• Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. (ebi.ac.uk)
  • Pondimin (fenfluramine - removed from us market) ( fenfluramine hydrochloride) is an anorectic drug for oral administration. (rxlist.com)
  • Immediate release tablets containing 20 mg fenfluramine hydrochloride are orange, scored, compressed tablets engraved AHR and 6447. (rxlist.com)
  • Fenfluramine HCl has the following chemical name: N-ethyl-alpha-methyl-3-(trifluoromethyl) benzeneethanamine hydrochloride. (rxlist.com)
  • Pondimin (fenfluramine hydrochloride) is a controlled substance in Schedule IV. (rxlist.com)
  • Each subject received 0.55 to 0.65 mg/kg d,l -fenfluramine hydrochloride, and the plasma prolactin concentration was measured over 3.5 hours. (ahajournals.org)
  • In the present study, central serotonergic activity was assessed with a neuroendocrine challenge with d,l -fenfluramine hydrochloride. (ahajournals.org)
  • fenfluramine hydrochloride manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
  • Furthermore, fenfluramine hydrochloride prices in regional markets can be found in the report with regards to countries and companies. (marketpublishers.com)
  • The report also focuses on fenfluramine hydrochloride consumers by providing data on companies that use it. (marketpublishers.com)
  • FENFLURAMINE HYDROCHLORIDE (CAS 404-82-0) Market Research Report 2018 contents were worked out and placed on the website in March, 2018. (marketpublishers.com)
  • Please note that FENFLURAMINE HYDROCHLORIDE (CAS 404-82-0) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • ZX008 drug product is an oral aqueous solution of fenfluramine hydrochloride buffered to pH 5 and provided in concentrations of 1.25 mg/mL, 2.5 mg/mL, and 5 mg/mL. (clinicaltrials.gov)
  • These studies examined the effect of fenfluramine on insulin action and insulin secretion in healthy subjects and patients with non-insulin-dependent diabetes mellitus (NIDDM). (diabetesjournals.org)
  • The effect of fenfluramine on hepatic drug metabolism was assessed by using the antipyrine test. (diabetesjournals.org)
  • Effect of fenfluramine on reinstatement of food seeking in female and male rats: implications for the predictive validity of the reinstatement model. (nih.gov)
  • We trained food-restricted female and male rats to lever-press for 45-mg food pellets (3-h sessions) and first assessed the effect of fenfluramine (0.75, 1.5, and 3.0 mg/kg, i.p.) on food-reinforced responding. (nih.gov)
  • Subsequently, we extinguished the food-reinforced responding and tested the effect of fenfluramine (1.5 and 3.0 mg/kg) on reinstatement of food seeking induced by yohimbine injections (2 mg/kg, i.p.) or pellet priming (four non-contingent pellets). (nih.gov)
  • The results support the contention that the effect of fenfluramine on human dietary intake may be mediated by alterations in serotonergic rather than dopaminergic mechanisms. (drugawareness.org)
  • The acute 5-HT depleting effect of fenfluramine was markedly attenuated in these regions 2 weeks after the 4-day regimen of fenfluramine. (aspetjournals.org)
  • K , Bethea, C & Van De Kar, LD 1984, ' Serotonin mediated effect of fenfluramine on prolactin but not corticosterone secretion ', Federation Proceedings , vol. 43, no. 3. (elsevier.com)
  • Van De Kar, L. D. / Serotonin mediated effect of fenfluramine on prolactin but not corticosterone secretion . (elsevier.com)
  • Between 1994 and 1997, American Home Products Corporation, now Wyeth, marketed and sold fenfluramine and dexfenfluramine, prescription weight loss drugs. (findlaw.com)
  • Fenfluramine and dexfenfluramine are appetite suppressants that were in widespread use in the United States. (cdc.gov)
  • Subsequently, reports of fenfluramine- or dexfenfluramine-associated valvulopathy increased. (cdc.gov)
  • Therefore, in this analysis, a case of fenfluramine- or dexfenfluramine-associated cardiac valvulopathy was defined as documented AR of mild or greater severity and/or MR of moderate or greater severity after exposure to these drugs. (cdc.gov)
  • In early September, FDA received echocardiographic reports from five independent, unpublished echocardiographic prevalence surveys of patients who had received dexfenfluramine or fenfluramine alone or in combination with phentermine ( Table_1 ). (cdc.gov)
  • More recently, pulmonary hypertension has been described in some patients taking other amphetamine-like, anorexic agents: fenfluramine and its d -isomer, dexfenfluramine. (ahajournals.org)
