Fatty acid composition fatty acid desaturases. Medical search. Frequent questions

In the biosynthesis of essential fatty acids, an elongase alternates with various desaturases (for example, Δ6-desaturase) repeatedly inserts an ethyl group, then forms a double bond. (wikipedia.org)
Enzymes involved in lipid biosynthesis are enriched at contacts and membrane lipid composition at contacts is distinct relative to surrounding membranes. (biorxiv.org)
This study compared the effect of incubation with 24:6ω-3 on the fatty acid composition of two related cell types, primary CD3+ T lymphocytes and Jurkat T cell leukemia, which differ in the integrity of the polyunsaturated fatty acid (PUFA) biosynthesis pathway. (soton.ac.uk)
reported that the cytochrome b5 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans (Zhang et al. (springeropen.com)
18 genes belonged to the acetyl-CoA carboxylase (ACC), malonyl-CoA:ACP transacylase (MCAT), ß-ketoacyl-ACP synthase (KAS), and fatty acyl-ACP thioesterase (FAT) gene families involved in fatty acid biosynthesis, and 16 genes belonged to the glycerol-3-phosphate acyltransferase (GPAT), diacylglycerol acyltransferase 3 (DGAT3), phospholipid:diacylglycerol acyltransferase (PDAT), FAD2, and lysophosphatidic acid acyltransferase (LPAAT) gene families playing important roles in triacylglycerol synthesis. (bvsalud.org)
Erratum: Serine/threonine Kinases Play Important Roles in Regulating Polyunsaturated Fatty Acid Biosynthesis in Synechocystis sp. (sciencegate.app)

Fish oils are sources of the long-chain omega-3s, eicosa-pentaenoic acid (EPA) and docosahexaenoic acid (DHA). (newhope.com)
Omega-3 (n-3) fatty acids, and the long-chain n-3 derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in particular, have been extensively researched for their nutritive effects. (edu.pl)
Furthermore, the levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were higher in treated cells than in control cells. (unboundmedicine.com)
Docosahexaenoic acid (DHA) is a structural constituent of membranes specifically in the central nervous system. (bioseek.eu)
Long chain polyunsaturated fatty acid (LC-PUFA), including docosahexaenoic acid (DHA) and arachidonic acid (AA), are incorporated into membrane phospholipids and, apart from their structural role in these membranes, they also act as precursors of autocoid signaling molecules (e.g., docosanoids) and as potent activators of a number of gene transcription factors (e.g., peroxisome proliferator activated receptors). (bioseek.eu)

Highly unsaturated fatty acids (HUFAs) are incorporated into phospholipids and participate in cell signaling. (wikipedia.org)
Circulating 15:0 and 17:0 (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesteryl esters (CE). (biomedcentral.com)
Cartwright I. J., A. G. Pockley, J. H. Galloway, M. Greaves, F. E. Preston (1985) The effects of dietary ω-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. (edu.pl)
Our aim was to study the influence of weight loss on the fatty acid (FA) composition of liver and erythrocyte phospholipids and oxidative stress status in obese, non-alcoholic, fatty liver disease (NAFLD) patients. (arasysperfector.com)
Cold acclimation of carp from 30°C to 10°C causes a restructuring of liver microsomal phospholipids characterised by increased proportions of monounsaturated fatty acid in phosphatidylcholine (PC) and phosphatidylethanolamine (PE). (silverchair.com)
Analysis of acyl distribution indicates that cold only caused the accumulation of monounsaturated fatty acids at the sn -1 and not at the sn -2 position of phospholipids. (silverchair.com)

