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Fatty Acid-Binding ProteinsFatty AcidsMyelin P2 ProteinNeoplasm ProteinsCarrier ProteinsOleic AcidNerve Tissue ProteinsOleic AcidsFatty Acids, UnsaturatedFatty Acids, NonesterifiedPalmitic AcidFatty Acid Transport ProteinsIntestinesLiverLipid MetabolismAspartate Aminotransferase, MitochondrialAdipocytesMolecular Sequence DataFatty Acids, Omega-3Tumor Suppressor ProteinsPhytolBody Weight ChangesBezafibratePalmitatesProtein BindingFatty Acid SynthasesRNA, MessengerAmino Acid SequenceBinding SitesPalmitic AcidsBase SequenceDiazepam Binding InhibitorAcaridaePlatycodonDietary FatsGene Expression RegulationAdipose TissueFatty LiverPhospholipidsFatty Acid DesaturasesFatty Acids, EssentialApoproteinsTriglyceridesAntigens, CD36Models, MolecularRecombinant ProteinsAcyl Coenzyme ALipidsBiological MarkersMyocardiumKineticsFatty Acids, Omega-63-Hydroxybutyric AcidBiological TransportSpectrometry, FluorescencePPAR gamma3T3-L1 CellsPPAR alphaAdipogenesisReceptors, Retinoic AcidLigandsIntestine, SmallGene ExpressionCloning, MolecularAcyl-CoA OxidaseCytosolRats, Inbred StrainsTranscription FactorsFatty Acids, MonounsaturatedStearic AcidsProtein ConformationDNAMice, Inbred C57BLCarnitine O-PalmitoyltransferaseInsulin ResistanceArachidonic AcidCreatine Kinase, MB FormImmunohistochemistryMice, TransgenicPoly(A)-Binding ProteinsCell DifferentiationCholesterolReverse Transcriptase Polymerase Chain ReactionCaco-2 CellsInsulinReceptors, Cytoplasmic and NuclearBlotting, WesternEscherichia coliCCAAT-Enhancer-Binding ProteinsMuscle, SkeletalCell LineCattleCells, CulturedBlotting, NorthernCell MembraneDNA-Binding ProteinsMice, KnockoutMolecular WeightCircular DichroismBinding, Competitive
MetabolismAcylTumorsCancersPathwaysSerumSynthaseMetabolicTumor suppressor proteinReceptorsPhosphorylationAbnormalKinaseEnzymesMoleculesSynthesisAntibodyKinasesPrimaryExpressionFASNTissuesAlbuminCytosolicProgressionSplicing factorTranscriptionAntibodiesEnrichmentMETHODSImmuneSimultaneouslyPathwayPrimarilyLevelsCharacteristicsIncreaseGrowthCellsLandscapeInflammationCellFrequentlyIdentifyShowChain
Metabolism5
  • FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endocannabinoids, phytocannabinoids (and less so for synthetic cannabinoid receptor (CBR) agonists and antagonists) and other hydrophobic molecules. (wikipedia.org)
  • Each FABP corresponds to particular organs/tissue around the body where they play a role in fatty-acid uptake, transport and metabolism. (wikipedia.org)
  • Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS. (lookformedical.com)
  • The current protein-protein interplay community evaluation recognized these mechanisms concerned within the adaptive and innate immunity, the metabolism of the glucose, most cancers cell development, apoptosis, cell cycle and DNA injury responses. (rbprotein.com)
  • The corresponding genes for the DFS-SEs were significantly enriched in mitochondria and their associated pathways according to Gene Ontology annotation and in the pathways of fatty acid metabolism, oxidative phosphorylation and Huntington's disease according to a Kyoto Encyclopedia of Genes and Genomes pathway analysis. (spandidos-publications.com)
Acyl4
  • FABP1 is unique in the wider range of other hydrophobic ligands it can bind including bilirubin, monoglycerides, bile acids and fatty acyl CoA. (wikipedia.org)
  • Lysophosphatidic acid (LPA) consists of an acyl chain at the sn-1 (or sn-2) position of a glycerol backbone and a phosphate head group. (hindawi.com)
  • Therefore, several species can be found, differing only in the length and saturation of the acyl or alkyl fatty acid chain [ 7 , 10 ]. (hindawi.com)
  • Starting from the N-terminus, these units include β-ketoacyl synthase (KS), acetyl/malonyl transacylase (AT/MT), β-hydroxyacyl dehydratase (DH), enoyl reductase (ER), β-ketoacyl reductase (KR), acyl carrier protein (ACP), and thioesterase (TE). (aging-us.com)
Tumors3
  • Fatty acid synthase expression is related to tumor-infiltrating immune cells in tumors (e.g. (aging-us.com)
  • Conclusions: This study provides a complete understanding of the oncogenic role of fatty acid synthase in human tumors. (aging-us.com)
  • The Cancer Genome Atlas (TCGA) project and gene expression omnibus (GEO) dataset contain useful genomic information sets of various tumors [ 1 - 3 ] and can be employed to identify the potential oncogenic role of fatty acid synthase (FASN). (aging-us.com)
Cancers6
  • The uncharacterized interactions with two lung most cancers suppressors (DOK3, DENND2D), a protein concerned within the elevated danger of the lung most cancers in people who smoke (CYP1A1) and a protein implicated in asthmatic reactions (CHIA) recommend potential roles of TPPII within the lung most cancers pathology . (rbprotein.com)
  • However, a systematic analysis of fatty acid synthase across pan-cancers has not been carried out. (aging-us.com)
  • Methods: We investigated the oncogenic roles of fatty acid synthase in 33 cancers based on the cancer genome atlas and gene expression omnibus. (aging-us.com)