  • Methods and Results Using the whole-cell, patch-clamp technique, we found that aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in smooth muscle cells taken from the small resistance pulmonary arteries of the rat lung. (ahajournals.org)
  • In the isolated, perfused rat lung, aminorex, fenfluramine, and dexfenfluramine induce a dose-related increase in perfusion pressure. (ahajournals.org)
  • 1 2 Another appetite suppressant, fenfluramine, and its d -isomer, dexfenfluramine (a phenyl-ethylamine derivative), have also been linked in case reports to the development of pulmonary hypertension. (ahajournals.org)
  • Estimates of excess risk of valvular heart disease among prior users of fenfluramine and dexfenfluramine have varied widely. (biomedcentral.com)
  • We examined data from all available echocardiographic studies reporting the prevalence of aortic regurgitation (AR) and mitral regurgitation (MR) among persons exposed to fenfluramine or dexfenfluramine and a suitable control group. (biomedcentral.com)
  • These findings provide strong support for the view that fenfluramine and dexfenfluramine are potent causal factors in the development of both aortic and mitral valvular heart disease. (biomedcentral.com)
  • Fenfluramine (Pondimin®- AH Robins) and dexfenfluramine are anorexients that induce the release and inhibit the reuptake of serotonin ( 7 , 8 ). (ispub.com)
  • Dexfenfluramine, the biologically active dextro-rotatory stereoisomer of fenfluramine, has been available in Europe for many years and was recently approved by the FDA in the United States ( 9 ). (ispub.com)
  • Unlike fenfluramine however, dexfenfluramine is not contraindicated in patients undergoing anesthesia. (ispub.com)
  • Since the initial case report by Bennett and Eltringham however, there have been no further reports of adverse events related to a anesthetic interaction with either fenfluramine or dexfenfluramine and unfortunately no definitive drug interaction studies have been conducted. (ispub.com)
  • Fenfluramine contains dexfenfluramine. (mit.edu)
  • Pondimin (fenfluramine - removed from us market) is available in 20 mg orange, scored, compressed tablets monogrammed AHR and 6447, in bottles of 100 and 500. (rxlist.com)
  • Fenfluramine, sold under the brand name Fintepla, is a medication used for the treatment of seizures associated with Dravet syndrome in people age two and older. (wikipedia.org)
  • EMERYVILLE, Calif. , June 25, 2020 /PRNewswire/ -- Zogenix, Inc. (NASDAQ: ZGNX), a global pharmaceutical company developing rare disease therapies, today announced that the U.S. Food and Drug Administration (FDA) has approved FINTEPLA ® (fenfluramine) oral solution, CIV for the treatment of seizures associated with Dravet syndrome in patients 2 years of age and older. (yahoo.com)
  • There is an association between serotonergic drugs with 5-HT2B receptor agonist activity, including fenfluramine (the active ingredient in FINTEPLA), and valvular heart disease and pulmonary arterial hypertension. (finteplahcp.com)
  • FINTEPLA is contraindicated in patients with hypersensitivity to fenfluramine or any of the excipients in FINTEPLA and with concomitant use of, or within 14 days of, the administration of monoamine oxidase inhibitors because of an increased risk of serotonin syndrome. (finteplahcp.com)
  • Because of the association between serotonergic drugs with 5-HT2B receptor agonist activity, including fenfluramine (the active ingredient in FINTEPLA), and valvular heart disease and pulmonary arterial hypertension, cardiac monitoring via echocardiogram is required prior to starting treatment, during treatment, and after treatment with FINTEPLA concludes. (finteplahcp.com)
  • Phentermine reduced the apparently aversive effects of fenfluramine when the two drugs were given together. (nih.gov)
  • Here, we assessed the predictive validity of the food reinstatement model by studying the effects of fenfluramine, a serotonin releaser with known anorectic effects, on reinstatement of food seeking. (nih.gov)
  • Therefore, we investigated the effects of fenfluramine on seizures and seizure-induced respiratory arrest (S-IRA) in DBA/1 mice. (cureepilepsy.org)
  • METHODS: The dose and time course of the effects of fenfluramine (i.p.) on audiogenic seizures (Sz) induced by an electric bell in DBA/1 mice were determined. (cureepilepsy.org)
