• The HES7 protein is a transcription factor that functions as a transcriptional repressor. (wikipedia.org)
  • The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. (nih.gov)
  • PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. (nih.gov)
  • 42329 iron %28metal%29 dependent repressor%2C DtxR family CP001857 CDS Arcpr_0049 complement(42326. (go.jp)
  • The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. (hmdb.ca)
  • TCF1 is inactivated by association with the transcriptional repressor TLE proteins. (biolegend.com)
  • During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. (biolegend.com)
  • Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. (jax.org)
  • retn is implicated as a major repressor of male courtship behavior in the absence of the fruitless ( fru ) male protein. (sdbonline.org)
  • Functions as a transcriptional repressor that suppresses cell elongation. (utoronto.ca)
  • However, these receptors exhibit a high degree of sequence variability at their NH(2)-terminal domain, which suggests the possibility of receptor-specific interactions with co-regulator proteins. (nih.gov)
  • We propose that HP0222 is a novel transcriptional regulator in H. pylori. (wustl.edu)
  • 14733) putative transcriptional regulator%2C AsnC family CP001857 CDS Arcpr_0015 complement(14711. (go.jp)
  • It is a nuclear protein and functions as a transcriptional regulator. (antikoerper-online.de)
  • Hairy-related proteins can direct these transcriptional corepressors to target genes. (wikipedia.org)
  • The transcriptional levels of p16 INK4A and MeCP2 genes did not display any difference between gastric cancerous and matched non-cancerous tissues. (wjgnet.com)
  • Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. (jax.org)
  • A new study by Mark Bedford, Ph.D. , professor of Molecular Carcinogenesis , and colleagues published in Molecular Cell sheds light on the mechanism by which TDRD3 - a protein that 'reads' epigenetic marks on chromosomal proteins - turns on certain genes. (mdanderson.org)
  • Several types of chemical modifications of the five major histone protein families give rise to a complex 'histone code' that signals the transcriptional machinery to turn genes on or off. (mdanderson.org)
  • The researchers studied the two proteins in breast cancer cell lines, where they discovered that TDRD3 recruits TOP3B to active chromatin (where genes are turned on) that is marked by arginine methylation. (mdanderson.org)
  • Deep RNA-DNA, RNA-protein interaction studies, and phenotype rescue analyses reveal that LETR1 is a nuclear trans-acting lncRNA modulating, via key epigenetic factors, the expression of essential target genes, including KLF4 and SEMA3C , governing the growth and migratory ability of LECs. (nature.com)
  • Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
  • Wnts are a family of genes that have been implicated in many human tumours, so far mainly studied in colorectal cancer where activated Wnt signalling occurs in a vast majority of tumours. (lu.se)
  • In this work we studied the relative contribution of the retinoblastoma family members to the regulation of Sox2 expression. (oncotarget.com)
  • Given the complexity of human transcriptional regulation in vivo and the multitude of potential epigenetic mechanisms cooperating to regulate transcriptional activity, questions remain about the interplay of regulatory mechanisms in patients with CMML. (nature.com)
  • The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. (nih.gov)
  • Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
  • Epigenetic regulation refers to the multiple chemical modifications of DNA or DNA-associated proteins that alter chromatin structure and DNA accessibility in a heritable manner, without changing DNA sequence. (frontiersin.org)
  • To date, most of our understanding of epigenetic regulation and its participation in leukemogenesis is based on the enzymatic activities and protein-protein interactions of histone and DNA modifiers. (frontiersin.org)
  • Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)
  • Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress. (lu.se)
  • Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
  • The encoded protein acts as a transcriptional activator. (novusbio.com)
