• To understand this, a screen was carried out for signals that could identify circadian output circuits in Drosophila melanogaster. (sdbonline.org)
  • In the fruitfly Drosophila melanogaster, hunger has a significant impact on its sensory systems and brain functions, and consequently modifies related behaviors. (sdbonline.org)
  • We leverage the power and versatility of the fruitfly Drosophila melanogaster to study glutamatergic synapses at the level of single active zones in identifiable neuronal populations. (mit.edu)
  • CG8590-PA [Drosophila melanogaster]. (nig.ac.jp)
  • CG7765-PA [Drosophila melanogaster]. (nig.ac.jp)
  • We analyzed how different odor features such as hedonic valence and intensity are functionally integrated in the lateral horn (LH) of the vinegar fly, Drosophila melanogaster . (elifesciences.org)
  • Laptenko O, Lee J, Lomakin I, Borukhov S. Transcript cleavage factors GreA and GreB act as transient catalytic components of DNA damage response of Drosophila melanogaster. (chrisdixie.com)
  • Some researchers have suggested that local, intra-axonal protein synthesis is the answer to this problem. (mblwhoilibrary.org)
  • At the Drosophila neuromuscular junction (NMJ), the small GTPase Rab3 controls the distribution of CAZ proteins across release sites, thereby regulating the efficacy of individual AZs. (eneuro.org)
  • We show here that Rab3-GEF is required for controlling the protein composition of release sites in the Drosophila neuromuscular junction (NMJ). (eneuro.org)
  • Overexpression of the RAPGEF2 mutant in Drosophila motor neurons reduces the stability of axonal microtubules and disrupts the distribution of mitochondria to distal axons and neuromuscular junction (NMJ) synapses. (en-journal.org)
  • At the Drosophila larval neuromuscular junction (NMJ) , the retrograde BMP pathway is part of the machinery that controls NMJ expansion concurrent with larval growth. (sdbonline.org)
  • Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors. (neurotree.org)
  • To assess the pathogenic effects of this variant, we have used patient-derived skin fibroblasts and motor neuron-specific overexpression of the RAPGEF2-E1357K mutant protein in Drosophila . (en-journal.org)
  • We are also studying mutants of the Drosophila Htt homolog to define the normal function of the protein within neurons. (mit.edu)
  • kinesin-like protein [Drosophila melan. (nig.ac.jp)
  • This study shows that Schip1 , a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. (sdbonline.org)
  • We show that guanylate kinase-associated kinesin (GAKIN), a kinesin-like motor protein, directly interacts with a PIP 3 -interacting protein, PIP 3 BP, and mediates the transport of PIP 3 -containing vesicles. (silverchair.com)
  • We used the amyotrophic lateral sclerosis-associated protein TDP-43 as a primary model to investigate the effects of clusterin on protein aggregation and neurotoxicity in complementary in vitro, neuronal cell and Drosophila systems. (biomedcentral.com)
  • Thus, these results reveal that hunger induces reduction of responses to noxious heat through the Lk/Lkr signaling pathway in Drosophila. (sdbonline.org)
  • Silencing synaptic communication between random interneurons during Drosophila larval locomotion. (neurotree.org)
  • To gain insight this study quantitatively investigated synaptic growth and connectivity in the Drosophila nociceptive network during larval development. (sdbonline.org)
  • Importins associated with dynein are an important component of retrograde injury signalling complexes and enable transport of direct importin cargoes, such as transcription factors, as well as secondary cargoes that bind scaffolding molecules associated with importins. (nature.com)
  • thus, long-distance retrograde signalling from axonal lesion sites to the soma and nucleus is required. (nature.com)
  • Figure 2: Retrograde signalling via the JUN kinase pathway after an axonal lesion. (nature.com)
  • However, the synaptic phenotype in the rab3-GEF mutant cannot be fully explained by defective transport and loss of GEF activity. (eneuro.org)
  • Role of ATP-dependent calcium regulation in modulation of Drosophila synaptic thermotolerance. (neurotree.org)
  • Sheng, Z. H. & Cai, Q. Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. (nature.com)
  • We are taking advantage of genetic manipulations available in Drosophila to explore the mechanisms by which autism-associated synaptic proteins alter neuronal activity or synaptic connectivity. (mit.edu)
  • Together, these results suggest that, in neurons, the GAKIN-PIP 3 BP complex transports PIP 3 to the neurite ends and regulates neuronal polarity formation. (silverchair.com)
  • In this work we generated a parallel set of Drosophila models for adult-onset RNAi and tagged neuronal expression of the fly orthologues of the three human proteins, named Smn, TBPH and Caz, respectively. (bvsalud.org)
  • We applied this approach in primary rat hippocampal neurons to test how local positioning of recycling endosomes contributes to axon outgrowth and found that dynein-driven removal of endosomes from axonal growth cones reversibly suppressed axon growth, whereas kinesin-driven endosome enrichment enhanced growth. (nature.com)