  • We began this global development program nearly six years ago after researchers in Belgium recognized the potential of fenfluramine, a drug with distinct pharmacology from all other anticonvulsant agents, to treat intractable seizures in Dravet syndrome. (yahoo.com)
  • The stereoselective pharmacology of fenfluramine led to studies on the individual enantiomers (30mg of each). (surrey.ac.uk)
  • Fenfluramine is used to control seizures in children from 2 years of age and older with Dravet syndrome (a disorder that begins in early childhood and causes seizures and later may lead to developmental delays and changes in eating, balance, and walking). (medlineplus.gov)
  • I am thrilled that all Phase 3 studies with fenfluramine demonstrated a clinically meaningful, highly statistically significant decrease of seizure frequency in Dravet syndrome patients. (globenewswire.com)
  • Recent studies have found that the addition of fenfluramine improved seizure control in patients with Dravet syndrome, which has a high incidence of SUDEP. (cureepilepsy.org)
  • The amphetamine derivative fenfluramine, previously marketed as an appetite suppressant to manage obesity, delivers a different promise in a new phase III trial by showing its anti-epileptic potential in children and young adults with Dravet syndrome. (mims.com)
  • Our findings] suggest that the use of low-dose fenfluramine … added to existing anti-epileptic therapy could be effective in reducing the frequency of convulsive seizures in patients with Dravet syndrome. (mims.com)
  • Crit Rev Toxicol 2016;46:477-489 ] Following which, approval for compassionate use was granted by the Belgian government in 2002 to allow Dravet syndrome patients to receive fenfluramine under a treatment protocol, said the researchers. (mims.com)
  • Since the initial report by Connolly, et al [ 1 ] of valvulopathy in women taking the combination of fenfluramine and phentermine (fen-phen), controversy has surrounded the issue of associated risk. (biomedcentral.com)
  • In July, the Mayo Clinic reported that 24 patients developed heart valve disease after taking a drug combination of fenfluramine and phentermine. (mit.edu)
  • Additionally, the renin response to d-fenfluramine was unaltered by repeated cocaine administration, while 8-OH-DPAT did not alter renin secretion in either pretreatment group. (elsevier.com)
  • Results: The veterans with PTSD had a significantly lower prolactin response to d-fenfluramine as compared to healthy control subjects. (uab.edu)
  • The prolactin response to d-fenfluramine was inversely correlated with the patient's level of PTSD symptomatology and measures of aggression. (uab.edu)
  • Conclusions: This study demonstrates a central serotonin dysfunction, as reflected in a lower prolactin response to d-fenfluramine, in patients with PTSD. (uab.edu)
  • Seven male and five female volunteers participated in an eight-session, double-blind study in which each subject received each of the following drug conditions: d-amphetamine (10 and 20 mg), phentermine (30 mg), fenfluramine (40 and 80 mg), phentermine (30 mg) with fenfluramine (40 mg), phentermine (30 mg) with fenfluramine (80 mg), and placebo. (nih.gov)
  • Phentermine produced effects that were similar to those of d-amphetamine, whereas fenfluramine produced different and apparently aversive effects (e.g., it increased measures of anxiety and confusion). (nih.gov)
  • The discriminative stimulus (DS) and subjective effects of d-amphetamine (AMP), phenmetrazine (PMT) and fenfluramine (FFL) were studied in a group of normal healthy adults. (amphetamines.com)
  • Differences between the anorexic actions of amphetamine and fenfluramine--possible effects on hunger and satiety. (semanticscholar.org)
  • The inhition of feeding in rats brought about by amphetamine and fenfluramine was continuously monitored for periods of up to 24 h using a pellet detecting eatometer. (semanticscholar.org)
  • For rats tested under conditions of food deprivation the two drugs gave rise to distinctive anorexic profiles: amphetamine delayed the onset of eating whereas fenfluramine allowed eating to commence normally but brought about an early termination of the initial bout of feeding. (semanticscholar.org)
  • Methods: We used the serotonin-releasing agent and reuptake inhibitor, d-fenfluramine, to assess the integrity of the serotonin- mediated prolactin release in 8 men with combat-induced PTSD and 8 healthy men. (uab.edu)
  • 05) in fat-fed rats receiving d -fenfluramine (fat+fen). (diabetesjournals.org)
