Middle cerebral arteryOcclusionLigationHindlimbRenalHind limbCarotidSubsequent reperfusionFocal cerebral ischemiaVascularSkeletalIschemicPost-ischemiaBrain ischemiaMyocardial ischaemiaHypothermiaLower extremityInjurySuperior mesentCerebral blooRatsCoronary arteriesProximalMiceSevereGroup underwentInflammationThrombolysisSpinal cordPretreatmentTourniquetMCAoRadialStenosisCatheterOrganVivoAcuteCardiacPhenotypeDurationDiabetesDiabeticAngiogenesis in a rat model
Middle cerebral artery1
- i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary endothelial cells, and expression of EPO and VEGF were assessed. (researchgate.net)
Occlusion7
- This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
- Low-dose urokinase infusion to manage femoral-popliteal occlusion. (medscape.com)
- Pretreatment anteroposterior (AP) pelvic image shows severe atherosclerotic disease with attenuated flow through the left superficial femoral artery (SFA), which suggests a distal occlusion. (medscape.com)
- Thrombolysis of an acute thrombolytic occlusion in the popliteal artery. (medscape.com)
- Anteroposterior (AP) angiogram of the knee shows acute occlusion in the middle of the popliteal artery above the knee. (medscape.com)
- Thrombolysis of acute thromboembolic occlusion of the popliteal artery. (medscape.com)
- Close-up angiogram of the adductor canal region shows an abrupt cut-off of the above-the-knee popliteal artery and poor collateral flow consistent with acute occlusion. (medscape.com)
Ligation13
- The tourniquet or femoral artery ligation is widely used to stop extremity hemorrhage or create a bloodless operating field in the combat scenario and civilian setting. (nebraska.edu)
- To fully evaluate animal models of limb IR injuries, we compared tourniquet- and femoral artery ligation-induced IR injuries in the hindlimb of mice. (nebraska.edu)
- In C57/BL6 mice, 3 h of unilateral hindlimb ischemia was induced by placement of a rubber band at the hip joint or a surgical ligation of the femoral artery. (nebraska.edu)
- The tourniquet or femoral artery ligation was then released, allowing for 24 h of reperfusion. (nebraska.edu)
- Compared to the femoral artery ligation/IR, the tourniquet/IR induced more severe skeletal muscle damage, including muscle necrosis and interruption of muscle fibers. (nebraska.edu)
- There was no gastrocnemius muscle contraction in tourniquet/IR, while femoral artery ligation/IR markedly weakened gastrocnemius muscle contraction. (nebraska.edu)
- Motor nerve terminals disappeared, and endplate potentials (EPPs) were undetectable in tourniquet/IR, whereas femoral artery ligation/IR only induced mild impairment of motor nerve terminals and decreased the amplitude of EPPs. (nebraska.edu)
- Additionally, western blot data showed that proinflammatory cytokine levels (IL-1β and TNF-α) were higher in the tourniquet/IR than that in femoral artery ligation/IR. (nebraska.edu)
- Moreover, tourniquet/IR caused significant tissue edema and dilation of lymphatic vessels in the hindlimb, compared to femoral artery ligation/IR. (nebraska.edu)
- The above data demonstrated that tourniquet/IR-induced acute hindlimb injuries are more severe than those induced by femoral artery ligation/IR. (nebraska.edu)
- This suggests that future investigators should determine which hindlimb IR model (tourniquet/IR or femoral artery ligation/IR) is optimal depending on the purpose of their study. (nebraska.edu)
- Methods: Aged female ApoE-/- and C57BL6 mice underwent femoral artery ligation, then were divided into sedentary and demand ischemia (exercise) groups on day 14. (johnshopkins.edu)
- Methods: We used a polyvinyl alcohol (PVA) sponge implantation mouse model as an inflammatory angiogenesis model and utilized a mouse femoral artery ligation model as a hind limb ischemia model. (visualsonics.com)
Hindlimb3
- In this study, we use a well-established, severe femoral-saphenous artery-vein pair resection model of unilateral hindlimb ischemia to test the relevance of Cx37 and Cx40 to postischemic tissue survival and recovery of limb perfusion. (figshare.com)
- Murine models of Matrigel plug and hindlimb ischemia were employed as in vivo angiogenic assays. (biomedcentral.com)
- Furthermore, M2 polarization and angiogenesis were induced upon the administration of exosomes in mouse Matrigel plug and hindlimb ischemia (HLI) models. (biomedcentral.com)
Renal4
- In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
- Kidney partial ischemia-reperfusion (IR) injury is defined as a reduction of the renal blood flow (RBF) followed by the recovery of RBF and reoxygenation [ 1 ]. (hindawi.com)
