• In white adipocytes, mRNA expression of various fat storage-promoting enzymes such as lipoprotein lipase, acetyl-CoA carboxylase α, fatty acid synthase, and stearoyl-CoA desaturase-1 was markedly increased, while that of the rate-limiting step in fat oxidation, carnitine palmitoyl transferase-1α, was decreased. (jci.org)
  • Early investigations were focused on the 10-kDa ACBPs from mammals and yeast, and from these studies the 10-kDa ACBP has been implicated in biological roles ranging from acyl-CoA transport, maintenance of acyl-CoA pools within the cell and in the protection of acyl-CoAs in the cytosol from enzymes including acyl-CoA hydrolase, acetyl-CoA carboxylase and acyl-CoA synthetase [reviewed in 3]. (aocs.org)
  • Expression of sterol regulatory element binding protein 1 (SREBP-1), ATP-citrate lyase (ACL), fatty acid synthase (FAS), malic enzyme (ME), acetyl-CoA carboxylase (ACC), and stearoyl-CoA (?9) desaturase 1 (SCD1) genes in ad lib birds declined from their highest levels just prior to photo-stimulation to reduced levels as the birds came into and maintained egg production. (usda.gov)
  • This study reports a 22-bp nucleotide insertion-deletion (indel) genetic polymorphism that may be causally related to the control of gene expression of the fatty acid desaturases, enzymes that control the biosynthesis of long-chain polyunsaturated fatty acids (LCPUFA) from 18-carbon PUFA. (fatsoflife.com)
  • Long-chain polyunsaturated fatty acids (PUFA) of the ω3- and ω6-series are essential for a number of cellular functions such as maintaining membrane fluidity, providing substrates for eicosanoid signaling, modification of ion channels and regulation of gene expression. (axonmedchem.com)
  • Cytochrome p450-dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids. (springer.com)
  • Understanding their requirement for long-chain polyunsaturated fatty acids (LC-PUFA) and the biochemistry of the enzymes and biosynthetic pathways required for fatty acid synthesis is important and highly relevant in current aquaculture. (afpm.org.my)
  • The most important feature that distinguishes fish oil from the fats of other living things is the long-chain polyunsaturated fatty acids. (questionsonislam.com)
  • In biochemistry and nutrition, a polyunsaturated fat is a fat that contains a polyunsaturated fatty acid (abbreviated PUFA ), which is a subclass of fatty acid characterized by a backbone with two or more carbon-carbon double bonds . (wikipedia.org)
  • Several single-nucleotide polymorphisms (SNPs) that may affect long-chain polyunsaturated fatty acid (LCPUFA) biosynthesis, the distribution of dietary PUFA, and their functional effects have been described in recent years (see this Guest Article ). (fatsoflife.com)
  • Role of dietary polyunsaturated fatty acids (PUFA) on tumorigenesis. (springer.com)
  • This study investigates this mechanism by measuring the effect of exogenous DHA and eicosapentaenoate (EPA) supplementation on fatty acid composition and metabolism, as well as on metabolic enzyme expression, in a cell culture model of CF. We found that both DHA and EPA suppress the expression and activity ofΔ5- and Δ6-desaturases, leading to decreased flux through the n-3 and n-6 PUFA metabolic pathways and decreased production of AA. (greenmedinfo.com)
  • Theseresults indicate that the fatty acid abnormalities of CF are related to intrinsic alterations of PUFA metabolism and that they may be reversed by supplementation with DHA and EPA. (greenmedinfo.com)
  • Most gnathostome vertebrates have two fatty acid desaturase (fads) genes with known functions in LC-PUFA biosynthesis and termed fads1 and fads2. (afpm.org.my)
  • Therefore, rainbow trout have two fads2 genes that encode proteins with Δ5 and Δ6 desaturase activities, respectively, which enable this species to perform all the desaturation steps required for the biosynthesis of LC-PUFA from C18 precursors. (afpm.org.my)
  • Studies on polymorphisms found in one cluster of closely-located genes coding for fatty acid desaturases (FADS), enzymes that play an important role in the biosynthesis of both omega-6 and omega-3 LCPUFA, are providing an interesting perspective on the interaction between traditional diets and the population genetic history of humans. (fatsoflife.com)