  • Rats (n = 96), previously allowed to drink sweetened condensed milk during daily 15-min sessions, were treated with fenfluramine (6.25 mg/kg/12 hr x 4 days) or saline. (aspetjournals.org)
  • The ACTH responses to d-fenfluramine and 8-OH-DPAT were inhibited in cocaine pretreated rats. (elsevier.com)
  • In another experiment, the rats were treated as above and were killed at various times after p-chloroamphetamine or d-fenfluramine injection to determine, in parallel, the indole levels in the whole brain and concentration of p-chloroamphetamine, d-fenfluramine and its metabolite d-norfenfluramine in the plasma and brain. (elsevier.com)
  • At these times, the brain concentrations of p-chloroamphetamine, d-fenfluramine and d-norfenfluramine were markedly lower in the L-cysteine-treated than in the control rats. (elsevier.com)
  • Analysis of the blood concentration of p-chloroamphetamine, d-fenfluramine and d-norfenfluramine showed that the rats treated with L-cysteine eliminated the drugs studied more rapidly than the control animals. (elsevier.com)
  • After the IP injection of fenfluramine (FA: at 5, 10, 15, and 20 mg/kg), serotonin-mediated behavior traits and the appearance of flushing were observed in rats fed experimental diets as stated above. (researchwithrutgers.com)
  • Fenfluramine causes the release of serotonin by disrupting vesicular storage of the neurotransmitter, and reversing serotonin transporter function. (wikipedia.org)
  • Fenfluramine enhances serotonin neurotransmission by both inducing presynaptic release of serotonin stores and inhibiting synaptic reuptake. (ahajournals.org)
  • Thereafter nine of these subjects (five high-insulin secretors and four low- or normal-insulin secretors) continued on the dietary therapy alone, and eleven of the remaining fourteen subjects (six high-insulin secretors and five low- or normal-insulin secretors) continued on the low-calorie diet with the addition of fenfluramine, and their glucose tolerance and insulin secretion were measured again after a further 10 weeks. (bmj.com)
  • The usefulness of fenfluramine (F), in association with diet therapy, was investigated in 13 obese noninsulin- dependent diabetic patients with poor diabetes control on a previous sulfonylurea regimen (SU). (diabetesjournals.org)
  • The ability of fenfluramine to block seizure-induced respiratory arrest selectively suggests the potential usefulness of fenfluramine in prophylaxis of SUDEP. (cureepilepsy.org)
  • Recent clinical reports indicate that combined administration of phentermine and fenfluramine may have useful effects in the treatment of drug abuse. (nih.gov)
  • These results suggest that the combination of phentermine and fenfluramine would have a low potential for abuse. (nih.gov)
  • To determine the long-term efficacy of the combination therapy of phentermine and fenfluramine in conjunction with diet, exercise, and behavior modification in the treatment of simple, moderate obesity. (clinicaltrials.gov)
  • At high concentrations, norfenfluramine, though not fenfluramine, also acts as a dopamine releasing agent, and so fenfluramine may do this at very high doses as well. (wikipedia.org)
  • In the second study, involving patients with NIDDM inadequately controlled on submaximal to maximal doses of oral hypoglycemic agents, a double-blind crossover strategy was used to compare baseline studies (conducted after a run-in period) with fenfluramine (60 mg orally) or placebo for 4 wk. (diabetesjournals.org)
  • Fenfluramine did not produce signs of dependence in animals and appears to produce sedation more often than CNS stimulation at therapeutic doses. (rxlist.com)
  • He also wants to know why research showing that therapeutic doses of fenfluramine can cause severe and sometimes permanent impairment in serotonin nerve cells in anals "[was] ignored, or how was it excused? (nature.com)
  • C ardiovascular (CV) safety is an important outcome measure in this patient setting in light of the cardiac valvulopathy and pulmonary arterial hypertension ( PAH ) found to be associated with high doses of fenfluramine (up to 220 mg/day). (mims.com)
  • Increasing doses of fenfluramine reduced food intake in a similar manner in both transgenic and wildtype mice. (ox.ac.uk)
  • The Fen-Phen anorexigen story has raised the question about the true incidence of fenfluramine-induced valvulopathy in the medical literature. (bmj.com)