These findings show exogenous 24:6ω-3 can be incorporated into primary human T lymphocytes and Jurkat cells and induces changes in fatty acid composition consistent with its conversion to 22:6ω-3 via a mechanism involving peroxisomal β-oxidation that is regulated independently from the integrity of the upstream PUFA synthesis pathway. (soton.ac.uk)
This study investigates this mechanism by measuring the effect of exogenous DHA and eicosapentaenoate (EPA) supplementation on fatty acid composition and metabolism, as well as on metabolic enzyme expression, in a cell culture model of CF. We found that both DHA and EPA suppress the expression and activity ofΔ5- and Δ6-desaturases, leading to decreased flux through the n-3 and n-6 PUFA metabolic pathways and decreased production of AA. (greenmedinfo.com)
Theseresults indicate that the fatty acid abnormalities of CF are related to intrinsic alterations of PUFA metabolism and that they may be reversed by supplementation with DHA and EPA. (greenmedinfo.com)
At the time of surgery, controls and obese patients exhibited a hepatic polyunsaturated fatty acid (PUFA) pattern that correlated with that of erythrocytes. (arasysperfector.com)
Docosapentaenoic acid (22:5n-3, n-3 DPA) is a n-3 polyunsaturated fatty acid (PUFA) found in fish oil, and has been reported to have health benefits. (unboundmedicine.com)

For the common fatty acids of the C18 variety, desaturases convert stearic acid into oleic acid. (wikipedia.org)
Other desaturases convert oleic acid into linolenic acid, which is the precursor to alpha-linolenic acid, gamma-linolenic acid, and eicosatrienoic acid. (wikipedia.org)
Δ9-desaturase, also known as stearoyl-CoA desaturase-1, is used to synthesize oleic acid, a monounsaturated, ubiquitous component of all cells in the human body, and the major fatty acid in mammalian adipose triglycerides, and also used for phospholipid and cholesteryl ester synthesis. (wikipedia.org)
Generally, the modern rapeseed varieties produce oil with less than 2% erucic acid, 5% to 8% saturated fats (mainly palmitic and stearic acids), 60% to 65% monounsaturated fats (mainly oleic acid) and 30% to 35% polyunsaturated fats (mainly linoleic and linolenic acids) [ 2 ]. (biomedcentral.com)

These data suggest that diet-induced mismatches between tumour fatty acid desaturation activity and the availability of specific fatty acid species determine whether low glycaemic diets impair tumour growth. (nature.com)
PPARalpha agonists affect both fatty acid elongation and desaturation pathways leading to changes in hepatic lipid composition. (oregonstate.edu)
known hemoproteins and does not require heme for electron trans- Most aerobic organisms synthesize heme by a multistep pathway port in the respiratory chain, protection against oxidative stress, or that is conserved in all three domains of life: bacteria, archaea, desaturation of fatty acids. (medicinelakex1.com)
Desaturation of the fatty acids in glycerolipids is catalyzed by acyl-lipid desaturase (Murata and Wada, 1995). (rehabsociety.org.hk)

Delta-9 desaturase (D9D) and D6D desaturase were estimated as product to precursor fatty acid ratios. (nel.edu)
In fruit flies, an enzyme called DESAT1, a delta-9-desaturase, is a key player in responses to temperature changes at both the cellular level, where it influences membrane fluidity by synthesizing monounsaturated fatty acids, and at the whole-organism level, where it controls temperature-influenced behaviors like mating. (asbmb.org)

arachidonic acid and adrenic acid (synthesized from linoleic acid). (wikipedia.org)
Bauman D.E., Corl B.A., Peterson D.G., The biology of conjugated linoleic acids in ruminants, in: Sébédio J.-L., Christie W.W., Adlof R. (Eds. (dairy-journal.org)
Chilliard Y., Ferlay A., Doreau M., Effect of different types of forages, animal fat or marine oils in cow's diet on milk fat secretion and composition, especially conjugated linoleic acid (CLA) and polyunsaturated fatty acids, Livest. (dairy-journal.org)
Chouinard P.Y., Corneau L., Butler W.R., Chilliard Y., Drackley J.K., Bauman D.E., Effect of dietary lipid source on conjugated linoleic acid concentrations in milk fat, J. Dairy Sci. (dairy-journal.org)
Dhiman T.R., Arnand G.R., Satter L.D., Pariza M.W., Conjugated linoleic acid content of milk from cows fed different diets, J. Dairy Sci. (dairy-journal.org)
Kelly M.L., Berry J.R., Dwyer D.A., Griinari J.M., Chouinard P.Y., van Amburgh M.E., Bauman D.E., Dietary fatty acid sources affect conjugated linoleic acid (CLA) concentrations in milk from lactating dairy cows, J. Nutr. (dairy-journal.org)
GLA is an anti-inflammatory compound that is found in very small amounts in some leafy greens and nuts, while the pro-inflammatory fats linoleic acid and arachidonic acid are present in ample amounts in vegetable oils and chicken, and eggs and meat, respectively. (lifeextension.com)
The body can make small amounts of GLA from linoleic acid. (lifeextension.com)