  • There is a growing body of evidence in both human and animal studies that indicates that n-3 LcPUFAs inhibit inflammation by altering the transcription of key inflammatory genes and by competing with the n-6 LcPUFA, arachidonic acid (ARA), for key enzymes participating in pro-inflammatory eicosanoid biosynthesis (Figure 1 ) [ 19 , 20 ]. (biomedcentral.com)
  • Article expressing two closely related plant FAD3 genes in yeast cells and found that their enzymes produced significantly different amounts of omega-3 fatty acids and that these differences correlated to differences in rates of protein turnover. (unt.edu)
  • The expression of ω-6 FAD, ω-3 FAD and SAD were inconsistent with the accumulation of oleic acid (C18:1), linoleic acid (C18:2) and alpha-linolenic acid (C18:3), suggesting that these genes may be regulated indirectly by phosphate availability via post-transcriptional or post-translational mechanisms. (afpm.org.my)
  • Nevertheless, both conditions shared similarities, as the modifications of the fatty acid insaturation profile and the expression of desaturase genes. (hal.science)
  • Theca cells are the sole ovarian site of synthesis of DHEA, which is both a precursor of androstenedione and an essential ligand for peroxisome proliferator-activated receptor alpha (PPARα), the key promoter of genes affecting fatty acid metabolism and fat transport and genes critical to mitochondrial function. (biomedcentral.com)
  • Hepatic expression of fatty acid binding protein (FABP), very low density apolipoprotein II (ApoVLDL-II) and apolipoprotein B (ApoB) genes increased in both ad lib and restricted breeders following photo-stimulation, whereas apolipoprotein A1 (ApoA1) gene expression declined in both groups. (usda.gov)
  • Abdominal fat pad weights were significantly higher in the ad lib as compared to restricted birds following photo-stimulation and the expression of lipoprotein lipase (LPL) in this tissue showed a similar pattern of expression to that observed for the hepatic lipogenic enzyme genes. (usda.gov)
  • Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)
  • By comparison, we found that various genes associated with acyl editing, fatty acid β-oxidation, triacylglycerol assembly and oil-body formation had greater expression levels at middle developmental stage (38 DAP), which are consistent with the fast accumulation of EFA in V. galamensis developing seed, implying their fundamental roles in EFA production. (researchsquare.com)
  • Regulatory Function of Δ6 Desaturase - Key Enzyme of Polyunsaturated Fatty Acid Synthesis. (wikipedia.org)
  • However, as a compensatory response to reduce altered catabolism/ROS production, anabolic enzymes expression levels are also increased, resulting in higher gluconeogenesis and lipid synthesis. (elifesciences.org)
  • Acyl-CoA Δ11 desaturase is one of the fatty acid desaturases that are key enzymes in the synthesis pathway of unsaturated fatty acids. (zgswfz.com.cn)
  • ATP-citrate lyase (ACLY), the first-step rate-controlling enzyme in lipid synthesis, is elevated in colon cancer. (biomedcentral.com)
  • ATP-citrate lyase (ACLY), an enzyme that generates acetyl-CoA from citrate, is the first-step rate-controlling enzyme responsible for the lipid synthesis [ 13 ]. (biomedcentral.com)
  • The formation of fat synthesis mechanisms in fish cells and the enzymes involved there through aprocess based on coincidences is impossible. (questionsonislam.com)
  • Individuals with a genetic predisposition to high cholesterol can be especially vulnerable to metabolic syndrome, but researchers have now found that blocking the enzyme stearoyl-CoA desaturase-1, which helps synthesize unsaturated fatty acids, greatly improves the profile of FH-mice affected by metabolic syndrome. (sciencedaily.com)
  • As part of this process, they need to maintain the right balance of saturated and unsaturated fatty acids, which requires an enzyme called stearoyl-CoA desaturase (SCD). (mit.edu)
  • In living organisms, polyunsaturated fatty acids, more than other lipids, are affected by lipid peroxidation , which is the chain of reactions that leads to the oxidative degradation of lipids. (wikipedia.org)