  • Neurons require specialized mechanisms of motor-facilitated signal transport for communication along long axonal distances to the cell body and the nucleus. (nature.com)
  • In PC12 cells and cultured hippocampal neurons, transport activity of GAKIN contributes to the accumulation of PIP 3 at the tip of neurites. (silverchair.com)
  • We further showed that the expression of TDP-43 in transgenic Drosophila neurons induced ER stress and that co-expression of clusterin resulted in a dramatic clearance of mislocalized TDP-43 from motor neuron axons, partially rescued locomotor activity and significantly extended lifespan. (biomedcentral.com)
  • Dynactin is often essential for dynein activity and can be thought of as a "dynein receptor" that modulates binding of dynein to cell organelles which are to be transported along microtubules. (wikipedia.org)
  • We have generated Drosophila Huntington's Disease (HD) transgenic models expressing fluorescently tagged wildtype and pathogenic Huntintin (Htt) proteins that allow for in vivo imaging of Htt localization, axonal transport and aggregate formation in live animals. (mit.edu)
  • As the Drosophila homologue of mammalian DENN/MADD and Caenorhabditis elegans AEX-3, Rab3-GEF is a guanine nucleotide exchange factor (GEF) for Rab3 that stimulates GDP to GTP exchange. (eneuro.org)
  • Within the dorsal thorax regarding Drosophila, series associated with mechanosensory bodily organs originate from the split regarding physical appendage progenitor (SOPs). (parpreceptor.com)
  • Recent evidence suggests that the early calcium wave elicited by an axonal injury induces epigenetic changes in the nucleus, thereby priming the system for subsequent transcriptional events. (nature.com)
  • Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
  • The modification of the Drosophila leucokinin receptor shows that substitution of any non-aromatic amino acid for the tryptophan leads to a loss of receptor function. (sdbonline.org)
  • Dynactin p25/DCTN5 and p27/DCTN6 are not essential for dynactin complex integrity, but are required for early and recycling endosome transport during the interphase and regulation of the spindle assembly checkpoint in mitosis. (wikipedia.org)
  • Hyperthermic preconditioning of presynaptic calcium regulation in Drosophila. (neurotree.org)
  • May be involved in the regulation of dopamine release and transport. (abcam.com)
  • Members of the RYK/Derailed family have recently been shown to regulate axon guidance in both Drosophila and mammals by acting as Wnt receptors. (biologists.com)
  • We also showed that in Drosophila photoreceptor cells, clusterin co-expression gave ER stress-dependent protection against proteotoxicity arising from both Huntingtin-Q128 and mutant (R406W) human tau. (biomedcentral.com)
  • These recent findings provide a coherent mechanistic framework for axon-soma communication in the injured nerve and shed light on the integration of cytoplasmic and nuclear transport in all eukaryotic cells. (nature.com)
  • Here we establish optical control of intracellular transport by using light-sensitive heterodimerization to recruit specific cytoskeletal motor proteins (kinesin, dynein or myosin) to selected cargoes. (nature.com)
  • Many of the components of axoplasm, such as soluble proteins and cytoskeleton, are slowly transported, taking weeks to months to travel the length of axons longer than a few millimeters after being synthesized in the cell body. (mblwhoilibrary.org)
  • Figure 1: Local and reversible activation of microtubule-based transport with light. (nature.com)
  • Furthermore, this slow rate of supply suggests that the axon itself might not have the capacity to respond fast enough to compensate for damage to transported macromolecules. (mblwhoilibrary.org)
  • In the largest subgroup, SPG4 , an axonal type of damage was evident. (biomedcentral.com)
  • In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki) . (sdbonline.org)
  • Vale, R. D. The molecular motor toolbox for intracellular transport. (nature.com)
  • Axonal degeneration is a critical, early event following TBI of all severities but whether axon degeneration is a driver of TBI remains unclear. (umassmed.edu)
  • The main features of dynactin were visualized by quick-freeze, deep-etch, rotary shadow electron microscopy. (wikipedia.org)
  • Whereas all patients showed clinical signs of spastic paraparesis, MEPs were normal in 27% of patients and revealed a broad spectrum with axonal or demyelinating features in the others. (biomedcentral.com)
  • The Click uses directly transported to music for Other years. (idealpack.com)
  • Click the video for a quick tour of our lab and to learn more about our research. (mit.edu)
  • Phosphatidylinositol-(3,4,5)-trisphosphate (PIP 3 ), a product of phosphatidylinositol 3-kinase, is an important second messenger implicated in signal transduction and membrane transport. (silverchair.com)
  • This fact raises a logistical problem with regard to axonal maintenance. (mblwhoilibrary.org)