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  • PUFAs
  • Chlorella vulgaris has the gene of n-3 fatty acid desaturase (CvFad3), which can synthesize the precursor of n-3 polyunsaturated fatty acids (PUFAs) or convert n-6 to n-3 PUFAs. (doaj.org)
  • This study demonstrates that the CvFad3 gene can dramatically balance the ratio of n-6/n-3 PUFAs and may provide an effective approach to the modification of the fatty acid composition of mammalian cells, also providing a basis for potential applications of its transfer in experimental and clinical settings. (doaj.org)
  • Among these lipids, the brain is particularly enriched with polyunsaturated fatty acids (PUFAs) represented by the omega-6 (ω6) and omega-3 (ω3) series. (frontiersin.org)
  • Potential mechanisms involved in the neuroprotective and corrective activity of ω3 PUFAs in the brain are discussed, in particular the sensing activity of free fatty acid receptors and the activity of the PUFAs-derived endocannabinoid system and the hypothalamic-pituitary-adrenal axis. (frontiersin.org)
  • delta
  • Plant stearoyl-acyl-carrier-protein desaturase ( EC:1.14.19.1 ) [ PMID: 2006187 ], this enzyme catalyzes the introduction of a double bond at the delta(9) position of steraoyl-ACP to produce oleoyl-ACP. (ebi.ac.uk)
  • Cyanobacterial DesA [ PMID: 2118597 ], an enzyme that can introduce a second cis double bond at the delta(12) position of fatty acid bound to membranes glycerolipids. (ebi.ac.uk)
  • While C16:1n7 and/or C18:1n9 were positively associated with CVD risk factors, the delta 9 desaturase activity index (D9D) (C18:1n9/C18:0) was only significantly increased in high quartile groups for TG and blood pressures ( p = 0.001, p = 0.002 or p = 0.003). (biomedcentral.com)
  • acyl
  • Stearoyl-acyl-carrier-protein desaturase from higher plants is structurally unrelated to the animal and fungal homologs. (ebi.ac.uk)
  • The soluble fatty acid desaturases, such as the plant Acyl-carrier-protein (ACP) desaturase family, use acyl carrier protein thioesters as substrates, and use ferredoxin oxidoreductase and ferredoxin as electron donors. (springeropen.com)
  • cell fatty acid
  • The objective of the present study was to examine whether the CvFad3 gene from C. vulgaris can be functionally and efficiently expressed in human breast cancer cells and whether its expression can exert a significant effect on cell fatty acid composition. (doaj.org)
  • Secondary endpoints will include rectal epithelial cell expression of COX-2 and 15-PGDH, rectal cell production of PGE2 and PGE3, rectal cell fatty acid concentrations, as well as, changes from baseline in biomarkers of inflammation (C-reactive protein), adipokines (leptin, adiponectin), and markers of insulin sensitivity (HOMA-IR). (knowcancer.com)
  • fish oil supplementation
  • Our specific aims i nclude: 1) to determine the efficacy of fish oil supplements on rectal epithelial cell proliferation indexes and markers of rectal crypt apoptosis, and 2) to determine the effect of genetically-determined fatty acid desaturase 1 activity on fish oil supplementation for colorectal cancer chemoprevention. (grantome.com)
  • To date, no previously published studies have investigated how genetic variants that influence fatty acid desaturase activity might modify the beneficial effects of fish oil supplementation. (knowcancer.com)
  • to determine the effect of genetically determined fatty acid desaturase activity on fish oil supplementation for markers of colorectal cancer risk. (knowcancer.com)
  • membrane lipids
  • the phase transition temperature of lipids of cellular membranes being dependent on the degree of unsaturation of fatty acids of the membrane lipids. (ebi.ac.uk)
  • supplementation
  • These findings suggest that high levels of 18:3n-3 supplementation may be necessary to exceed the []6-desaturase K[] and significantly affect physiological levels of n-3 LCPUFA in the dog. (tamu.edu)
  • substrate