characterized 19 genes encoding fatty acid desaturases and analyzed their expression profiles in Gossypium raimondii under low temperature (Liu et al. (springeropen.com)

This body of evidence provides strong support for future studies to evaluate the effects of increasing dietary n-3 fatty acid status on CHD comorbidity and mortality in MDD patients. (hindawi.com)
As background, mammals are incapable of synthesizing n-3 fatty acids de novo and are therefore entirely dependent on dietary sources to procure and maintain adequate concentrations in peripheral and central phospholipid membranes. (hindawi.com)
We performed cross-sectional analyses in a subsample of 869 Dutch post-MI patients of the Alpha Omega Cohort who had data on dietary intake and circulating fatty acids. (biomedcentral.com)
The reason is that fatty acids primarily coming from exogenous sources are usually considered good candidates as biomarkers for intake [ 3 ] and more objective than self-reported dietary assessment. (biomedcentral.com)
Cats fed the CG-CO diet had the lowest concentrations of LCPUFAs, suggesting that dietary lipids and protein quality each influence fatty acid composition in tissues. (uaeu.ac.ae)
Conclusions and Clinical Relevance - These data provide direct evidence that dietary protein quality alters fatty acid composition of tissues during weight loss in cats. (uaeu.ac.ae)
2004). These include (i) defective dietary intake of n-3 LCPUFA and of their essential precursor a-linolenic acid (18: 3 n-3) (Baylin et al. (arasysperfector.com)

It is well accepted that foods prepared with long-chain polyunsaturated fatty acids have an increased vulnerability to rancidity, which is caused by oxidation, the chemical reaction of lipids with oxygen. (newhope.com)
We hypothesize that the composition of lipids plays an important role in phenol tolerance. (biomedcentral.com)
The Japanese Black breed is genetically predisposed to producing carcass lipids containing higher concentrations of monounsaturated fatty acids than other breeds. (animbiosci.org)
The hepatic fatty acid composition was analyzed using gas chromatography mass (GC-MS). The relative expression of lipids metabolism genes was analyzed using reverse transcriptase-polymerase chain reaction (RT-PCR). (biomedcentral.com)

Now, the team is going back a step further in the pathway leading to DESAT1 degradation, trying to understand how temperature changes are sensed inside the cell to lead to changes in fatty acid composition and consequent effects on the whole organism. (asbmb.org)

Long-chain n-3 fatty acids enhance neonatal insulin-regulated protein metabolism in piglets by differentially altering muscle lipid composition. (edu.pl)

a key enzyme for the synthesis of DHA and sapienic acid. (ocl-journal.org)
However, some researches revealed that the cytochrome b5 domain play a key role in the synthesis of unsaturated fatty acids as an electron donor to activate desaturase (Pereira et al. (springeropen.com)
Liver is the main organ for lipid uptake, de novo synthesis and fatty acid lipolysis [ 3 ]. (biomedcentral.com)
For example, acetyl-CoA carboxylase ( ACC ) converts the acetyl-CoA to malonyl-CoA, which is the direct carbon donor for de novo synthesis of fatty acid. (biomedcentral.com)
Stearoyl-CoA desaturase 1 ( SCD1 ) is a critical rate-limiting enzyme of de novo synthesis of monounsaturated fatty acids (MUFAs) [ 4 ]. (biomedcentral.com)
In vivo mitochondrial function [maximal ATP synthesis rate (ATPmax), ATPflux/O 2 (P/O)] was determined by 31 P-magnetic resonance spectroscopy and optical spectroscopy, and body composition was determined by dual-energy X-ray absorptiometry. (medscape.com)

