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  • Lipid
  • Lipid analysis demonstrates a disturbed fatty acid composition of epidermal ceramides, in particular a decrease in the C26:0 and C26:0-OH fatty acid substitutes. (uniprot.org)
  • The α/β hydrolase CGI-58 and peroxisomal transport protein PXA1 coregulate lipid homeostasis and signaling in Arabidopsis. (semanticscholar.org)
  • Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). (abcam.com)
  • Pharmacologic blockade of FATPs with the small-molecule inhibitor Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion. (aacrjournals.org)
  • In liver PPARα is critical for the coordinate transcriptional activation of genes involved in lipid catabolism, including cellular fatty acid uptake and activation, mitochondrial β-oxidation, peroxisomal fatty acid oxidation, ketone body synthesis, fatty acid elongation and desaturation, and apolipoprotein synthesis ( 35 , 37 ). (physiology.org)
  • Thus, lauroyl-CoA is considered to be a fatty ester lipid molecule. (hmdb.ca)
  • Collectively, these findings support the notion that increased lipid or fatty acid accumulation within the myocyte leads to structural and mechanical changes in the heart that compromise pump function. (ahajournals.org)
  • Excess lipid in the heart is stored in droplets as neutral triglyceride, 16 which is synthesized from fatty-CoA and diacylglycerol (DAG) in a reaction that is catalyzed by diacylglycerol acyl transferase (DGAT). (ahajournals.org)
  • We adapted the biophysical properties of hyaluronic acid-based hydrogels to support the differentiation of white adipose tissue-derived multipotent stem cells (ADMSCs) into lipid-accumulating, UCP1-expressing beige adipose tissue. (diabetesjournals.org)
  • dietary fatty
  • In order to investigate the genetic pathways that mediate the physiological effects of dietary fatty acids, we have developed a method to supplement the C. elegans diet with unsaturated fatty acids. (jove.com)
  • In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). (abcam.com)
  • PPAR
  • The peroxisome proliferator-activated receptor alpha (PPARα) is a fatty acid-activated transcription factor that governs a variety of biological processes. (physiology.org)
  • binds
  • p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. (uniprot.org)
  • esters
  • RPE65, which catalyzes isomerization of all- trans retinyl fatty acid esters to 11- cis -retinol (11 c ROL) in the visual cycle, controls the rhodopsin regeneration rate and photoreceptor susceptibility to light-induced degeneration. (jneurosci.org)
  • vitro
  • These studies identified two compounds, 5′-bromo-5-phenyl-spiroij3H- 1,3,4-thiadiazole-2,3′-indoline]-2′-one), now referred to as Lipofermata, and 2-benzyl-3-(4-chlorophenyl)-5- (4-nitrophenyl)pyrazoloij1,5-a]pyrimidin-7IJ4H)-one, now called Grassofermata, that are effective fatty acid transport inhibitors both in vitro using a series of model cell lines and in vivo using a mouse model. (unl.edu)
  • In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. (uniprot.org)
  • amino acid
  • It always involves more than one amino acid and includes all residues involved in nucleotide-binding. (uniprot.org)
  • 2-Methylbutyryl-CoA dehydrogenase deficiency, also called 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency or MBHD, is an inherited disorder in which the body is unable to process the amino acid isoleucine properly. (hmdb.ca)
  • phospholipids
  • excess dietary nutrients [e.g., triacylglycerides (TAGs), carbohydrates, and phospholipids] consumed during periods of feeding are transported to and stored at specific fat storage sites. (physiology.org)
  • Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. (abcam.com)
  • maternal
  • Adolescents had lower docosahexaenoic acid (DHA, 22:6 n -3) and total n -3 FA levels in maternal erythrocytes and placenta, but these were not different in fetal erythrocytes. (mdpi.com)
  • mRNA
  • de Sousa AR, Penalva LO, Marcotte EM, Vogel C (2009) Global signatures of protein and mRNA expression levels. (springer.com)
  • obesity
  • Cardiovascular disease and heart failure are leading complications in patients with type 2 diabetes, prediabetes, and obesity in whom circulating fatty acid (FA) levels are commonly elevated. (diabetesjournals.org)
  • vivo
  • While several classes of compounds were identified as potential inhibitors of fatty acid transport, in vivo studies using a mouse model failed to provide evidence these compounds were effective in blocking or attenuating fatty acid transport. (unl.edu)
  • In an ex vivo experiment using isolated upper small intestine, oleic acid induced only a slight increase in GIP release, which was markedly enhanced by coadministration of bile and oleic acid together with attenuated GIP response in the FABP5 −/− sample. (physiology.org)
  • composition
  • We also describe a gas chromatography protocol to monitor the changes in fatty acid composition that occur in supplemented worms. (jove.com)