• functional" genes encoding proteins such as late embryogenesis-associated proteins, detoxification enzymes, heat shock proteins and molecular chaperones, which directly protect plants from abiotic stress, and "regulatory" genes encoding proteins such as protein kinases and transcription factors (TFs), which have roles in the perception and transduction of stress signals. (biomedcentral.com)
  • The NAC domain was deduced from three previously characterized proteins, petunia NAM (no apical meristem), Arabidopsis thaliana ATAF1/2 ( Arabidopsis thaliana activation factor 1/2) and CUC2 (cup-shaped cotyledon) [ 13 , 14 ]. (biomedcentral.com)
  • Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. (nih.gov)
  • Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
  • Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (homeodomains.com)
  • Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members of a family of transcription factors which bind GC/GT-rich promoter elements through three C 2 H 2 -type zinc fingers that are present at their C-terminal domains. (houstonmethodist.org)
  • There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor. (houstonmethodist.org)
  • As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
  • Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
  • When STAT proteins are activated, they can increase the transcription of several target genes , which leads to unchecked cellular proliferation , anti-apoptotic reactions, and angiogenesis. (bvsalud.org)
  • Here, we give a succinct summary of the various functions that each member of the STAT family plays in lung cancer and go into more detail about the advantages and disadvantages of pharmacologically targeting STAT proteins and their upstream activators in the context of lung cancer treatment . (bvsalud.org)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • YtrASa, a GntR-family transcription factor represses two genetic loci encoding membrane proteins in Sulfolobus acidocaldarius. (vub.be)
  • Dof domain proteins:plant-specific transcription factors associated with diverse phenomena unique to plants[J]. Plant and Cell Physiology,2004,45(4):386-391. (nefu.edu.cn)
  • The Arabidopsis Athb-8,-9 and-14 genes are members of a small gene family coding for highly related HD-ZIP proteins[J]. Plant Molecular Biology,1998,38(4):609-622. (nefu.edu.cn)
  • Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
  • The numerous members of this family are organized in several subgroups according to structural identities found within the proteins. (bvsalud.org)
  • Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (nih.gov)
  • The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
  • Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
  • This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
  • In this study, we characterized the interaction between p53 family-dependent signaling pathways and the regulation of AFP at the gene and protein levels as essential determinants of therapeutic response and prognosis in HCC. (jgld.ro)
  • Thus, our findings reveal a novel interaction of p53 family-dependent signaling pathways and AFP regulation at the gene and protein levels in HCC. (jgld.ro)
  • The HD-Zip transcription factor family is a kind of special protein in plant, playing crucial roles in plant development processes and abiotic stresses response. (nefu.edu.cn)
  • The protein family includes a highly conserved homeodomain(HD) and a leucine zipper domain(LZ), forming a special structural model. (nefu.edu.cn)
  • The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
  • STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
  • Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)
  • A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
  • A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. (bvsalud.org)
  • We have used Southern blot technique to test whether a gene of the CCAAT/enhancer binding protein (C/EBP) family, CHOP, which maps to 12q13 and is assumed to be involved in adipocyte differentiation, could be the 12q gene in question. (lu.se)
  • Families of molecules such as those of Wnt, Hh (hedgehog), FGFs (Fibroblast Growth Factor) and BMPs (Bone Morphogenetic Protein, of TGFßs - Transforming Growth Factor family) have been identified, in different proportions and sites, with tissue-specific and stage-specific functions 1-2 . (bvsalud.org)
  • The NAC [NAM (No Apical Meristem), ATAF1 ( Arabidopsis thaliana Activation Factor 1), and CUC2 (Cup-shaped Cotyledon)] transcription factor family is one of the largest transcription factor families in plants. (biomedcentral.com)
  • The Arabidopsis ERFIb / RAP2.4 transcription factor family consists of eight members with highly conserved DNA binding domains. (fu-berlin.de)