Unsaturated fatty acids help maintain structure and function of membranes. (wikipedia.org)
Unsaturated fatty acids and their derived fats increase the fluidity of membranes. (wikipedia.org)
Unsaturated fatty acids, which contain one or more double bonds, are the major structural components of cell membranes. (springeropen.com)

Healthy fats such as gamma-linolenic acid (GLA) and omega-3s work by several pathways to reduce the dangers of inflammation throughout the body. (lifeextension.com)
Fatty acids are the simplest fats synthesized in cells and they participate in the structure of complex fats that are to perform specific tasks in cells. (questionsonislam.com)
The most important feature that distinguishes fish oil from the fats of other living things is the long-chain polyunsaturated fatty acids. (questionsonislam.com)

We show that loss of p97-UBXD8 results in perturbed contacts due to an increase in membrane lipid saturation via SREBP1 and the lipid desaturase SCD1. (biorxiv.org)
Our results suggest that contacts are exquisitely sensitive to alterations to membrane lipid composition and saturation in a manner that is dependent on p97-UBXD8. (biorxiv.org)
A rapidly emerging body of evidence suggests that membrane omega-3 (n-3) fatty acid deficiency is a preventable risk factor for both CHD [ 18 ] and MDD [ 19 ]. (hindawi.com)
According to localization and cofactor requirements, fatty acid desaturases have been broadly classified into two evolutionary groups: soluble and membrane-bound desaturases. (springeropen.com)
The membrane-bound fatty acid desaturases, which include Δ5-, Δ6-, Δ9-, Δ12- and Δ15-desaturase in the mammals, fungi, insects, higher plants and cyanobacteria, use fatty acids esterified to complex lipid as the substrate, and use cytochrome (cyt) b5 oxidoreductase and cyt b5 as electron donors. (springeropen.com)
These results indicate that phenol adaptation affected mycolic acid membrane composition. (biomedcentral.com)
Our results suggest that the alteration of the mycolic acid and phospholipid membrane composition may be a strategy of R. opacus for phenol tolerance. (biomedcentral.com)
Fadhlaoui M., Pierron F. , Couture P. (2018) Temperature and metal exposure affect membrane fatty acid composition and transcription of desaturases and elongases in fathead minnow muscle and brain, Ecotoxicology and Environmental Safety , 148, 632-643, doi: 10.1016/j.ecoenv.2017.10.040 . (u-bordeaux1.fr)
It differs from most FeS clusters in that two of the amino acid residues that This proton gradient across the thylakoid membrane creates a power, i.e. (rehabsociety.org.hk)

Two major QTLs, uuqA5-6 and uuqA5-7 , simultaneously affected the fatty acids, except C18:0, in most of environments, with the homologous genes fatty acid desaturase 2 ( FAD2 ) and glycerol-3-phosphate sn-2-acyltransferase 5 ( GPAT5 ) occurring in the confidence interval of uuqA5-6 , while phosphatidic acid phosphohydrolase 1 ( PAH1 ) was assigned to uuqA5-7 . (biomedcentral.com)

The aim of the study was to investigate the composition of FA in plasma cholesterol esters (CE) and phosphatidylcholine (PC) as well as indices of insulin resistance and oxidative stress in the patients with depressive disorder. (nel.edu)

Arachidonic acid (AA) is also the catalyst to the formation of the two main endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG). (wikipedia.org)
An omega-6 fat called arachidonic acid forms necessary pro -inflammatory substances like prostaglandin E2. (lifeextension.com)

