferritin levels are the important parameters to monitor iron deficiency. (sems-journal.ch)
  • FGF23 interacts with a FGFR/KL-receptor complex to propagate cellular signaling, where its C-terminal C26 peptide is critical for engaging the co-receptor KL. (phoenixpeptide.com)
  • However, its effects on glucose metabolism in individuals with type 2 diabetes (T2DM) remain to be fully clarified. (bvsalud.org)
  • Changes in glucose metabolism markers, including homeostatic model assessment (HOMA2) scores and disposition index, were assessed. (bvsalud.org)
  • In the majority patients, the insulin requirements or glucose level was not influenced by iron depletion. (medscape.com)
  • We conducted a secondary analysis of 27 plasma biomarkers representing glucose metabolism, inflammation, adipokines, endothelial dysfunction, IGF axis, and iron store plus age and BMI at blood collection from an existing case-control study nested in the Nurses' Health Study (NHS), including 1,303 incident diabetes case subjects and 1,627 healthy women. (diabetesjournals.org)
  • In the absence of hepcidin, plasma iron and ferritin levels increase resulting in iron accumulation in the organs. (baskent.edu.tr)
  • HFE accumulation was accompanied by tightly at neutral (pH 7.5) than at acidic pH (pH 6) and the a large (V10-fold) decrease in H- and L-ferritin levels, by a binding reduces TfR a¤nity for Fe-transferrin [14,15]. (healthdrugpdf.com)
  • HeLa cell clones gether with transferrin receptor, indicating a physical association which is the likely cause for the observed V30% decrease in overexpressing HFE showed low levels of endogenous ferritins 55Fe-transferrin incorporation after 18 h incubation. (healthdrugpdf.com)
  • Administration of MR16-1 to mice bearing LC-06-JCK significantly suppressed levels of both serum hepcidin and ferritin, with increased values of MCV and MCH. (biomedcentral.com)
  • By deacetylating and activating antioxidants, SIRT3 helps regulate ROS levels. (mdpi.com)
  • This in turn causes depletion of macrophage iron, relatively low levels of serum ferritin, and preferential portal and hepatocyte iron loading [ 13 , 23 ]. (hindawi.com)
  • Therefore, fungi evolved fine-tuned mechanisms for uptake and storage of iron, such as the production of siderophores (low-molecular mass iron-specific chelators). (frontiersin.org)
  • During iron sufficiency, SreA represses iron uptake, including reductive iron assimilation and siderophore-mediated iron uptake, to avoid toxic effects. (frontiersin.org)
  • The expression of genes encoding formate uptake transporter (PG0209) and formate tetrahydrofolate ligase ( fhs ) was drastically elevated, which indicates that formate metabolism plays a major role under aerobic conditions. (microbiologyresearch.org)
  • In addition, metal transport was affected, and while iron-uptake genes such as the genes encoding the haemin uptake locus ( hmu ) were downregulated, expression of manganese transporter genes, such as feoB2 , was elevated in the presence of oxygen. (microbiologyresearch.org)
  • 1995) The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. (prelekara.sk)
  • 2002) The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion. (prelekara.sk)
  • Iron uptake by H. pylori is enhanced during the growth of the bacteria [ 24 ]. (biomedcentral.com)
  • Hepcidin secretion is regulated by iron stores, oxygenation, and inflammatory signals. (biomedcentral.com)
  • Several clinical observations point to an intricate crosstalk between iron (Fe) metabolism and chronic hepatitis C virus (HCV) infection. (microbiologyresearch.org)
  • This Narrative Review article aims to evaluate the performance of QSM compared to other methods of assessing iron deposition in the clinical field. (springeropen.com)
  • IRP2 is homologous to IRP1 but undergoes iron-dependent degradation in iron-replete cells. (nih.gov)
  • Holotransferrin (iron) activates HSC fibrogenesis and the TGF-β pathway, while iron depletion by chelation reverses this, suggesting that this could be a useful adjunct therapy for patients with fibrosis. (westminster.ac.uk)
