• We randomly divided 8 female cynomolgus macaques ( Macaca fascicularis ) into 2 groups of 4 each (treatment and control) and injected each animal intramuscularly with a lethal dose of LASV, strain Josiah (1 × 10 4 50% tissue culture infective dose [TCID 50 ]) ( Table ). (cdc.gov)
  • So her research group instead studies TB using cynomolgus macaques ( Macaca fascicularis ), which do form granulomas. (globalwomenshealthacademy.org)
  • Here, we show that combinations of two or three pan-lineage neutralizing human monoclonal antibodies (8.9F, 12.1F, 37.D) known as Arevirumab-2 or Arevirumab-3 can protect up to 100% of cynomolgus macaques against challenge with both lineage II and III LASV isolates when treatment is initiated at advanced stages of disease on day 8 after LASV exposure. (bvsalud.org)
  • Additionally, we demonstrate that a single dose of the αCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. (nature.com)
  • Marburg virus (MARV) causes a hemorrhagic fever disease in human and non-human primates with high levels of morbidity and mortality. (bvsalud.org)
  • The family , known as filoviruses, contains several viruses that are known to cause hemorrhagic, often lethal disease in humans and nonhuman primates (NHPs) all of which are within the Marburgvirus or Ebolavirus genera. (biomedcentral.com)
  • Among these, NHPs have demonstrated the closest resemblance to human HNV disease, although other animal models replicate some key disease features. (bvsalud.org)
  • Cuevavirus, Striavirus, and Thamnovirus are not known to cause disease in humans or NHPs. (biomedcentral.com)
  • Common immortalized cell lines used to study Alzheimer's disease include: human embryonic kidney 293 (HEK293), human neuroblastoma (SH-SY5Y), human neuroglioma (H4), human embryonic mesencephalic (LUHMES), human neural progenitor (ReN), and pheochromocytoma (PC12) cells. (wikipedia.org)
  • Moreover, it has recently been shown that mouse and human ES cells can develop into a three-dimentional (3D) optic cup in culture that remarkably resembles the embryonic vertebrate eye 20 , 21 . (nature.com)
  • This review will compare various animal models to the available descriptions of human pathogenesis and aims to evaluate their effectiveness in modeling important aspects of Marburg virus disease. (biomedcentral.com)
  • Marburg virus (MARV) is the causative agent of Marburg virus disease (MVD) in humans, with a case fatality rate ranging from 23 to 90%, depending on the outbreak [ 1 ]. (biomedcentral.com)
  • Coronavirus-induced disease 2019 (COVID-19) is caused by a zoonotic virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has rapidly spread during the last year and a half, infecting over 100 million humans and causing more than two million deaths worldwide. (nature.com)
  • this animal model reliably recapitulates several hallmarks of Lassa fever infection in humans ( 7 ). (cdc.gov)
  • Human cytomegalovirus induces a pro-inflammatory monocyte following infection. (refine.bio)
  • Without field efficacy studies, researchers must rely on animal models of MARV infection to assess the efficacy of vaccines and treatments, with the limitations being the accuracy of the animal model in recapitulating human pathogenesis. (biomedcentral.com)
  • This product is for research use only and is not approved for use in humans or in clinical diagnosis. (novusbio.com)
  • Animal models of MVD are necessary to develop and test potential vaccines and treatments, and the ability of these models to reflect human pathogenesis is essential to moving forward into clinical trials. (biomedcentral.com)
  • These models often have genetic modifications that enable them to be more representative of human Alzheimer's disease and its associated pathology: extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). (wikipedia.org)
  • Researchers commonly use post-mortem human tissue or experimental models to conduct experiments relating to Alzheimer's disease. (wikipedia.org)
  • As these cultures are derived directly from rodent brain tissue, they morphologically and physiologically resemble human brain cells, contain multiple neuronal cell types, and do not proliferate. (wikipedia.org)
  • Here we have succeeded in inducing human iPSC to recapitulate the main steps of retinal development and to form fully laminated 3D retinal tissue by exploiting the intrinsic cues of the system to guide differentiation ( Supplementary Fig. 1 ). (nature.com)
  • Here we report that hiPSC can, in a highly autonomous manner, recapitulate spatiotemporally each of the main steps of retinal development observed in vivo and form three-dimensional retinal cups that contain all major retinal cell types arranged in their proper layers. (nature.com)
  • Studies using mice have helped researchers to understand the immune response to the bacterium, but they do not fully recapitulate human disease. (globalwomenshealthacademy.org)
  • Experimental models of Alzheimer's disease are particularly useful as they allow complex manipulation of biological systems to elucidate questions about Alzheimer's disease without the risk of harming humans. (wikipedia.org)
  • Outbreaks of HeV and NiV have led to severe respiratory disease and encephalitis in humans and animals characterized by a high mortality rate. (bvsalud.org)
  • Most human infections are acquired from the natural rodent reservoir, the multimammate rat ( Mastomys natalensis ). (cdc.gov)
  • Human and mouse SOX1 share 97% amino acid sequence identity. (novusbio.com)
  • However, in 1999 an outbreak was identified in the Democratic Republic of Congo, where multiple spillover events into the human population are thought to have taken place over the course of 2 years. (biomedcentral.com)
  • We randomly divided 8 female cynomolgus macaques ( Macaca fascicularis ) into 2 groups of 4 each (treatment and control) and injected each animal intramuscularly with a lethal dose of LASV, strain Josiah (1 × 10 4 50% tissue culture infective dose [TCID 50 ]) ( Table ). (cdc.gov)
  • In contrast to tissues from cynomolgus monkeys ( Macaca fascicularis ), our data did not convincingly demonstrate detectable PINK1 expression in pig tissues. (zoores.ac.cn)
  • This study aimed to determine its PK/PD parameter with target values for cefditoren against S. pneumoniae in S. pneumoniae lung-infected mice and to simulate MIC range of S. pneumoniae that can be expected to be treated at approved cefditoren doses in human using population pharmacokinetic (PPK) data from patients. (bvsalud.org)
  • Common immortalized cell lines used to study Alzheimer's disease include: human embryonic kidney 293 (HEK293), human neuroblastoma (SH-SY5Y), human neuroglioma (H4), human embryonic mesencephalic (LUHMES), human neural progenitor (ReN), and pheochromocytoma (PC12) cells. (wikipedia.org)
  • Experimental models of Alzheimer's disease are particularly useful as they allow complex manipulation of biological systems to elucidate questions about Alzheimer's disease without the risk of harming humans. (wikipedia.org)
  • The present work evaluates a novel primary human cell-based 3D organotypic small intestinal microtissues to be a potential pathway for evaluating in vitro bioequivalence, but also using formulated API to estimate the impact of formulation in promotion of absorption and to make comparison of adultversus pediatric forms which are currently in development, at doses corresponding to those employed in clinics. (afssi-connexions.fr)