Upregulation of stearoyl-CoA desaturase (SCD), which synthesises monounsaturated fatty acids, is required for cancer cells to proliferate in a lipid-depleted environment, and CR also impairs tumour SCD activity to cause an imbalance between unsaturated and saturated fatty acids to slow tumour growth. (nature.com)
JWFT normalized hepatic fatty acid composition of hyperlipidemia rats by up-regulating hepatic acetyl-CoA carboxylase ( ACC ), stearoyl-CoA desaturase 1 ( SCD1 ) and fatty acid synthase ( FAS ) gene expression, and down-regulating carnitine palmitoyl transferase-1 ( CPT1 ). (biomedcentral.com)

Alexander J. W (1998) Immunonutrition: the role of omega-3 fatty acids. (edu.pl)

With the advent of cooking and new mutations producing even more FADS2 , the brain reached its maximum size in Homo neanderthalensis , in a food ecosystem that provided favorable quantities of α-Linolenic acid and DHA. (ocl-journal.org)
A flurry of studies supports a role for gamma-linolenic acid to further suppress chronic inflammatory reactions. (lifeextension.com)
This article describes published scientific findings as to how gamma-linolenic acid (GLA) and healthier diets can suppress chronic inflammatory reactions that are a leading killer of aging Americans. (lifeextension.com)
Of particular interest is the omega-6 fat GLA ( gamma-linolenic acid ), which has remarkable anti-inflammation mechanisms. (lifeextension.com)
Flax contains not only the omega-3 fatty acid alpha-linolenic acid (ALA), but also lignans, a major class of oestrogenlike compounds, antioxidants and fibre. (newhope.com)

Aberrant contacts in p97-UBXD8 loss of function cells can be rescued by supplementation with unsaturated fatty acids or overexpression of SCD1. (biorxiv.org)

Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases. (oregonstate.edu)

Adult rats fed the peroxisome proliferator-activated receptor alpha (PPARalpha) agonist WY14,643 have increased hepatic elongase activity, Elovl-1, Elovl-5, Elovl-6, Delta5, Delta6, and Delta9 desaturase mRNA abundance, and mead acid (20:3,n-9) content. (oregonstate.edu)
Developmental changes in hepatic elongase activity paralleled the postnatal induction of Elovl-5 mRNA and mRNAs encoding the PPARalpha-regulated transcripts, Delta5 and Delta6 desaturase, and cytochrome P450 4A. (oregonstate.edu)
In contrast, Elovl-6, Delta9 desaturase, and FAS mRNA abundance paralleled changes in hepatic sterol regulatory element binding protein 1c (SREBP-1c) nuclear content. (oregonstate.edu)

Fatty acid desaturases are found in almost all organisms, including plants, animals, bacteria and fungi. (springeropen.com)
Delta-9-desaturases are found in all organisms, from bacteria to humans. (asbmb.org)

2005 ). Although fatty acid desaturases orthologs of different organisms share some obvious structure characteristics, the structural and functional features were distinctive among plants, animals and fungi. (springeropen.com)

Clarke S. D., D. Jump (1997) Polyunsaturated fatty acids regulate lipogenic and peroxisomal gene expression by independent mechanisms. (edu.pl)

Background: The fatty acid (FA) composition of adipose tissue influences the nutritional quality of meat products. (ehu.eus)
Results - Following weight loss, fatty acid composition of the liver and adipose tissue was primarily affected by protein quality in that cats fed CA had significantly higher percentages of 20:4(n-6) and 22:6(n-3) fatty acids than those fed CG. (uaeu.ac.ae)

Clarke S. D. (2000) Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance. (edu.pl)

Bartsch B.D., Graham E.R.B., McLean D.M., Protein and fat composition and some manufacturing properties of milk from dairy cows fed hay and concentrate in various ratios, Austr. (dairy-journal.org)
The soluble fatty acid desaturases, such as the plant Acyl-carrier-protein (ACP) desaturase family, use acyl carrier protein thioesters as substrates, and use ferredoxin oxidoreductase and ferredoxin as electron donors. (springeropen.com)
1984. "Men who developed coronary heart disease also had a higher mean intake of percentage of calories from protein, fat, saturated fatty acids, and polyunsaturated fatty acids than men who remained free of coronary heart disease. (blogspot.com)
The fatty acid patterns observed suggest that protein quality may alter fatty acid composition through modulation of desaturase activity. (uaeu.ac.ae)
Even if amino acids are biologically present in a place, no protein can form spontaneously. (questionsonislam.com)

