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  • Annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • high
  • This elevation is suggested to occur as a compensatory up-regulation of the protein in an attempt to counter the high metabolic stress associated with obesity. (wikipedia.org)
  • type
  • To the Editor We read with interest the systematic review and meta-analysis by Bruins Slot et al concerning early diagnosis of myocardial infarction (MI) using heart-type fatty acid-binding protein (H-FABP). (bmj.com)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • anandamide
  • Cholesterol stimulates both the insertion of anandamide into synthetic lipid monolayers and bilayers, and its transport across bilayer membranes, suggest that besides putative anandamide protein-transporters, cholesterol could be an important component of the anandamide transport machinery, and as cholesterol-dependent modulation of CB1 cannabinoid receptors in nerve cells. (wikipedia.org)
  • PPAR
  • PPAR signaling pathway, organism-specific biosystem Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. (nih.gov)
  • endocannabinoids
  • However, since the endocannabinoids are water immiscible, protein transporters have been described that act as carriers to solubilize and transport the endocannabinoids through the aqueous cytoplasm. (wikipedia.org)
  • FABP3
  • FABP3 is known to interact with TNNI3K in the context of interacting with cardiac troponin I. The protein also interacts with, VPS28, KIAA159,NUP62, PLK1, UBC, and Xpo1. (wikipedia.org)
  • In HIV, a synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fatty acid binding protein 3 (FABP3) in peptide-treated PBMCs. (wikipedia.org)
  • polymorphism
  • Carriers of this particular single nucleotide polymorphism (SNP) exhibit higher baseline plasma-free fatty acid levels, lower BMI and a smaller waist circumference. (wikipedia.org)
  • affinity
  • The importance of the conserved tertiary structure of Lep is most likely explained by requirements for specific LepR-binding affinity and is constrained by the structure of the receptor-binding pocket. (wikipedia.org)
  • obesity
  • Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease, diabetes, asthma, obesity, and fatty liver disease. (wikipedia.org)
  • Altered expression of the protein has been linked to metabolic conditions including obesity. (wikipedia.org)
  • This elevation is suggested to occur as a compensatory up-regulation of the protein in an attempt to counter the high metabolic stress associated with obesity. (wikipedia.org)
  • mice
  • FAT/ CD36 (show CD36 ELISA Kits ) and FABPpm protein content was increased in red muscles in IL-6 (show IL6 ELISA Kits )(-/-) mice compared to WT mice at 4 (RG) and 12 months (soleus and RG). (antibodies-online.com)
  • This ob/ob mice model also exhibits hyperglycemia, insulin resistance, hyperinsulinemia, glucose intolerance, and fatty infiltration of liver. (diabetesjournals.org)
  • These truxillic acids and their derivatives have been known to have anti-inflammatory and anti-nociceptive effects in mice and are active components of a Chinese herbal medicine ((−)-Incarvillateine Incarvillea sinensis) used to treat rheumatism and pain in human. (wikipedia.org)
  • motifs
  • Of these, only the longest form conserved all functionally important domains (such as three fibronectin type III domains, the Ig C2-like domain, a pair of WSXWS motifs, two JAK2-binding motif boxes, and a STAT-binding domain), while the other four forms have only the intra-cellular region. (wikipedia.org)
  • S100A7 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (wikipedia.org)
  • endocannabinoid
  • The catalytic efficiency (i.e., the ratio between maximal velocity and Michaelis-Menten constant) of the AEA membrane transporter (AMT) is almost doubled compared with control cells, demonstrate that, among the proteins of the "endocannabinoid system," only CB1 and AMT critically depend on membrane cholesterol content, an observation that may have important implications for the role of CB1 in protecting nerve cells against (endo)cannabinoid-induced apoptosis. (wikipedia.org)
  • metabolic
  • These include concentration gradients of small molecules such as calcium, large complexes of enzymes that act together to carry out metabolic pathways, and protein complexes such as proteasomes and carboxysomes that enclose and separate parts of the cytosol. (wikipedia.org)
  • amino acid
  • Portions of the amino acid sequences of HSL, JAK2, and AFABP/aP2 that align with the E X YK motif. (nih.gov)
  • Initial phylogenetic analysis has revealed that amino acid conservation with other vertebrate Lep orthologues is low, with only 13.2% sequence identity between torafugu and human LEP. (wikipedia.org)
  • Subsequent investigations have confirmed the low amino acid identity of teleost leps compared to mammalian LEP. (wikipedia.org)
  • These contradicting results have been explained by the relatively large differences in amino acid sequences observed between mammals and fish. (wikipedia.org)