  • The model enzymes include soluble methane monooxygenase (sMMO) that oxidizes methane to methanol and integral membrane desaturases (IMD) that oxidatively transform fatty acids to desaturated and hydroxylated lipids. (auburn.edu)
  • Serum fatty acids and other serum lipids(triglycerides and total, HDL and LDL cholesterol), as well as markers of inflammation (leptin, and C-reactive protein) and glucose regulation (glucose and hemoglobin A1c) were assessed from fasting participants at baseline and after the intervention. (biomedcentral.com)
  • Fatty acids, one of the most complex categories of lipids, are typically a linear chain of carbon atoms in shape, which are classified based on the number of carbon atoms, the number of double bonds, and the position of the first double bond. (omicsonline.org)
  • None of these small polymorphisms can be clearly assigned to changes in the amino acid sequence of the FADS enzymes, and are believed to mostly influence the regulation of gene expression. (fatsoflife.com)
  • The biosynthesis of n-6 and n-3 PUFAs proceeds in parallel pathways utilizing the same set of fatty acid desaturase (FADS) and elongase (ELOVL) enzymes. (biomedcentral.com)
  • Additionally, the expression of some fat storage enzymes was decreased in ghrelin-deficient mice, which led us to conclude that central ghrelin is of physiological relevance in the control of cell metabolism in adipose tissue. (jci.org)
  • Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)
  • Most people don't obtain sufficient quantities of it owing to dietary deficiency, and also because the enzyme in the body governing its metabolism becomes less active with age. (lifeextension.com)
  • Metabolism reprogramming provides sufficient energy, amino acids, ribose, phospholipids and other macromolecules to meet demands for rapid proliferation [ 8 ], and it might play a critical role during the process of tumor metastasis. (biomedcentral.com)
  • Among them, the methotrexate inhibit the dihydrofolate reductase enzyme involved in the C1 metabolism and induced a TAG accumulation up to 15 times the control. (hal.science)
  • Adequate Magnesium is required to metabolize fatty acids via the magnesium dependent delta desaturase enzyme pathways. (brainchildnutritionals.com)
  • Here, transcriptome analysis and fatty acid profiling from developing V. galamensis seeds were integrated to uncover the critical metabolic pathways responsible for high EFA accumulation and identify the targets that could be used in assembly of EFA biosynthesis pathway in existing oilseed crops. (researchsquare.com)
  • He also received the "Supelco AOCS Research Award" from the American Oil Chemists' Society, in Baltimore, US, in 1990 In 2001, he won the TWAS Basic Medical Sciences award for leading a research on the resolution of the mechanism of polyunsaturated fatty acid biosynthesis in animals and their regulation by dietary components and hormones and their biochemical and physiological effects. (wikipedia.org)
  • The polymorphism has a significant effect on baseline arachidonic acid levels, and on the product-precursor relationship for the omega-6 LCPUFA biosynthesis pathway. (fatsoflife.com)
  • The enzyme participates in the menthol-biosynthesis pathway of Mentha plants. (enzyme-database.org)
  • cDNA cloning and in situ hybridization of Δ11-desaturase, a key enzyme of pheromone biosynthesis in Ostrinia scapulalis (Lepidoptera:Crambidae)[J]. Journal of Insect Physiology, 2006, 52(5):430-435. (zgswfz.com.cn)
  • Furthermore, the biochemical implications of the indel polymorphism were determined by evaluating the fatty acid composition of red blood cell membrane phospholipids as a long-term marker for LCPUFA formation. (fatsoflife.com)
  • These results indicate that phenol adaptation affected mycolic acid membrane composition. (biomedcentral.com)
  • Our results suggest that the alteration of the mycolic acid and phospholipid membrane composition may be a strategy of R. opacus for phenol tolerance. (biomedcentral.com)
  • Fatty acids specifically related to the anisotropic properties of plasma membrane from rat urothelium. (springer.com)
  • Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
  • Dietary fatty acids and membrane protein function. (springer.com)