  • Results: Fatty acid synthase is profoundly expressed in most cancers and is an important factor in predicting the outcome of cancer patients. (aging-us.com)
  • Additionally, several features (e.g., gene expression, survival prognosis, genetic alteration, DNA methylation, protein phosphorylation, immune cells, or relevant cellular pathways) were gathered to evaluate the regulatory mechanism of FASN in the tumorigenesis of cancers. (aging-us.com)
  • Several cancers produce proteins that are physiologically expressed in utero by embryonic and fetal cells but not expressed by normal adult cells. (medscape.com)
Pathways3
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • LPA activates at least six G-coupled protein receptors (LPA 1-6 ) stimulating different signaling pathways through heterotrimeric G proteins such as G i/0 , G 12/13 , G q/11 , and G s . (hindawi.com)
  • Moreover, hormone receptor binding- and fatty acid metabolic process-associated pathways are involved in the functional mechanisms of fatty acid synthase. (aging-us.com)
Serum3
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
  • Relationship between serum adipocyte fatty acid-binding protein and endothelial/hemostatic markers in dyslipidemic subjects. (nel.edu)
  • Karasek D, Vaverkova H, Frysak Z, Orsag J, Novotny D, Halenka M, Slavik L. Relationship between serum adipocyte fatty acid-binding protein and endothelial/hemostatic markers in dyslipidemic subjects. (nel.edu)
Synthase2
  • The immunohistochemistry and/or Western blot analysis of liver tissues showed a prominent increase in fatty acid synthase (FASN) and cluster of differentiation 36 (CD36) expressions in OVX and SHAM rats who received DEN and/ or F compared to SHAM rats. (bvsalud.org)
  • Co-immunoprecipitation experiments were performed to clarify the interaction between FABP5 and fatty acid synthase (FASN). (bvsalud.org)
Metabolic4
  • Altered expression of the protein has been linked to metabolic conditions including obesity. (wikipedia.org)
  • This elevation is suggested to occur as a compensatory up-regulation of the protein in an attempt to counter the high metabolic stress associated with obesity. (wikipedia.org)
  • OBJECTIVE: To study the mechanism of Dangfei Liganning capsule in the treatment of rats with metabolic associated fatty liver disease (MAFLD). (bvsalud.org)
  • Stearoyl-CoA desaturase (SCD) synthesizes monounsaturated fatty acids (MUFAs) and has been associated with the development of metabolic syndrome, tumorigenesis, and stem cell characteristics. (nih.gov)
Tumor suppressor protein1
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
Receptors1
  • LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
Phosphorylation1
  • Further, the level of S207 phosphorylation was found to be improved in several neoplasms (e.g., colon cancer). (aging-us.com)
Abnormal2
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
Kinase2
  • CSL is an download Your Brain on Latino Comics: From Gus Arriola to Los Bros Hernandez of a possible DNA-binding histone cause that releases kinase of invalid genome interests in one decision, but hormone of the Canadian developments in another endocytosis. (evakoch.com)
  • This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
Enzymes2
  • RNA enzymes may observe from also translocated proteins, they may phosphorylate suggested in proteins with delayed strategies, or they may outline known in membranes of factor factors. (evakoch.com)
  • CDDs are slowly metabolized in mammalian tissues via oxidation and reductive dechlorination reactions catalyzed by cytochrome P450 enzymes, followed by conjugation to more polar molecules such as glutathione and glucuronic acid (ATSDR 1998). (cdc.gov)
Molecules2
  • It has been proposed that FABP1 plays a significant role in preventing cytotoxicity by binding heme, fatty acids and other molecules that are potentially toxic when unbound. (wikipedia.org)
  • Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. (hindawi.com)
Synthesis1
  • Endogenous fatty acid synthesis is catalyzed by FASN, a human lipogenic enzyme capable of de novo synthesis of fatty acids [ 4 , 5 ]. (aging-us.com)
Antibody1
  • As the Fc fragment of the anti-GCA antibody could normally bind to proteins A on the previously reported red-colored bacterias (conjugate) is normally formed because of the combination of proteins A on as well as the Fc portion from the mAb. (eprf.ca)
Kinases1
  • The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
Primary1
Expression3
  • We further showed that FABP5 regulates the expression of FASN via the ubiquitin proteasome pathway and both proteins facilitate the progression of pNENs. (bvsalud.org)
  • We examined the effects of SCD inhibition on Wnt signaling, including the expression and stability of low-density lipoprotein-receptor-related proteins 5 and 6 (LRP5 and LRP6), by immunoblot and quantitative polymerase chain reaction analyses. (nih.gov)
  • 9-cis-retinoic acid enhances fatty acid-induced expression of the liver fatty acid-binding protein gene. (unil.ch)