  • Using 18:3n-3 as substrate, the apparent []6-desaturase maximal velocity was 50.9 pmol/min/mg protein and using 18:2n-6 substrate, the maximal velocity was 5.4 pmol/min/mg protein. (tamu.edu)
  • Possible explanations include the presence of high endogenous fatty acid concentration (especially 18:2n-6) inherent in the dog liver microsome preparations providing high amounts of competitive non-radioactively labeled substrate, or methodological differences used in other studies. (tamu.edu)
  • histidine
  • FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. (nih.gov)
  • In addition, most of fatty acid desaturases share three highly conserved histidine boxes: ʻHXXXXHʼ, ʻHXXHHʼ and ʻQXXHHʼ included in the fatty acid desaturases domain. (springeropen.com)
  • Sayanova, O., Shewry, P. R., and Napier, J. A (1999) Histidine-41 of the cytochrome b 5 domain of the Borage Δ 6 -desaturase is essential for enzyme activity. (springer.com)
  • protein
  • Secondary endpoints will include rectal epithelial cell expression of COX-2 and 15-PGDH, rectal cell production of PGE2 and PGE3, rectal mucosal tissue levels of fatty acids, and changes in biomarkers of inflammation (C-reactive protein), adipokines (leptin, adiponectin), and markers of insulin sensitivity. (grantome.com)
  • FADS1 (Fatty Acid Desaturase 1) is a Protein Coding gene. (genecards.org)
  • Both induction of SCD1 protein and sensitivity to growth inhibition by SCD1 inhibition could be reversed by supplementing growth media with unsaturated fatty acids, the product of the enzymatic reaction catalyzed by SCD1. (aacrjournals.org)
  • variants
  • Recent genome-wide association and haplotype studies have demonstrated that up to 28% of the additive variance in tissue levels of ARA is explained by variants in a single gene, fatty acid desaturase 1 (FADS1). (grantome.com)
  • Homology
  • Homology modeling and docking studies of a Δ9-fatty acid desaturase from a Cold-tolerant Pseudomonas sp. (peerj.com)
  • In this paper we report homology modeling and docking studies of a Δ9-fatty acid desaturase from a Cold-tolerant Pseudomonas sp. (peerj.com)
  • The dmpCDEFG and pWWO xylGFJQK regions exhibit consistently high levels of nucleotide and amino acid homology to pDK1 xylGFJQK throughout the entire region. (unt.edu)
  • mRNA
  • When the expression of plastidial omega-3 desaturases was analysed, a transient accumulation of GmFAD7-2 mRNA was detected upon cold exposure in mature soybean trifoliate leaves while GmFAD7-1 transcripts remained unchanged. (csic.es)
  • The mRNA level of the plastid ω-3 desaturase gene increased to about 2-fold. (oup.com)
  • The mRNA level of the plastid ω-3 desaturase gene increased to about 2-fold that of unwounded controls at 12 h after a wounding treatment. (oup.com)
  • On the other hand, the mRNA level of the microsome ω-3 desaturase gene remained constant in the wounded leaves. (oup.com)
  • precursors
  • Fatty acids (FAs) serve many important physiological functions including energy reserves, structural components of cell membranes, precursors of eicosanoids, and regulators of gene expression. (hindawi.com)
  • Soybean
  • The objective of this research was to study whether this enzyme has a role in reducing the fatty acid levels in the soybean genotypes A5 and A23. (springer.com)
  • This study analysed the contribution of each omega-3 desaturase to the cold response in soybean. (csic.es)
  • significantly
  • plasma eicosapentaenoic acid and docosahexaenoic acid elevated in T2D patients, but significantly reduced in CAD patients. (nih.gov)
  • transgenic
  • The present invention is drawn to methods and compositions for the stable transformation of wheat with nucleic acid sequences of interest and the regeneration of fertile transgenic wheat plants. (google.com)
  • plastid
  • The amino terminal extension of the deduced amino acid sequence of this clone had a characteristic feature of the transit peptides of plastid-destined proteins. (oup.com)