- 8) A bifurcated graft of the neo-graft was anastomosed to the common iliac arteries first, followed by reattachments of the left renal artery, superior mesenteric artery and celiac axis without aortic cross-clamp. (authorea.com)
- Since the right renal artery is located on the bottom of the aneurysm, the reconstruction was performed after initiating a left heart bypass (LHB). (authorea.com)
Hind limb2
- Results: Hind limb ischemia was similar in ApoE-/- and C57 mice before the onset of exercise. (johnshopkins.edu)
- We found that wild type (WT) C57BL/6 mice, subjected to hind limb ischemia (HLI) and supplemented with carnosine (1g/L) in drinking water, had improved blood flow recovery and limb function, enhanced revascularization and regeneration of myocytes compared with HLI mice placed on water alone. (frontiersin.org)
Carotid4
- This multicentre randomised controlled trial is the largest to date evaluating use of a neuroprotection device during TAVR - the SentinelTM Transcatheter Cerebral Embolic Protection (TCEP) device, two filters placed in the brachiocephalic and the left common carotid arteries and removed after TAVR. (shda.org.au)
- Panel B shows the proximal filter is placed in the innominate artery and the distal filter is placed in the left carotid artery. (shda.org.au)
- The CT angio showed a type A aortic dissection extending from the aortic root proximally to the carotid and left subclavian artery and distally to the common femoral arteries. (blogspot.com)
- Epidemiology, repair technique, and predictors of stroke and mortality in penetrating carotid artery injuries. (sc-ctsi.org)
Subsequent reperfusion2
- However, these procedures with subsequent reperfusion also induce ischemia-reperfusion (IR) injuries. (nebraska.edu)
- IPC is described as short, transient, and nonlethal ischemia periods and subsequent reperfusion which is performed before IR injury and can protect the kidney against long-term ischemia [ 6 - 8 ]. (hindawi.com)
Focal cerebral ischemia1
- The fate of the brain tissue after focal cerebral ischemia is determined by the degree and duration of ischemia, and even without preconditioning, resident brain cells naturally respond to brain ischemia by mobilizing a host of defences and counter responses to mitigate cell injury and death [ 5 ]. (biomedcentral.com)
Vascular3
- Recurrent, unabated ischemia is the underlying cause of tissue loss in peripheral arterial disease (PAD) or peripheral vascular disease (PVD). (frontiersin.org)
- In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia. (biomedcentral.com)
- Since then, techniques for thrombolysis have branched in several directions with the treatment of thrombus and/or thrombosis in the coronary arteries, peripheral vascular and visceral arteries, dialysis grafts, veins, and IV catheters. (medscape.com)
Skeletal1
- Background: We designed studies to determine whether the ApoE-/- phenotype modulates the local skeletal muscle and systemic inflammatory (plasma) responses to lower extremity demand ischemia. (johnshopkins.edu)
Ischemic7
- 5) Previous reports have described the utility of "visceral branch-first techniques" in reducing visceral ischemic time with minimal reperfusion injury. (authorea.com)
- Ischemic tolerance defines transient resistance to lethal ischemia gained by a prior sublethal noxious stimulus (i.e., preconditioning). (biomedcentral.com)
- When the lethal ischemic insult is applied onto this latent protective phenotype, a separate set of responses are triggered that constitute ischemia-tolerant phenotype, which strikingly differs from the unprimed or unpreconditioned brain's phenotype (Figure 1 ). (biomedcentral.com)
- In the absence of ischemic preconditioning (IPC), MCAO induces a large infarction (ischemia-sensitive phenotype). (biomedcentral.com)
- The in vivo experiment results indicated that SBP had angiogenesis effects in both inflammatory and ischemic angiogenesis models with dose- and time-dependent effects. (visualsonics.com)
- Ischemic ST depression includes posterior OMI and subendocardial ischemia. (blogspot.com)
- The patient underwent right femoral-anterior tibial bypass with ischemic symptoms in the right lower extremity. (medscape.com)
Post-ischemia2
- or = 24h post-ischemia were included in the histologic analysis. (silverchair.com)
- In this study, we tested the hypothesis that carnosine protects against post ischemia by augmenting HIF-1α angiogenic signaling by Fe 2+ chelation. (frontiersin.org)
Brain ischemia2
- Recent studies have reported that dexamethasone worsens neuronal injury after brain ischemia. (silverchair.com)
- In the current study, dexamethasone administration before brain ischemia resulted in a worsening of postischemic outcome that was relate to drug-induced hyperglycemia. (silverchair.com)
