• Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
  • The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. (embl.de)
  • To begin to build such an interaction map, we have initially focused on integrins, the major receptors for extracellular matrix proteins. (uiowa.edu)
  • Integrins mediate cell adhesion and migration during development, in homeostasis, and in a variety of pathological settings, including tumor cell metastasis. (uiowa.edu)
  • Thus at present there is no satisfactory explanation for how different integrins that share a common β subunit are able to mediate different cellular responses. (uiowa.edu)
  • For example, tumor cell motility mediated by α3β1 integrin on its ligand, laminin-332 (laminin-5), can be 3-4 fold faster than motility mediated by other β1 integrins, such as the collagen receptor, α2β1, or the fibronectin receptor, α5β1. (uiowa.edu)
  • We hypothesize that the diversity in the functions of different β1 integrins may derive in part from their differing patterns of lateral cell surface interactions. (uiowa.edu)
  • Our earlier studies helped to establish that α3β1 integrin is distinguished from other β1 integrins, such as α2β1 and α5β1, by its ability to avidly engage in complexes with members of the tetraspanin family of cell surface adaptor proteins. (uiowa.edu)
  • Another form of integrin functional diversity is the ability of individual integrins to mediate different responses in different cell types. (uiowa.edu)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
  • These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta 1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [ 4 ]. (biomedcentral.com)
  • This could be considered to be part of a feedback loop as changes in ECM composition results in changes in HSC cell surface receptors, particularly integrins indicating that the ECM should not be regarded simply as an inert physical scaffold but a dynamic structure that is able to influence the phenotype of HSCs [ 2 , 8 , 9 ]. (biomedcentral.com)
  • Rap-1 is an essential protein involved in signaling mediated by integrins. (medscape.com)
  • These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. (wikipedia.org)
  • The cell surface receptors that interpret these cues engage cytoplasmic partners to transduce signals, but recent work reveals that many receptors also interact laterally with cell surface proteins that can be critical for proper receptor function. (uiowa.edu)
  • Tetraspanins, so named because of their four transmembrane domains, are a large family of proteins known for their ability to assemble multi-protein cell surface complexes. (uiowa.edu)
  • Integrin α3β1 strongly interacts with one particular tetraspanin, CD151, which in turn links α3β1 into larger cell surface complexes that may contain other tetraspanins, Ig superfamily (IgSF) proteins, growth factor receptors, membrane-bound growth factors, and novel proteins (Figure 1). (uiowa.edu)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
  • In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
  • The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (cancer-genetics.org)
  • Like the other Vav proteins, Vav3 is phosphorylated (activated) following ligand binding to a variety of receptor tyrosine kinases (TKs), including EGF receptor, PDGF receptor, insulin receptor, and insulin-like growth factor I receptor. (cytoskeleton.com)
  • A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
  • These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
  • To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)
  • The RPSA gene encodes a multifunctional protein, which is both a ribosomal protein and a high-affinity, non-integrin laminin receptor. (wikipedia.org)
  • While both subunits contribute to ligand-binding specificity, the β subunit cytoplasmic tail mediates most of the established integrin signaling and cytoskeletal interactions that have been identified. (uiowa.edu)
  • HSCs express numerous cell surface receptors including both discoidin domain receptors (DDRs)-which are receptors for collagen I and many of the integrin subunits, which are a major family of cell surface receptors for extracellular molecules and play a critical role in many biological functions [ 7 , 10 ]. (biomedcentral.com)
  • Interaction with ECM is a major driver of HSC morphology [ 11 ], and signal transduction from integrin activation occurs at least partly through aggregation and subsequent activation of focal adhesion kinases (FAKs) by autophosphorylation of tyrosine 397 (Y397). (biomedcentral.com)
  • AAV2 for example can attach to heparan sulfate proteoglycan (HSPG) cell surface receptors, fibroblast growth factor receptor-1 (FGFR1), hepatocyte growth factor (HGF) receptor, and laminin receptor, whereas ανβ5 integrin and α5β1 integrin can act as co-receptors. (progen.com)
  • Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. (cusabio.com)
  • The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. (cusabio.com)
  • Vav3 is involved in integrin-mediated signaling, wound healing, angiogenesis, bone remodeling, development of the cerebellum, an area important for motor coordination, and GABAergic innervation of the brainstem which controls cardiovascular, respiratory, and renal functions. (cytoskeleton.com)
  • Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by β 3 integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization. (rupress.org)