Furthermore, a comprehensive analysis was performed to characterize conserved motifs and gene structures, which could provide an intuitive comprehension to learn the relationship between structure and functions of the fatty acid desaturases genes in different Aspergillus species. (springeropen.com)
This study provided a better understanding of the evolution and functions of the fatty acid desaturases gene family in the four Aspergillus species, and would be useful for seeking methods to improve the production of unsaturated fatty acids and enhance efforts for the genetic improvement of strains to adapt to the complex surrounding environment. (springeropen.com)
Here, we have used electrospray ionisation mass spectrometry (ESI-MS) to determine the patterns of alteration to individual molecular species compositions of PC, PE and phosphatidylinositol (PI) in response to gradually decreasing temperature. (silverchair.com)
By contrast, the PI species that increased during cold acclimation were characterised by an sn -1 monounsaturated fatty acid in combination with arachidonoyl or eicosapentaenoyl fatty acid at the sn -2 position. (silverchair.com)
The number and amount of fatty acids in fish oil varies according to many factors such as species, season, habitat and nutritional status. (questionsonislam.com)

We investigated the effects of energy-restricted diet containing EVOO on body composition and metabolic disruptions related to obesity. (researchgate.net)
Non-alcoholic fatty liver disease (NAFLD) is becoming a major cause of chronic liver disease in relation to the increasing prevalence of obesity and type-2 diabetes in the general population. (arasysperfector.com)
While the deficiency of SCD1 increased the oxidation of fatty acid, insulin sensitivity and resistance to diet-induced obesity and liver steatosis [ 6 ]. (biomedcentral.com)
The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass. (cdc.gov)

2006). In particular, hepatic steatosis can be influenced by insulin resistance through induction of a higher peripheral lipolysis with enhanced fluxes of fatty acids (FA) and glycerol to the liver, thus favouring lipogenesis (Saltiel & Khan, 2001). (arasysperfector.com)

Fatty acid synthase ( FAS ) organizes the structural skeleton of fatty acid with malonyl-CoA. (biomedcentral.com)

Tetracosahexaenoic acid (24:6ω-3) is an intermediate in the conversion of 18:3ω-3 to 22:6ω-3 in mammals. (soton.ac.uk)

It was surprising that it is regulated by only two amino acids," Umeda said. (asbmb.org)

Dewhurst R.J., Shingfield K.J., Lee M.R.F., Scollan N.D., Increasing the concentrations of beneficial polyunsaturated fatty acids in milk produced by dairy cows in high-forage systems, Anim. (dairy-journal.org)

Fatty acid desaturases (also called unsaturases) are a family of enzymes that convert saturated fatty acids into unsaturated fatty acids and polyunsaturated fatty acids. (wikipedia.org)
This is a multi-stage process requiring successive actions by elongase and desaturase enzymes. (wikipedia.org)
[ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)

Among their many purported benefits, n-3 acids have been implicated as positive mediators of cardiovascular health and body composition. (edu.pl)
Angiotensin-Converting Enzyme Ins/Del Polymorphism and Body Composition: The Intermediary Role of Hydration Status. (cdc.gov)

By contrast, although KD also impairs tumour SCD activity, KD-driven increases in lipid availability maintain the unsaturated to saturated fatty acid ratios in tumours, and changing the KD fat composition to increase tumour saturated fatty acid levels cooperates with decreased tumour SCD activity to slow tumour growth. (nature.com)

The findings also uncover other metabolic abnormalities, including increased fatty acid uptake and markedly increased retroconversion of DHA to EPA, in CF cells. (greenmedinfo.com)