FASN2
  • The human FASN protein is composed of six catalytic units. (aging-us.com)
  • Further, the "HomoloGene" function of the NCBI was used to conduct conserved functional domain analysis of the FASN protein in different species. (aging-us.com)
Tissues2
  • We investigated the mRNA and protein levels of FABP5 in pNEN tissues and cell lines and found them to be upregulated. (bvsalud.org)
  • Information from studies of exposed humans and laboratory animals indicates that absorbed CDDs are distributed preferentially to fatty tissues and to a lesser extent, the liver (ATSDR 1998). (cdc.gov)
Albumin1
  • ATX generates LPA from plasma membrane phospholipids and from circulating lysophosphatidylcholine (LPC) bound to albumin [ 23 ]. (hindawi.com)
Cytosolic2
  • FABP1 is expressed abundantly in the human liver where it accounts for 7-11% of the total cytosolic protein, and can also be found in the intestine, kidney, pancreas stomach and lung. (wikipedia.org)
  • This loop required MUFA inhibition of binding of Ras-related nuclear protein 1 (Ran1) to transportin 1 and reduced nuclear import of elav-like protein 1 (HuR), increasing cytosolic levels of HuR and HuR-mediated stabilization of mRNAs encoding LRP5 and LRP6. (nih.gov)
Progression1
  • High levels of fatty acid binding protein 5 (FABP5) are involved in tumor progression, but its role in pNENs remains unclear. (bvsalud.org)
Splicing factor1
  • A correlation network between DFS-SEs of splicing factors and non-splicing factors was constructed to determine the potential mechanisms in PRAD, which included the potential regulatory interaction between the splicing event of splicing factor RNA binding motif protein 5-alternate terminator (AT)-64957 and the splicing event of non-splicing factor heterochromatin protein 1 binding protein 3-AT-939. (spandidos-publications.com)
Transcription1
  • In rodent HSCs and TICs, the Wnt effector β-catenin increased sterol regulatory element binding protein 1-dependent transcription of Scd, and β-catenin in return was stabilized by MUFAs generated by SCD. (nih.gov)
Antibodies1
  • When a tumor arises, the body may produce antibodies to fight it by binding to and destroying tumor cells. (medscape.com)
Enrichment1
  • The interplay community constructed primarily based on the publicly out there protein-protein interplay information was prolonged by the utility GeneMania, which was additional used for the pathway enrichment, the protein operate prediction and the protein node prioritisation evaluation. (rbprotein.com)
METHODS1
  • Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
Immune1
  • Paraneoplastic syndromes are rare disorders that are triggered by an altered immune system response to a neoplasm. (medscape.com)
Simultaneously1
  • FABP1 has been found to have a unique structure compared to other members of the FABP family, allowing it to bind multiple ligands simultaneously. (wikipedia.org)
Pathway1
  • The main pathway is the cleavage of membrane phospholipids into lysophospholipids by the removal of a fatty acid chain by phospholipase A (PLA1 or PLA2). (hindawi.com)
Primarily1
  • Tripeptidyl peptidase II (TPPII) is primarily thought-about a house-keeping exopeptidase, which contributes to the features of the ubiquitin-proteasome system by the upkeep of the mobile amino acid homeostasis. (rbprotein.com)
Levels1
  • Carriers of this particular single nucleotide polymorphism (SNP) exhibit higher baseline plasma-free fatty acid levels, lower BMI and a smaller waist circumference. (wikipedia.org)
Characteristics1
  • Figure ?Physique11c shows the characteristics of the anti-GCA mAb purified by caprylic acid-ammonium sulfate precipitation. (eprf.ca)
Increase1
Growth1
  • Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. (cancerindex.org)
Cells1
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
Landscape1
  • landscape fatty makes a introduction l with congestive pupils that are a default of unmarried private and VPN site. (schuylercitrus.com)
Inflammation1
Cell1
  • 14) strand proteins in gene-internal of FGFR3 and capable sunshine amyloid or proteotoxic cell increasing( Otsuki, 1999). (evakoch.com)
Frequently2
  • It is also frequently known as liver-type fatty acid-binding protein (LFABP). (wikipedia.org)
  • Pancreatic neuroendocrine neoplasms (pNENs) are among the most frequently occurring neuroendocrine neoplasms (NENs) and require targeted therapy. (bvsalud.org)
Identify2
  • The fatty acid-binding proteins (FABPs) were initially discovered in 1972 with experiments using 14C labelled oleate to identify the presence of a soluble fatty acid carrier in the enterocyte responsible for intestinal absorption of (LCFAs). (wikipedia.org)
  • We performed nano-bead pull-down assays, liquid chromatography-mass spectrometry, computational modeling, and ribonucleoprotein immunoprecipitation analyses to identify MUFA-interacting proteins. (nih.gov)
Show1
Chain1
  • PLA removes a fatty acid chain from PC, PE, or PS converting them into lysophospholipids. (hindawi.com)