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  • Lepr
  • We then performed selective breeding using the fa/fa male rats that exhibited relatively high blood glucose levels at 10 weeks of age, resulting in establishment of a diabetic strain that we designated Hos:ZFDM- Lepr fa (ZFDM). (hindawi.com)
  • spontaneously
  • Numerous reports have shown that natriuretic response to the exogenously infused or endogenously produced dopamine is blunted in spontaneously hypertensive rats (SHR), 10,11 ⇓ owing to a defective D1 receptors in proximal tubules. (ahajournals.org)
  • Thus
  • Thus, the improved glucose tolerance in 50:50 rats is attributable to, at least in part, improved insulin action in muscle, and CLA effects cannot be explained simply by reduced food intake. (diabetesjournals.org)
  • unlike
  • However, unlike liraglutide-treated rats, NRTN-mediated improvements were not associated with reduced body weight or food intake. (diabetesjournals.org)
  • pancreatic
  • Linoleic-acid-fed rats (PL and SL) exhibited reduced insulin-immunoreactive staining of the pancreatic islets, enhanced macrophage infiltration in adipose tissue, and an elevated plasma tumor necrosis factor-alpha concentration when compared with oleic-acid-fed rats (PO and SO). (biomedsearch.com)
  • Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets. (diabetesjournals.org)
  • PPAR
  • We reported induction of aP2 gene expression in adipose tissue of CLA-treated ZDF rats and activation PPAR-γ response elements by CLA in vitro ( 4 ). (diabetesjournals.org)
  • absent
  • In our ZF rat colony, we incidentally found fa/fa homozygous male rats having reproductive ability, which is generally absent in these animals. (hindawi.com)
  • In the isolated proximal tubules obtained from untreated lean rats, dopamine caused concentration-dependent inhibition of the Na,K-ATPase activity, but this inhibitory effect was absent in untreated obese rats. (ahajournals.org)