Myocardial ischaemia1
- Although an underlying arrhythmogenic substrate is necessary, the arrhythmia itself will compromise an already impaired haemodynamic state, by increasing myocardial ischaemia or left ventricular wall distension, and so exacerbate the situation. (bmj.com)
Hypothermia1
- The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
Lower extremity1
- 30%) with acute symptoms of right lower-extremity ischemia. (medscape.com)
Injury16
- While studies using various materials to overcome ischemia-reperfusion (IR) injury are becoming increasingly common, studies on the effects of botulinum toxin A (BoTA) on IR injury in musculocutaneous flaps are still limited. (hindawi.com)
- The purpose of this study was to examine our hypotheses that BoTA provide protection of musculocutaneous flap from ischemia-reperfusion injury. (hindawi.com)
- In this study, we found that local BoTA preconditioning yielded significant protection against IR injury in a rat musculocutaneous flap model. (hindawi.com)
- Ischemia-reperfusion injury occurs when circulation is abruptly restored following prolonged ischemia and it is well-known that high levels of calcium and tissue neutrophil accumulation cause cellular damage and produce reactive oxygen species (ROS) during reperfusion and trigger IR injury [ 1 ]. (hindawi.com)
- 7 The metabolism of fatty acids and glucose undergoes adaptive changes in the myocardium due to ischemia-reperfusion injury after cardiopulmonary resuscitation (CPR). (dirjournal.org)
- We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. (silverchair.com)
- The present study was undertaken to study the effects of exogenous H2S on ischemia/reperfusion (I/R) injury of spinal cord and the underlying mechanisms. (biomedcentral.com)
- In rat model of I/R injury, pretreatment of pre-miR-30c or 3-MA (an inhibitor for autophagy) can abrogated spinal cord protective effect of H2S. (biomedcentral.com)
- Ischemia/reperfusion (I/R) injury of the spinal cord is a dynamic process that frequently occurs during a variety of clinical situations such as thoracoabdominal aortic surgery or spinal cord injury [ 1 ]. (biomedcentral.com)
- Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. (hindawi.com)
- The preclinical work focuses on animal models of myocardial ischemia-reperfusion injury, which is an experimental model for STEMI, as well as ex-vivo models of myocardial ischemia. (gu.se)
- This may minimize the risk or degree of ischemia-reperfusion injury even if no selective organ perfusion was applied. (authorea.com)
- An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
- However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
- A resuscitation from an HS regards as a reperfusion insult which may induce neurological injury in patients with an UCCAO disease. (medsci.org)
- The resuscitation after an HS causes a reperfusion or reoxygenation insult [ 2 - 4 ], gut injury, and multiple organ dysfunctions [ 5 , 6 ]. (medsci.org)
Superior mesent1
- During septic shock in pigs superior mesenteric artery and hepatic microcirculation flow decreased about 50% and hydroxyethylstarch administration improved splanchnic blood flow but not microvascular liver perfusion [ 4 ]. (biomedcentral.com)
Cerebral bloo1
- Cranial - monitor cerebral blood flow hyperaemia, ischaemia, brain death, detection of vasospasm, fat and other emboli, stroke related artery reperfusion following thrombolysis. (derangedphysiology.com)
Rats4
- and (3) normoglycemic, dexamethasone- and insulin-treated rats (group DI) received the same treatment as group D, plus an intravenous insulin infusion shortly before ischemia. (silverchair.com)
- In contrast, all group D rats died of cerebral ischemia. (silverchair.com)
- The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
- Cardio- and nephroprotective effects of fractions isolated from Lycium barbarum (goji berry) in models of cardio- and nephrotoxicity in rats. (referencecitationanalysis.com)
Coronary arteries1
- Correction to: Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women. (amedeo.com)
Proximal2
- Next, the thoracic intercostal arteries were reimplanted using the island technique followed by proximal anastomosis of the main graft at the aortic isthmus. (authorea.com)
- Oblique pelvic image shows complex postsurgical anatomy with a graft ostium at the proximal superficial femoral artery (SFA). (medscape.com)
Mice3
- Increased poly-ADP-ribose activity and mature muscle regeneration were associated with demand ischemia in the C57BL6 mice, compared with the ApoE-/- mice (P = 0.01). (johnshopkins.edu)