  • 1. The Stoffers laboratory recently identified the polyC binding protein (PCBP) family of RBPs as important players in the post-transcriptional regulatory landscape of pancreatic beta cells. (upenn.edu)
  • Therefore, this complex regulatory network requires precise control of gene expression patterns at both transcriptional and post-transcriptional levels in order to ensure proper maturation, differentiation, and formation of blood and lymphatic vessels. (nature.com)
  • The HES7 protein also represses expression of Lunatic Fringe (LFNG) thereby both directly and indirectly regulating the Notch signalling pathway. (wikipedia.org)
  • By self-regulating and regulating the Lfng protein, HES7 both directly and indirectly alters expression in the Notch signalling pathway. (wikipedia.org)
  • Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. (jax.org)
  • We use genomic and proteomic approaches integrated with genetic mouse models and primary human islet investigations to define the partners of PDX1 and its downstream transcriptional targets. (upenn.edu)
  • HAM and WUS share common targets in vivo and their physical interaction is important in driving downstream transcriptional programs and in promoting shoot stem cell proliferation. (caltech.edu)
  • We report the biochemical characterization, the tertiary structure determined by solution nuclear magnetic resonance (NMR) methods and the putative function of the previously uncharacterized protein HP0222 (JHP0208) from H. pylori. (wustl.edu)
  • HES7 also negatively regulates Lunatic Fringe protein (Lfng). (wikipedia.org)
  • We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
  • Our current efforts on this project are directed at (1) determining the mechanisms whereby Pdx1 and Oc1 cooperate to establish a chromatin landscape permissive for endocrine differentiation and proliferation, (2) Defining the roles of the Pdx1 and Oc1 IDPRs in protein-protein interaction and endocrine differentiation, and (3) Defining the molecular mechanisms by which the Pdx1 C-terminal domain regulates protein stability and function during pancreas organogenesis and endocrine differentiation. (upenn.edu)
  • Chemical modification of these histones is one way that the cell regulates the packing and unpacking of the DNA and its associated proteins (collectively called chromatin), which in turn helps to determine whether a given gene is activated or repressed. (mdanderson.org)
  • The HES7 transcription factor belongs to the Hairy and Enhancer of split families of bHLH transcription factors. (wikipedia.org)
  • The gene product is a transcription factor protein. (wikipedia.org)
  • 40535) Transcription factor TFIIB cyclin-related protein CP001857 CDS Arcpr_0047 complement(40887. (go.jp)
  • TCF1 is the first identified member of the T-cell-specific transcription factor family. (biolegend.com)
  • This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. (novusbio.com)
  • The homeodomain transcription factor Pdx1 is a critical member of the beta cell transcriptional network during embryonic beta cell formation and in postnatal beta cell function. (upenn.edu)
  • It has shown that miR-429 could inhibit the development of colorectal cancer via targeting in large tumor suppressor kinase (LATS2), and decreased miR-429 could promote the expression of SRY-box transcription factor 2 (SOX2) and B-cell lymphoma 2 (BCL2) to attenuate the neuronal injury induced by accumulation of amyloid β -protein [ 12 ]. (hindawi.com)
  • Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (antibodies-online.com)
  • Different dimer combinations act as transcriptional activators or repressors, respectively. (abcam.com)
  • However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
  • NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. (hmdb.ca)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Furthermore, EPO-induced neuroprotection as well as phosphorylation of the proapoptotic Bcl family member Bad was reduced by the phosphoinositide-3 kinase (PI3K) inhibitor LY294002. (jneurosci.org)
  • Our previous report showed that FO inhibits HCC cell invasion via AKT-, mitogen-activated protein kinase- (MAPK-), and EMT-related signals [ 7 ]. (hindawi.com)
  • Bruton's tyrosine kinase (Btk) is a member of the Tec family of kinases. (medscape.com)
  • Its activation is tightly controlled by numerous other signaling proteins including protein kinase C (PKC), Sab/SH3BP, and caveolin-1. (medscape.com)