  • Mice deleted for the HFE or the subcloned into vector pET12b for expression in Escherichia coli, fused L2m gene show a fast accumulation of iron in the parenchyma to a polyhistidine tag. (healthdrugpdf.com)
  • 3,8,10,11 Deletion of this amino acid causes loss of function and when studied in vitro causes accumulation of iron in cultured cells. (intrinsiclifesciences.com)
  • AIMS/INTRODUCTION: Few studies have investigated the renoprotective effect of glucagon-like peptide-1 (GLP-1) receptor in patients with chronic kidney disease (CKD). (bvsalud.org)
  • The pattern of iron accumulation and the predilection of iron to target organs in NTDT is markedly different from transfusion-dependent thalassemia (TDT). (hindawi.com)
  • In previous years, our laboratory identified and characterized the cis and trans elements mediating iron-dependent alterations in the abundance of ferritin and the transferrin receptor. (nih.gov)
  • To ensure iron supply but to avoid iron toxicity, all organisms evolved sophisticated mechanisms to balance acquisition, storage, and consumption of iron. (frontiersin.org)
  • 4. AlmeidaRS, WilsonD, HubeB (2009) Candida albicans iron acquisition within the host. (prelekara.sk)
  • 5. KornitzerD (2009) Fungal mechanisms for host iron acquisition. (prelekara.sk)
  • 2008) the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. (prelekara.sk)
  • Diabetes, often requiring insulin therapy, occurs due to progressive iron accumulation in the pancreas. (medscape.com)
  • We show that in vivo inhibition of FGF23 signaling by carboxyl-terminal FGF23 peptide is a safe and efficacious therapeutic strategy to rescue bone mineralization and deposition in mice with β-thalassemia, normalizing the expression of niche factors and restoring hematopoietic stem cell (HSC) function. (phoenixpeptide.com)
  • The relatively narrow intercellular space of the primordial follicle allows ferritin and possibly other molecules of similar size to cross, whereas in the late stages of rapid follicular growth, the shape of granulosa cells must accommodate the increasing flow of egg yolk precursors that accumulate at the surface of the plasma membrane of the follicle [ 7 ]. (biomedcentral.com)
  • Given that mitochondrial energy production is required to maintain axonal integrity and that motor neurons have the longest and most vulnerable axons, we hypothesize that mitochondrial dysfunction resulting from iron deficiency causes axonal degeneration. (nih.gov)
  • We identify a distinct peptide sequence C28 residing in the FGF23 C terminus that regulates its interaction with KL. (phoenixpeptide.com)
  • The rate of iron loading is significantly different in thalassemia major ranging between 0.30 and 0.60 mg/kg/day versus 0.01 mg/kg/day in NTDT [ 14 ]. (hindawi.com)
  • Treatment of iron deficiency consists of nutritional counselling and oral iron supplementation or, in specific cases, by intravenous injection. (sems-journal.ch)
  • A combination of iron deposition and melanin causes the skin bronzing or hyperpigmentation that is typical of the disease. (medscape.com)
  • But sometimes, for various reasons, the amount of iron deposition in different areas of the brain increases, which leads to problems related to the nervous system. (springeropen.com)
  • Based on the results, we introduced related basic definitions, some neurodegenerative diseases, methods of examining iron deposition in these diseases, and their advantages and disadvantages. (springeropen.com)
  • Iron deposition happens in various brain areas in some diseases of the nervous system and the aging process. (springeropen.com)
  • There are different imaging methods based on MRI for examining and measuring iron deposition in the brain, like T2*-weighted imaging (T2*WI), T2-weighted imaging(T2WI), relaxation rate (R2*), field-dependent relaxation rate increase (FDRI), and susceptibility-weighted imaging (SWI) [ 2 ]. (springeropen.com)
  • A long-term daily oral iron intake or iv-supplementation in the presence of normal or even high ferritin values does not make sense and may be harmful. (sems-journal.ch)