• C. fasciculata is an example of a non-human infective trypanosomatid and is related to several human parasites, including Trypanosoma brucei (which causes African trypanosomiasis) and Leishmania spp. (wikipedia.org)
  • An Insight into the Proteome of Crithidia fasciculata Choanomastigotes as a Comparative Approach to Axenic Growth, Peanut Lectin Agglutination and Differentiation of Leishmania spp. (wikipedia.org)
  • The 2 non- Leishmania trypanosomatids ( Leptomonas seymore and Crithidia fasciculata ) were included in the phylogenetic tree because they were previously described as co-infecting parasites in human leishmaniasis cases. (cdc.gov)
  • During the last several decades, researchers have described rare cases of patients co-infected with both Leishmania and other groups of protozoan parasites that usually infect insects, including Crithidia . (sciencedaily.com)
  • Pour identifier les espèces de Leishmania , des techniques moléculaires ont été appliquées sur des échantillons prélevés chez 64 patients atteints de leishmaniose cutanée orientés vers l'hôpital régional d'Herat en 2013. (who.int)
  • It entails several kDNA replication specific proteins that have been primarily characterized in T. brucei Leishmania and Crithidia fasciculata [2]. (healthandwellnesssource.org)
  • In this work, we designed and built light sources based upon commercially available Organic Light Emitting Diode (OLED) and LED parts to experimentally validate the combination with methylene blue photosensitizer to kill Leishmania major and Crithidia fasciculata cells in vitro. (peertechzpublications.org)
  • C. fasciculata is often used as a model organism in research into trypanosomatid biology that may then be applied to understanding the biology of the human infective species. (wikipedia.org)
  • Thus, the biosynthesis and degradation of trypanothione are similar in African and American trypanosomes, and different from the insect trypanosomatid, C. fasciculata. (dundee.ac.uk)
  • The heterologous enzymes originated from the related insect-confined trypanosomatid Crithidia fasciculata and the human. (itg.be)
  • The DNA polymerase beta from the trypanosomatid Crithidia fasciculata, however, was the first mitochondrial enzyme of this type described. (neb.com)
  • As is typical of the trypanosomatids, but unlike many other protists, C. fasciculata possess one mitochondrion. (wikipedia.org)
  • To determine which route operates in T. brucei, we have cloned and expressed a single copy gene with similarity to C. fasciculata and T. cruzi TRYS. (dundee.ac.uk)
  • Despite the presence of peroxisomal targeting signal in hCAT, both human and C. fasciculata catalases localized to the cytosol of T. brucei . (itg.be)
  • The minicircle replication origins include the universal minicircle sequence (UMS GGGGTTGGTGTA) that is present in varying copy numbers and well conserved among different kinetoplastids [15 16 The exact sequence of the maxicircle replication origin is not yet known although it has been mapped to the variable region of T. brucei and C. fasciculata [17]. (healthandwellnesssource.org)
  • C. fasciculata have low host species specificity and can infect many species of mosquito. (wikipedia.org)
  • The current study of parasites isolated from a Brazilian patient confirms that Crithidia parasites also can infect people. (sciencedaily.com)
  • To confirm that these Crithidia parasites could infect mammals, the researchers exposed mice to the parasites isolated from the patient, both intravenously and by injection into the skin, and found that both types of parasite infected the liver. (sciencedaily.com)
  • C. fasciculata parasitizes several species of insects and has been widely used to test new therapeutic strategies against parasitic infections. (wikipedia.org)
  • Crithidia fasciculata is a species of parasitic excavates. (wikipedia.org)
  • C. fasciculata, like other species of Crithidia have a single host life cycle with insect host, in the case of C. fasciculata this is the mosquito. (wikipedia.org)
  • As is common with parasitic species C. fasciculata requires a high nutrient content broth (including heme and folic acid) in which to grow under laboratory conditions. (wikipedia.org)
  • One is approximately 70% identical to the C. fasciculata pol beta and is likely the homolog of this enzyme. (neb.com)
  • Transmission of C fasciculata primarily occurs when amastigotes, washed into standing water, are ingested by mosquito larvae. (wikipedia.org)
  • They expressed concern that the disease may be mosquito-borne because Anopheles and Culex mosquitoes can host the Crithidia parasite. (sciencedaily.com)
  • C. fasciculata is found in two morphologically different life cycle stages - the free swimming choanomastigote form, which has a long external flagellum for motility, and the attached, immotile, amastigote form in the mosquito gut. (wikipedia.org)
  • Analysis of treated C. fasciculata by scanning electron microscopy showed rounding of the cell body. (fiocruz.br)
  • C. fasciculata is found in two morphologically different life cycle stages - the free swimming choanomastigote form, which has a long external flagellum for motility, and the attached, immotile, amastigote form in the mosquito gut. (wikipedia.org)
  • Transmission of C fasciculata primarily occurs when amastigotes, washed into standing water, are ingested by mosquito larvae. (wikipedia.org)
  • They expressed concern that the disease may be mosquito-borne because Anopheles and Culex mosquitoes can host the Crithidia parasite. (nih.gov)
  • Incubation of C. fasciculata with the trypanocydal agent benznidazole did not affect parasite growth at concentrations up to 500 µg/ml, but the IC50 of this drug against T. cruziwas 15.8 µg/ml, a value about 2-5 times higher than that of constituents in the triple combination. (fiocruz.br)
  • Instead, they were more closely related to Crithidia fasciculata , a parasite that usually colonizes mosquitoes. (nih.gov)
  • To confirm that these Crithidia parasites could infect mammals, the researchers exposed mice to the parasites isolated from the patient, both intravenously and by injection into the skin, and found that both types of parasite infected the liver. (nih.gov)
  • Metabolism of hydrogen peroxide in Crithidia fasciculata is accomplished by three distinct proteins, tryparedoxin, tryparedoxin peroxidase and trypanothione reductase, working in concert with the substrates NADPH and trypanothione. (dundee.ac.uk)
  • Here, we report the cloning and characterisation of the tryparedoxin ( TryX ) and tryparedoxin peroxidase ( TryP ) genes from C. fasciculata . (dundee.ac.uk)
  • The constituents were initially added individually at different concentrations to C. fasciculata cultures to estimate the IC50/24h. (fiocruz.br)
  • If Crithidia infections represent an emerging infectious disease in people, there will be an urgent need to develop novel effective treatments, the researchers write. (nih.gov)
  • Presence of a poly(A) binding protein and two proteins with cell cycle-dependent phosphorylation in Crithidia fasciculata mRNA cycling sequence binding protein II. (wakehealth.edu)