- DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin) is a synthetic opioid peptide with high μ-opioid receptor specificity. (wikipedia.org)
- Intrathecal (i.t.) administration of peptidic MOR agonist [D-Ala 2 , N-Me-Phe 4 ,Gly 5 -ol]-enkephalin (DAMGO, 0.00032-0.01 mg) evoked scratching, but i.v, DAMGO (0.01-1 mg/kg) did not increase scratching. (ewha.ac.kr)
- It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin. (wikipedia.org)
- Intravenous (i.v.) administration of μ opioid receptor (MOR) agonists (fentanyl, alfentanil, remifentanil, and morphine) evoked scratching in a dose- and time-dependent manner. (ewha.ac.kr)
- Antagonist studies revealed that i.v. administration of an opioid receptor antagonist (naltrexone, 0.0032-0.1 mg/kg) dose dependently attenuated scratching induced by i.v. fentanyl (0.018 mg/kg) or morphine (1 mg/kg). (ewha.ac.kr)
- It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin. (wikipedia.org)
- Studies in an exon 11 knockout mouse suggest the functional importance of these exon 11-associated variants in mediating the analgesic actions of a subset of mu opioids, including morphine-6β-glucuronide (M6G) and heroin, but not others such as morphine and methadone. (biomedcentral.com)
- [ 5 , 6 ] These guidelines recommend against using opioid analgesics for CNCP as a first-line medication because the harms frequently outweigh the benefits. (medscape.com)