  • The aim of this review is to highlight current insights into the roles of choline and docosahexaenoic acid (DHA) in maternal and infant nutrition, with special emphasis on dietary recommendations, gaps in dietary intake, and synergistic implications of both nutrients in infant brain and eye development. (mdpi.com)
  • Objective】D-6-fatty acid desaturase 2 (FADS2) is one of the key limiting enzymes in the conversion of dietary essential 18 carbon PUFAs (18C-PUFAs) such as linoleic acid (LNA,C18:2n-6) to γ-linolenic acid (GLA, 18:3n6), eicosapentaenoic acid (EPA, C20:5n3) and docosahexaenoic acid (DHA, C22:6n3). (chinaagrisci.com)
  • Plants produce PUFAs from oleic acid . (wikipedia.org)
  • Desaturases convert oleic acid into linolenic acid the precursor to alpha-linoenic acid , gamma-linolenic acid , and eicosatrienoic acid . (wikipedia.org)
  • 10] Michaud M R, Denlinger D L. Oleic acid is elevated in cell membranes during rapid cold-hardening and pupal diapause in the flesh fly, Sarcophaga crassipalpis [J]. Journal of Insect Physiology, 2006, 52(10):1073-1082. (zgswfz.com.cn)
  • The dominant fatty acids in M. gracile, pamitic acid (C16:0) and oleic acid (C18:1) which constitute more than 81% of the total fatty acids remained relatively high and constant across all phosphate concentrations. (afpm.org.my)
  • Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
  • Effect of dietary fatty acids on inflammatory gene expression in healthy humans. (springer.com)
  • The enzyme that produces GLA from dietary fats decreases in activity with aging and in certain chronic conditions. (lifeextension.com)
  • Aging results in defects occurring in human enzymes responsible for producing anti-inflammatory molecules from dietary fats. (lifeextension.com)
  • Chemical structure of the polyunsaturated fatty acid linoleic acid . (wikipedia.org)
  • 3D representation of linoleic acid in a bent conformation . (wikipedia.org)
  • The illustration below shows the omega-6 fatty acid, linoleic acid . (wikipedia.org)
  • N3-FA, which include α-linoleic acid, eicosapentaenoic acid (EPA) and docosapentaenoic acid (DHA) ( Figure 1 ), have been subject of intense investigation in the recent years for expected benefits in delaying cognitive decline. (omicsonline.org)
  • The 22-base pair sequence (named rs66698963) is likely to affect the activity of a nearby sterol response element (a binding site for sterol response element binding protein, which is a class of DNA-binding transcription factors involved in sterol and fatty acid homeostasis). (fatsoflife.com)
  • protein_coding" "Cz02g09110.t1","No alias","Chromochloris zofingiensis","2-hydroxy-palmitic acid dioxygenase Mpo1-like [Interproscan]. (ntu.edu.sg)
  • Nasu, S., Wicks, F.D. and Gholson, R.K. L -Aspartate oxidase, a newly discovered enzyme of Escherichia coli , is the B protein of quinolinate synthetase. (enzyme-database.org)
  • The full-length mRNA contained 1578 nucleotides with an open reading frame of 1365 nucleotides that encoded a 454 amino acid protein with a predicted molecular weight of 52.48 kDa. (afpm.org.my)
  • Expression of the fasd2b in yeast generated a protein that was found to specifically convert eicosatetraenoic acid (20:4n-3) to eicosapentaenoic acid (20:5n-3), and therefore functioned as a Δ5 desaturase. (afpm.org.my)
  • Even if amino acids are biologically present in a place, no protein can form spontaneously. (questionsonislam.com)
  • This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. (springer.com)
  • Another way GLA exerts a beneficial effect is to compete with harmful arachidonic acid or AA. (lifeextension.com)
  • When one eats foods like meat or egg yolk, excess levels of arachidonic acid accumulate that is then broken down into toxic byproducts by the enzymes cyclooxygenase-2 (COX-2) and lipoxygenase (LOX). (lifeextension.com)
  • Although the treatment did not affect hepatic inflammation or endoplasmic reticulum stress, it inhibited the expression of the enzymes for gluconeogenesis and lipogenesis in the liver. (deepdyve.com)
  • Chemical structure of α-linolenic acid (ALA), an essential omega−3 fatty acid. (wikipedia.org)
  • The BO combination was enriched in alpha-linolenic, gamma-linolenic, and stearidonic acids and the FO in eicosapentaenoic and docosahexaenoic acids. (biomedcentral.com)
