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  • antibody
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • BRCA1 and BRCA2
  • This protein is monoubiquitinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 and BRCA2) involved in homology-directed DNA repair (see Figure: Recombinational repair of DNA double-strand damages). (wikipedia.org)
  • BRCA1 and BRCA2 are unrelated proteins, but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired. (wikipedia.org)
  • Genome
  • BRCA1 combines with other tumor suppressors, DNA damage sensors and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). (wikipedia.org)
  • Cytoskeletal Proteins
  • The spectrins are a family of widely distributed cytoskeletal proteins which are involved in actin crosslinking, cell adhesion, intercellular communication and cell cycle regulation. (wikipedia.org)
  • foci
  • In response to DNA damage, proteins involved in double-strand break repair by homologous recombination relocalize into discrete nuclear foci. (genetics.org)
  • ubiquitin
  • E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene. (wikipedia.org)
  • The ring domain is an important element of ubiquitin E3 ligases, which catalyze protein ubiquitination. (wikipedia.org)
  • Ubiquitin is a small regulatory protein found in all tissues that direct proteins to compartments within the cell. (wikipedia.org)
  • Cdk1 phosphorylation also leads to the activation of the ubiquitin-protein ligase APCCdc20, an activation which allows for chromatid segregation and, furthermore, degradation of M-phase cyclins. (wikipedia.org)
  • Spectrin
  • Alpha II-spectrin, also known as Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene. (wikipedia.org)
  • Thirdly, an insert of five amino acids in the fifteenth spectrin motif bears a highly antigenic epitope resembling an ankyrin-like p53 binding protein binding site. (wikipedia.org)
  • Elevated protein expression of alpha II-spectrin has been detected in cerebrospinal fluid in patients with Guillain-Barré syndrome. (wikipedia.org)
  • homologous recombination
  • DNA interstrand crosslinks are highly deleterious damages that are repaired by homologous recombination involving coordination of FA proteins and breast cancer susceptibility gene 1 (BRCA1). (wikipedia.org)
  • DNA interstrand crosslinks are highly deleterious damages that are repaired by homologous recombination involving coordination of FA proteins and breast cancer susceptibility gene 1 (BRCA1), but the exact biochemical roles of these proteins is currently unclear. (wikipedia.org)
  • The protein encoded by this gene delays the onset of apoptosis and promotes homologous recombination repair of damaged DNA. (wikipedia.org)