  • The NAC domain transcription factors in Arabidopsis function in plant development, senescence, and stress regulation. (frontiersin.org)
  • Octadecanoid-responsive arabidopsis 59 (ORA59) is an ethylene response factor (ERF) transcription factor and has been suggested to integrate ethylene and jasmonic acid signaling and regulate resistance to necrotrophic pathogens. (figshare.com)
  • According to gene annotations in Arabidopsis thaliana, the functions of HD-Zip transcription factor in poplarwere predicted.The conserved domains, structural characteristics and chemical properties of HD-Zip family members were also studied by bioinformatics, providing reference for gene functions of HD-Zip family in poplar. (nefu.edu.cn)
  • The HAT2 gene,a member of the HD-Zip gene family,isolated as an auxin inducible gene by DNA microarray screening,affects auxin response in Arabidopsis [J]. The Plant Journal,2002,32(6):1011-1022. (nefu.edu.cn)
  • ClassⅢ homeodomain-leucine zipper gene family members have overlapping,antagonistic,and distinct roles in Arabidopsis development[J]. The Plant Cell,2005,17(1):61-76. (nefu.edu.cn)
  • Characterization of the class Ⅳ homeodomain-leucine zipper gene family in Arabidopsis [J]. Plant Physiology,2006,141(4):1363-1375. (nefu.edu.cn)
  • Within the transcription factor family, RAP2.4a has a unique function as a general transcriptional activator of chloroplast peroxidase activity. (fu-berlin.de)
  • Transactivation assay in yeast cells revealed that CmNAC1 functions as a transcription activator, and its transactivation domain is located in the C-terminus. (frontiersin.org)
  • Signal transducer and activator of transcription (STAT) family of transcription factors are involved in lung cancer cell proliferation , metastasis , immunological control, and treatment resistance. (bvsalud.org)
  • These transcription factors bound, like RAP2.4c and RAP2.4g, the tAPx promoter, but hardly the 2CPA promoter.The RAP2.4 transcription factors form an environmentally and developmentally regulated transcription factor network, in which the various members affect the expression intensity of the others. (fu-berlin.de)
  • They are caused by genetic translocations which fuse transcription factor genes, TFE3 or TFEB, with a promoter region leading to overexpression of the transcription factor. (dundee.ac.uk)
  • The ETS (Erythroblast Transformation Specific)family is divided into 12 subfamilies, which are listed below: All ETS (Erythroblast Transformation Specific) family members are identified through a highly conserved DNA binding domain, the ETS domain, which is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. (wikipedia.org)
  • All organisms-bacteria, archaea, and eukaryotes-have a transcription initiation factor that contains a structural module that binds within the RNA polymerase (RNAP) active-center cleft and interacts with template-strand single-stranded DNA (ssDNA) in the immediate vicinity of the RNAP active center. (osti.gov)
  • Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)
  • Binds to the GAS element and activates PRl-induced transcription. (lu.se)
  • This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. (nih.gov)
  • These genes comprise 289 Transcription Factors (TFs) representing Basic Helix-loop Helix (bHLH), Ethylene Response Factors (ERFs), myeloblastosis (MYB), No apical meristem (NAC), and WRKY amino acid motif (WRKY) type major families known to be involved in the mechanism of stress tolerance. (frontiersin.org)
  • Because this genetic change affects CBF, the condition is classified as core binding factor AML (CBF-AML). (medlineplus.gov)
  • Genetic factors might play a substantial role in the incidence of YEL-AVD. (cdc.gov)
  • We predicted SIRs for homeodomain (HD), helix-loop-helix, LacI and GntR families of TFs using these methods and compared to MI. (wustl.edu)
  • Redox regulation of plant homeodomain transcription factors[J]. Journal of Biological Chemistry,2002,277(38):34800-34807. (nefu.edu.cn)
  • Genome-wide identification,evolutionary expansion,and expression profile of homeodomain-leucine zipper gene family in poplar ( Populus trichocarpa )[J]. PLoS One,2012,7(2):e31149. (nefu.edu.cn)
  • The PITX gene encode the paired-like homeodomain transcription factor family. (nature.com)
  • The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
  • The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis. (wikipedia.org)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • Underlining the importance of the crosstalk between the p53 family-dependent pathways and AFP regulation we identified eight novel putative binding sites for the members of the p53 family within the introns 1, 2, 3, 4, 7, 8, 11, and 12 of the AFP gene. (jgld.ro)