  • We demonstrate that α v β 3 integrin enhances BMDC recruitment and retention at angiogenic sites by mediating cellular adhesion and transmigration of BMDCs through the endothelial monolayer but not their release from the bone niche. (rupress.org)
  • This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
  • During liver fibrosis, the composition of the ECM changes from one dominated by collagen IV and laminin [ 4 ], to one of fibrillar collagen, predominantly collagen I and III, as well as fibronectin [ 5 ]. (biomedcentral.com)
  • ii) Serial deletions of RPSA have shown that the segment of residues 236-262, included in the C-domain, is involved in the interaction between RPSA and the 40S subunit of ribosome. (wikipedia.org)
  • The folding intermediate is predominant at 37 °C. Several interactions of RPSA that had originally been discovered by methods of cellular biology, have subsequently been confirmed by using recombinant derivatives and in vitro experiments. (wikipedia.org)
  • RPSA is a potential cellular receptor for several pathogenic Flaviviruses, including the dengue virus (DENV), and Alphaviruses, including the Sindbis virus (SINV). (wikipedia.org)
  • Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
  • This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)
  • Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)
  • In OA, cartilage damage is the outcome of an abnormal extra-cellular matrix (ECM) remodelling leading to an overwhelm of tissue breakdown mediated by metalloproteinases (MMPs). (biomedcentral.com)
  • Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)
  • They gated mediated to facilitate a JmjC cellular debris, specifically secreted in direct receptors( Clissold & Ponting 2001). (erik-mill.de)
  • To this end, molecular and cellular interactions may influence the tissue reactions to biomaterials. (bvsalud.org)
  • Likely other tissues, many events occur when a given biomaterial is in contact with the biological bone environment, with molecular and cellular interactions influencing on the tissue features surrounding the biomaterial. (bvsalud.org)
  • Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)
  • The ESCRT portion tends typically human for receptor-ligand transport that is fulfilment metabolized unidirectional binds. (erik-mill.de)
  • Both recombinant N-domain and C-domain of RPSA bind laminin in vitro, and they bind with similar dissociation constants (300 nM). (wikipedia.org)
  • Engler, O.B., Strasser, I., Naisbitt, D.J., Cerny, A. and Pichler, W.J. (2004) A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals. (scirp.org)
  • Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). (cusabio.com)
  • 2004) T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage. (scirp.org)
  • These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
  • Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. (cusabio.com)
  • Estrone is only a weak agonist of estrogen receptor but it serves as a precursor for biosynthesis of 17β-estradiol, 16α-hydroxyestrone and catechol estrogens. (helsinki.fi)
  • The MutS requirements suppress with conformational enzymes binding other MLH and MutL, the later bind aromatic release family favour and catalytic cytokine to the MLH Canadians, widely eventually as RPA, EXO1, RFC, well long, and D-fructose less intrinsic lipids. (erik-mill.de)
  • The SH3-SH2-SH3 C-terminal domains bind directly with the auto-phosphorylated cytoplasmic tails of the receptor TKs while the B- and T-cell receptors activate cytosolic TKs. (cytoskeleton.com)
  • RPSA is also a receptor for small molecules. (wikipedia.org)
  • Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
  • Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)
  • GAGs and PGs perform multiple functions in specific stages of the metastatic cascade due to their defined structure and ability to interact with both ligands and receptors regulating cancer pathogenesis. (hindawi.com)
  • Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
  • dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
  • There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)
  • The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
  • Activation of Escherichia coli F1-ATPase by lauryldimethylamine oxide and ethylene glycol: relationship of ATPase activity to the interaction of the .epsilon. (mcmaster.ca)
  • Currently, a major focus in the lab is determining (i) the extent to which assembly into tetraspanin complexes can help to explain α3β1 integrin's ability to mediate unusually rapid tumor cell migration, and (ii) the implications of tetraspanin association for the role of α3β1 in metastatic tumor cell spread. (uiowa.edu)
  • The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
  • The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
  • targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, and it led to a significant delay in tumor engraftment plus a strong reduction in tumor size and invasion. (cusabio.com)
  • This report provides a novel insight into the mechanism, involving interaction with high temperature requirement A2, by which ITGA7 acts as a tumor suppressor. (cusabio.com)
  • ILK interaction with MCM7 and MCM7 phosphorylation may be a critical event in ITGA7 signaling pathway, leading to tumor suppression. (cusabio.com)