  • Fenfluramine , chlorphentermine , and aminorex , which are also amphetamines and relatives, were formerly used as appetite suppressants but were discontinued due to concerns of cardiac valvulopathy . (wikipedia.org)
  • Since fenfluramine and its active metabolite norfenfluramine stimulate serotonin receptors, this may have led to the valvular abnormalities found in patients using fenfluramine. (wikipedia.org)
  • Fenfluramine and its active metabolite norfenfluramine affect the 5-HT2B receptors, which are plentiful in human cardiac valves. (wikipedia.org)
  • In addition to monoamine release, while fenfluramine binds only very weakly to the serotonin 5-HT2 receptors, norfenfluramine binds to and activates the serotonin 5-HT2B and 5-HT2C receptors with high affinity and the serotonin 5-HT2A receptor with moderate affinity. (wikipedia.org)
  • The hepatic metabolite of (+)-fenfluramine, (+)-norfenfluramine, has affinity for 5-hydroxytryptamine (5-HT) 2A and 5-HT 2B receptors. (aspetjournals.org)
  • The areas under the plasma time curve for 1-fenfluramine and 1-norfenfluramine were greater than for the d-isomers. (surrey.ac.uk)
  • However, ratios of fenfluramine to norfenfluramine were the same and thus the stereoselectivity seemed to reside in the deamination stage. (surrey.ac.uk)
  • A definitive pharmacokinetic study with d-fenfluramine showed slight first pass metabolism, the product of which appeared not to be norfenfluramine. (surrey.ac.uk)
  • Plasma prolactin measurements were obtained with double antibody radioimmunoassay before and after both placebo and fenfluramine challenges, and fenfluramine and norfenfluramine blood levels after each challenge were determined by gas chromatography. (elsevier.com)
  • There were no significant differences in age, gender, fenfluramine, or norfenfluramine blood levels between depressed patients with and without anger attacks. (elsevier.com)
  • In the first study, a double-blind crossover design was used in healthy subjects to compare the effect of short-term fenfluramine therapy (60 mg orally for 3 days) with placebo. (diabetesjournals.org)
  • These studies demonstrated that adjunctive fenfluramine treatment provided a highly statistically significant and clinically meaningful reduction in convulsive seizure frequency compared to placebo and was generally well-tolerated. (globenewswire.com)
  • All patients received a single-blind placebo challenge followed by a fenfluramine challenge (60 mg orally) the next day. (elsevier.com)
  • In several relatively short term clinical trials (e.g., 16 weeks), it has been shown that appetite control medications such as fenfluramine and phentermine were more effective than placebo in inducing weight loss. (clinicaltrials.gov)
  • Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. (uthscsa.edu)
  • Ther Adv Neurol Disord 2015;8:328-338 ] " This study was the first randomized, double-blind, placebo-controlled clinical trial to assess the safety and efficacy of fenfluramine [in this patient setting. (mims.com)
  • To further explore the role of serotonin ( 5-HT ) in anxiety, 28 healthy volunteers received in a double-blind study d-fenfluramine (30 mg, p.o.) or placebo , and were submitted to a simulated public speaking test (SPS), consisting of speaking in front of a video camera. (bvsalud.org)
  • Acute administration of fenfluramine produced a dose-dependent decrease in milk intake and 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels in cortex, hypothalamus and hippocampus. (aspetjournals.org)
  • Levels of 5-HT and 5-HIAA in somatosensory cortex, hypothalamus, striatum and hippocampus were depleted significantly 2 weeks after the last daily fenfluramine injection. (aspetjournals.org)
  • We tested this hypothesis in a community sample by evaluating the relationship between resting BP and a neuropharmacologic index of brain serotonergic activity (the fenfluramine challenge test). (ahajournals.org)
  • These data reveal that in white but not black adults, fenfluramine-induced prolactin release correlates inversely with BP and may indicate a role of central serotonergic activity in the pathogenesis of hypertension. (ahajournals.org)
  • Therefore, the rise in plasma prolactin concentration after fenfluramine administration reflects "net" serotonergic responsivity, as influenced by variability in presynaptic events (ie, synthesis, storage, release, and reuptake) and activation of hypothalamic 5-HT receptors. (ahajournals.org)
  • We wanted to compare the prolactin response to fenfluramine challenge, as an indirect measure of central serotonergic function, in depressed patients with and without anger attacks. (elsevier.com)