  • Here we show that AFP gene regulation occurs via a combined action of the p53 family members p53, p63 and p73. (jgld.ro)
  • The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
  • Transcription factors of the NFAT family: regulation and function. (axonmedchem.com)
  • Despite the availability of six completely sequenced legume genomes, a comprehensive investigation of bZIP family members in legumes has yet to be presented. (datadryad.org)
  • EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses. (ikarosfamily.com)
  • The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
  • An inhibitory molecule of the IKB family interacts with NF-KB to sequester it in the cytoplasm. (medscape.com)
  • FOXC2 is a member of the forkhead/winged-helix family of transcription factors, whose members are involved in diverse developmental pathways. (nih.gov)
  • Transcriptions are key functions in signal transduction pathways. (homeodomains.com)
  • Our results indicated that CmNAC1 is a critical factor in ABA signaling pathways and it can be utilized in transgenic breeding to improve the abiotic stress tolerance of crops. (frontiersin.org)
  • Finally, we conducted a comprehensive analysis of the TCP gene family and identified 16 tendril-related ( TEN ) genes in 11 Cucurbitaceae species. (unl.edu)
  • In conclusion, this study will serve as a reference for studying the relationship between gene family evolution and genome duplication. (unl.edu)
  • The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)
  • Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (homeodomains.com)
  • NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. (homeodomains.com)
  • In the neurons to which information is input, MAPK(1) activates transcription factor CREB(2) by training with an interval, and expresses c-fos(3). (sciencedaily.com)
  • Conclusions: In summary, this genome-wide identification, characterization and expression analysis of legume bZIP genes provides valuable information for understanding the molecular functions and evolution of the legume bZIP transcription factor family, and highlights potential legume bZIP genes involved in regulating tissue development and abiotic stress responses. (datadryad.org)
  • Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
  • A genome-wide survey of HD-Zip genes in rice and analysis of drought-responsive family members[J]. Plant Molecular Biology,2008,66(1-2):87-103. (nefu.edu.cn)
  • As a transcription factor, Pax6 acts at the molecular level in the signaling and formation of the central nervous system 11 . (biolegend.com)
  • Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)
  • NAC family members are known to regulate plant growth and abiotic stress response. (biomedcentral.com)
  • Transcription factors (TFs) regulate plant growth at the transcription level. (unl.edu)
  • This finding allows us to pursue a more comprehensive approach to understand fat biology and provides an opportunity to learn about the cascade of events that regulate KLF activation, repression and interaction with other factors in exerting its biological function at an organismal level. (ijbs.com)
  • Thus, the p53 family members were identified to be major regulators of AFP repression. (jgld.ro)
  • During plant growth and development, MYB transcription factors play an important role in responding to abiotic stresses and regulating the synthesis of secondary metabolites. (biomedcentral.com)
  • November 3, 2023 ACD Meeting Transcription we're in a pretty good place, less than 3 percent of counties in the country are high community levels where we are recommending people step up. (cdc.gov)
  • Transcription factors (TFs) are major modulators of transcription and subsequent cellular processes. (wustl.edu)
  • Sp transcription elements like Sp1 Sp3 and Sp4 have an effect on multiple cellular procedures and also have been involved with development numerous kinds of malignancies including pancreatic breasts gastric and thyroid cancers [7]. (colinsbraincancer.com)
  • In addition, ETS factors, e.g. the vertebrate Etv1 and the invertebrate Ast-1, have been shown to be important players in the specification and differentiation of dopaminergic neurons in both C. elegans and olfactory bulbs of mice. (wikipedia.org)
  • In 2000, the International Incontinentia Pigmenti Consortium reported that incontinentia pigmenti is caused by a genomic rearrangement of the gene for NEMO, or nuclear factor kappa B essential modulator (IKBKG-IKK gamma). (medscape.com)
  • Pax6 is a transcription factor present during embryonic development. (biolegend.com)
