The described technique provides access to the tumor in the proximal femoral epiphysis and local tumor control. (bvsalud.org)
The distal femoral and proximal tibial epiphyses are most frequently involved, followed by the proximal humerus, where approximately 18% of chondroblastomas appear. (medscape.com)
Etiology of chondroblastoma2
The etiology of chondroblastoma is uncertain, as there is no specific characteristic abnormality or chromosomal breaking point observed, despite cytogenetic abnormalities being highly specific for some tumors. (wikipedia.org)
Although the exact etiology of chondroblastoma remains uncertain, the presentation, appropriate evaluation, and treatment of patients with the condition have been well described. (medscape.com)
Benign chondroblastoma6
[ 1 ] A decade later, Jaffe and Lichtenstein renamed the Codman tumor a benign chondroblastoma to emphasize the chondroblastic genesis of the lesion and to distinguish it from the classic giant cell tumor of bone . (medscape.com)
Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or apophyses of long bones. (wikipedia.org)
Chondroblastoma is very uncommon, accounting less than 1% of all bone tumors. (wikipedia.org)
The work of Aigner et al suggests that chondroblastoma should be reclassified as a bone-forming neoplasm versus a cartilaginous neoplasm due to the presence of osteoid matrix, type I collagen, and absence of true cartilage matrix (collagen II). (wikipedia.org)
A chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. (medscape.com)
[ 4 ] They considered the term chondroblastoma to be a misnomer and believed that the tumor should be reclassified as a bone-forming neoplasm. (medscape.com)
Brien et al compared the characteristics of chondroblastoma of bone to chondroblastoma of soft tissue, giant cell tumor of the tendon sheath (GCTTS), and pigmented villonodular synovitis (PVNS). (medscape.com)
[ 5 ] On examination of about 15 examples of GCTTS and PVNS, large areas of chondroid differentiation were noted that could not be distinguished from chondroblastoma of bone by either histologic or electron microscopic features. (medscape.com)
The researchers theorized that chondroblastoma of bone stems from an intraosseous proliferation of tendon sheath cells that have a predilection for chondroid formation. (medscape.com)
Sagittal T2-weighted image of the knee 2 weeks after injury demonstrates a kissing bone contusion in the lateral femoral condyle (arrowhead) and lateral tibial plateau (arrow). (medscape.com)
Giant cell tumor1
2 ] A decade later, Jaffe and Lichtenstein renamed it as chondroblastoma and clearly separated it from giant cell tumor. (faoj.org)
Neoplasms1
Romeo et al have observed chondroblastoma neoplasms to be composed of mesenchymal cells that have completed normal chondrogenesis along with the production of osteoid and collagen I that could be the result of transdifferentiation of chondrocytes towards osteoblasts. (wikipedia.org)
Excision1
Use of a Cannulated, Percutaneous Expandable Reamer for Physeal Sparing Excision of a Femoral Head Chondroblastoma. (bvsalud.org)
Cartilage3
Additionally, rare prevalence of chondroblastoma in intra-membranous ossification suggests a close relationship with growth plate cartilage. (wikipedia.org)
In chondroblastoma, growth signaling molecules may be present due to the pre-pubertal signaling network as well as cartilage growth. (wikipedia.org)
Chondroblastoma is a benign tumor of immature cartilage cells which primarily occurs in the epiphysis of long bones in the second decade of life with slight male preponderance. (faoj.org)
Tumor1
The highly heterogeneous nature of the tumor makes classification particularly difficult especially considering the origins of chondroblastoma. (wikipedia.org)
Valgus1
Femoral Neck - Varus, Valgus, or Torsional Deformity - if varus and short - a regular implant will restore length - if varus and not short - may need special implants with increased offset to avoid overlengthening - if valgus - beware the overhanging trochanter, and the medial metaphysis may be small, requiring special implants - if severe torsion - matching the anteversion of the patient may lead to significant internal rotation contracture or instability. (orthonet.on.ca)
Chondroid1
However, Edel et al found that collagen II, a marker for mature chondrocytes, was expressed in chondroblastoma, supporting the chondroid nature of the neoplasm. (wikipedia.org)
Dislocation3
The treatment of chondroblastoma in the epiphysis of the femoral head in skeletally immature individuals is challenging and often requires surgical hip dislocation . (bvsalud.org)
We present a unique method of percutaneous use of an expandable reamer (X-REAM, Wright Medical) to treat a chondroblastoma of the femoral head in a 9-year-old boy without requiring surgical hip dislocation . (bvsalud.org)
A percutaneous expandable reamer can be used to treat chondroblastoma of the femoral head while avoiding surgical hip dislocation . (bvsalud.org)
Medial3
In the knee joint, the medial femoral condyle is the most commonly involved site. (medscape.com)
Anteroposterior radiograph of the knee reveals osteochondritis dissecans in the lateral aspect (arrowhead) of the medial femoral condyle. (medscape.com)
Axial CT of the knee demonstrates a completely detached osteochondral fracture (arrowhead) in the lateral aspect of the medial femoral condyle. (medscape.com)
Long bones1
Romeo et al has noted that chondroblastoma arising in long bones mainly affects the epiphyses, while in other locations it is close to ossification centers. (wikipedia.org)
Cortex1
Most of the talus was involved except the lateral cortex head. (faoj.org)
Epiphyseal2
Both Indian Hedgehog/parathyroid hormone-related protein (IHh/PtHrP) and fibroblast growth factor (FGF) signaling pathways, important for development of the epiphyseal growth plate, are active in chondroblastoma leading to greater proliferation among the cells in the proliferating/pre-hypertrophic zone (cellular-rich area) versus the hypertrophic/calcifying zone (matrix-rich area). (wikipedia.org)
On radiographs chondroblastoma presents as an epiphyseal lytic lesion with lobular contours and well-defined sclerotic margins (Figure 3). (appliedradiology.com)
Recurrence1
7 ] In chondroblastoma of the foot and ankle, recurrence is common, and outcomes are generally worse than in other locations in the skeleton. (faoj.org)
Symptoms1
it was found that the average duration of symptoms for patients with chondroblastoma was about 20 months, ranging from 5 weeks to 16 years. (wikipedia.org)
Commonly1
Chondroblastoma in the foot most commonly occurs in subchondral areas of the talus and calcaneal apophysis. (faoj.org)
Cells1
The results of Romeo and colleagues favor the view of Edel et al of chondroblastoma being cartilaginous in nature but recognize that any definitive determinations regarding the origin of this neoplasm are not possible because of the plasticity of mesenchymal cells when set into different microenvironments and static approaches used in literature. (wikipedia.org)