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FarnesyltranstransferaseAlkyl and Aryl TransferasesProtein PrenylationPolyisoprenyl PhosphatesGeranyltranstransferaseQuinolonesTransferasesPiperidinesMevalonic AcidEnzyme InhibitorsPrenylationDimethylallyltranstransferasePyridinesFarnesolSesquiterpenesrhoB GTP-Binding Proteinras ProteinsLovastatinGenes, rasAntineoplastic AgentsBenzodiazepinesHemiterpenesFarnesyl-Diphosphate FarnesyltransferaseMethionineHydroxymethylglutaryl-CoA Reductase InhibitorsGlutathione TransferaseImidazolesBenzamidesApoptosisTumor Cells, CulturedDose-Response Relationship, DrugMultiple MyelomaCell DivisionCell Line, TumorCarbon-Carbon LyasesMolecular Sequence DataSignal TransductionTransferases (Other Substituted Phosphate Groups)TerpenesOrganophosphorus CompoundsAmino Acid SequenceDiterpenesSubstrate SpecificityGeranylgeranyl-Diphosphate GeranylgeranyltransferaseSqualeneDNA NucleotidylexotransferaseCoenzyme A-TransferasesKineticsDiphosphonatesDiphosphatesSesquiterpenes, GermacraneHydroxymethylglutaryl CoA ReductasesCarbon-Carbon Double Bond IsomerasesDolicholTricarboxylic AcidsProto-Oncogene Proteins p21(ras)Base SequenceSalicylatesHydroxymethylglutaryl-CoA SynthaseProgeriaIsomerasesEscherichia coliCloning, MolecularArtemisiaProtein Processing, Post-TranslationalPeptidyl TransferasesN-AcetylglucosaminyltransferasesMicrococcus luteusSequence Homology, Amino AcidCatalysisRecombinant ProteinsMenthaBinding SitesADP Ribose TransferasesRubberNitrogen CompoundsDolichol PhosphatesHeveaChromatography, Thin LayerOncogene Protein p21(ras)CysteineCell LineMutationCentellaSimvastatinLiverCyclizationProtein MethyltransferasesModels, MolecularMutagenesis, Site-DirectedAcyltransferasesOncogene Protein pp60(v-src)Molecular StructureProtein Phosphatase 2Crystallography, X-RayProto-Oncogene Proteins pp60(c-src)PentanesDrug Antagonism
DiphosphateSynthaseEnzymeMembrane
Diphosphate3
  • Squalene synthase (SQS) or farnesyl-diphosphate:farnesyl-diphosphate farnesyl transferase is an enzyme localized to the membrane of the endoplasmic reticulum. (wikipedia.org)
  • Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce (Picea abies) and their relation to induced oleoresin formation. (mpg.de)
  • 2Z,6Z-Farnesyl diphosphate is synthesized by Z-farnesyl diphosphate synthase (M. tuberculosis) from neryl diphosphate. (echelon-inc.com)
Synthase2
  • Squalene synthase (SQS) catalyzes the reductive dimerization of farnesyl pyrophosphate (FPP), in which two identical molecules of FPP are converted into one molecule of squalene. (wikipedia.org)
  • In the first half-reaction, two identical molecules of farnesyl pyrophosphate (FPP) are bound to squalene synthase (SQS) in a sequential manner. (wikipedia.org)
Enzyme1
  • Geranylgeranyl transferase-I (GGTase-I) is an essential enzyme mediating posttranslational modification, especially the geranylgeranylation of small GTPase, Rac1. (hindawi.com)
Membrane1
  • Yck2p lacking C-terminal Cys residues fails to associate with any membrane, whereas substitution of these residues with a farnesyl transferase signal sequence allows sec-dependent plasma membrane targeting and biological function, suggesting that modification is required for interaction with early secretory membranes but that targeting does not require a particular modification. (elsevierpure.com)