  • The expression of Wnt-5a protein co-variates with that of Syk, a tyrosine kinase that is lost in up to 30% of invasive breast carcinomas and associated with poor prognosis. (lu.se)
  • The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (cancerindex.org)
  • The protein encoded by this gene has sequence homology to members of the histone deacetylase family. (caslab.com)
  • DNA is tightly packaged into chromosomes along with histone proteins. (mdanderson.org)
  • A few years ago the lab identified TDRD3, a protein that 'reads' methyl-arginine marks on histone tails. (mdanderson.org)
  • A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. (bvsalud.org)
  • Both the human and the mouse protein have been shown to contain 225 amino acids and feature an orange domain as well as a conserved sequence of four amino acids at the C-terminal end. (wikipedia.org)
  • This conserved sequence of four amino acids binds Groucho/TLE family members. (wikipedia.org)
  • The human EGR-1 protein contains (in its unprocessed form) 543 amino acids with a molecular weight of 57.5 kDa , and the gene is located on the chromosome 5 . (wikipedia.org)
  • The Bedford lab studies one such modification, the methylation of arginine amino acids in histones and other chromatin-associated proteins. (mdanderson.org)
  • AML has a characteristic dependency on chromatin and transcriptional regulators, which has been discussed in many reviews. (frontiersin.org)
  • 3. We hypothesize that PDX1-Onecut1 (OC1) interactions, in part mediated by their intrinsically disordered protein regions (IDPRs), regulate Pdx1 stability, cell cycle progression, and pancreatic endocrine differentiation during development. (upenn.edu)
  • This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. (caslab.com)
  • It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. (antikoerper-online.de)
  • The authors set out to find clues to TDRD3's function by looking for physical interactions between TDRD3 and other proteins in the cell. (mdanderson.org)
  • Here we demonstrate that the Arabidopsis HAIRY MERISTEM (HAM) family of transcription regulators act as conserved interacting cofactors with WUS/WOX proteins. (caltech.edu)
  • Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
  • J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. (jax.org)
  • Deduced protein sequence of PSY1 or PSY2 between species has higher homology than between PSY1 and PSY2 within species. (usda.gov)
  • Find USP14 Proteins for a variety of species such as anti-Human USP14, anti-C. elegans USP14, anti-Chimpanzee USP14. (antibodies-online.com)
  • EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene . (wikipedia.org)
  • Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)
  • Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)
  • In addition to its function in thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3. (biolegend.com)
  • The transcriptional networks critical for the proper development, differentiation, and expansion of beta cells, work through islet enhancers, super enhancers and active promoters that form 3- dimensional hubs. (upenn.edu)
  • WUS/WOX family proteins are evolutionarily and functionally conserved throughout the plant kingdom and emerge as key actors in the specification and maintenance of stem cells within all meristems. (caltech.edu)
  • In this study, we developed a robust dual-fluorescent reporter assay to detect drugs repressing the transcription of survivin, a cancer biomarker from the inhibitor of apoptosis family, in breast cancer cells cultured in three-dimensional (3D) microbioreactors. (bvsalud.org)
  • Breast cancer MCF-7 cells were engineered to express enhanced green fluorescent protein driven by a survivin promoter and red fluorescent protein driven by a cytomegalovirus promoter as internal control to detect changes in survivin expression in cells as affected by drugs. (bvsalud.org)
  • [ 17 , 18 ] TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and in primary adipocyte stem cells. (medscape.com)
  • Thus, enhanced extracellular matrix or beta-glucan synthesis during biofilm growth might prevent antifungals, such as azoles and polyenes, from reaching biofilm cells, thus limiting their toxicity to these cells and the associated transcriptional responses. (who.int)