  • As previous studies have shown blunted prolactin responses to fenfluramine in impulsive aggression among patients with personality disorders, our results support our hypothesis that depressed patients with anger attacks may have a relatively greater serotonergic dysregulation than depressed patients without these attacks. (elsevier.com)
  • We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. (uthscsa.edu)
  • As part of the REMS requirements, prescribers and patients must adhere to the required cardiac monitoring with echocardiograms to receive fenfluramine. (wikipedia.org)
  • This observation together with the urinary metabolite ratios, indicated that d-fenfluramine could be deaminated directly without being first N-deethylated. (surrey.ac.uk)
  • The deaminated metabolite of benfluorex was not found as a metabolite of fenfluramine indicating that the N-ethyl-substitution had influenced the deamination route as well as the overall metabolic fate of the 1-(m-trifluoro-methylphenyl)-2-aminopropane nucleus. (surrey.ac.uk)
  • The fact that the effect of p-chloroamphetamine and d-fenfluramine seen at shorter times was associated with a marked reduction in the blood and brain drug concentration in the L-cysteine-treated animals suggests that the reduced availability of p-chloroamphetamine, d-fenfluramine and its active metabolite may be responsible for the partial prevention by L-cysteine of their neurochemical effects. (elsevier.com)
  • The U.S. Food and Drug Administration (FDA) fenfluramine labeling includes a boxed warning stating the drug is associated with valvular heart disease (VHD) and pulmonary arterial hypertension (PAH). (wikipedia.org)
  • On July 8, 1997, 24 cases of valvular heart disease in women who had been treated with fenfluramine and phentermine were publicly reported (1). (cdc.gov)
  • The anorexigen (+)-fenfluramine was used for treatment of obesity until the association of use with valvular heart disease and primary pulmonary hypertension. (aspetjournals.org)
  • Following this, a retrospective study 9 reinforced the possible role of fenfluramine derivatives as risk factors for PAH development and the results of the International Primary Pulmonary Hypertension Study (IPPHS) 10 conclusively demonstrated a strong association between PAH and the use of anorexic drugs (mainly derivatives of fenfluramine). (ersjournals.com)
  • Fenfluramine derivatives share with aminorex such characteristics as being potent serotonin (5-HT) uptake inhibitors and interacting directly with the 5-HT transporter 11 . (ersjournals.com)
  • The mechanism by which aminorex or fenfluramine might cause pulmonary hypertension is unknown but might resemble that responsible for hypoxic pulmonary vasoconstriction, in which K + channel inhibition leads to membrane depolarization and Ca 2+ entry through the voltage-dependent Ca 2+ channels. (ahajournals.org)
  • 14 We hypothesized that inhibition of an I K , which initiates hypoxic pulmonary vasoconstriction in pulmonary vascular smooth muscle, 13 15 might play a role in the pulmonary hypertension sometimes associated with aminorex and fenfluramine ingestion. (ahajournals.org)
  • The aim of the present study was to describe a large cohort of fenfluramine-associated pulmonary arterial hypertension (fen-PAH) and its possible prognostic markers. (ersjournals.com)
  • Fenfluramine-associated pulmonary arterial hypertension shares clinical, functional, haemodynamic and genetic features with idiopathic pulmonary arterial hypertension, as well as overall survival rates. (ersjournals.com)
  • Therefore, the present authors conclude that fenfluramine exposure characterises a potent trigger for pulmonary arterial hypertension without influencing its clinical course. (ersjournals.com)
  • Fen-Phen is a combination of two drugs -- fenfluramine, an appetite suppressant, and phentermine, a mild stimulant. (cnn.com)
  • In these patients, the duration of exposure to fenfluramine was significantly lower than in patients without mutation. (ersjournals.com)
  • The median effective dose (ED50 ) of fenfluramine for significantly reducing Sz at 30 minutes was 21 mg/kg. (cureepilepsy.org)
  • However, the prolactin responses to d-fenfluramine and 8-OH-DPAT were not significantly modified by cocaine exposure. (elsevier.com)
  • Depressed patients with anger attacks showed a significantly blunted prolactin response to fenfluramine challenge compared to patients without anger attacks. (elsevier.com)