- CS were transplanted subcutaneously to mice with surgically induced limb ischemia and followed by laser Doppler perfusion measurements. (biomedcentral.com)
- The cholesterol-fed LDLR-/- mice offer a new model for the study of environmental and genetic factors that modify the processes of atherosclerosis and xanthomatosis. (jci.org)
Severe1
- The patient had severe cardiac dysfunction and atrial fibrillation and presented with acute ischemia in the right lower limb 24 h after receiving an inferior vena cava filter. (medscape.com)
Group underwent1
- On day 14, animals in the demand ischemia group underwent daily treadmill exercise through day 28. (johnshopkins.edu)
Inflammation1
- An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
Thrombolysis2
- Thrombolysis of an occluded left femoral below-the-knee popliteal bypass by using the McNamara technique. (medscape.com)
- Thrombolysis of an occluded saccular popliteal artery aneurysm. (medscape.com)
Spinal cord2
- In recent years various techniques have been inspired and refined to reduce the duration and risk of visceral ischemia such as mild, moderate, or deep hypothermic repair with left heart bypass, or complete or partial cardiopulmonary bypass combined with selective perfusions to vital viscera, the lower extremities and the spinal cord. (authorea.com)
- During these reattachments, antegrade pulsatile blood flow to the spinal cord was guaranteed not only via the Adamkiewicz artery but also the collateral network, which ultimately minimizes spinal cord ischemia. (authorea.com)
Pretreatment1
- Pretreatment angiogram shows an intraluminal nonocclusive thrombus of the left common iliac artery. (medscape.com)
Tourniquet2
- Ischemia was created by a tourniquet strictly wrapping the pedicle containing skin and muscle for 8 h. (hindawi.com)
- After ischemia, the tourniquet was cut, and the musculocutaneous flap was reperfused. (hindawi.com)
MCAo1
- if MCAO is applied during this phase, mainly cortical areas are spared (early ischemia-tolerant phenotype). (biomedcentral.com)
Radial1
- Of note, the authors compare the benefits of femoral vs. radial approaches. (shda.org.au)
Stenosis2
- A modified rabbit model of tracheal stenosis and a household endoscope. (ooir.org)
- A high-grade left external iliac artery stenosis is incidentally noted. (medscape.com)
Catheter2
- REBOA is performed first by achieving access to the common femoral artery (CFA) and advancing a catheter within the aorta. (wikipedia.org)
- REBOA is performed by gaining access to the common femoral artery and inserting a small endovascular catheter with an inflatable balloon within the aorta. (wikipedia.org)
Organ1
- 743 wordsMinimization of end organ ischemia is a key tenet in successful thoracoabdominal aortic aneurysm (TAAA) surgery. (authorea.com)
Vivo1
- In vivo rat hearts or isolated Langendorff-perfused mouse hearts were subjected to ischemia followed by reperfusion with intralipid (0.5%, 1% and 2% ex-vivo, and 20% in vivo), cyclosporine-A (0.2 μM, 0.8 μM, and 1.5 μM ex- vivo and 10 mg/kg in vivo), or vehicle. (silverchair.com)
Acute1
- Unstable coronary artery plaque is the most common underlying cause of acute coronary syndromes (ACS) and can manifest as unstable angina, non-ST segment elevation infarction (NSTE-ACS), and ST elevation myocardial infarction (STEMI), but can also manifest as sudden cardiac arrest due to ischaemia induced tachyarrhythmias. (romanianjournalcardiology.ro)
Cardiac1
- To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. (spandidos-publications.com)
Phenotype3
- The ApoE-/- phenotype is an experimental model for atherosclerosis in humans. (johnshopkins.edu)
- Conclusions: Demand limb ischemia in the ApoE-/- phenotype exacerbated the expression of select systemic cytokines in plasma and blunted indices of muscle regeneration. (johnshopkins.edu)
- Delayed phase of IT occurs in days, when the latent cerebroprotective phenotype is complete, the brain is again ischemia-tolerant. (biomedcentral.com)
Duration1
- Forebrain ischemia of 10 min duration was produced using an established model. (silverchair.com)
Diabetes2
- To examine the effects of L-arginine, we used a streptozotocin (STZ) model of diabetes to examine how an increase in NO bioavailability would impact the major biochemical defects induced by high glucose. (californiaehealth.org)
- The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. (spandidos-publications.com)
Diabetic1
- Coronary Artery Lesion Lipid Content and Plaque Burden in Diabetic and Nondiabetic Patients: PROSPECT II. (amedeo.com)
Angiogenesis in a rat model1
- SBP has been proven to promote angiogenesis in a rat model of myocardial infarction (MI). (visualsonics.com)