  • MTM-SDK and MTM-SK (Amount 1) were attained by targeted inactivation from the ketoreductase in charge of the last stage of MTM biosynthesis [33 35 In biochemical and mobile assays both ELF3 substances acted AZD8931 as powerful repressors of Sp1-governed transcription [35]. (colinsbraincancer.com)
  • During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. (homeodomains.com)
  • RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
  • The members of the family have been implicated in the development of different tissues as well as cancer progression. (wikipedia.org)
  • Amongst members of the ETS family, there is extensive conservation in the DNA-binding ETS domain and, therefore, a lot of redundancy in DNA binding. (wikipedia.org)
  • TFE3 and TFEB are members of the MiT family of transcription factors. (dundee.ac.uk)
  • Other tumors also driven by overexpression of members of the MiT family include alveolar soft part sarcoma, clear cell sarcoma and 30%-40% of melanomas. (dundee.ac.uk)
  • The present findings provide data resources for the subsequent study of the functions of MYB transcription factor family members in ginseng, and provide an experimental basis for the anti-salt functions of MYB transcription factors in Panax ginseng . (biomedcentral.com)
  • The HD-Zip transcription factor family, including 63 members, can be classified into 4 subfamilies HD-Zip Ⅰ, HD-Zip Ⅱ, HD-Zip Ⅲ and HD-Zip Ⅳ. (nefu.edu.cn)
  • The NFAT family consists of five members: NFAT1 (also known as NFATp or NFATc2), NFAT2 (also known as NFATc or NFATc1), NFAT3 (also known as NFATc4), NFAT4 (also known as NFATx or NFATc3) and NFAT5. (axonmedchem.com)
  • In this descriptive study, we describe the epidemiologic investigation of the 2 clusters of YEL-AVD among family members. (cdc.gov)
  • Risk and Protective Factors for Cancer Mortality Among United States Service Members and Veterans (2001-2018). (cdc.gov)
  • The redox-sensitive transcription factor RAP2.4a mediates chloroplast-to-nucleus redox signaling and controls induction of the three most prominent chloroplast peroxidases, namely 2-Cys peroxiredoxin A (2CPA) and thylakoid- and stromal ascorbate peroxidase (tAPx and sAPx). (fu-berlin.de)
  • Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. (medlineplus.gov)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • Our findings revealed that the recent WGD events that had occurred in Cucurbitaceae played important roles in the expansion of most TF families. (unl.edu)
  • Belongs to the transcription factor STAT family. (lu.se)
  • SARS-CoV-2 belongs to the family Coronaviridae and genus Betacoronavirus . (who.int)
  • Work in mouse has shown that the family of Krüppel-like factors (KLFs), a conserved and important class of transcription factors, regulates adipocyte differentiation in mammals. (ijbs.com)
  • R62D-induced phenotypes strongly resemble neurons lacking SRF (Serum Response Factor). (jneurosci.org)
  • ETS factors act as transcriptional repressors, transcriptional activators, or both. (wikipedia.org)
  • regulatory T cells (Treg) markers (CD4, CD25, forkhead box P3) and Helios (also known as IKAROS Family Zinc Finger 2 [IKZF2]) were detected using flow cytometry. (ikarosfamily.com)
  • Gsn ) and is the archetypical transcription factor to study actin interplay with transcription. (jneurosci.org)
  • Hep3B cells were transfected with plasmids encoding for p53, p63 and p73 to analyze the interplay of the p53 family with AFP. (jgld.ro)
  • FOXC2 represents the second known gene to result in hereditary lymphedema, and LD is only the second hereditary disorder known to be caused by a mutation in a forkhead-family gene. (nih.gov)
  • The founding member of this family was identified as a gene transduced by the leukemia virus, E26. (wikipedia.org)
  • Other domains are also present and vary from ETS member to ETS member, including the Pointed domain, a subclass of the SAM domain family. (wikipedia.org)
  • This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. (nih.gov)
  • The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors. (musc.edu)
  • Panax ginseng , a member of the perennial herb genus Ginseng in the family of Araliaceae, has been used medicinally for millennia. (biomedcentral.com)
  • Forms a homodimer or a heterodimer with a related family member. (lu.se)
  • Using NMR spectroscopy, we identified and characterized a previously unrecognized structured domain near the N-terminus (residues 35-121) of the ETS family transcription factor GABP alpha. (ubc.ca)
  • Currently, no reports are available on the functions of the NAC family in pearl millet. (biomedcentral.com)
  • Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)