Fatty acids with at least 20 carbons (C20) and three double bonds (20:3) bind to CB1 receptors. (wikipedia.org)
Fatty acid desaturases play a key role in producing polyunsaturated fatty acids by converting single bonds to double bonds. (springeropen.com)
2003 ). Unsaturated fatty acids are synthesized by individual fatty acid desaturases via introducing double bonds into the hydrocarbon chains of fatty acids (Chi et al. (springeropen.com)

Clarke S. D. (2001) Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. (edu.pl)

International Organization for Standar-dization (ISO), Milk fat, Preparation of fatty acid methyl ester, ISO standard 15884 (2002). (dairy-journal.org)
Albert C. M., H. Campos, M. J. Stampfer, P. M. Ridker, J. E. Manson, W. C. Willett, J. Ma (2002) Blood levels of long-chain n-3 fatty acids and the risk of sudden death. (edu.pl)

Thus, conditional QTL mapping for fatty acids may uncover numerous additional QTLs that were inhibited by the effects of other traits. (biomedcentral.com)

Calder P. C. (2006) n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. (edu.pl)

Accordingly, this hypothesis predicts that optimization of n-3 fatty acid status and associated cardiovascular and cerebrovascular integrity prior to onset will be an efficacious preventive strategy for both MDD and CHD. (hindawi.com)

In conclusion, changes in Elovl-5 expression may account for much of the nutritional and developmental control of fatty acid elongation activity in the rat liver. (oregonstate.edu)
Liver biopsy specimens and samples of perirenal, subcutaneous, and abdominal fat were obtained and analyzed for fatty acid content. (uaeu.ac.ae)

Plasma fatty acid profile in depressive disorder resembles insulin resistance state. (nel.edu)
Insulin resistance (IR), connected with altered fatty acid (FA) composition, namely with decreased proportion of polyunsaturated FA could participate in these associations. (nel.edu)
Esterified FA composition of depressive patients revealed changes, similar to those, usually observed in insulin resistance. (nel.edu)

Milk composition, and in particular, milk fat content and fatty acid profiles may be significantly altered due to a variety of factors. (ac.be)
In both strains, mycolic acids had fewer double bond numbers in phenol conditions than the glucose condition, and evol40 had significantly shorter mycolic acid chain lengths than the WT strain in phenol conditions. (biomedcentral.com)
Fatty acid (FA) composition significantly affects the function, quality and nutritional properties of vegetable oils. (biomedcentral.com)

Four desaturases occur in humans: Δ9-desaturase, Δ6-desaturase, Δ5-desaturase, and Δ4-desaturase. (wikipedia.org)

Here evidence implicating omega-3 (n-3) fatty acid deficiency in the pathoaetiology of CHD and MDD is reviewed, and the hypothesis that n-3 fatty acid deficiency is a preventable risk factor for CHD comorbidity in MDD patients is evaluated. (hindawi.com)
Although this evidence was obtained from studies conducted largely in parallel in the fields of cardiology and psychiatry, the potential contribution of n-3 fatty acid deficiency to increased CHD morbidity and mortality in MDD has been postulated previously [ 22 , 23 ]. (hindawi.com)
To evaluate the hypothesis that n-3 fatty acid deficiency is a risk factor for CHD morbidity and mortality in MDD, it is important to consider that the age at onset for unipolar and bipolar depression peaks in young adulthood (15-19 years) [ 24 , 25 ], whereas CHD mortality peaks substantially later (75-84 years) [ 26 ]. (hindawi.com)

The fatty acid composition of B. napus ' seeds determines the oil's nutritional and industrial values, and affects seed germination. (biomedcentral.com)

Anatomy3

Organisms5

Diseases1

Chemicals and Drugs49

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Phenomena and Processes7

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Information Science3

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Docosahexaenoic5

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PUFA5

Oleic acid4

Desaturation4

Delta-9-desatura2

Linoleic8

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Dietary7

Lipids4

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Metabolism1

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Membranes3

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Glycerol-3-phospha1

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Stearoyl2

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Linolenic acid5

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Elongases1

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