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  • inhibits
  • Previously reported observations have shown that trans-trans farnesol inhibits incorporation of choline into phosphatidylcholine and reduces the growth rate of the human acute leukemia CEM-C1 cell line (Melnykovych, G., Haug, J.S. and Goldner, C.M. (1992) Biochem. (nih.gov)
  • isoprenoid
  • Previously, we demonstrated that the Aspergillus nidulans calC2 mutation in protein kinase C pkcA was able to confer tolerance to farnesol (FOH), an isoprenoid that has been shown to inhibit proliferation and induce apoptosis. (nih.gov)
  • fungal
  • The viability of fungal cells was determined by MTT assay and by counting the colony forming units, after each farnesol treatment. (biomedcentral.com)
  • In concentrations that do not affect fungal viability, farnesol retards the germ-tube formation of P. brasiliensis , suggesting that the morphogenesis of this fungal is controlled by environmental conditions. (biomedcentral.com)
  • biofilms
  • Northern blot analysis of RNA extracted from cells in biofilms indicated that the levels of expression of HWP1 , encoding a hypha-specific wall protein, were decreased in farnesol-treated biofilms compared to the levels in controls. (asm.org)
  • We investigated the influence of apigenin and tt -farnesol, alone and in combination, on the accumulation, polysaccharide composition and viability of S. mutans UA159 biofilms. (oup.com)
  • Apigenin and tt -farnesol affected the accumulation and polysaccharide content of S. mutans biofilms without major impact on the bacterial viability. (oup.com)
  • mimics
  • While neither offers protection from candidiasis, one analog mimics farnesol in acting as a virulence factor, whereas the other has no effect. (unl.edu)
  • Specifically, we have demonstrated that Tac1 and Znc1 are functionally activated by farnesol through a mechanism that mimics other means of hyperactivation of Zn cluster transcription factors. (asm.org)
  • viability
  • The present results show that after incubation in the presence of farnesol the cells decrease in viability. (nih.gov)
  • Under 120‐min UVB exposure, screening with plural gel composed of 0.0025% farnesol, 0.5% HA, and 0.5% XG containing 1.5% or 2% HPMC retained normal fibroblast viability. (deepdyve.com)
  • When employing levels which don't compromise cell viability (5 to 15 μM), it was shown that farnesol also affected the morphogenesis of this fungus. (biomedcentral.com)
  • planktonic
  • Our results demonstrated that there was a higher CFU log reduction of S. epidermidis planktonic cells when farnesol was combined with NAC at 1 × MIC relatively to each agent alone. (scielo.br)
  • incorporation
  • Farnesol concentrations greater than 10 µg/mL abolished the enhanced incorporation, and the magnitude of the increased incorporation was dependent on cell-surface hydrophobicity. (fairfield.edu)
  • dependent
  • These results suggest that the purified enzyme is a novel NAD(P)+-dependent farnesol dehydrogenase. (sigmaaldrich.com)
  • This is consistent with our observation that many genes acutely induced by farnesol are dependent on TAC1 , ZNC1 , or both. (asm.org)
  • nuclear
  • Transcription factors that directly respond to farnesol as a nuclear receptor/effector to regulate gene expression, however, have not been identified. (asm.org)
  • Molecular
  • Therefore, recombinant farnesol dehydrogenase may provide a useful molecular tool in manipulating juvenile hormone biosynthesis to generate transgenic plants for pest control. (sigmaaldrich.com)
  • exposure
  • After 60‐min exposure to UVB, screening with plural gel composed of farnesol, HA, XG, and 0.5%, 1.0%, 1.5%, or 2% HPMC decreased the ratio of the G1 phase and increased ratio of the S phase in comparison with the accumulated cell cycle of the normal fibroblasts without screening. (deepdyve.com)
  • results
  • In vivo histopathological results showed that the prepared plural gels with 0.5% or 2% HPMC and farnesol, HA, and XG had greater antiphotoaging and reparative effects against UVB‐induced changes and damage in the skin. (deepdyve.com)
  • In conclusion, the current in vitro and in vivo results demonstrated that the prepared plural composed of 0.0025% farnesol, 0.5% HA, 0.5% XG, and 2% HPMC possessed the greatest UVB‐screening capacity and the strongest restorative effects on UVB‐induced sunburned skin. (deepdyve.com)
  • protein
  • Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response. (nih.gov)
  • cellular
  • This farnesol-induced effect was also demonstrated by flow cytometry by staining the cellular DNA with propidium iodide and was partially reversible with phosphatidylcholine. (nih.gov)
  • Kuo, Shyh Ming 2018-01-01 00:00:00 Farnesol, a natural 15‐carbon organic compound, has various microbiological and cellular activities. (deepdyve.com)
  • Among these are a thorough accounting of the cellular receptors and transporters for farnesol. (asm.org)
  • decrease
  • The recoverable viable counts of S. mutans were slightly lower (0.5 to 1 log 10 decrease in cfu/biofilm) after apigenin and tt -farnesol treatments compared with the vehicle control. (oup.com)
  • study
  • This study demonstrated that no synergy was observed between farnesol and NAC. (scielo.br)
  • In this study, farnesol dehydrogenase was extracted from Polygonum minus leaves and purified 204-fold to apparent homogeneity by ion-exchange chromatography using DEAE-Toyopearl, SP-Toyopearl, and Super-Q Toyopearl, followed by three successive purifications by gel filtration chromatography on a TSK-gel GS3000SW. (sigmaaldrich.com)
  • previously
  • The amino acid sequences of 4 tryptic peptides of the enzyme were analyzed by MALDI-TOF/TOF-MS spectrometry, and showed no significant similarity to those of previously reported farnesol dehydrogenases. (sigmaaldrich.com)
  • Influence
  • Influence of heterocyclic and oxime-containing farnesol analogs on quo" by Roman Shchepin, Dhammika H.M.L.P. Navarathna et al. (unl.edu)
  • treatment
  • The ABC ( A TP- b inding c assette) transporter Cdr1 was found upregulated upon 2 to 24 h of farnesol treatment ( 21 , 22 ) and has been proposed to play a role in farnesol efflux ( 22 ). (asm.org)