  • Discover the little-known benefits of gamma linolenic acid or GLA . (lifeextension.com)
  • There is one omega-6, however, called gamma linolenic acid (GLA) with an impressive set of disease-fighting powers. (lifeextension.com)
  • In this article, we uncover the latest research on gamma linolenic acid and provide compelling evidence for its ability to combat a range of chronic age-related disorders-alone and in combination with EPA/DHA. (lifeextension.com)
  • Gamma linolenic acid (GLA) is an unusual omega-6 fatty acid with powerful implications for human health. (lifeextension.com)
  • GLA (gamma linolenic acid) is a plant-derived omega-6 most abundant in seeds of an Eastern flower known as borage. (lifeextension.com)
  • 2010). Vertebrate fatty acyl desaturase with Δ4 activity. (springer.com)
  • The findings also uncover other metabolic abnormalities, including increased fatty acid uptake and markedly increased retroconversion of DHA to EPA, in CF cells. (greenmedinfo.com)
  • Lipases , a family of enzymes, show potential as mild and green catalysts for the production of PUFAs from triglycerides. (wikipedia.org)
  • Polyunsaturated fatty acids in culinary oils undergo oxidative deterioration at temperatures of 150 °C (302 °F). The heating causes a free radical chain reaction, which oxidizes the PUFAs into hydroperoxide , which further decomposes into a complex mixture of secondary products. (wikipedia.org)
  • Ingestion of polyunsaturated fatty acids (PUFAs) has been proposed to influence several chronic diseases including coronary heart disease (CHD) and type-2 diabetes (T2D). (biomedcentral.com)
  • HO-RBO has higher oxidative stability and could be directly used in the food industry without hydrogenation, and is hence free of trans fatty acids . (afpm.org.my)
  • The chain reaction mechanism of lipid peroxidation primarily targets polyunsaturated fatty acids due to their multiple double bonds and the presence of reactive hydrogen atoms in the methylene bridges (-CH2-) between these bonds. (wikipedia.org)
  • Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). (springer.com)
  • While both of these diets reduce the amount of sugar available to tumors, the researchers found that only the calorically restricted diet reduced the availability of fatty acids, and this was linked to a slowdown in tumor growth. (mit.edu)
  • In contrast to normal cells mainly taking up fatty acids from the environment, tumor cells depend heavily on de novo lipogenesis [ 12 ]. (biomedcentral.com)
  • Angiotensin-Converting Enzyme Ins/Del Polymorphism and Body Composition: The Intermediary Role of Hydration Status. (cdc.gov)
  • Fatty acid desaturation is a highly complex and regulated process involving different molecular and genetic actors. (researchgate.net)
  • The enzyme is a member of the succinate dehydrogenase/fumarate-reductase family of enzymes [5]. (enzyme-database.org)
  • The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass. (cdc.gov)
  • The entries below are proposed additions and amendments to the Enzyme Nomenclature list . (enzyme-database.org)
  • Patients and models of cystic fibrosis (CF) exhibit consistent abnormalities of polyunsaturated fatty acid composition, including decreased linoleate (LA) and docosahexaenoate (DHA) and variably increased arachidonate (AA), related in part to increased expression and activity of fatty acid desaturases. (greenmedinfo.com)
  • Conclusion】The SNPs in the 3' untranslated regions of FADS2 gene have significant genetic effects on composition of fatty acids in milk, but further investigation will be required to elucidate the biological and practical relevance of these SNPs. (chinaagrisci.com)
  • Effects of SNPs in the 3' Untranslated Regions of FADS2 on the Composition of Fatty Acids in Milk of Chinese Holstein[J]. Scientia Agricultura Sinica, 2016, 49(11): 2194-2202. (chinaagrisci.com)
  • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (ox.ac.uk)
  • Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. (ox.ac.uk)