  • p-Chloroamphetamine (2.5 and 5 mg/kg i.p.) and d-fenfluramine (13.4 mg/kg i.p.) significantly reduced serotonin and 5-hydroxyindoleacetic acid levels in the striatum, hippocampus and cortex, particularly in the latter areas. (elsevier.com)
  • L-cysteine (500 mg/kg i.p.), administered 30 min before and 5 h after p-chloroamphetamine or d-fenfluramine, significantly reduced the effect of either drug on the concentrations of both indoles without causing any effect by itself. (elsevier.com)
  • L-cysteine had no effect on the indole concentrations but significantly reduced the effect of p-chloroamphetamine and d-fenfluramine 16 and 24 h after injection. (elsevier.com)
  • Also, the physiological measurements were not significantly changed by d-fenfluramine. (bvsalud.org)
  • Chronic d -fenfluramine also reduces hypothalamic noradrenergic tone, which correlates highly with hepatic glucose output. (diabetesjournals.org)
  • Impaired suppression of hepatic glucose output by insulin, caused by fat feeding, was totally reversed by d -fenfluramine. (diabetesjournals.org)
  • We hypothesize that d -fenfluramine improves insulin action by reducing hypothalamic noradrenergic tone, which in turn reduces the neural drive to hepatic glucose output and improves the hepatic response to insulin. (diabetesjournals.org)
  • A double-blind trial of orally administered fenfluramine was conducted in 7 non-obese adults with various neurological disorders. (drugawareness.org)
  • Fenfluramine acts primarily as a serotonin releasing agent. (wikipedia.org)
  • Fenfluramine is a drug that enhances serotonin release in the brain. (cureepilepsy.org)
  • D-Fenfluramine (D-Fen) increases serotonin (5-HT) content in the synaptic cleft and exerts anorexigenic effects in animals and humans. (nih.gov)
  • Fenfluramine HCl is indicated in the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. (rxlist.com)
  • The median duration of fenfluramine exposure was 6 months, with a median of 4.5 yrs between exposure and onset of symptoms. (ersjournals.com)
  • Duration of fenfluramine exposure showed no relation to survival, while cardiac index was the only independent predictor of multivariate analysis. (ersjournals.com)
  • It was postulated that fenfluramine may have had a catecholamine-depleting effect that may have led to cardiovascular collapse upon exposure to halothane. (ispub.com)
  • The effect of L-cysteine on the depletion of serotonin and 5-hydroxyindoleacetic acid concentrations caused by p-chloroamphetamine and d-fenfluramine was studied in various brain regions one week after drug injection. (elsevier.com)
  • Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine. (aspetjournals.org)
  • The fenfluramine REMS requires health care professionals who prescribe fenfluramine and pharmacies that dispense fenfluramine to be specially certified in the fenfluramine REMS and that patients be enrolled in the REMS. (wikipedia.org)
  • Chronic fenfluramine therapy can lower fasting plasma glucose and increase insulin sensitivity without affecting insulin secretion in patients with NIDDM. (diabetesjournals.org)
  • We conclude that in patients with inadequately controlled NIDDM, fenfluramine may serve as a useful adjunct to sulfonylurea therapy. (diabetesjournals.org)
  • Fenfluramine therefore seems to be useful as an adjunct to diet and SU therapy in obese non-insulin-dependent diabetic patients. (diabetesjournals.org)
  • 3 Fenfluramine is reported to have been used by 50 million patients worldwide. (ahajournals.org)
  • In this real-world study, fenfluramine provided a clinically meaningful reduction in convulsive seizure frequency in the majority of patients with DS and was well tolerated. (cureepilepsy.org)
  • While DS is largely resistant to treatment with existing anti-epileptic drugs, promising results have been obtained in clinical trials with human patients treated with the serotonin agonist fenfluramine as an add-on therapeutic. (semanticscholar.org)
  • The manufacturer's prescribing information advises that fenfluramine is contraindicated in patients undergoing general anesthesia because of a single case report of a fatal cardiac arrest following the induction of anesthesia with halothane in a patient who had been taking fenfluramine prior to surgery ( 10 )( 12 ). (ispub.com)