  • These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors. (spandidos-publications.com)
  • Inhibition is removed by tyrosine kinase (TK)-mediated phosphorylation of the conserved Tyr174 residue (on Vav3, Tyr173 corresponds to Vav1 Tyr174 based on Vav1 amino acid numbering) in the AC helix. (cytoskeleton.com)
  • Komatsu, T., Moriya, N. and Shiohara, T. (1996) T cell receptor (TCR) repertoire and function of human epidermal T cells: Restricted TCR V alpha-V beta genes are utilized by T cells residing in the lesional epidermis in fixed drug eruption. (scirp.org)
  • Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). (cancer-genetics.org)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • Depending on the serotype, different receptors and co-receptors located in the host membrane mediate the entry process. (progen.com)
  • Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
  • Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. (neurotree.org)
  • Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
  • While 16α-hydroxyestrone has relatively weak affinity for estrogen receptor, it has prolonged effect due to covalent binding to the receptor. (helsinki.fi)
  • Laminin is a large molecular weight glycoprotein present only in basement membranes in almost every animal tissue. (embl.de)
  • The tissue tropism of the different AAV serotypes is determined by the different cell surface receptors used for the attachment to the target cell. (progen.com)
  • With the role decisions recently caused on the ongoing actin of the phosphatidylinositol domain, the family hydrogen temperature acts reviewed for reversible involving. (erik-mill.de)
  • The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
  • Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. (cusabio.com)
  • Thus, a more sophisticated understanding of cell migration will require a "cell surface interaction map" describing the physical and functional connections between receptors and their cell surface partners. (uiowa.edu)
  • wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. (neurotree.org)
  • Low affinity receptor for granulocyte-macrophage colony-stimulating factor. (cusabio.com)
  • National Science Foundation, and cleaved on BBC World, Science 360, and continuous viral receptors enzymes. (erik-mill.de)
  • 1998) Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: Evidence for antigenic selection of T cells in the synovium. (scirp.org)
  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. (cancer-genetics.org)
  • Further investigation of their regulative roles and interaction may provide new insights into the pathological mechanisms and therapeutic targets for KBD. (nature.com)
  • RPSA is a ribosomal protein which has acquired the function of laminin receptor during evolution. (wikipedia.org)
  • This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
  • During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. (cusabio.com)
  • There are numerous downstream signalling targets of FAK with many of the effects ultimately mediated by changes in gene expression [ 11 - 13 ]. (biomedcentral.com)
  • This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
  • Proteomic results were analyzed with gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interactions (PPI). (nature.com)
  • Each laminin is a heterotrimer assembled from alpha, beta and gamma chain subunits, secreted and incorporated into cell-associated extracellular matrices. (embl.de)
  • 2011) Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. (scirp.org)
  • Laminin IV domain is also found in the perlecan protein, an integral component of basement membranes, which serves also as an attachment substrate for cells, but it is not found in short laminin chains (alpha4 or beta3). (embl.de)
  • 2012) Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. (scirp.org)
  • In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
  • All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
  • 1994) T cell receptor V alpha repertoire of infiltrating T cells in labial salivary glands from patients with Sjogren's syndrome. (scirp.org)
  • 1992) T cell receptor repertoire of infiltrating T cells in lips of Sjogren's syndrome patients. (scirp.org)
  • Wucherpfennig, K.W. and Hafler, D.A. (1995) A review of T-cell receptors in multiple sclerosis: Clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. (scirp.org)
  • Many of the effects of laminin are mediated through interactions with cell surface receptors. (wikipedia.org)
  • Of the theoretical training needs, topics related to pharmacokinetics and special characteristics of using medicines in the elderly, effects, adverse effects and interactions of medicines, were most important. (helsinki.fi)
  • The different laminin chains share a 600-residue domain I/II which oligomerises into a rod-like coiled-coil structure forming the long arm of laminins. (embl.de)
  • Jay inhibited and generated family of nucleic NaPi-IIc surfactant residue Imagine Research, which bound observed by protease in March 2012. (erik-mill.de)
  • The adeno-associated virus (AAV) is a small (25 nm), non-enveloped virus of the parvoviridae family, including 12 different AAV serotypes. (progen.com)
  • The N-terminal short arms consist of rod-like elements (domain III and V) formed by tandem arrays of laminin-type EGF modules and several globular domains: domains IV and domain VI (laminin N-terminal). (embl.de)