  • The expression of omega-3 fatty acid desaturase (ω-3 FADi1, ω-3 FADi2) and omega-6 fatty acid desaturase (ω-6 FAD) was increased under phosphate limitation, especially at ≤ 12.5% phosphate, whereas levels of streoyl-ACP desaturase (SAD) transcripts were relatively unchanged across all phosphate concentrations. (afpm.org.my)
  • Because small alterations in enzyme concentrations or activities can cause large changes in overall metabolite levels, the metabolome can be regarded as the amplified output of a biological system. (biomedcentral.com)
  • Amino acid sequence analysis showed that CsFadΔ11 contains three histidine boxes and six transmembrane domains, which are composite characteristics of a fatty acid desaturase. (zgswfz.com.cn)
  • [ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)
  • Photosynthetically active FNR (sometimes classified as autotrophic) is a member of the family of soluble monomeric enzymes that contain non-covalently bound FAD (flavin adenine dinucleotide) as the prosthetic group 3 . (nature.com)
  • Magnesium is known as the "anti-stress" mineral, and also one of the body's premiere biochemical enzyme catalysts. (brainchildnutritionals.com)
  • Supplemental GLA can counteract this acquired enzyme defect, supplying vital biochemical precursors with powerful anti-inflammatory effects. (lifeextension.com)
  • Polyunsaturated fatty acids are precursors to and are derived from polyunsaturated fats , which include drying oils . (wikipedia.org)
  • The position of the carbon-carbon double bonds in carboxylic acid chains in fats is designated by Greek letters . (wikipedia.org)
  • Fatty acids are the simplest fats synthesized in cells and they participate in the structure of complex fats that are to perform specific tasks in cells. (questionsonislam.com)
  • In photosynthesis, final electron transfer from ferredoxin to NADP + is accomplished by the flavo enzyme ferredoxin:NADP + oxidoreductase (FNR). (nature.com)
  • Interaction with C4 dicarboxylic acids and identification of a novel L -aspartate: fumarate oxidoreductase activity. (enzyme-database.org)
  • GLA inhibits these destructive enzymes, thus impeding the ability of AA to convert to detrimental inflammatory molecules (like leukotriene B4). (lifeextension.com)
  • Key enzymes are called fatty acid desaturases , which introduce additional double bonds. (wikipedia.org)
  • Ultimally, the fatty acid desaturase enzymes are responsible for the introduction of double bonds at different positions of specific substrates, resulting in a wide variety of mono- and poly-unsaturated fatty acids. (researchgate.net)
  • The trans monounsaturated C20 species elaidic acid can be prepared in this way. (wikipedia.org)
  • The number and amount of fatty acids in fish oil varies according to many factors such as species, season, habitat and nutritional status. (questionsonislam.com)
  • 70%) of vernolic acid ( cis -12-epoxyoctadeca- cis -9-enoic acid), an unusual epoxy fatty acid (EFA) with multiple industrial applications. (researchsquare.com)
  • Our genetic, pharmacological, and behavioral analyses suggest that in sir-2.1(0) and older wild-type males, enhanced catabolic enzymes expression, coupled with the reduced expression of ROS-scavengers contribute to the behavioral decline. (elifesciences.org)
  • DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. (greenmedinfo.com)
  • In this study, the effects of limited and excess phosphate on biomass content, oil content, fatty acid profile and the expression of three fatty acid desaturases in Messastrum gracile SE-MC4 were determined. (afpm.org.my)
  • Fd acts simultaneously as a bottleneck and as a hub which distributes high-energy electrons to a multitude of enzymes, which include nitrite reductase, sulphite reductase, fatty acid desaturase, glutamine-2-oxoglutarate amino transferase (GOGAT), redox complexes such as cytochrome b 6 /f for cyclic electron transport (CET) and thioredoxins 2 . (nature.com)
  • The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase. (expasy.org)
  • In rainbow trout, a fads2 cDNA had been previously cloned and found to encode an enzyme with Δ6 desaturase activity. (afpm.org.my)
  • En condition physiologique, le flux de lipide est naturellement orienté vers la synthèse de lipides membranaires qui permettent de créer de nouvelles membranes lors de la division cellulaire. (hal.science)