  • Nevertheless, the manufacturer recommends that potent anesthetic agents be administered with caution to patients taking fenfluramine and if general anesthesia cannot be avoided, full cardiac monitoring and facilities for instant resuscitation measures are a minimum necessity ( 12 ). (ispub.com)
  • More recently, a letter from the Texas Society of Anesthesiologists concerning the administration of anesthesia to patients taking fenfluramine warned of the potential medical-legal risks ( 13 ). (ispub.com)
  • Based on the new data, manufacturers agreed to withdraw both Redux and fenfluramine, and the FDA recommended patients stop taking the drugs. (mit.edu)
  • Because of the risks of VHD and PAH, fenfluramine is available only through a restricted drug distribution program, under a risk evaluation and mitigation strategy (REMS). (wikipedia.org)
  • There was a longer plasma half-life for both total radioactivity and parent drug with [14C]-1-fenfluramine. (surrey.ac.uk)
  • Information obtained under the Freedom of Information Act from the U.S. Food and Drug Administration also failed to reveal any additional reports of adverse events related to the use of fenfluramine and anesthesia. (ispub.com)
  • Thus the question remains: Is there a drug interaction between fenfluramine and anesthetic agents? (ispub.com)
  • The results show that L-cysteine partially prevents the depletion of the brain content of serotonin and 5-hydroxyindoleacetic acid caused by p-chloroamphetamine and d-fenfluramine one week after drug administration. (elsevier.com)
  • MATERIALS AND METHODS: We measured free-feeding food intake and observed the behavioural satiety sequence (BSS) after food deprivation in mice at baseline and after administration of the anorectic drug fenfluramine. (ox.ac.uk)
  • Acute fenfluramine treatment in healthy individuals has no effect on glucose metabolism. (diabetesjournals.org)
  • The Metabolism and Kinetics of Fenfluramine, its Optical Isomers and a Structural Analogue, Benfluorex. (surrey.ac.uk)
  • Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine. (ox.ac.uk)
  • There is evidence that fenfluramine improves insulin action independently of its anorectic and weight-loss-inducing properties. (diabetesjournals.org)
  • It is not known exactly how fenfluramine works, but it increases the amount of natural substances in the brain that may reduce seizure activity. (medlineplus.gov)
  • Tolerance to the anorectic properties of fenfluramine develops rapidly and long-lasting depletions of brain 5-HT have been reported to occur after repeated administration. (aspetjournals.org)
  • We do know that fenfluramine and phentermine alter the way the brain chemical serotonin is metabolized, and serotonin that circulates in the blood can cause [heart] valve injury. (cnn.com)
  • There have been reports associating chronic fenfluramine treatment with emotional instability, cognitive deficits, depression, psychosis, exacerbation of pre-existing psychosis (schizophrenia), and sleep disturbances. (wikipedia.org)
  • We report that chronic d -fenfluramine (5 mg · kg −1 · day −1 ) ameliorates insulin resistance induced by high-fat feeding. (diabetesjournals.org)
  • Thirty minutes after 20-40 mg/kg of fenfluramine, significant reductions of seizure incidence and severity, as well as S-IRA susceptibility occurred, which were long-lasting (less than or equal to 48 hours). (cureepilepsy.org)
  • SIGNIFICANCE: This study presents the first evidence for the effectiveness of fenfluramine in reducing seizure incidence, severity, and seizure-induced respiratory arrest susceptibility in a mammalian SUDEP model. (cureepilepsy.org)
  • Investigation of the urinary metabolites of d-fenfluramine showed a greater abundance of deaminated products and less parent compound compared with 1-fenfluramine. (surrey.ac.uk)
  • tell your doctor and pharmacist if you are allergic to fenfluramine, any other medications, or any of the ingredients in fenfluramine oral solution. (medlineplus.gov)
  • Insulin secretion and whole-body insulin sensitivity (determined by frequently sampled intravenous glucose tolerance tests with analysis by the minimal-model method) were unchanged by fenfluramine. (diabetesjournals.org)
  • The eleven subjects placed on fenfluramine in addition to the diet also showed maintenance of the improvement in glucose tolerance achieved during the first 10-week period with a significant decrease in insulin secretion in the six high-insulin secreting subjects and no significant change in insulin secretion in the five lowor normal-secretors. (bmj.com)