  • Aquaporin-9 Protein Is the Primary Route of Hepatocyte Glycerol Uptake for Glycerol Gluconeogenesis in Mice. (lu.se)
  • To date, only 16 protein structures from, this organism have been determined, and more than 30% of its 1500 protein functions remain unknown. (wustl.edu)
  • Steroid receptor family members share significant homology at their DNA and ligand-binding domains. (nih.gov)
  • Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
  • Forms a homodimer or a heterodimer with a related family member (at least STAT1). (lu.se)
  • ZNF398 (NP_065832.1, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. (novusbio.com)
  • Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. (novusbio.com)
  • NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. (abcam.com)
  • NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. (hmdb.ca)
  • Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
  • Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
  • Transcriptional co-regulators that interact with the AR may have a role in defining AR activity and may be involved in directing AR-specific responses. (nih.gov)
  • SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
  • We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. (who.int)
  • The AR is part of a large family of steroid receptors that also includes the glucocorticoid, progesterone, and mineralocorticoid receptors. (nih.gov)
  • Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)
  • HES7) or bHLHb37 is protein coding mammalian gene found on chromosome 17 in humans. (wikipedia.org)
  • NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. (hmdb.ca)
  • There is ample evidence that distinct types of vasculature undergo tight transcriptional control to preserve their structure, identity, and functions. (nature.com)
  • 9766 conserved hypothetical protein CP001857 CDS Arcpr_0009 complement(9767. (go.jp)
  • 10378) hypothetical protein CP001857 CDS Arcpr_0010 complement(10422. (go.jp)
  • 13428) hypothetical protein CP001857 CDS Arcpr_0013 complement(13425. (go.jp)
  • 13751) hypothetical protein CP001857 CDS Arcpr_0014 complement(13789. (go.jp)
  • 19702 hypothetical protein CP001857 CDS Arcpr_0022 complement(19723. (go.jp)
  • 21298 hypothetical protein CP001857 CDS Arcpr_0025 complement(21287. (go.jp)
  • 23242 hypothetical protein CP001857 CDS Arcpr_0028 23232. (go.jp)
  • 29158) hypothetical protein CP001857 CDS Arcpr_0035 complement(29143. (go.jp)
  • 29526) hypothetical protein CP001857 CDS Arcpr_0036 29596. (go.jp)
  • 36678) hypothetical protein CP001857 CDS Arcpr_0042 complement(36769. (go.jp)
  • 42520) hypothetical protein CP001857 tRNA Arcpr_R0002 complement(42639. (go.jp)
  • 43572) hypothetical protein CP001857 CDS Arcpr_0052 43655. (go.jp)
  • 47353) hypothetical protein CP001857 CDS Arcpr_0058 complement(47350. (go.jp)
  • 52977 conserved hypothetical protein CP001857 CDS Arcpr_0062 complement(52960. (go.jp)
  • 53727) hypothetical protein CP001857 CDS Arcpr_0063 complement(53793. (go.jp)
  • EGR-1 has also been found to regulate the expression of VAMP2 (a protein important for synaptic exocytosis ). (wikipedia.org)
  • MiRNAs are characterized by binding the 3 - UTR of special mRNA to regulate the expression of the related proteins [ 10 , 11 ]. (hindawi.com)
  • Whereas the oncogenic Wnt-1 is the main Wnt protein investigated in breast cancer, very little work has been focused on Wnt-5a, a protein supposedly antagonizing the oncogenic effects of Wnt-1. (lu.se)
  • HES7 is a member of the Hairy and Enhancer of Split families of Basic helix-loop-helix proteins. (wikipedia.org)
  • Interacts with HCV core protein. (lu.se)
  • RT-PCR analysis indicated that PSY-B has a different transcriptional behavior from PSY-A, similar to tomato PSY2. (usda.gov)
  • This protein is the full-length p52 subunit and partial p100 subunit. (abcam.com)
  • This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
  • 20759) Protein of unknown function DUF54 CP001857 CDS Arcpr_0024 20798. (go.jp)
  • 43228) protein of unknown function UPF0153 CP001857 CDS Arcpr_0051 complement(43225. (go.jp)
  • 44065 protein of unknown function UPF0047 CP001857 CDS Arcpr_0053 complement(44048. (go.jp)
  • 45260 protein of unknown function DUF121 CP001857 CDS Arcpr_0055 complement(45235. (go.jp)
  • They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. (bvsalud.org)